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Search Results (5)

Search Parameters:
Keywords = radioisotope targetry

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12 pages, 4843 KiB  
Article
Development of TR-19 Cyclotron Parameter Settings for Fully Automated Production of Radiometals with Applications in Nuclear Medicine
by Liviu Ștefan Crăciun, Tiberiu Relu Eșanu, Radu Leonte, Hermann Anton Schubert, Raul Victor Erhan and Dana Niculae
Instruments 2025, 9(1), 3; https://doi.org/10.3390/instruments9010003 - 26 Feb 2025
Viewed by 1302
Abstract
At the Radiopharmaceutical Research Center (CCR) of the Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH), we operate a TR-19 cyclotron for radio isotope production. To broaden our spectrum of radioisotopes with applications in nuclear medicine, we add a [...] Read more.
At the Radiopharmaceutical Research Center (CCR) of the Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH), we operate a TR-19 cyclotron for radio isotope production. To broaden our spectrum of radioisotopes with applications in nuclear medicine, we add a new external beam line towards a state-of-the-art solid target station. Besides practical experience with the implementation of the Comecer ALCEO metal solid targetry system, a new, more efficient way of tuning the beam onto the target and the design of a dedicated neutron local layered shielding are presented. Full article
(This article belongs to the Special Issue Medical Applications of Particle Physics, 2nd Edition)
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9 pages, 1781 KiB  
Article
Niobium as Preferential Material for Cyclotron Target Windows
by Sergio J. C. do Carmo and Francisco Alves
Instruments 2024, 8(2), 33; https://doi.org/10.3390/instruments8020033 - 27 May 2024
Viewed by 1658
Abstract
The present work promotes and validates the benefits of using niobium instead of Havar® as the material for the target windows in most routine irradiations in cyclotrons. Calculation of the material activation and measurements of the contamination of the transferred target liquids [...] Read more.
The present work promotes and validates the benefits of using niobium instead of Havar® as the material for the target windows in most routine irradiations in cyclotrons. Calculation of the material activation and measurements of the contamination of the transferred target liquids show major improvements with the use of niobium. Also, the data of the daily routine productions at our production center are presented, proving that Havar® is not mandatory unless large target currents and/or pressures are required. Full article
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15 pages, 2394 KiB  
Review
Production of Medical Radionuclides in the Center for Radiopharmaceutical Tumor Research—A Status Report
by Martin Kreller, Santiago Andrés Brühlmann, Torsten Knieß, Klaus Kopka and Martin Walther
Instruments 2024, 8(1), 10; https://doi.org/10.3390/instruments8010010 - 7 Feb 2024
Cited by 1 | Viewed by 2337
Abstract
A new Center for Radiopharmaceutical Cancer Research was established at the Helmholtz-Zentrum Dresden-Rossendorf in 2017 to centralize radionuclide and radiopharmaceutical production, as well as enable chemical and biochemical research. Routine production of several radionuclides was put into operation in recent years. We report [...] Read more.
A new Center for Radiopharmaceutical Cancer Research was established at the Helmholtz-Zentrum Dresden-Rossendorf in 2017 to centralize radionuclide and radiopharmaceutical production, as well as enable chemical and biochemical research. Routine production of several radionuclides was put into operation in recent years. We report on the production methods of radiopharmaceutical radionuclides, in particular 11C, 18F, and radio metals like 61Cu, 64Cu, 67Cu, 67Ga, 131Ba, and 133La that are used regularly. In the discussion, we report typical irradiation parameters and achieved saturation yields. Full article
(This article belongs to the Special Issue Selected Papers from the 15th Workshop of the European Cyclotron Network (CYCLEUR 2023))
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8 pages, 3315 KiB  
Communication
Solid Target System with In-Situ Target Dissolution
by William Z. Gelbart and Richard R. Johnson
Instruments 2019, 3(1), 14; https://doi.org/10.3390/instruments3010014 - 11 Feb 2019
Cited by 5 | Viewed by 4632
Abstract
A significant number of medical radioisotopes use solid, often metallic, parent materials. These materials are deposited on a substrate to facilitate the cooling and handling of the target during placing, irradiation, and processing. The processing requires the transfer of the target to a [...] Read more.
A significant number of medical radioisotopes use solid, often metallic, parent materials. These materials are deposited on a substrate to facilitate the cooling and handling of the target during placing, irradiation, and processing. The processing requires the transfer of the target to a processing area outside the irradiation area. In this new approach the target is processed at the irradiation site for liquid only transport of the irradiated target material to the processing area. The design features common to higher energy production target systems are included in the target station. The target is inclined at 14 degrees to the beam direction. The system has been designed to accept an incident beam of 15 to 16 mm diameter and a beam power between 2 and 5 kW. Thermal modeling is presented for targets of metals and compounds. A cassette of five or 10 prepared targets is housed at the target station as well as a target dissolution assembly. Only the dissolved target material is transported to the chemistry laboratory so that the design does not require additional irradiation area penetrations. This work presents the design, construction, and modeling details of the assembly. A full performance characterization will be reported after the unit is moved to a cyclotron facility for beam related measurements. Full article
(This article belongs to the Special Issue Instruments and Methods for Cyclotron Produced Radioisotopes)
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5 pages, 12705 KiB  
Communication
Molybdenum Sinter-Cladding of Solid Radioisotope Targets
by William Z. Gelbart and Richard R. Johnson
Instruments 2019, 3(1), 11; https://doi.org/10.3390/instruments3010011 - 2 Feb 2019
Cited by 3 | Viewed by 4400
Abstract
In solid targets for radioisotope production, the parent materials—mostly metallic—are usually attached to a substrate (metal part, often copper or silver) to support it during handling and irradiation and to facilitate liquid or gas cooling to remove the heat generated by the particle [...] Read more.
In solid targets for radioisotope production, the parent materials—mostly metallic—are usually attached to a substrate (metal part, often copper or silver) to support it during handling and irradiation and to facilitate liquid or gas cooling to remove the heat generated by the particle beam. This cladding process is most frequently done by electroplating. One of the biggest challenges of preparing solid, high-current, 100Mo targets is the difficulty of cladding the substrate with molybdenum—metal that cannot be electroplated. A number of cladding techniques are used with varying degrees of complexity, success, and cost. A simple cladding process, especially suitable for the production of radioisotope targets, was developed. The process uses a metal slurry (metal powder and binder) painted on the substrate and heated in a hydrogen atmosphere where the metal is sintered and diffusion-bound to the substrate in a single step. Full article
(This article belongs to the Special Issue Instruments and Methods for Cyclotron Produced Radioisotopes)
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