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Keywords = protoilludanes

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29 pages, 5794 KiB  
Review
A Review of Fungal Protoilludane Sesquiterpenoid Natural Products
by Melissa M. Cadelis, Brent R. Copp and Siouxsie Wiles
Antibiotics 2020, 9(12), 928; https://doi.org/10.3390/antibiotics9120928 - 19 Dec 2020
Cited by 11 | Viewed by 4045
Abstract
Natural products have been a great source for drug leads, due to a vast majority possessing unique chemical structures. Such an example is the protoilludane class of natural products which contain an annulated 5/6/4-ring system and are almost exclusively produced by fungi. They [...] Read more.
Natural products have been a great source for drug leads, due to a vast majority possessing unique chemical structures. Such an example is the protoilludane class of natural products which contain an annulated 5/6/4-ring system and are almost exclusively produced by fungi. They have been reported to possess a diverse range of bioactivities, including antimicrobial, antifungal and cytotoxic properties. In this review, we discuss the isolation, structure elucidation and any reported bioactivities of this compound class, including establishment of stereochemistry and any total syntheses of these natural products. A total of 180 protoilludane natural products, isolated in the last 70 years, from fungi, plant and marine sources are covered, highlighting their structural diversity and potential in drug discovery. Full article
(This article belongs to the Special Issue Terpenoids from Microorganisms: Their Chemistry and Biology)
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10 pages, 1785 KiB  
Article
Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds
by Hitomi Sasaki, Yuzuru Kubohara, Hirotaka Ishigaki, Katsunori Takahashi, Hiromi Eguchi, Akihiro Sugawara, Yoshiteru Oshima and Haruhisa Kikuchi
Molecules 2020, 25(12), 2895; https://doi.org/10.3390/molecules25122895 - 23 Jun 2020
Cited by 7 | Viewed by 3158
Abstract
We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by [...] Read more.
We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry. Full article
(This article belongs to the Special Issue Bioactive Natural Products from Microorganisms)
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