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Keywords = seroimmunotype

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19 pages, 2447 KB  
Article
Administration Routes and Doses of the Attenuated African Swine Fever Virus Strain PSA-1NH Influence Cross-Protection of Pigs against Heterologous Challenge
by Mikhail Vlasov, Irina Sindryakova, Dmitriy Kudryashov, Sergey Morgunov, Olga Kolbasova, Valentina Lyska, Sergey Zhivoderov, Elena Pivova, Vladimir Balyshev, Sanzhi Namsrayn, Timofey Sevskikh, Alexey Sereda and Denis Kolbasov
Animals 2024, 14(9), 1277; https://doi.org/10.3390/ani14091277 - 24 Apr 2024
Cited by 7 | Viewed by 1969
Abstract
African swine fever (ASF) is a lethal hemorrhagic disease of Suidae, i.e., domestic pigs and wild boars, caused by African swine fever virus (ASFV). The development of cross-protective vaccines against ASF is imperative for effective disease control, particularly in regions where ASF [...] Read more.
African swine fever (ASF) is a lethal hemorrhagic disease of Suidae, i.e., domestic pigs and wild boars, caused by African swine fever virus (ASFV). The development of cross-protective vaccines against ASF is imperative for effective disease control, particularly in regions where ASF is endemic, potentially featuring multiple circulating ASFV isolates. The investigation of non-hemadsorbing naturally attenuated isolates and laboratory recombinant strains with a deletion in the EP402R gene has attracted interest. Our study aimed to assess the impacts of various administration routes and doses of the naturally attenuated ASFV-PSA-1NH (immunotype IV, genotype I) isolate on the manifestation of clinical signs of ASF and the level of protection against the heterologous ASFV-Stavropol 01/08 strain (seroimmunotype VIII, genotype II). The results demonstrated that the intranasal administration of a low dose of ASFV-PSA-1NH to pigs minimized the clinical signs of ASF and established a high level of protection against the heterologous strain ASFV-Stavropol 01/08. Despite the challenges in standardizing the dosage for intranasal administration, this approach appears as a viable alternative in ASF vaccination. Full article
(This article belongs to the Section Veterinary Clinical Studies)
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13 pages, 1831 KB  
Article
Subsequent Immunization of Pigs with African Swine Fever Virus (ASFV) Seroimmunotype IV Vaccine Strain FK-32/135 and by Recombinant Plasmid DNA Containing the CD2v Derived from MK-200 ASFV Seroimmunotype III Strain Does Not Protect from Challenge with ASFV Seroimmunotype III
by Alexey D. Sereda, Anna S. Kazakova, Sanzhi G. Namsrayn, Mikhail E. Vlasov, Irina P. Sindryakova and Denis V. Kolbasov
Vaccines 2023, 11(5), 1007; https://doi.org/10.3390/vaccines11051007 - 21 May 2023
Cited by 5 | Viewed by 3087
Abstract
Understanding the immunological mechanisms of protection and the viral proteins involved in the induction of a protective immune response to the African swine fever virus (ASFV) is still limited. In the last years, the CD2v protein (gp110-140) of the ASFV has been proven [...] Read more.
Understanding the immunological mechanisms of protection and the viral proteins involved in the induction of a protective immune response to the African swine fever virus (ASFV) is still limited. In the last years, the CD2v protein (gp110-140) of the ASFV has been proven to be a serotype-specific protein. Current work is devoted to the investigation of the possibility of creating protection against virulent ASFV strain Mozambique-78 (seroimmunotype III) in pigs previously vaccinated with vaccine strain FK-32/135 (seroimmunotype IV) and then immunized with the pUBB76A_CD2v plasmid, containing a chimeric nucleotide sequence from the CD2v protein gene (EP402R, nucleotides from 49 to 651) from the MK-200 strain (seroimmunotype III). Vaccination with the ASFV vaccine strain FK-32/135 protects pigs from the disease caused by the strain with homologous seroimmunotype—France-32 (seroimmunotype IV). Our attempt to create balanced protection against virulent strain Mozambique-78 (seroimmunotype III) by induction of both humoral factors of immunity (by vaccination with strain FK-32/135 of seroimmunotype IV) and serotype-specific cellular immunity (by immunization with the plasmid pUBB76A_CD2v of seroimmunotype III) was unsuccessful. Full article
(This article belongs to the Special Issue African Swine Fever Virus (ASFV): Immunity and Vaccine Development)
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15 pages, 5432 KB  
Article
Inoculation with ASFV-Katanga-350 Partially Protects Pigs from Death during Subsequent Infection with Heterologous Type ASFV-Stavropol 01/08
by Mikhail E. Vlasov, Irina P. Sindryakova, Dmitry A. Kudrjashov, Sergey Y. Morgunov, Olga L. Kolbasova, Valentina M. Lyska, Sergey P. Zhivoderov, Elena Y. Pivova, Vladimir M. Balyshev, Alexey D. Sereda and Denis V. Kolbasov
Viruses 2023, 15(2), 430; https://doi.org/10.3390/v15020430 - 3 Feb 2023
Cited by 7 | Viewed by 2060
Abstract
African swine fever virus (ASFV) is an extremely genetically and phenotypically heterogeneous pathogen. Previously, we have demonstrated that experimental inoculation of pigs with an attenuated strain, Katanga-350 (genotype I, seroimmunotype I) (ASFV-Katanga-350), can induce protective immunity in 80% of European domestic pigs against [...] Read more.
African swine fever virus (ASFV) is an extremely genetically and phenotypically heterogeneous pathogen. Previously, we have demonstrated that experimental inoculation of pigs with an attenuated strain, Katanga-350 (genotype I, seroimmunotype I) (ASFV-Katanga-350), can induce protective immunity in 80% of European domestic pigs against the homologous virulent European strain Lisbon-57. At least 50% of the surviving pigs received protection from subsequent intramuscular infection with a heterologous virulent strain, Stavropol 01/08 (genotype II, seroimmunotype VIII) (ASFV-Stavropol 01/08). In this study, we assessed clinical signs, the levels of viremia, viral DNA, anti-ASFV antibodies and post-mortem changes caused by subsequent intramuscular injection with ASFV-Katanga-350 and heterologous ASFV-Stavropol 01/08. Inoculation of pigs with the ASFV-Katanga-350 did not protect animals from the disease in the case of the subsequent challenged ASFV-Stavropol 01/08. However, 40% of pigs were protected from death. Moreover, the surviving animals showed no pathomorphological changes or the presence of an infectious virus in the organs after euthanasia at 35 days post challenging. The ability/inability of attenuated strains to form a certain level of protection against heterologous isolates needs a theoretical background and experimental confirmation. Full article
(This article belongs to the Special Issue African Swine Fever Virus: Infection and Immunity)
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19 pages, 3663 KB  
Article
Immunobiological Characteristics of the Attenuated African Swine Fever Virus Strain Katanga-350
by Alexey D. Sereda, Mikhail E. Vlasov, Galina S. Koltsova, Sergey Y. Morgunov, Dmitry A. Kudrjashov, Irina P. Sindryakova, Olga L. Kolbasova, Valentina M. Lyska, Andrei Y. Koltsov, Sergey P. Zhivoderov, Elena Y. Pivova, Vladimir M. Baluishev, Andrey E. Gogin and Denis V. Kolbasov
Viruses 2022, 14(8), 1630; https://doi.org/10.3390/v14081630 - 26 Jul 2022
Cited by 8 | Viewed by 2540
Abstract
The African swine fever virus (ASFV) is the cause of a recent pandemic that is threatening the global pig industry. The virus infects domestic and wild pigs and manifests with a variety of clinical symptoms, depending on the strain. No commercial vaccine is [...] Read more.
The African swine fever virus (ASFV) is the cause of a recent pandemic that is threatening the global pig industry. The virus infects domestic and wild pigs and manifests with a variety of clinical symptoms, depending on the strain. No commercial vaccine is currently available to protect animals from this virus, but some attenuated and recombinant live vaccine candidates might be effective against the disease. This article describes the immunobiological characteristics of one such candidate—the laboratory-attenuated ASFV strain, Katanga-350—which belongs to genotype I. In this study, we assessed clinical signs and post-mortem changes, the levels of viremia and the presence of viral DNA caused by injection of ASF virus strains Katanga-350, Lisbon-57, and Stavropol 08/01. Intramuscular injection of this strain protected 80% of pigs from a virulent strain of the same genotype and seroimmunotype (Lisbon-57). At least 50% of the surviving pigs received protection from subsequent intramuscular infection with a heterologous (genotype II, seroimmunotype VIII) virulent strain (Stavropol 08/01). Virus-specific antibodies were detectable in serum and saliva samples between 8–78 days after the first inoculation of the Katanga-350 strain (the observational period). The results suggested that this strain could serve as a basis for the development of a recombinant vaccine against ASF viruses belonging to seroimmunotype I. Full article
(This article belongs to the Special Issue African Swine Fever Virus: Infection and Immunity)
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12 pages, 257 KB  
Review
Protective Properties of Attenuated Strains of African Swine Fever Virus Belonging to Seroimmunotypes I–VIII
by Alexey D. Sereda, Vladimir M. Balyshev, Anna S. Kazakova, Almaz R. Imatdinov and Denis V. Kolbasov
Pathogens 2020, 9(4), 274; https://doi.org/10.3390/pathogens9040274 - 9 Apr 2020
Cited by 55 | Viewed by 4859
Abstract
This article summarizes the study results on the generation of attenuated strains of African swine fever virus (ASFV) of seroimmunotypes I–VIII and the creation of live vaccines for temporary protection of pigs during a period of epizootics in the surveillance zone (a zone [...] Read more.
This article summarizes the study results on the generation of attenuated strains of African swine fever virus (ASFV) of seroimmunotypes I–VIII and the creation of live vaccines for temporary protection of pigs during a period of epizootics in the surveillance zone (a zone adjacent to the area of outbreak). These studies were initiated at the Federal Research Center for Virology and Microbiology (FRCVM, formerly VNIIVViM) at the time of introduction of the pathogen to the Iberian Peninsula in the middle of the 20th century. The developed experimental vaccines against ASFV seroimmunotypes I–V provided protection against virulent strains of homologous seroimmunotypes by day 14 after vaccination, lasting at least four months. Full article
(This article belongs to the Special Issue African Swine Fever Virus Infection)
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