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Keywords = polysaccharide hydrogel-microsphere powder

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18 pages, 3487 KB  
Article
Synthetic Haemostatic Sealants: Effectiveness, Safety, and In Vivo Applications
by Federica Curcio, Paolo Perri, Paolo Piro, Stefania Galassi, Roberta Sole, Sonia Trombino and Roberta Cassano
Pharmaceuticals 2024, 17(3), 288; https://doi.org/10.3390/ph17030288 - 23 Feb 2024
Cited by 8 | Viewed by 3356
Abstract
Rapid haemostasis during surgery is essential when one wants to reduce the duration of operations, reduce the need for transfusions, and above all when one wants to achieve better patient management. The use of haemostatic agents, sealants, and adhesives improves the haemostatic process [...] Read more.
Rapid haemostasis during surgery is essential when one wants to reduce the duration of operations, reduce the need for transfusions, and above all when one wants to achieve better patient management. The use of haemostatic agents, sealants, and adhesives improves the haemostatic process by offering several advantages, especially in vascular surgery. These agents vary widely in their mechanism of action, composition, ease of application, adhesion to wet or dry tissue, immunogenicity, and cost. The most used are cyanoacrylate-based glues (Glubran 2) or polysaccharide hydrogel-microsphere powder (AristaTMAH). This work is based on a retrospective study carried out on a sample of patients with different vascular diseases (FAV, pseudoaneurysm, and PICC application) in which two different haemostatic sealants were used. The aim was to assess the safety, the advantages, and the ability of both sealants to activate the haemostatic process at the affected site, also in relation to their chemical-physical characteristics. The obtained results showed that the application of Glubran 2 and AristaTMAH as surgical wound closure systems is effective and safe, as the success achieved was ≥94% on anastomoses of FAV, 100% on stabilization of PICC catheters, and ≤95% on pseudoaneurysms. Full article
(This article belongs to the Section Medicinal Chemistry)
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