Search Results (76)

Background/Objectives: Chronic inflammation and Western-style diets elevate colorectal cancer (CRC) risk, particularly in individuals with colitis, a feature of inflammatory bowel disease (IBD). Diets rich in polyphenol-containing functional foods, such as cocoa, may reduce gut inflammation and modulate the gut microbiome. This study investigated the impact of cocoa polyphenol (CP) supplementation on inflammation and microbiome composition in mice with colitis, fed either a healthy or Western diet, before, during, and after the onset of disease. We hypothesized that CPs would attenuate inflammation and promote distinct shifts in the microbiome, especially in the context of a Western diet. Methods: A 2 × 2 factorial design tested the effects of the basal diet (AIN93G vs. total Western diet [TWD]) and CP supplementation (2.6% w/w CocoaVia™ Cardio Health Powder). Inflammation was induced using the AOM/DSS model of colitis. Results: CP supplementation did not reduce the severity of colitis, as measured by disease activity index or histopathology. CPs did not alter gene expression in healthy tissue or suppress the colitis-associated pro-inflammatory transcriptional profile in either of the two diet groups. However, fecal microbiome composition shifted significantly with CPs before colitis induction, with persistent effects on several rare taxa during colitis and recovery. Conclusions: CP supplementation did not mitigate inflammation or mucosal injury at the tissue level, nor did it affect the expression of immune-related genes. While CPs altered microbiome composition, most notably in healthy mice before colitis, these shifts did not correspond to changes in inflammatory signaling. Basal diet remained the primary determinant of inflammation, mucosal damage, and colitis severity in this model. Full article

Background/Objectives: Protecting students’ mental health during university is essential for their future quality of life. Therefore, diet should be emphasized as a complementary and preventive strategy in supporting and maintaining mental health. This study aimed to examine the association between dietary inflammatory and antioxidant indices and mental health indicators (depression, anxiety, stress, and well-being) in university students. Methods: This cross-sectional study included 907 university students. We collected dietary data using a 24 h recall. Based on this data, we used 33 food parameters to calculate the Dietary Inflammatory Index (DII) and 6 antioxidant nutrients to calculate the Dietary Antioxidant Index (DAI). We evaluated mental health using the Depression, Anxiety, and Stress Scales-21 (DASS-21), and assessed well-being using the World Health Organization Five Well-Being Index (WHO-5). Results: Overall, 62.4% of participants reported symptoms of depression, 56.2% anxiety, and 40.7% stress. Anxiety and stress levels were significantly higher among females compared to males (p < 0.001 and p = 0.005, respectively). In fully adjusted models, depression scores were significantly higher in the highest DII tertile compared to the lowest (B = 1.74; 95% CI: 0.24–3.26), while well-being was lower (B = −0.82; 95% CI: −1.65 to −0.00). For DAI, participants in tertile 2 had significantly lower anxiety (B = −1.38; 95% CI: −2.63 to −0.14), depression (B = −1.69; 95% CI: −3.19 to −0.19), and stress (B = −1.70; 95% CI: −3.22 to −0.18) scores compared to tertile 1. No significant association was found between DAI and well-being. Conclusions: In this study, university students’ pro-inflammatory diets were associated with poorer mental health profiles. Enhancing the diet’s anti-inflammatory potential may be a promising strategy to support mental health in this population. Full article

Background/objectives: The interplay between genetic factors and nutritional patterns is critical in understanding metabolic health. This analysis evaluated the potential reciprocal relationships between the TNF-α -308 G/A gene polymorphism, the Composite Dietary Antioxidant Index (CDAI), and insulin-related variables in Spanish adults with obesity. Methods: A cross-sectional analysis was conducted in 292 adults with obesity. Anthropometric, biochemical, and dietary variables were assessed. TNF-α -308 G/A genotyping was performed. Associations and potential interactions between CDAI and genotype on insulin and homeostatic model assessment for insulin resistance (HOMA-IR) were examined using multivariate regression and two-way ANOVA. Results: Higher CDAI scores were significantly associated with lower insulin levels (p < 0.001) and HOMA-IR (p < 0.001), regardless of genotype. Carriers of the A allele (GA/AA) showed a non-significant trend toward higher insulin levels (p = 0.087) and a steeper decrease in insulin levels with increasing CDAI, with a significant interaction observed between TNF-α genotype and CDAI (interaction p = 0.003). Multivariate analyses confirmed that CDAI and TNF-α genotype were independently associated with insulin and HOMA-IR levels. However, interaction terms were not consistently significant across all models. Conclusions: These findings emphasize the potential of antioxidant-rich diets to help modulate the influence of pro-inflammatory genotypes on insulin resistance, highlighting the relevance of integrating genetic and dietary factors in managing obesity-related metabolic risks. Further studies are warranted to confirm these preliminary findings and to better understand the mechanisms underlying gene–diet interactions in metabolic regulation. Full article

Background/Objectives: Studies have reported an increased risk of type 2 diabetes among people with higher protein intake. Moreover, branched-chain amino acids (BCAA) are reported to be positively associated with insulin resistance (IR). However, it is not understood whether elevated levels of BCAA are causal to IR development, or if higher BCAA are a marker of IR. The objective of this study was to examine the effects of long-term protein and carbohydrate supplementation on plasma BCAA levels, and the relationship between plasma BCAA and IR in postmenopausal women. Methods: Stored samples and data from 84 postmenopausal women who participated in a protein supplementation trial (SPOON) were included. Exclusion criteria consisted of protein intakes less than 0.6 g/kg or greater than 1.0 g/kg, a body mass index (BMI) greater than 32 kg/m² or less than 19 kg/m² diseases, and conditions and medications known to impact musculoskeletal health. Subjects were randomized to a whey protein (PRO: n = 38) or maltodextrin supplement (CHO: n = 46) for 18 months. Plasma BCAA, homeostatic model assessment of insulin resistance (HOMA-IR) and body composition were analyzed at baseline and 18 months. Results: At baseline, there were no significant associations between plasma BCAA and IR. There were also no significant changes in plasma BCAA or IR by study arm. However, there was a significant positive association between plasma BCAA and IR in both groups at 18 months (CHO: r = 0.35, p = 0.02; PRO: r = 0.35, p = 0.03). Conclusions: Findings from this study warrant future research to examine other diet and lifestyle factors that may mediate the relationship between circulating BCAA and IR in postmenopausal women. Full article

Background: Population aging presents major public health challenges. Nutrition education has emerged as a key intervention to improve diet quality and reduce the risk of chronic diseases among older adults. Methods: This pilot cross-sectional study assessed the effects of a brief nutrition education session on dietary patterns, lifestyle behaviors, and health perceptions among 151 community-dwelling Polish seniors aged 60 and over. Data were collected using the KomPAN® questionnaire, the Pro-Healthy Diet Index (pHDI-10), the Non-Healthy Diet Index (nHDI-14), and self-reported health indicators. Results: The findings revealed suboptimal dietary patterns, including low consumption of whole grains, legumes, and fish. A high prevalence of chronic diseases was observed, particularly hypercholesterolemia (67.7%) and hypertension (53.1%). A weak but significant correlation was found between BMI and the number of diagnosed conditions (r = 0.3, p = 0.003). Despite limited prior nutritional knowledge, participants perceived the educational session as beneficial, and many expressed an intention to share the acquired information with peers, indicating a potential “domino effect”. Conclusions: Although the sample size limits generalizability, the results support the effectiveness of brief, tailored nutrition education as a scalable, cost-effective public health strategy. Such interventions may promote healthy aging, reduce diet-related disease burden, and enhance peer-driven knowledge dissemination among older adults. Full article

Background/Objectives: This study aims to assess dietary quality among Chinese pregnant women across three gestational trimesters using different assessment indices while investigating the relationship between dietary patterns and longitudinal alterations in maternal body composition parameters and bone mineral density (BMD) during pregnancy. Methods: A total of 556 healthy pregnant women were recruited. Dietary intake was assessed utilizing a semi-quantitative food frequency questionnaire (FFQ). Diet quality was evaluated through three indices: the Dietary Balance Index for Pregnant Women (DBI-P), the Dietary Inflammatory Index (DII), and the Eastern Health Diet Index (EHDI). Multiple linear regression models and mediation analyses were constructed to elucidate the relationships between dietary indices, body composition parameters, and BMD. Results: In the first trimester, excessive dietary intake was associated with increased maternal fat mass but reduced BMD, while insufficient intake correlated with declines in muscle mass, water compartments, and inorganic salt levels. Pro-inflammatory diets further exacerbated reductions in non-fat body composition, including protein and muscle mass. By the second trimester, low-quality diets continued to negatively affect muscle mass and water balance, whereas no significant dietary effects on body composition or BMD were observed in the third trimester. Mediation analyses revealed that body composition partially mediated the relationship between dietary imbalance and reduced BMD. Conclusions: Unbalanced, pro-inflammatory, and low-quality diets during early-to-mid pregnancy contribute to adverse changes in maternal body composition and bone health, especially in the first and second trimesters, with the DBI-P index demonstrating superior applicability for assessing dietary impacts in Chinese pregnant women. Full article

Objectives: Dietary conditions are closely related to maternal health. This study aims to investigate the causal relationship between the first–second-trimester Dietary Inflammatory Index (DII) and developing anemia in the third trimester. Methods: This prospective cohort study comprised 545 pregnant women, with dietary data assessed via a semi-quantitative food frequency questionnaire (FFQ). Hemoglobin levels were obtained by hospital laboratory tests and used to diagnose anemia. Multivariable logistic regression models—adjusted for baseline serum iron, age, pre-pregnancy body mass index (BMI), occupation, education, history of adverse pregnancy outcomes, parity, serum iron, passive smoking exposure, and iron supplementation use during pregnancy—were employed to evaluate the relationships between the first-trimester DII, second-trimester DII, first–second-trimester average DII, and third-trimester anemia. Results: After multivariable adjustment, the first–second-trimester average DII in the pro-inflammatory diet group demonstrated a 3.73-fold elevated risk of third-trimester anemia compared to the anti-inflammatory diet group (Odds Ratio [OR] = 3.73, 95% Confidence Interval [CI]: 1.50–9.25). Conclusions: Pro-inflammatory dietary patterns during pregnancy exhibit a significant correlation with developing third-trimester anemia. This study demonstrates that reducing dietary pro-inflammatory components through prenatal nutrition programs may lower third-trimester anemia risk. Notably, this study carries potential risks of bias, including self-reporting bias in dietary data and incompletely controlled confounding factors (such as unmeasured biomarkers). Full article

Background/Objectives: Aging increases the risk of metabolic diseases, such as diabetes, hypertension, dyslipidemia, and obesity, which may contribute to cataract development. This study examined whether metabolic diseases mediate the relationship between the dietary inflammatory index (DII) and cataract prevalence using structural equation modeling (SEM). Methods: Data were obtained from 9260 individuals aged 40 and older who participated in the 8th Korea National Health and Nutrition Examination Survey (KNHANES 2019–2021). DII scores, calculated from 24 h dietary recall, reflect the inflammatory potential of the diet, with higher scores indicating a more pro-inflammatory profile. SEM was applied to assess mediation effects, and analyses were conducted using SPSS 29.0 and AMOS 29.0. Results: Among the participants, 1853 individuals (20.0%) were diagnosed with cataracts, and the mean DII was 1.5 ± 2.8. In the high DII group, the risk of hypertension (β = 0.077, p < 0.001) and dyslipidemia (β = 0.033, p = 0.001) increased significantly. Hypertension (β = 0.187, p < 0.05), diabetes mellitus (β = 0.132, p < 0.05), dyslipidemia (β = 0.108, p < 0.05), and obesity (β = 0.025, p < 0.05) had direct effects on cataract prevalence. Diabetes 0.002 (p < 0.05), hypertension 0.014 (p < 0.05), and dyslipidemia 0.004 (p < 0.05) also showed significant indirect effects. Conclusions: Metabolic diseases mediate the relationship between DII and cataracts. Managing inflammation and metabolic health may reduce cataract risk. Full article

Background: Current research inadequately substantiates the impacts of dietary inflammatory potential based on the dietary inflammatory index (DII) on population health and environmental sustainability in Chinese adults. Objectives: We aimed to investigate the associations between the DII with the risk of all-cause mortality and greenhouse gas (GHG) emissions in Chinese adults. Methods: Data from adults (N = 15,318) in the China Health and Nutrition Survey 1997–2015 wave were included in the analysis. DII and energy-adjusted DII (E-DII) were calculated using dietary intake data collected with a combination of 3-day consecutive 24-h dietary recalls and the food weighing method. The total GHG emissions were calculated by summing the amount of emissions from all the food groups consumed by the participants. Cox proportional hazards regression models and linear regression models were conducted for statistical analysis. Results: A pro-inflammatory diet, as reflected by higher DII and E-DII scores was associated with an increased risk of all-cause mortality (DII: Q5 vs. Q1: HR = 1.82; 95% CI: 1.45–2.30; p-trend < 0.0001; E-DII: Q5 vs. Q1: HR = 1.86; 95% CI: 1.38–2.52; p-trend < 0.0001) and higher amounts of GHG emissions (both p-trend < 0.0001). Conclusions: These findings demonstrated positive associations between pro-inflammatory potentials with an increased risk of all-cause mortality and higher GHG emissions among Chinese adults, suggesting dual adverse impacts of a pro-inflammatory diet on health and environmental sustainability. Full article

(1) Background: Prenatal depression is prevalent and can adversely affect maternal and infant health. This study aimed to analyze the relationship between the energy-adjusted dietary inflammatory index (E-DII) and prenatal depression, as well as to explore the mediating effect of sleep quality. (2) Methods: In this cross-sectional study, a total of 749 pregnant women were enrolled. The E-DII scores were evaluated using semi-quantitative Food Frequency Questionnaires (FFQ); the Edinburgh Postpartum Depression Scale (EPDS) was used to measure depression levels; and the Pittsburgh Sleep Quality Index (PSQI) to evaluate the sleep quality of pregnant women. Binary logistic regression analysis was employed to analyze the relationships of E-DII with prenatal depression, of E-DII with sleep quality, and of sleep quality with prenatal depression. The bootstrap approach was employed to investigate the mediating effect of sleep quality. (3) Results: Findings indicated that a higher E-DII score was significantly associated with an increased risk of prenatal depression compared to the lowest score, and this association still existed after adjusting for sleep quality. In addition, the lowest E-DII score was also associated with a lower risk of poor sleep quality. Sleep quality played a partial mediating role in the association between E-DII and prenatal depression, and the proportion of the mediation effect relative to the total effect was 34.30%. (4) Conclusions: Sleep quality partially mediated the association between E-DII and prenatal depression. Close monitoring and proactive improvement of sleep quality among pregnant women following a pro-inflammatory diet may help reduce the risk of developing prenatal depression. Full article

Objectives: Dietary habits are identified as a potential factor influencing the quality of life of individuals diagnosed with Hashimoto’s disease (HAT). The objective of this study was to analyze the relationship between quality of diet and selected parameters of nutritional status, and quality of life in female patients with HAT. Methods: A descriptive cross-sectional study was conducted among 147 women aged 39.9 ± 10.39 years. Diet quality was determined with the Pro-Healthy Diet Index (pHDI-10), quality of life with a thyroid-specific questionnaire (ThyPROpl), and gastrointestinal symptoms with the Gastrointestinal Symptom Rating Scale (GSRS). Results: The mean pHDI-10 score was 25.5 ± 9.59; 80% of women had a low pro-healthy diet quality (LQD group, 21.9 ± 6,89 pts.) and 20% had a medium pro-healthy diet quality (MQD group, 39.7 ± 4.69 pts.). Nutritional status and anthropometric and health risk parameters did not differ between the groups. The ThyPROpl score was 49.15 ± 31.16 (LQD: 49.58 ± 31.01, MQD: 47.41 ± 32.28, p = 0.73). Conclusions: Quality of diet was not associated with the quality of life or nutritional status of HAT patients. However, the majority of participants showed poor healthy eating habits, elevated body mass index and unsatisfactory quality of life in areas, such as tiredness, hypothyroid symptoms, depression, emotional vulnerability, and anxiety. Full article

Background/Objectives: An increase in body fat is linked to abnormalities in energy metabolism. We aimed at determining cardiometabolic risk in Algerian participants with obesity alone and with or without type 2 diabetes. The study measured the concentrations of circulating adipocytokines (leptin, adiponectin, resistin), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) to identify and examine how imbalances in adipocytokines may affect the parameters of cardiometabolic health. Methods: Algerian participants (n = 300) were recruited and divided into three groups: control, obese, and type 2 diabetics (with two sub-groups: with and without obesity). Insulin resistance was evaluated using HOMA-IR, while ELISA was used to measure adipocytokines. Atherogenic index in plasma (AIP), adiponectin-leptin ratio (ALR), and visceral adiposity index (VAI) were also assessed. One-way ANOVA was used to compare obesity and diabetes groups to the control one (p < 0.05). Logistic regression analysis was conducted to strengthen the robustness of statistical correlations. Results: Participants with reduced adiponectin-leptin ratio (ALR) and elevated levels of resistin, TNF-α, and IL-6 are found to be at higher risk of cardiovascular diseases. An imbalance in adipocytokine levels is caused by a decrease in adiponectin concentrations, and an increase in pro-inflammatory adipocytokines that maintain and exacerbate energy imbalance and induces hyperinsulinemia, exposing individuals to a high risk of cardiovascular diseases. Conclusions: Given that ALR is a functional biomarker of inflammation, insulin resistance, and adipose tissue dysfunction, targeting ALR could potentially be a therapeutic approach to coping with obesity-related cardiometabolic risks. Mediterranean diet, weight loss, and increased physical activity can be key components to promote healthy adipose tissue through the increase in ALR. Full article

Background/Objectives: Although physical activity and balanced diet may increase peripheral brain-derived neurotrophic factor (BDNF) concentration, little is known about whether these factors modify BDNF content in physically active individuals and whether the serum fatty acid (FA) profile is related. This study aimed to evaluate quality of diet, identify specific dietary patterns and assess their influence on BDNF and FA levels in serum. It is hypothesized that there is a correlation between diet quality and the concentrations of BDNF and FA in the serum of physically active male individuals. Methods: Physically active young adult male students at Jozef Pilsudski University of Physical Education in Warsaw (Poland) were enrolled. Dietary patterns were identified with cluster analysis and linear discriminant analysis (LDA) based on responses to a validated food frequency questionnaire, KomPAN^® version 1.1. Results: Consumption of beverages, vegetables, milk, wholemeal bread/rolls, fruit and vegetable juices, butter, tinned vegetables and fruits were significant in the LDA model, in which three clusters were distinguished. Cluster 1 was characterized by more frequent consumption of wholemeal bread/rolls, milk, fruits, vegetables, fruit and vegetable juices and sweetened hot beverages and by significantly greater values for the pro-healthy diet index (p < 0.0001) and diet quality index (p < 0.0001) compared to Clusters 2 and 3. The diet of Cluster 2 was of the worst quality, as indicated by the higher values of the not-healthy diet index. Cluster 1 had the tendency for the highest BDNF levels (of the best quality of diet), and a tendency for decreased BDNF concentration with an increased physical activity level was observed. Conclusions: Physical activity, diet quality and BDNF level depend, correlate and interact with each other to provide both optimal physical and mental health. Full article

Diet is one modifiable risk factor for hypertension. The low-sodium DASH (Dietary Approaches to Stop Hypertension) eating plan has been shown to significantly reduce the risk of hypertension and cardiovascular disease. However, there is a lack of available health information on the economic feasibility and cultural acceptability of DASH for low-income African American (AA) populations who are at the most risk for hypertension. An integrative review was conducted to summarize empirical literature on the economic feasibility and cultural acceptability of the DASH plan for low-income AAs using these databases: PubMed, EMBASE, CINAHL Complete, AGRICOLA, Web of Science Core Collection, ProQuest’s Dissertations, Theses Citation Index, and Google Scholar. Study elements from articles in the final analysis were extracted. Eleven (11) published works met the study’s inclusion criteria. Major themes were the availability and access of healthy foods, economic impact of obtaining healthy foods, material resources for cooking, food literacy, and the cultural acceptability of the DASH plan. These findings suggest that cost and cultural familiarity inhibit low-income AAs from benefiting from the DASH plan. Additional research is needed to develop and pilot test low-cost, culturally sensitive DASH eating plans for low-income AAs. Full article

Objectives: The present study aimed to examine the relationship between screen time (ST), sleep time (SLT), physical fitness (PF), Mediterranean diet (MD) adherence, eating behaviours, and body mass index (BMI) in a sample of pre-schoolers from Granada (Spain). In order to address this aim, an explanatory model was developed to examine existing relationships between ST, SLT, PF, MD, pro-intake (PRO-I) and anti-intake (ANT-I) behaviours, and BMI. Further, the proposed structural model was examined via multi-group analysis as a function of sex and BMI. Methods: A cross-sectional study was conducted with 653 three- to six-year-old pre-schoolers attending 18 different schools invited to take part in the present study. Structural equation modelling (SEM) was employed to analyse relationships between study variables as a function of sex and BMI. Results: SEM analysis revealed negative associations between ST and PF (p < 0.005), ST and MD adherence (p < 0.005), ST and SLT (p < 0.005), MD adherence and ANT-I behaviours (p < 0.005), and MD adherence and BMI (p = 0.033). In contrast, positive associations emerged between SLT and MD adherence (p < 0.005), and PRO-I behaviours and BMI (p < 0.005). SEM revealed differences according to sex and BMI. Conclusions: The study highlights significant relationships between lifestyle behaviours and physical and dietary outcomes in pre-schoolers from southern Spain, with variations based on sex and BMI. These findings suggest the need for interventions aimed at reducing ST and promoting better sleep, PF, and dietary habits in order to limit weight-related and general health risks in pre-schoolers from southern Spain. Full article