Search Results (6,388)

Open-pit coal mining in arid and desert regions causes extensive and persistent surface disturbance, yet long-term monitoring of disturbance and backfilling processes remains challenging. Existing time-series change detection approaches can identify spectral changes but provide limited information on mining disturbance types and their evolution pathways. To address this issue, an automated surface disturbance detection method (Auto-SD) was developed for open-pit coal mines in arid and desert environments. This method integrates disturbance-type identification and temporal information extraction using the tasseled cap brightness (TCB) component to characterize changes associated with surface material exposure and accumulation. Using Landsat imagery from 1990 to 2023, Auto-SD was applied to 89 open-pit coal mines in China’s arid and desert regions, achieving an overall classification accuracy of 0.84. The cumulative disturbed area reached 423.10 km², while the internal dumping area reached 94.25 km², indicating limited backfilling recovery. Disturbance intensified after 2006, whereas backfilling lagged behind, forming a trajectory of rapid expansion, delayed recovery, and gradual stabilization. Spatially, mining areas exhibited a progressive transition from external dumping to internal dumping and backfilling. Furthermore, cumulative pit area generally followed an S-shaped growth pattern with mining duration. These findings provide new insights into long-term mining landscape evolution and support ecological restoration assessment and sustainable resource management in arid mining regions. Full article

Random communication delay, delay jitter, and packet loss cause remote bearing measurements in dual-UAV bearing-only cooperative passive localization to arrive after their generation times. Direct fusion of these historical measurements with current local measurements misaligns the observation rays, platform geometry, and target state. Within the Cubature Kalman filter (CKF) framework, this article constructs a timestamped cache that preserves historical states, measurements, and platform geometry, and investigates two processing strategies. The Predictive Compensation Strategy (PCS) migrates a historical angular innovation to the current geometry and inflates its covariance. Timestamp-Aligned Replay (TSA) activates the historical record at the measurement generation time, restores the corresponding dual-platform observation geometry, and propagates the corrected state to the current time. The evaluation jointly considers the baseline terminal-window error B, average-delay sensitivity S, delay-jitter sensitivity J, and packet-loss response intensity L. Monte Carlo communication scans show that, under the tested conditions, TSA achieves lower terminal-window localization error and a more favorable overall communication-disturbance response than CDS and PCS, while incurring higher average computational cost. Full article

Trehalose-6-phosphate (T6P) is a key signalling metabolite that integrates carbon availability with development and stress responses in plants. T6P levels are controlled by trehalose phosphate synthase (TPS) and trehalose-6-phosphate phosphatase (TPP) enzymes; however, while TPS enzymes have been studied extensively, the physiological functions of individual TPPs remain incompletely understood. Here, we investigated the role of TPPI in Arabidopsis using loss-of-function tppi mutants, a complemented line (tppi+35S::TPPI), and TPPI-overexpressing (TPPI-OEX) plants. The tppi mutant exhibited delayed flowering accompanied by reduced expression of CO, FT, and SPL3, while complementation restored wild-type (WT) flowering time. TPPI-OEX plants displayed an intermediate flowering phenotype with moderate reductions in CO and FT expression. Under nitrogen starvation, tppi plants showed enhanced anthocyanin accumulation, altered nitrate reductase regulation, characterised by lower total enzyme activity but a higher activation state, and enhanced expression of nitrate assimilation and uptake genes (NIA1, NIA2, NRT1.1, and NRT2.1). TPPI deficiency also altered photosynthetic performance, with enhanced photosystem I (PSI) acceptor-side limitation, increased non-photochemical quenching (NPQ), and a tendency toward reduced photosystem II (PSII) electron transport, indicating altered photosynthetic electron transport and energy dissipation. Taken together, these results indicate that TPPI contributes to the regulation of flowering time, nitrogen responses, and photosynthetic performance, suggesting broader effects of TPPI on plant developmental and physiological processes. Full article

Enterotoxigenic Escherichia coli K88 (ETEC-K88) is a primary causative agent of post-weaning diarrhea in piglets, yet most in vitro infection models evaluate epithelial injury at a limited number of endpoint time points, failing to capture the temporal dynamics of host–pathogen interactions. Here, we established a time-resolved ETEC-K88 challenge model in IPEC-J2 cells from 0 h to 48 h. The data showed that ETEC-K88 adhesion significantly increased after 4 h and peaked after 24 h, with a critical response transition at 4–8 h characterized by coordinated changes in mRNA expression of tryptophan metabolism, tight junction, aquaporins, and Solute Carrier Transporters (SLC). Additionally, we also evaluated the protective effects of L-tryptophan supplementation in IPEC-J2 with ETEC-K88 infection and found that its addition significantly restored the disrupted gene expression related to tryptophan metabolism, transporter channels, aquaporins, and cell cycle. Finally, two different mouse strains, C57BL/6J and BALB/c mice, were challenged with ETEC-K88 to assess strain- and segment-specific intestinal responses. Although overt diarrhea was not clearly induced in mice, the ETEC-K88 fimbria receptor genes were induced in both mice strains. Additionally, both mice strains exhibited obvious intestinal histomorphological abnormalities and showed the strain- and segment-specific expression of intestinal stem cell marker genes (Lgr5, SOX9), goblet cell marker gene TFF3, and aquaporin genes. In conclusion, we have defined a temporal epithelial response framework for ETEC-K88 infection in IPEC-J2 cells and mice, providing a theoretical basis for developing nutritional strategies against ETEC-associated intestinal dysfunction in pig production. Full article

Delayed post-sowing watering may leave treated wheat (Triticum aestivum) seeds in dry soil for several weeks before germination begins, raising the question of how long the effects of seed-applied biostimulants remain biologically active under these conditions. This study evaluated the persistence of the biological effects of a seed-applied biostimulant, applied alone (BS) or combined with a triticonazole-based fungicide (TBS), after delayed watering of wheat seeds. Seeds were watered immediately after sowing or after 2, 3, 4, or 5 weeks and evaluated in Petri dishes and growth pots. Compared with the untreated control, BS and TBS reduced mean germination time by up to 9.4 h and 8.7 h, respectively (p < 0.05), while also promoting greater seminal root development after prolonged exposure to dry conditions. In the pot experiment, treatments including the biostimulant maintained greater root dry weight at both BBCH 11 and BBCH 12, indicating that a measurable stimulatory response was still observed beyond germination and early seedling establishment. The strongest responses were observed when watering was delayed by 2–3 weeks, remained evident after 4 weeks, and declined after 5 weeks of dry sowing conditions. Under the conditions of this experiment, the results demonstrate that, although the biostimulant supports early root system development after moisture restoration, the magnitude of the treatment response is conditioned by the duration of the pre-germination waiting period. Full article

Extreme weather couples spatially correlated component damage with photovoltaic (PV) derating, changing electric-vehicle (EV) demand, repair delay, and time-varying network topology. This paper develops a coordinated restoration architecture for multi-area feeders containing PV, battery energy storage, and charging stations. Its weather-facing layer constructs joint outage-risk, renewable-error, charging-demand, and voltage-vulnerability descriptors. Those descriptors parameterize a two-stage mixed-integer second-order-cone program with a finite-support optimal-transport ambiguity set that remains well defined for discontinuous mixed-integer recourse. Regional actor–critic agents propose five-minute corrections around the hourly robust schedule; constrained projection, non-linear AC power-flow screening, emergency fallback, and margin-tightened re-optimization retain the authority to accept or reject each proposal. The evaluation uses public 33-node and 123-node feeders together with synthetic 240-node and 850-node stress networks. A pre-fit manifest allocates 240 records to training, 80 to validation, and 320 to final testing, while aggregate operational outcomes cover 50 random streams. Within this controlled benchmark, accepted schedules restore 93.6% of critical-load energy (SD 2.1 percentage points), serve 96.7% of total demand (SD 1.8 percentage points), retain 82–86% of EV service across hazard classes, and reduce the modeled 24 h objective by 25.8% relative to deterministic dispatch. The full pipeline records two to four candidate-stage voltage-limit events by hazard, and 4.9% of candidates undergo tightened re-optimization before accepted schedules reach zero reported AC voltage-limit violations. Between-method comparisons are descriptive and unpaired; the larger synthetic cases are structural stress tests rather than feeder-transfer tests. Full article

Urban landscapes are increasingly understood as dynamic systems in which natural, cultural, and socio-spatial layers continuously overlap and evolve. Within this perspective, heritage and memory are often treated as stable qualities of place, to be preserved or restored amid ongoing urban transformation. This paper challenges that static understanding by advancing memory-in-transformation, a theoretical framework positioned within the broader concept of Temporal Urbanism. Drawing on an integrative synthesis of landscape theory, critical heritage studies, memory studies, and urban theory, the paper argues that urban landscape transformation does not simply affect heritage and memory but actively produces, reconfigures, and redefines them over time. The framework rests on three interrelated dimensions: temporal layering, mediated interpretation, and dialectical production, through which transformation operates as a mediating process linking spatial change, collective memory, and the continuous formation of heritage landscapes. Illustrative cases (Superkilen, Copenhagen; the Slussen redevelopment, Stockholm) show how transformation can destabilize existing heritage while generating new heritage systems. The paper further introduces the notion of temporal justice, foregrounding whose memories are sustained or marginalized in processes of change, and outlines new directions for research and practice in heritage urbanism, land-use planning, landscape architecture, and sustainable urban development. Full article

Autoimmune rheumatic diseases are still treated predominantly through broad or targeted suppression of inflammatory pathways, yet durable restoration of self-tolerance remains a central unmet therapeutic goal. This narrative review examines restoration of immune tolerance as an emerging translational framework in rheumatology, integrating checkpoint agonism, antigen-specific immunotherapy, regulatory cell-based strategies, and immune-reset approaches within a unified therapeutic perspective. Rather than treating these strategies as isolated innovations, the review evaluates how each attempts to restore, reinforce, or reconfigure immune restraint at distinct biological levels, spanning inhibitory receptor signaling, antigen-selective non-responsiveness, dominant regulatory control, and deeper reconfiguration of pathogenic immune architecture. Their relevance is considered across rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s disease, and systemic sclerosis, with emphasis on mechanistic rationale, translational maturity, disease-specific therapeutic fit, biomarkers, therapeutic timing, and major barriers to clinical implementation. Collectively, these approaches suggest a shift in rheumatology from repeated control of inflammatory consequences toward more selective and potentially durable recalibration of autoreactive immunity. Although the field remains biologically and clinically immature, restoration of immune tolerance is emerging as an important organizing principle for the development of more precise and potentially disease-modifying therapies in autoimmune rheumatic disease. Full article

Growing demand for pavement maintenance promotes reclaimed asphalt pavement (RAP) recycling, yet multi-scale comparative research on rejuvenators remains limited. This study compared a commercial bio-based Rejuvenator A and a petroleum-based Rejuvenator B to reveal how chemical compositions control asphalt regeneration. Following JTG 3410-2025 standards, asphalt binders underwent extended RTFOT aging (75, 112.5, and 150 min) and were externally blended with rejuvenators at 5%, 7.5%, and 10% by binder mass. A multi-scale framework combining macro tests, interfacial characterization, SARA fraction analysis, ATR-FTIR, and molecular dynamics (MD) simulations was established. Results indicated that the two rejuvenators acted via different mechanisms. Rejuvenator B contained 31.64% saturates and restored aged asphalt mainly through physical dilution and softening. This rejuvenator formed 0–80 hydrogen bonds dominated by weak C–H···O interactions, and the corresponding rejuvenated asphalt yielded a CII of 0.293. It was effective for 75 min-aged binders yet produced more oxidation products after re-aging. Conversely, Rejuvenator A, characterized by 68.10% aromatics and 20.17% resins, exhibited a 3–5° lower equilibrium contact angle, and a roughly 13% shorter relative penetration time than Rejuvenator B. Its network of 150–250 hydrogen bonds effectively disrupted asphaltene aggregates, reducing the CII to 0.180. Consequently, Rejuvenator A successfully restored 112.5 min- and 150 min-aged asphalt with significantly lower secondary oxidation. These performance differences were governed by aromatic and polar fractions rather than feedstock origins. While quantitative findings are sample-specific, the established framework provides theoretical references for engineering rejuvenator selection and high-performance regenerant design. Full article

Sepsis-associated acute lung injury (SALI) is characterized by disruption of the alveolar–capillary barrier, uncontrolled inflammation, oxidative stress, and impaired tissue repair. Ferroptosis and cellular senescence have emerged as potentially interacting stress-response programs that may jointly shape the progression of septic lung injury. Ferroptosis promotes epithelial and endothelial damage through iron-dependent lipid peroxidation, glutathione depletion, and impaired GPX4-mediated lipid repair. In parallel, senescence-associated remodeling may contribute to persistent cell-cycle arrest, senescence-associated secretory phenotype (SASP) production, endothelial dysfunction, and defective regenerative capacity. This review summarizes current evidence on the molecular and cellular crosstalk between ferroptosis and cellular senescence in SALI. Candidate regulatory intersections include context-dependent mitochondrial dysfunction, reactive oxygen species accumulation, iron dyshomeostasis, metabolic reprogramming, lysosomal dysfunction, DNA-damage responses, and stress-responsive pathways involving p53, NRF2, ATF4, STAT3, and FOXO1. Direct SALI evidence is currently strongest for ferroptosis-induced senescence-associated remodeling in pulmonary endothelial cells, whereas senescence-associated ferroptosis resistance is supported mainly by non-pulmonary models. Likewise, SASP-mediated paracrine ferroptosis in neighboring pulmonary cells remains insufficiently validated. We therefore propose an evidence-informed, temporally and cell-type-dependent ferroptosis–senescence framework in SALI, in which acute senescence-associated responses may coexist with ferroptotic injury, whereas persistent senescence-associated remodeling may contribute to defective repair and microenvironmental injury amplification. Targeting this axis through ferroptosis inhibition, restoration of endogenous antioxidant defenses, senotherapeutic modulation, and regenerative strategies may offer stage-informed therapeutic opportunities. Further time-resolved and cell-specific studies are required to define causal relationships and clinically actionable therapeutic windows. Full article

Calcium silicate-based cements are hydraulic biomaterials that form a calcium silicate hydrate (C-S-H) gel during hydration, a process fundamental to their setting and progressive physicochemical development. Although these materials are widely used in vital pulp therapy, evidence regarding the effects of adhesive strategy and restoration timing on bonding performance, particularly for newer premixed formulations, remains limited. This study evaluated the effects of cement type, adhesive strategy, and restoration timing on the shear bond strength (SBS) of resin composite bonded to MTA Angelus and Well-Root PT. A total of 270 specimens were distributed across two cement types, three adhesive strategies, and three restoration intervals (45 min, 24 h, and 7 days). After thermocycling, SBS and failure modes were assessed. SBS data were analyzed using three-way ANOVA, whereas failure-mode distributions were evaluated using chi-square or Fisher’s exact tests (α = 0.05). Cement type, adhesive strategy, restoration timing, and their interactions significantly influenced SBS (p < 0.001). Well-Root PT exhibited higher early bond strength than MTA Angelus. The two-step etch-and-rinse adhesive produced the highest SBS values, whereas the universal adhesive produced the lowest. Restoration after 24 h significantly increased SBS compared with restoration after 45 min, with no additional improvement observed at 7 days. Within the limitations of this in vitro study, bonding performance was influenced by cement type, adhesive strategy, and restoration timing. The time-dependent increase in SBS is consistent with continued hydration and development of the C-S-H gel-based cement matrix, although the specific microstructural changes underlying this behavior were not directly characterized. Full article

Sleep supports cognition across the lifespan, but its significance may differ developmentally: in adults, it largely maintains and restores functioning within mature neural systems, whereas in children and adolescents it may also support the formation of cognitive, emotional, and self-regulatory capacities. This systematic review and evidence and gap map, prospectively registered in PROSPERO and conducted according to PRISMA 2020, searched PubMed, PsycINFO, Scopus, and Web of Science for studies of sleep duration, quality/fragmentation, timing/regularity, and daytime sleepiness in relation to executive function/self-regulation, attention/vigilance, emotion/behavior regulation, and academic functioning among typically developing children and adolescents. Twenty-five studies contributed 46 study–outcome links. Across nearly all populated evidence cells, more adequate sleep profiles were associated with better developmental outcomes. The strongest and most experimentally supported evidence concerned sleep duration in relation to executive function, emotion/behavior regulation, and academic functioning; evidence for sleep timing/regularity and daytime sleepiness was weaker and predominantly cross-sectional. Unlike adults, for whom sleep primarily restores a mature system, children may lose not only today’s functioning but tomorrow’s developmental trajectory when sleep is chronically curtailed. Sleep duration currently provides the strongest basis for intervention, whereas the long-term developmental effects of sleep quality, timing, regularity, and sleepiness require further longitudinal and experimental investigation during this formative period. Full article

Land consolidation (LC) is increasingly expected to support food security, ecological restoration, rural development, and climate mitigation, yet evidence on its carbon effects remains fragmented across engineering, ecological, spatial, and governance research. This review combines bibliometric mapping with structured evidence synthesis of 355 records from WoS and CNKI to examine knowledge evolution, analytical paradigms, and their integration. The field has expanded from component-based assessments of construction emissions, soil carbon, and land-cover change toward life-cycle accounting, carbon fractions, ecosystem-service interactions, spatial optimization, and policy evaluation. WoS-indexed and Chinese-language literature show distinct but increasingly convergent orientations shaped by differences in intervention contexts, disciplinary traditions, analytical scales, and available evidence. Four complementary paradigms are identified: carbon accounting, biogeochemical processes, spatial land systems, and decision support and governance. Together, these paradigms reveal interconnected carbon pathways but remain constrained by inconsistent accounting boundaries, weak process–scale–time linkages, and limited integration with land-governance decisions. Future research should therefore advance standardized life-cycle and multi-scale accounting, mechanism-based assessment of long-term carbon and ecosystem-service dynamics, and digitally and institutionally enabled low-carbon governance. Full article

Automatic carrier landing of fixed-wing UAVs remains challenging under deck motion, carrier airwake, gusts, and actuator faults. This paper proposes a robust flexible predefined-time prescribed performance control (RFPTPPC) framework with beneficial disturbance utilization (BDU). A control-oriented six-degree-of-freedom cascaded model with direct lift control is first established. To address the temporary infeasibility of fixed predefined-time PPC boundaries, direction-selective flexible boundaries restore the admissible attitude error region when the nominal envelope is threatened, while a smoothly coordinated recovery branch drives the error inward. An adaptive super-twisting extended state observer (ASTESO) reconstructs lumped disturbances in the cascaded loops. Using the ASTESO outputs, BDU evaluates each disturbance component, retains those that favor error convergence, and compensates for adverse components, thereby improving attitude tracking accuracy and maintaining PPC feasibility. Lyapunov analysis establishes practical predefined-time stability of the closed-loop system. Comparative simulations demonstrate improved trajectory tracking, attitude regulation, actuator coordination, and robustness under randomized landing conditions. Full article

Skin photoaging is closely associated with oxidative stress, inflammatory responses, and dysregulated collagen metabolism. Paeonol (Pae) possesses antioxidant and anti-inflammatory activities; however, its poor water solubility and short skin retention time limit its topical application. In this study, a transdermal delivery system based on a carboxymethyl chitosan (CMCS)/Carbomer 940 (Carb940) composite gel loaded with hydroxypropyl-β-cyclodextrin inclusion complexes of paeonol (Pae-CD) was developed. Pae-CD was prepared using an ultrasound-assisted saturated aqueous solution method, and the physicochemical properties, sustained-release behavior, transdermal permeation, antioxidant activity, and safety of Pae-CD/gel were evaluated. Furthermore, a mouse model of skin photoaging induced by combined ultraviolet A (UVA)/ultraviolet B (UVB) irradiation was established to investigate its reparative effects in vivo. The results showed that Pae-CD/gel exhibited a homogeneous three-dimensional porous structure, favorable sustained-release characteristics, enhanced skin retention capacity, and good cellular compatibility. In vivo experiments demonstrated that Pae-CD/gel markedly ameliorated ultraviolet-induced skin dryness, abnormal epidermal thickening, and dermal collagen loss. It also reduced oxidative stress and inflammatory factor levels, down-regulated matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-3 (MMP-3) expression, and promoted the restoration of collagen type I (COL-1) and hydroxyproline (HYP) levels. Systemic safety evaluation revealed no obvious toxicity. In summary, Pae-CD/gel exerts antioxidant and anti-inflammatory effects and regulates collagen metabolism by enhancing transdermal delivery and local retention, thereby providing a safe and effective topical delivery strategy for the repair of skin photoaging. Full article