Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (61)

Search Parameters:
Keywords = screening and treatment skills

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
21 pages, 2460 KiB  
Article
Enhancing Competencies and Professional Upskilling of Mobile Healthcare Unit Personnel at the Hellenic National Public Health Organization
by Marios Spanakis, Maria Stamou, Sofia Boultadaki, Elias Liantis, Christos Lionis, Georgios Marinos, Anargiros Mariolis, Andreas M. Matthaiou, Constantinos Mihas, Varvara Mouchtouri, Evangelia Nena, Efstathios A. Skliros, Emmanouil Smyrnakis, Athina Tatsioni, Georgios Dellis, Christos Hadjichristodoulou and Emmanouil K. Symvoulakis
Healthcare 2025, 13(14), 1706; https://doi.org/10.3390/healthcare13141706 - 15 Jul 2025
Viewed by 519
Abstract
Background/Objectives: Mobile healthcare units (MHUs) comprise flexible, ambulatory healthcare teams that deliver community care services, particularly in underserved or remote areas. In Greece, MHUs were pivotal in epidemiological surveillance during the COVID-19 pandemic and are now evolving into a sustainable and integrated service [...] Read more.
Background/Objectives: Mobile healthcare units (MHUs) comprise flexible, ambulatory healthcare teams that deliver community care services, particularly in underserved or remote areas. In Greece, MHUs were pivotal in epidemiological surveillance during the COVID-19 pandemic and are now evolving into a sustainable and integrated service for much-needed community-based healthcare. To support this expanded role, targeted, competency-based training is essential; however, this can pose challenges, especially in coordinating synchronous learning across geographically dispersed teams and in ensuring engagement using an online format. Methods: A nationwide, online training program was developed to improve the knowledge of the personnel members of the Hellenic National Public Health Organization’s MHUs. This program was structured focusing on four core themes: (i) prevention–health promotion; (ii) provision of care; (iii) social welfare and solidarity initiatives; and (iv) digital health skill enhancement. The program was implemented by the University of Crete’s Center for Training and Lifelong Learning from 16 January to 24 February 2025. A multidisciplinary team of 64 experts delivered 250 h of live and on-demand educational content, including health screenings, vaccination protocols, biomarker monitoring, chronic disease management, treatment adherence, organ donation awareness, counseling on social violence, and eHealth applications. Knowledge acquisition was assessed through a pre- and post-training multiple-choice test related to the core themes. Trainees’ and trainers’ qualitative feedback was evaluated using a 0–10 numerical rating scale (Likert-type). Results: A total of 873 MHU members participated in the study, including both healthcare professionals and administrative staff. The attendance rate was consistently above 90% on a daily basis. The average assessment score increased from 52.8% (pre-training) to 69.8% (post-training), indicating 17% knowledge acquisition. The paired t-test analysis demonstrated that this improvement was statistically significant (t = −8.52, p < 0.001), confirming the program’s effectiveness in enhancing knowledge. As part of the evaluation of qualitative feedback, the program was positively evaluated, with 75–80% of trainees rating key components such as content, structure, and trainer effectiveness as “Very Good” or “Excellent.” In addition, using a 0–10 scale, trainers rated the program relative to organization (9.4/10), content (8.8), and trainee engagement (8.9), confirming the program’s strength and scalability in primary care education. Conclusions: This initiative highlights the effectiveness of a structured, online training program in enhancing MHU knowledge, ensuring standardized, high-quality education that supports current primary healthcare needs. Future studies evaluating whether the increase in knowledge acquisition may also result in an improvement in the personnel’s competencies, and clinical practice will further contribute to assessing whether additional training programs may be helpful. Full article
Show Figures

Figure 1

17 pages, 602 KiB  
Systematic Review
Addressing the Shortage of GLP-1 RA and Dual GIP/GLP-1 RA-Based Therapies—A Systematic Review
by Velimir Altabas, Zrinka Orlović and Maja Baretić
Diabetology 2025, 6(6), 52; https://doi.org/10.3390/diabetology6060052 - 5 Jun 2025
Viewed by 2310
Abstract
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual glucose-dependent insulinotropic peptide/glucagon-like peptide-1 receptor agonists (GIP/GLP-1 RAs) have transformed disease management, particularly in diabetes and obesity. However, recent shortages have disrupted patient care. This review explores the current evidence regarding their direct impact [...] Read more.
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual glucose-dependent insulinotropic peptide/glucagon-like peptide-1 receptor agonists (GIP/GLP-1 RAs) have transformed disease management, particularly in diabetes and obesity. However, recent shortages have disrupted patient care. This review explores the current evidence regarding their direct impact on patient populations and reviews the mitigation strategies recommended by relevant health organizations. Materials and Methods: We systematically searched PubMed, Scopus, and Web of Science for studies published from the earliest available data to 10 January 2025, using these terms: “GLP-1 AND shortage”, “liraglutide AND shortage”, “dulaglutide AND shortage”, “semaglutide AND shortage”, “exenatide AND shortage”, and “tirzepatide AND shortage”. Eligible studies needed to report measurable outcomes like prescription counts, specific laboratory findings, or the proportion of a study population achieving a defined outcome related to the shortage. Only English-language clinical research was considered, while other manuscripts were not included. The risk of bias was assessed using the Critical Appraisal Skills Programme checklist. Study characteristics and findings were summarized in tables. Results: Out of 295 identified manuscripts, 85 works were retained for further screening. Consequently, 8 studies met the inclusion criteria, covering 1036 participants with type 2 diabetes and 573 treated for obesity. In addition, two studies reported prescription prevalence, and one examined prescription counts. Key findings included reduced prescription rates and shifts in treatment practices. No studies assessed impacts on cardiovascular, renal outcomes, or mortality. Discussion and Conclusions: Evidence on the health effects of these shortages is limited. Existing studies highlight disruptions in diabetes and obesity care, but broader impacts remain unclear. Preventing future shortages requires coordinated efforts among all stakeholders. Therefore, we advocate for ethical planning, sustainable production, and fair distribution strategies to mitigate long-term consequences. Full article
Show Figures

Figure 1

34 pages, 1208 KiB  
Review
Barriers and Nursing Strategies in Oncology Care for LGBTQIA+ People: A Scoping Review
by Gianluca Azzellino, Ernesto Aitella, Lia Ginaldi and Massimo De Martinis
Cancers 2025, 17(7), 1146; https://doi.org/10.3390/cancers17071146 - 28 Mar 2025
Cited by 1 | Viewed by 1065
Abstract
LGBTQIA+ individuals with cancer face significant challenges in their interactions with nurses, which can negatively affect the quality of care, treatment adherence, and access to healthcare. Barriers such as implicit biases, discrimination, and inadequate communication skills contribute to these disparities, alongside a lack [...] Read more.
LGBTQIA+ individuals with cancer face significant challenges in their interactions with nurses, which can negatively affect the quality of care, treatment adherence, and access to healthcare. Barriers such as implicit biases, discrimination, and inadequate communication skills contribute to these disparities, alongside a lack of nursing education on gender and sexual diversity. Despite the recognized role of nurses in reducing health inequalities, knowledge about effective strategies to overcome these barriers remains fragmented. This scoping review aims to identify and categorize the main barriers affecting the nurse–patient relationship in oncology and to explore evidence-based nursing interventions that promote equitable and inclusive care. A systematic literature search was conducted between January and February 2025 in PUBMED, SCOPUS, and Web of Science, including studies published in the last 10 years. Study management was performed using Zotero (version 6.0.30), and quality assessment was conducted with the JBI Critical Appraisal Tools. Two independent reviewers screened the studies, resolving discrepancies through discussion and consensus. This review follows the PRISMA-ScR checklist and the JBI scoping review methodology. The findings will provide insights into the primary barriers, highlight effective nursing interventions, and identify gaps in education and clinical guidelines, contributing to the development of more inclusive oncology care practices. Full article
(This article belongs to the Special Issue Impact of Social Determinants on Cancer Care)
Show Figures

Figure 1

11 pages, 542 KiB  
Review
Auditory Processing Disorders: Navigating the Diagnostic Maze of Central Hearing Losses
by Marco Gitto, Noemi Motta, Mirko Aldè, Diego Zanetti and Federica Di Berardino
J. Clin. Med. 2025, 14(7), 2256; https://doi.org/10.3390/jcm14072256 - 26 Mar 2025
Viewed by 1341
Abstract
Background: Auditory Processing Disorder (APD) manifests as impaired auditory information processing despite normal peripheral hearing. Current clinical protocols lack standardization, hampering evidence-based intervention development. Objective: This review analyzes APD research developments from 2011 to 2025, examining diagnostic criteria, assessment protocols, and treatment effectiveness. [...] Read more.
Background: Auditory Processing Disorder (APD) manifests as impaired auditory information processing despite normal peripheral hearing. Current clinical protocols lack standardization, hampering evidence-based intervention development. Objective: This review analyzes APD research developments from 2011 to 2025, examining diagnostic criteria, assessment protocols, and treatment effectiveness. Methods: Medline, Embase, Scopus, and Cochrane Library databases were analyzed (January 2011–January 2025), following PRISMA guidelines. Two reviewers independently screened 413 articles, with 156 meeting inclusion criteria. Analysis included chi-square tests for intervention distribution and t-tests for diagnostic comparisons (α = 0.05). Results: Among 156 studies analyzed, medical interventions were markedly underrepresented (n = 4) compared to rehabilitative approaches (n = 52; χ2 = 50.28, p < 0.001). The Random Gap Detection Test and Dichotic Digits Difference Test were most frequently used (12.86% and 10.48% of studies, respectively). Cognitive skill enhancement dominated intervention strategies (52.8%), followed by computer-based rehabilitation (26.4%). Publication frequency showed consistent annual growth, peaking at 57 studies in 2024. Sample sizes were comparable between APD and CAPD studies (mean difference = 4.2 cases, t = 0.416, p = 0.679). Environmental modifications appeared in 15.1% of interventions, while speech therapy was reported in only 3.8% of studies. Conclusions: The substantial imbalance between medical and rehabilitative interventions necessitates standardized diagnostic protocols and enhanced multidisciplinary collaboration. Implementation of a hierarchical processing framework is recommended for assessment and treatment. Future research should prioritize large-scale controlled trials and unified diagnostic criteria development. Full article
(This article belongs to the Section Otolaryngology)
Show Figures

Figure 1

15 pages, 1481 KiB  
Article
Personal Quality of Life as an Outcome Measure of Antipsychotic Drug Management of Problem Behaviours in Adults with Intellectual Developmental Disorders with or Without Autism Spectrum Disorder
by Marco O. Bertelli, Annamaria Bianco, Micaela Piva Merli, Maria Stella Vescio, Michele Rossi and Elisabetta F. Buonaguro
Brain Sci. 2025, 15(3), 316; https://doi.org/10.3390/brainsci15030316 - 18 Mar 2025
Viewed by 639
Abstract
Background/Objectives: First-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) are frequently prescribed for the management of problem behaviours (PBs) in people with intellectual developmental disorders (IDDs) with or without autism spectrum disorder (ASD). However, the different effectiveness of these two groups of drugs has [...] Read more.
Background/Objectives: First-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) are frequently prescribed for the management of problem behaviours (PBs) in people with intellectual developmental disorders (IDDs) with or without autism spectrum disorder (ASD). However, the different effectiveness of these two groups of drugs has not been adequately investigated, especially in terms of person-centred outcomes, such as quality of life (QoL). The aim of the present observational study was to compare the personal QoL of two groups of people with IDDs with and without ASD, attending the same residential facility, but receiving FGAs and SGAs, respectively, for the management of PBs. Methods: Twenty-two people with IDDs (ten with ASD) receiving FGAs and twenty-three (eleven with ASD) receiving SGAs for the management of PBs were consecutively recruited. The participants underwent a complex clinical and instrumental evaluation, including the systematic psychopathological assessment for persons with intellectual and developmental disabilities—general screening (SPAIDD-G), the Wing’s handicaps, behaviours, and skills schedule (HBS), the DOTES, and the BASIQ (QoL Assessment tool battery). Follow-up evaluations were carried out after 6, 12, and 18 months. Results: The use of antipsychotics was withdrawn only in 16 cases, of which only 4 were for significant improvement. Treatment with FGAs was associated with more frequent discontinuation, a higher incidence of side effects, and a trend toward a lower efficacy on PBs than treatment with SGAs. FGAs also improved generic QoL significantly less than SGAs. Conclusions: The present pilot study is the first to compare FGAs and SGAs with respect to the generic QoL in people with IDDs and PBs. SGAs resulted to have a significantly greater positive impact on QoL than FGAs, despite demonstrating similar efficacy in treating PBs. Full article
(This article belongs to the Section Neuropsychiatry)
Show Figures

Figure 1

24 pages, 950 KiB  
Systematic Review
Interventions Addressing Health Literacy in Cancer Care: A Systematic Review of Reviews
by Celine Jeitani, Stephan Van den Broucke and Charlotte Leemans
Int. J. Environ. Res. Public Health 2025, 22(2), 212; https://doi.org/10.3390/ijerph22020212 - 2 Feb 2025
Cited by 2 | Viewed by 1869
Abstract
(1) Background: Interventions addressing the health literacy (HL) of people suffering from an illness such as cancer can improve the understanding of the illness and lead to better-adapted behaviors, regarding the participation in cancer screenings, adhering to the complex multimodal therapy, participating in [...] Read more.
(1) Background: Interventions addressing the health literacy (HL) of people suffering from an illness such as cancer can improve the understanding of the illness and lead to better-adapted behaviors, regarding the participation in cancer screenings, adhering to the complex multimodal therapy, participating in cancer treatment, and self-managing everyday health. This study provides a review of systematic reviews that include intervention articles addressing the HL of patients, healthcare professionals, and/or organizations in cancer, to identify the factors related to their effectiveness, as well as the missing elements, in light of the recent developments in HL research and practice. (2) Methods: A literature search was performed in Embase, Pubmed, PsycINFO, and Science Direct. Existing published reviews of studies targeting the interventions in the oncology domain, and which explicitly mentioned HL as a factor/outcome, were included. (3) Results: One hundred and fifty-five studies were retrieved. Ten fit the criteria and were included in this review. (4) Conclusions: Most of the interventions addressing HL in people with cancer included the target patients’ information and communication skills through education. To keep the full scope of the concept, as investigated in the recent literature, clinical applications of HL in patients with cancer should also consider organizational HL. Full article
Show Figures

Figure 1

18 pages, 266 KiB  
Article
Clinical Competency in Managing Malnutrition–Sarcopenia Syndrome Among Physical Therapists: A Cross-Sectional Survey
by Roy Netzer, Netanel Levi, Kayla Ganchrow, Yfat Naan and Michal Elboim-Gabyzon
Nutrients 2025, 17(2), 281; https://doi.org/10.3390/nu17020281 - 14 Jan 2025
Viewed by 1266
Abstract
Background/objectives: Malnutrition and sarcopenia are interrelated health concerns among the elderly. Each condition is associated with increased mortality, morbidity, rehospitalization rates, longer hospital stays, higher healthcare costs, and reduced quality of life. Their combination leads to the development of “Malnutrition–Sarcopenia Syndrome” (MSS), characterized [...] Read more.
Background/objectives: Malnutrition and sarcopenia are interrelated health concerns among the elderly. Each condition is associated with increased mortality, morbidity, rehospitalization rates, longer hospital stays, higher healthcare costs, and reduced quality of life. Their combination leads to the development of “Malnutrition–Sarcopenia Syndrome” (MSS), characterized by reductions in body weight, muscle mass, strength, and physical function. Despite being preventable and reversible through nutritional and physical interventions, the clinical competence of physical therapists (PTs) in managing MSS remains underexplored. This study aims to assess the clinical competency of PTs in MSS management. Methods: An anonymous cross-sectional survey was conducted from January to August 2024 among 337 certified PTs in Israel, using the “Qualtrics” platform. The survey assessed prior familiarity with MSS concepts, MSS knowledge levels, screening and treatment skills, attitudes and beliefs toward MSS management, and interprofessional collaboration practices. Results: While 52% of PTs were familiar with MSS, familiarity with diagnostic guidelines was low (EWGSOP2: 3.6%; GLIM: 0.6%). The MSS knowledge score was moderate, but screening and treatment skills were low. Attitudes toward MSS management were moderately positive, but self-belief in diagnosing and treating MSS was low. Interprofessional collaboration was limited, particularly in malnutrition care. PTs familiar with MSS had higher knowledge, better skills, more positive attitudes and beliefs, and greater interprofessional collaboration. Conclusions: Significant gaps exist in the clinical competency of Israeli PTs in MSS management. Integrating MSS content into physical therapy curricula and providing continuing professional development are necessary to enhance competencies. Equipping PTs with essential tools, clarifying roles, and promoting interprofessional collaboration can optimize MSS management and improve patient outcomes. Full article
(This article belongs to the Special Issue Protein and Skeletal Muscle Metabolism)
15 pages, 641 KiB  
Article
Preoperative Home-Based Multimodal Physiotherapy in Patients Scheduled for a Knee Arthroplasty Who Catastrophize About Their Pain: A Randomized Controlled Trial
by Marc Terradas-Monllor, Hector Beltran-Alacreu, Mirari Ochandorena-Acha, Ester Garcia-Oltra, Francisco Aliaga-Orduña and José Hernández-Hermoso
J. Clin. Med. 2025, 14(1), 268; https://doi.org/10.3390/jcm14010268 - 5 Jan 2025
Cited by 2 | Viewed by 1729
Abstract
Background: Chronic pain affects about 20% of total knee arthroplasty (TKA) patients, with high pain catastrophizing being a key predictor. Screening and addressing this modifiable factor may improve postoperative outcomes. Objective: We aimed to compare the effectiveness of two preoperative home-based [...] Read more.
Background: Chronic pain affects about 20% of total knee arthroplasty (TKA) patients, with high pain catastrophizing being a key predictor. Screening and addressing this modifiable factor may improve postoperative outcomes. Objective: We aimed to compare the effectiveness of two preoperative home-based multimodal physical therapy interventions on pain catastrophizing in high-catastrophizing TKA patients. Secondarily, the study aimed to assess postoperative outcomes over six months. Methods: A total of 40 patients with symptomatic osteoarthritis and moderate pain catastrophizing were randomly allocated to the control, therapeutic patient education (TPE), and multimodal physiotherapy (MPT) groups. Preoperative interventions comprised pain neuroscience education, coping skills training, and therapeutic exercise, differing in the number of sessions and degree of supervision. All outcomes were assessed before and after the treatment in the preoperative period, and 1, 3, and 6 months post-surgery. The primary outcome measure was pain catastrophizing. Results: Both intervention groups showed a preoperative reduction in pain catastrophizing. TPE patients had lower pain ratings at rest and lower catastrophizing scores at 1 and 6 months post-surgery, reduced kinesiophobia and improved dynamic balance at 3 and 6 months post-surgery, and higher self-efficacy at 1 month post-surgery. MPT patients exhibited lower pain catastrophizing and pain intensity during walking at 1 month post-surgery, and better outcomes in kinesiophobia, self-efficacy, and dynamic balance at 1, 3, and 6 months post-surgery, along with higher walking speed at 6 months post-surgery. Conclusions: Preoperative physiotherapy reduces preoperative pain catastrophizing and improves postoperative pain-related outcomes, behaviors, and cognitions in high-catastrophizing TKA patients. Registration is with the United States Clinical Trials Registry (NCT03847324). Full article
(This article belongs to the Special Issue Knee Osteoarthritis: Clinical Updates and Perspectives)
Show Figures

Figure 1

20 pages, 3485 KiB  
Article
Evaluating a New Short Self-Management Tool in Heart Failure Against the Traditional Flinders Program
by Pupalan Iyngkaran, David Smith, Craig McLachlan, Malcolm Battersby, Maximilian de Courten and Fahad Hanna
J. Clin. Med. 2024, 13(22), 6994; https://doi.org/10.3390/jcm13226994 - 20 Nov 2024
Cited by 2 | Viewed by 1256
Abstract
Background/Objective: Heart failure (HF) is a complex syndrome, with multiple causes. Numerous pathophysiological pathways are activated. Comprehensive and guideline-derived care is complex. A multidisciplinary approach is required. The current guidelines report little evidence for chronic disease self-management (CDSM) programs for reducing readmission and [...] Read more.
Background/Objective: Heart failure (HF) is a complex syndrome, with multiple causes. Numerous pathophysiological pathways are activated. Comprehensive and guideline-derived care is complex. A multidisciplinary approach is required. The current guidelines report little evidence for chronic disease self-management (CDSM) programs for reducing readmission and major adverse cardiovascular events (MACE). CDSM programs can be complex and are not user-friendly in clinical settings, particularly for vulnerable patients. The aim of this study was to investigate whether a simplified one-page CDSM tool, the SCReening in Heart Failure (SCRinHF), is comparable to a comprehensive Flinders Program of Chronic Disease Management, specifically in triaging self-management capabilities and in predicting readmission and MACE. Methods:SELFMAN-HF is a prospective, observational study based on community cardiology. Eligible patients, consecutively recruited, had HF with left ventricular ejection fraction <40% and were placed on sodium–glucose co-transporter-2 inhibitors (SGLT2-i) within 3 months of recruitment. SGLT2-i is the newest of the four HF treatment pillars; self-management skills are assessed at this juncture. CDSM was assessed and scored independently via the long-form (LF) and short-form (SF) tools, and concordance between forms was estimated. The primary endpoint is the 80% concordance across the two CDSM scales for predicting hospital readmission and MACE. Results: Of the 117 patients, aged 66.8 years (±SD 13.5), 88 (75%) were male. The direct comparisons for SF versus LF patient scores are as follows: “good self-managers”, 13 vs. 30 patients (11.1% vs. 25.6%); “average”, 46 vs. 21 patients (39.3% vs. 17.9%), “borderline”, 20 vs. 31 patients (17.1% vs. 26.5%), and “poor self-managers” (vulnerable), 38 vs. 35 patients (32.5% vs. 29.9%). These findings underscore the possibility of SF tools in picking up patients whose scores infer poor self-management capabilities. This concordance of the SF with the LF scores for patients who have poor self-management capabilities (38 vs. 35 patients p = 0.01), alongside readmission (31/38 vs. 31/35 p = 0.01) or readmission risk for poor self-managers versus good self-managers (31/38 vs. 5/13 p = 0.01), validates the simplification of the CDSM tools for the vulnerable population with HF. Similarly, when concurrent and predictive validity was tested on 52 patients, the results were 39 (75%) for poor self-managers and 14 (27%) for good self-managers in both groups, who demonstrated significant correlations between SF and LF scores. Conclusions: Simplifying self-management scoring with an SF tool to improve clinical translation is justifiable, particularly for vulnerable populations. Poor self-management capabilities and readmission risk for poor self-managers can be significantly predicted, and trends for good self-managers are observed. However, correlations of SF to LF scores across an HF cohort for self-management abilities and MACE are more complex. Translation to patients of all skill levels requires further research. Full article
(This article belongs to the Special Issue Clinical Management of Patients with Heart Failure)
Show Figures

Figure 1

11 pages, 1236 KiB  
Article
Comparison between Motor Performance of People with Multiple Sclerosis during a Virtual Reality Task Practiced on Concrete and Abstract Devices: A Cross-Sectional Randomized Study
by Camila Miliani Capelini, Giulianna Mendes Ferrero, Ana Maria Canzonieri, Roger Pereira Silva, Mauricio Ossamu Bando, Renata Martins Rosa, Cintia Ramari Ferreira, Talita Dias da Silva, Alessandro Hervaldo Nicolai Ré, Marcelo Massa, Luciano Vieira de Araújo, Fernando Henrique Magalhães and Carlos Bandeira de Mello Monteiro
Brain Sci. 2024, 14(9), 916; https://doi.org/10.3390/brainsci14090916 - 12 Sep 2024
Viewed by 1162
Abstract
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system with unknown etiology, resulting in various impairments that necessitate continuous rehabilitation to enhance functionality, quality of life, and motor function, including through Virtual Reality (VR) therapy. Comparing tasks in virtual [...] Read more.
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system with unknown etiology, resulting in various impairments that necessitate continuous rehabilitation to enhance functionality, quality of life, and motor function, including through Virtual Reality (VR) therapy. Comparing tasks in virtual environments and their potential skill transfer to real-world settings could aid in optimizing treatment programs to improve motor performance in individuals with MS. This study aimed to determine whether practicing acquisition and retention phases using two distinct interfaces (concrete—Touch Screen or abstract—Kinect system) affects performance in a subsequent task using a different interface (transfer phase). A randomized clinical trial was conducted with 56 volunteers with MS and 41 controls. Participants engaged in a computer game where they burst as many bubbles as possible within 10 s per attempt. After the acquisition and retention phases, all participants switched interfaces (e.g., those using Kinect switched to Touchscreen and vice versa). Significant performance improvements were observed in both groups during the acquisition phase, which were maintained in the retention phase. Although the abstract interface was more challenging for both groups, only the MS group that practiced with the abstract interface successfully transferred their improvements to the concrete interface. Thus, despite the increased difficulty of the abstract task during practice, it led to better performance transfer when required to complete a subsequent concrete task, suggesting that abstract devices may be beneficial in clinical practice for improving motor function in people with MS. Full article
(This article belongs to the Special Issue The Biomarkers, Symptoms, and Treatment of Multiple Sclerosis)
Show Figures

Figure 1

36 pages, 384 KiB  
Systematic Review
Brain Neuroplasticity Leveraging Virtual Reality and Brain–Computer Interface Technologies
by Athanasios Drigas and Angeliki Sideraki
Sensors 2024, 24(17), 5725; https://doi.org/10.3390/s24175725 - 3 Sep 2024
Cited by 26 | Viewed by 21092
Abstract
This study explores neuroplasticity through the use of virtual reality (VR) and brain–computer interfaces (BCIs). Neuroplasticity is the brain’s ability to reorganize itself by forming new neural connections in response to learning, experience, and injury. VR offers a controlled environment to manipulate sensory [...] Read more.
This study explores neuroplasticity through the use of virtual reality (VR) and brain–computer interfaces (BCIs). Neuroplasticity is the brain’s ability to reorganize itself by forming new neural connections in response to learning, experience, and injury. VR offers a controlled environment to manipulate sensory inputs, while BCIs facilitate real-time monitoring and modulation of neural activity. By combining VR and BCI, researchers can stimulate specific brain regions, trigger neurochemical changes, and influence cognitive functions such as memory, perception, and motor skills. Key findings indicate that VR and BCI interventions are promising for rehabilitation therapies, treatment of phobias and anxiety disorders, and cognitive enhancement. Personalized VR experiences, adapted based on BCI feedback, enhance the efficacy of these interventions. This study underscores the potential for integrating VR and BCI technologies to understand and harness neuroplasticity for cognitive and therapeutic applications. The researchers utilized the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method to conduct a comprehensive and systematic review of the existing literature on neuroplasticity, VR, and BCI. This involved identifying relevant studies through database searches, screening for eligibility, and assessing the quality of the included studies. Data extraction focused on the effects of VR and BCI on neuroplasticity and cognitive functions. The PRISMA method ensured a rigorous and transparent approach to synthesizing evidence, allowing the researchers to draw robust conclusions about the potential of VR and BCI technologies in promoting neuroplasticity and cognitive enhancement. Full article
(This article belongs to the Special Issue Advances in Brain–Computer Interfaces and Sensors)
9 pages, 6167 KiB  
Communication
A Pressure Sensing Device to Assist in Colonoscopic Procedures to Prevent Perforation—A Case Study
by Se-Eun Kim, Young-jae Kang, Chang-ho Jung, Yongho Jeon, Yunho Jung and Moon Gu Lee
Sensors 2024, 24(17), 5711; https://doi.org/10.3390/s24175711 - 2 Sep 2024
Viewed by 1276
Abstract
Colonoscopy has a limited field of view because it relies solely on a small camera attached to the end of the scope and a screen displayed on a monitor. Consequently, the quality and safety of diagnosis and treatment depend on the experience and [...] Read more.
Colonoscopy has a limited field of view because it relies solely on a small camera attached to the end of the scope and a screen displayed on a monitor. Consequently, the quality and safety of diagnosis and treatment depend on the experience and skills of the gastroenterologist. When a novice attempts to insert the colonoscope during the procedure, excessive pressure can sometimes be applied to the colon wall. This pressure can cause a medical accident known as colonic perforation, which the physician should prevent. We propose an assisting device that senses the pressure applied to the colon wall, analyzes the risk of perforation, and warns the physician in real time. Flexible pressure sensors are attached to the surface of the colonoscope shaft. These sensors measure pressure signals during a colonoscopy procedure. A simple signal processor is used to collect and process the pressure signals. In the experiment, a colonoscope equipped with the proposed device was inserted into a simulated colon made from a colon extracted from a pig. The processed data were visually communicated to the gastroenterologist via displays and light-emitting diodes (LEDs). The device helps the physician continuously monitor and prevent excessive pressure on the colon wall. In this experiment, the device appropriately generated and delivered warnings to help the physicians prevent colonic perforation. In the future, the device is to be improved, and more experiments will be performed in live swine models or humans to confirm its efficacy and safety. Full article
(This article belongs to the Special Issue Biomedical Imaging, Sensing and Signal Processing)
Show Figures

Figure 1

14 pages, 228 KiB  
Article
Exploring the Acceptability of HIV Testing in the UK Dental Setting: A Qualitative Study
by Janine Yazdi-Doughty, Anthony J. Santella, Stephen Porter, Richard G. Watt and Fiona Burns
Dent. J. 2024, 12(8), 246; https://doi.org/10.3390/dj12080246 - 2 Aug 2024
Viewed by 1193
Abstract
HIV point of care testing (POCT) is a common approach to expanding testing into non-specialised settings. Dental services have untapped potential to screen for health conditions including HIV. However, the perspectives of UK dental patients, dental professionals, and people with HIV are unknown. [...] Read more.
HIV point of care testing (POCT) is a common approach to expanding testing into non-specialised settings. Dental services have untapped potential to screen for health conditions including HIV. However, the perspectives of UK dental patients, dental professionals, and people with HIV are unknown. Ten focus groups were undertaken with dental patients, professionals, and people with HIV. The Framework method was used to analyse the qualitative data. Six themes were generated from the focus group data. The themes explored perceptions of HIV, the purpose, appropriateness, and acceptability of HIV testing in dental settings, and new processes that would need to be established in order to successfully implement point of care HIV testing in UK dental settings. Training needs were identified including communication skills and updates to current knowledge about HIV. HIV testing in dental settings is generally acceptable to dental patients, dental professionals, and PWH. However, of concern were logistical challenges and the risk of patients surprised at being offered an HIV test during a visit to the dentist. Nonetheless, the public health benefits of the intervention were well understood, i.e., early detection of HIV and initiation of treatment to improve health outcomes. Dental teams were able to generate novel solutions that could help to overcome contextual and logistical challenges to implementing HIV testing in dental settings. Full article
(This article belongs to the Special Issue A Commemorative Issue of the Work of Prof. Dr. Ruth Freeman)
14 pages, 1681 KiB  
Article
Functional and Structural Changes in Patients with Spinal Muscular Atrophy Treated in Poland during 12-Month Follow-Up: A Prospective Cohort Study
by Aleksandra Bieniaszewska, Magdalena Sobieska and Ewa Gajewska
J. Clin. Med. 2024, 13(14), 4232; https://doi.org/10.3390/jcm13144232 - 19 Jul 2024
Cited by 1 | Viewed by 1775
Abstract
Background: In recent years, rapid advances in diagnosis and treatment have been observed in spinal muscular atrophy (SMA) patients. The introduction of modern therapies and screening tests has significantly changed the clinical picture of the disease. The previous classification has, therefore, been replaced [...] Read more.
Background: In recent years, rapid advances in diagnosis and treatment have been observed in spinal muscular atrophy (SMA) patients. The introduction of modern therapies and screening tests has significantly changed the clinical picture of the disease. The previous classification has, therefore, been replaced by new phenotypes: non-sitters, sitters, and walkers, defined by the patient’s functional level. However, despite the change in the clinical picture of the disease, patients still suffer from accompanying structural disorders such as scoliosis or joint contractures. Their presence also significantly affects the acquisition of subsequent motor skills. Due to this, monitoring structural changes and ensuring therapists are aware of improvements or declines in patient functionality are essential components of clinical practice. This study aims to compare the assessment of structural and functional changes after a 12-month follow-up in SMA patients who have already experienced the effects of the disease and are now receiving modern therapy. Methods: We present a study of 34 SMA patients being treated with modern therapies and tested twice 12 months apart. The participants were tested using structural measurements and validated scales such as The Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP-INTEND) and Hammersmith Functional Motor Scale–Expanded (HFMSE). Results: During the 12-month follow-up, patients showed deteriorating, non-statistically significant structural changes. We also proved that patients showed a trend toward functional improvement. Analyzing the individual scale items, we distinguished which participants obtained the maximum score for a given parameter and no longer had an opportunity to improve during the second examination. Conclusions: Our study proved that most patients improved overall motor function. The examination of structural measurements should become a standard in the evaluation of SMA patients. Full article
(This article belongs to the Section Clinical Neurology)
Show Figures

Figure 1

12 pages, 8477 KiB  
Communication
Development of a Colorimetric Loop-Mediated Isothermal Amplification Assay for the Detection of Trypanosoma cruzi in Low-Resource Settings
by Taylor J. Moehling, Myla D. Worthington, Pui-Yan G. Wong, Season S. Wong and Robert J. Meagher
Diagnostics 2024, 14(11), 1193; https://doi.org/10.3390/diagnostics14111193 - 5 Jun 2024
Cited by 1 | Viewed by 2221
Abstract
Chagas disease is an inflammatory parasitic infection caused by Trypanosoma cruzi (T. cruzi). Early diagnosis is crucial in guiding treatment and slowing disease progression; however, current diagnostic methods have insufficient detection limits and often require skilled technicians. Molecular tests, especially isothermal [...] Read more.
Chagas disease is an inflammatory parasitic infection caused by Trypanosoma cruzi (T. cruzi). Early diagnosis is crucial in guiding treatment and slowing disease progression; however, current diagnostic methods have insufficient detection limits and often require skilled technicians. Molecular tests, especially isothermal nucleic acid assays, are advantageous due to their excellent sensitivity, specificity, speed, and simplicity. Here, we optimized a colorimetric loop-mediated isothermal amplification (LAMP) assay for T. cruzi. We can detect as few as 2 genomic copies/reaction using three different T. cruzi strains. We examined selectivity using other parasitic protozoans and successfully detected T. cruzi DNA extracted from parasites in human whole blood down to 1.2 parasite equivalents/reaction. We also performed a blinded study using canine blood samples and established a 100% sensitivity, specificity, and accuracy for the colorimetric LAMP assay. Finally, we used a heated 3D printer bed and an insulated thermos cup to demonstrate that the LAMP incubation step could be performed with accessible, low-cost materials. Altogether, we have developed a high-performing assay for T. cruzi with a simple colorimetric output that would be ideal for rapid, low-cost screening at the point of use. Full article
(This article belongs to the Section Point-of-Care Diagnostics and Devices)
Show Figures

Figure 1

Back to TopTop