Search Results (4)

Ruminal acidosis, particularly subacute ruminal acidosis, remains a major metabolic disorder that compromises animal health, production efficiency, and the sustainability of intensive ruminant systems. Although traditionally defined by reduced ruminal pH, it is increasingly recognized as a multidimensional disorder involving microbial ecological destabilization, disrupted metabolic cross-feeding, impaired epithelial barrier function, and dysregulated host inflammatory responses. This review synthesizes current knowledge of the microbial and metabolic mechanisms underlying acute and subacute ruminal acidosis and highlights processes that extend beyond pH depression alone. High-concentrate feeding shifts the balance among amylolytic and lactate-producing microorganisms, lactate-utilizing populations, and fibrolytic guilds, thereby promoting organic acid accumulation, reducing functional redundancy, and weakening microbial resilience. Concurrent increases in volatile fatty acids, lactate, lipopolysaccharide, histamine, and other microbially derived bioactive compounds increase epithelial acid load, disrupt tight-junction integrity, and facilitate inflammatory signaling. The principal novelty of this review is the integration of microbial functional guilds, metabolic cross-feeding, ecological resilience, epithelial barrier dysfunction, and host inflammation into a unified microbiota–metabolism–barrier–inflammation framework linking dietary perturbation with microbial dysfunction and host pathology. We further critically evaluate nutritional regulation, buffering agents, probiotics, yeast-derived products, postbiotics, and plant bioactive compounds according to their capacity to restore microbial function rather than merely correct ruminal pH. Additionally, this review may support multidimensional risk assessment, guide targeted intervention, and facilitate the integration of continuous ruminal monitoring with precision nutrition for earlier prediction and individualized prevention of ruminal acidosis. Full article

Background: Healthcare 5.0 represents a shift toward intelligent, human-centric care systems. Intensive care units generate vast amounts of data that require real-time decisions, but current decision support systems lack comprehensive frameworks for safe integration of artificial intelligence. Objective: We developed and validated the Learn–Predict–Monitor–Detect–Correct (LPMDC) framework as a methodology for systematic artificial intelligence integration across the critical care workflow. The framework improves predictive analytics, continuous patient monitoring, intelligent alerting, and therapeutic decision support while maintaining essential human clinical oversight. Methods: Framework development employed systematic theoretical modeling integrating Healthcare 5.0 principles, comprehensive literature synthesis covering 2020–2024, clinical workflow analysis across 15 international ICU sites, technology assessment of mature and emerging AI applications, and multi-round expert validation by 24 intensive care physicians and medical informaticists. Each LPMDC phase was designed with specific integration requirements, performance metrics, and safety protocols. Results: LPMDC implementation and aggregated evidence from prior studies demonstrated significant clinical improvements: 30% mortality reduction, 18% ICU length-of-stay decrease (7.5 to 6.1 days), 45% clinician cognitive load reduction, and 85% sepsis bundle compliance improvement. Machine learning algorithms achieved an 80% sensitivity for sepsis prediction three hours before clinical onset, with false-positive rates below 15%. Additional applications demonstrated effectiveness in predicting respiratory failure, preventing cardiovascular crises, and automating ventilator management. Digital twins technology enabled personalized treatment simulations, while the integration of the Internet of Medical Things provided comprehensive patient and environmental surveillance. Implementation challenges were systematically addressed through phased deployment strategies, staff training programs, and regulatory compliance frameworks. Conclusions: The Healthcare 5.0-enabled LPMDC framework provides the first comprehensive theoretical foundation for systematic AI integration in critical care while preserving human oversight and clinical safety. The cyclical five-phase architecture enables processing beyond traditional cognitive limits through continuous feedback loops and system optimization. Clinical validation demonstrates measurable improvements in patient outcomes, operational efficiency, and clinician satisfaction. Future developments incorporating quantum computing, federated learning, and explainable AI technologies offer additional advancement opportunities for next-generation critical care systems. Full article

In the context of the high dependency on fossil fuels, the strong efforts aiming to shift towards a more sustainable world are having significant economic and political impacts. The electricity market is now encouraging prosumers to consume their own production, and thus reduce grid exchanges. Self-consumption can be increased using storage systems or rescheduling the loads. This effort involves not only residential prosumers but also industrial ones. The rescheduling process is an optimisation problem that can be effectively solved with evolutionary algorithms (EAs). In this paper, a specific procedure for bridging demand-side management from the theoretical application to a practical industrial scenario was introduced. In particular, the toroidal correction was used in the differential evolution with the aim of preventing the local minima worsening the effectiveness of the proposed method. Moreover, to achieve reasonable solutions, two different cost contributions have been considered: the energy cost and the labour cost. The method was tested on real data from a historical textile factory, Ratti S.p.A. Due to the nature of the loads, the design variables were the starting time of the 30 shiftable loads. The application of this procedure achieves a reduction in the total cost of approximately 99,500 EUR/year. Full article

The load shifting strategy is a form of demand side management program suitable for increasing the reliability of power supply in an electrical network. It functions by clipping the load demand that is above an operator-defined level, at which time is known as peak period, and replaces it at off-peak periods. The load shifting strategy is conventionally performed using the preventive load shifting (PLS) program. In this paper, the corrective load shifting (CLS) program is proven as the better alternative. PLS is implemented when power systems experience contingencies that jeopardise the reliability of the power supply, whereas CLS is implemented only when the inadequacy of the power supply is encountered. The disadvantages of the PLS approach are twofold. First, the clipped energy cannot be totally recovered when it is more than the unused capacity of the off-peak period. The unused capacity is the maximum amount of extra load that can be filled before exceeding the operator-defined level. Second, the PLS approach performs load curtailment without discrimination. This means that load clipping is performed as long as the load is above the operator-defined level even if the power supply is adequate. The CLS program has none of these disadvantages because it is implemented only when there is power supply inadequacy, during which the amount of load clipping is mostly much smaller than the unused capacity of the off-peak period. The performance of the CLS was compared with the PLS by considering chronological load model, duty cycle and the probability of start-up failure for peaking and cycling generators, planned maintenance of the generators and load forecast uncertainty. A newly proposed expected-energy-not-recovered (EENR) index and the well-known expected-energy-not-supplied (EENS) were used to evaluate the performance of proposed CLS. Due to the chronological factor and huge combinations of power system states, the sequential Monte Carlo was employed in this study. The results from this paper show that the proposed CLS yields lower EENS and EENR than PLS and is, therefore, a more robust strategy to be implemented. Full article