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Search Results (472)

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10 pages, 568 KB  
Article
Mini-Open Fifth Metatarsal Osteotomy with Intramedullary Rigid Fixation for Symptomatic Coughlin Type II and III Bunionette Deformity
by Mesut Uluöz, Mehmet Yiğit Gökmen, Özhan Pazarcı, Evren Karaali and Osman Çiloğlu
J. Clin. Med. 2026, 15(13), 5134; https://doi.org/10.3390/jcm15135134 - 1 Jul 2026
Viewed by 124
Abstract
Background: Bunionette deformity is commonly treated with distal or diaphyseal osteotomy, but concerns remain regarding correction loss, implant irritation, and metatarsal shortening. This study evaluated outcomes of mini-open fifth metatarsal osteotomy stabilized with intramedullary rigid fixation in symptomatic Coughlin type II and [...] Read more.
Background: Bunionette deformity is commonly treated with distal or diaphyseal osteotomy, but concerns remain regarding correction loss, implant irritation, and metatarsal shortening. This study evaluated outcomes of mini-open fifth metatarsal osteotomy stabilized with intramedullary rigid fixation in symptomatic Coughlin type II and III deformity. Methods: This single-center retrospective observational study included 32 consecutive patients treated between February 2018 and February 2023. Radiographic outcomes included the fourth-to-fifth intermetatarsal angle (IMA), fifth metatarsophalangeal angle (MPA), maintenance of correction, and fifth metatarsal shortening. Clinical outcomes included the American Orthopaedic Foot and Ankle Society (AOFAS) score, visual analog scale (VAS) pain score, and complications. An exploratory subgroup analysis compared isolated correction with combined procedures. Results: The mean follow-up was 31.5 ± 6.8 months. The mean AOFAS score improved from 52.5 ± 4.2 to 93.4 ± 3.4, and the mean VAS score decreased from 7.8 ± 0.9 to 1.2 ± 0.6 (both p < 0.001). The mean MPA improved from 19.4° ± 3.6° to 2.3° ± 1.1°, and the mean IMA improved from 14.0° ± 1.4° to 4.5° ± 2.5° (both p < 0.001). Minor but statistically significant correction loss occurred between early postoperative and final follow-up radiographs. Mean fifth metatarsal shortening was 1.3 ± 0.8 mm. One patient required implant removal for hardware irritation. No nonunion, transfer metatarsalgia, or wound complications were observed. Conclusions: Mini-open fifth metatarsal osteotomy with intramedullary rigid fixation was associated with pain relief, functional improvement, maintained radiographic correction, limited shortening, and a low observed complication rate in this series. Full article
(This article belongs to the Special Issue Foot and Ankle Surgery: Current Advances and Prospects)
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13 pages, 693 KB  
Systematic Review
Administration Routes for Perioperative Prophylactic Antibiotics: A Scoping Review of Intravenous Push Versus Infusion
by Canyu Yang, Shuhua Deng, Yuan Wei, Yuxi Xia, Xiaoning Yuan, Ning Shen, Li Yang, Rongsheng Zhao, Suodi Zhai and Yingqiu Ying
Antibiotics 2026, 15(7), 643; https://doi.org/10.3390/antibiotics15070643 - 27 Jun 2026
Viewed by 161
Abstract
Objectives: Surgical site infections (SSIs) represent a significant postoperative challenge. Although timely perioperative prophylaxis with cephalosporins is essential to prevention, adherence to the recommended 30–60 min administration window may be challenging with traditional intravenous infusion (IVI) in settings with high surgical turnover, as [...] Read more.
Objectives: Surgical site infections (SSIs) represent a significant postoperative challenge. Although timely perioperative prophylaxis with cephalosporins is essential to prevention, adherence to the recommended 30–60 min administration window may be challenging with traditional intravenous infusion (IVI) in settings with high surgical turnover, as is the case in China. Intravenous push (IVP) has been proposed as a more time-efficient alternative. This scoping review aims to map the available evidence comparing IVP with IVI for perioperative cephalosporin administration across four domains: safety, pharmacokinetics/pharmacodynamics (PK/PD), efficacy, and economic impact. Methods: A systematic search was conducted across PubMed, Embase, Web of Science, the Cochrane Library, and gray literature up to February 2026. Data were systematically charted and extracted using a standardized form. Results: Of the 14 included sources, only 3 were peer-reviewed comparative studies; the remaining 11 (78.6%) were gray literature documents. Among the gray literature, 72.7% (8/11) permitted or recommended IVP for cephalosporin prophylaxis; however, this proportion reflected practice patterns of heterogeneous methodological rigor. The 3 peer-reviewed studies focused on the safety, PK/PD, and economic outcomes. Two studies—in orthopedic and bariatric surgery, respectively—found no significant difference in adverse event rates between IVP and IVI, though both were limited by small samples. A single small study suggested similar PK/PD target attainment between IVI and IVP cefazolin. No study directly compared SSI rates between the two routes. One study suggested potential cost savings with IVP, but the evidence was dated and based on limited patient numbers. Conclusions: The available evidence for IVP is predominantly derived from gray literature, while peer-reviewed articles suggest that safety and PK/PD profiles do not differ markedly from IVI in the limited populations, surgical procedures, and agents studied; economic data are suggestive but dated. Direct comparative data on clinical efficacy outcomes, such as SSI rates, are absent. Well-powered, multi-center comparative studies comparing IVP and IVI with SSI as a primary endpoint are needed. Full article
(This article belongs to the Section Antibiotics Use and Antimicrobial Stewardship)
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12 pages, 572 KB  
Article
Efficacy of Combined Ramosetron and Dexamethasone on Postoperative Recovery in Patients Undergoing General Anesthesia: A Multicenter Randomized Controlled Trial
by Kuen Su Lee, Sang Hun Kim, Yoon Ji Choi, Eun-A Jang, Sun Yeul Lee, Jong Bum Choi, Jun-Mo Park and Hye Won Shin
J. Clin. Med. 2026, 15(13), 5021; https://doi.org/10.3390/jcm15135021 - 27 Jun 2026
Viewed by 135
Abstract
Background/Objectives: Postoperative nausea and vomiting (PONV) is a frequent complication following general anesthesia. Ramosetron is a standard prophylactic agent for PONV; the efficacy of adjunctive dexamethasone in this specific population is not well established. We aimed to evaluate whether adding dexamethasone to ramosetron [...] Read more.
Background/Objectives: Postoperative nausea and vomiting (PONV) is a frequent complication following general anesthesia. Ramosetron is a standard prophylactic agent for PONV; the efficacy of adjunctive dexamethasone in this specific population is not well established. We aimed to evaluate whether adding dexamethasone to ramosetron enhances antiemetic efficacy across diverse surgical procedures. Methods: This prospective, randomized, double-blind, multicenter trial enrolled adults undergoing gynecological, orthopedic, otolaryngologic, general, or plastic surgery managed without postoperative patient-controlled analgesia. We randomized 385 patients into two groups. Group D received 5 mg of dexamethasone immediately after anesthesia induction and ramosetron (0.3 mg) at the end of surgery, whereas Group C received only ramosetron. We assessed the incidence and severity of nausea and vomiting, pain scores, rescue antiemetic and analgesic requirements, and adverse events immediately after surgery and at 6 and 24 h postoperatively. Results: At 6 h, the incidence of nausea was significantly lower in Group D than in Group C (41.7% vs. 58.3%; p = 0.047). Group D also exhibited lower pain scores (VAS: 3.0 ± 1.8 vs. 3.5 ± 1.7; p = 0.012) and reduced consumption of additional analgesics (44.1% vs. 55.9%; p = 0.028). At 24 h, there were no significant differences between the two groups in the incidence of nausea, pain scores, or consumption of additional analgesics. Multivariable logistic regression analysis identified dexamethasone administration as an independent predictor of reduced postoperative nausea at 6 h (odds ratio 0.575; 95% confidence interval 0.344–0.962; p = 0.035). Conclusions: Low-dose dexamethasone to ramosetron substantially reduced postoperative nausea and improved analgesic profiles at 6 h in patients managed without PCA. However, no significant between-group differences were observed at 24 h. Full article
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28 pages, 2694 KB  
Systematic Review
Human Digital Twins in Personalized Medicine: A Systematic Review and Bibliometric–Thematic Synthesis of Methodological Advances and Clinical Applications
by Carlotta Fontana and Sina Zinatlou Ajabshir
Computation 2026, 14(7), 143; https://doi.org/10.3390/computation14070143 - 23 Jun 2026
Viewed by 403
Abstract
Human digital twins (HDTs) are patient-specific computational models that combine medical imaging, physiological measurements and predictive algorithms. They are moving from an exciting concept to a realistic clinical opportunity. The key question is no longer whether HDTs can be built. The key question [...] Read more.
Human digital twins (HDTs) are patient-specific computational models that combine medical imaging, physiological measurements and predictive algorithms. They are moving from an exciting concept to a realistic clinical opportunity. The key question is no longer whether HDTs can be built. The key question is which methods are mature enough to support clinical decisions and what is still missing for routine use. This systematic review maps the methodological landscape of HDTs and highlights practical bottlenecks that limit clinical translation. A PRISMA 2020 guided search of PubMed, Scopus, IEEE Xplore, and the Cochrane Library, covering publications from 2016 to 2026, identified 151 eligible studies. Bibliometric mapping and thematic synthesis were used to characterize research clusters, computational paradigms, and collaboration patterns. Three dominant application streams were identified: cardiovascular HDTs for hemodynamic simulation and procedural planning, musculoskeletal HDTs for biomechanics-driven orthopedic innovation, and neurological HDTs integrating neuroimaging with computational neuroscience. Across domains, the strongest technical trend is the rise in hybrid pipelines that combine physics-based simulation, including finite element and computational fluid dynamics models, with machine learning for segmentation, parameter identification, reduced-order modeling, and faster inference. However, reporting of verification, validation, uncertainty quantification, and explicit context of use remains uneven and prospective clinical evidence is still limited. Overall, the literature shows rapid progress toward clinically credible HDTs, while highlighting the need for scalable computation, standardized credibility pipelines, and workflow-integrated platforms to support safe and reproducible clinical adoption. Full article
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11 pages, 4447 KB  
Technical Note
Contralateral-Structure-Preserving Endoscopic Resection of Cervical Osteochondroma: A Technical Note
by Chun-Gon Park, Hyun-Seong Kim and Sung-Kyu Kim
J. Clin. Med. 2026, 15(12), 4575; https://doi.org/10.3390/jcm15124575 - 12 Jun 2026
Viewed by 175
Abstract
Background: Cervical osteochondromas invading the vertebral canal are rare but may cause spinal cord compression requiring surgical resection. Conventional open laminectomy may disrupt posterior stabilizing structures and potentially increase the risk of postoperative cervical deformity. This technical note describes a contralateral-structure-preserving endoscopic technique [...] Read more.
Background: Cervical osteochondromas invading the vertebral canal are rare but may cause spinal cord compression requiring surgical resection. Conventional open laminectomy may disrupt posterior stabilizing structures and potentially increase the risk of postoperative cervical deformity. This technical note describes a contralateral-structure-preserving endoscopic technique for cervical osteochondroma resection. Methods: A 25-year-old man with multiple hereditary exostosis presented with neck pain, mild numbness, and a positive Lhermitte’s sign. Computed tomography and magnetic resonance imaging revealed a 9 × 6 × 10 mm osteochondroma originating from the base of the C3 spinous process and extending into the vertebral canal with spinal cord compression and cord signal change. Preoperative clinical assessment included a Visual Analog Scale (VAS) for neck pain of 6/10, a modified Japanese Orthopedic Association (mJOA) score of 16/18, a Neck Disability Index (NDI) of 30%, and Nurick grade 1. The lesion was treated using unilateral biportal endoscopic spine surgery through a partial unilateral laminectomy and sublaminar endoscopic corridor, aiming for en bloc resection while preserving the contralateral lamina, posterior ligamentous complex, and posterior tension band. Continuous intraoperative neurophysiological monitoring (SSEP and MEP) was used throughout the procedure. Results: The osteochondroma was completely resected en bloc using a diamond burr and Kerrison rongeur. Histopathological examination confirmed osteochondroma, and negative margins were identified without residual tumor. The patient’s symptoms resolved completely without postoperative complications, and he was discharged on postoperative day 3. At the 18-month clinical and radiological follow-up, the patient remained symptom-free, with VAS improved to 1–2/10, mJOA improved to 18/18, NDI improved to 4%, and Nurick grade improved to 0, with partial regression of the cord signal change and no evidence of tumor recurrence on follow-up imaging. Cervical lordosis was maintained at the immediate postoperative timepoint. Conclusions: Contralateral-structure-preserving endoscopic resection may represent a potential minimally invasive alternative to conventional wide laminectomy or fusion-based approaches in carefully selected cases of benign cervical osteochondroma. Larger comparative studies with long-term follow-up are required to confirm the potential biomechanical and clinical benefits of this approach. Full article
(This article belongs to the Special Issue Recent Advances and Future Perspectives on Spinal Surgeries)
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13 pages, 2814 KB  
Article
Plating of a Single Bone Is Promising for the Treatment of Both-Bone Forearm Fractures in Children
by Shou En Cheng, Kai Xuan Lim, Shang-Ming Lin, Ching-Ting Liang and Tsung-Yu Lan
Life 2026, 16(6), 978; https://doi.org/10.3390/life16060978 - 10 Jun 2026
Viewed by 210
Abstract
Background: Forearm fractures involving both bones are common orthopedic injuries. Children have a higher tolerance for greater displacement and angulation owing to the remodeling potential. The optimal fixation method for managing pediatric forearm fractures has not been definitively established. This study evaluated the [...] Read more.
Background: Forearm fractures involving both bones are common orthopedic injuries. Children have a higher tolerance for greater displacement and angulation owing to the remodeling potential. The optimal fixation method for managing pediatric forearm fractures has not been definitively established. This study evaluated the safety and efficacy of a stepwise surgical algorithm, wherein single-bone plating was attempted first, and both-bone fixation was strictly reserved for cases demonstrating persistent intraoperative instability. Methods: In this retrospective analysis, we evaluated 48 skeletally immature children with both-bone forearm fractures managed via our stepwise protocol. Initially, single-bone plating was performed. Dynamic manual stress testing was then applied under fluoroscopy. If the unplated bone exhibited rotational instability, residual angulation >15°, or translation >50%, the procedure was converted to both-bone plating (Group B, n = 16). Patients who achieved stable alignment without requiring a second plate formed Group A (n = 32). Results: Both groups achieved 100% union. Postoperative angulations of the radius on the anteroposterior view were 1.91 ± 2.73° in Group A and 0.88 ± 1.96° in Group B; meanwhile, the lateral angulation of the radius in Groups A and B was 1.88 ± 3.56° and 0.00 ± 0.00°, respectively. The anteroposterior angulation of the ulna was 2.31 ± 3.60° in Group A and 2.19 ± 4.00° in Group B, whereas the lateral angulation of the ulna was 2.81 ± 3.74° in Group A and 1.75 ± 3.47° in Group B. Only the lateral angulation of the radius showed a significant difference (p = 0.0418). In the subgroup analysis, minor differences in ulna angulation on the anteroposterior view reached statistical significance in the older cohort (p = 0.027) and in the distal-third fracture group (p = 0.001). No differences in bone healing or functional outcomes were observed, and complication rates were similar. Conclusion: Our stepwise surgical algorithm appears to be a safe and effective approach. By adhering to this protocol, 66.7% of patients were successfully spared the morbidity of a second incision, while all patients achieved solid union and excellent functional outcomes. However, further high-quality studies are essential to establish comprehensive protocols for intraoperative stability assessment and postoperative care. Full article
(This article belongs to the Special Issue New Challenges in Fracture Management)
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19 pages, 4334 KB  
Systematic Review
The Prognostic Value of Frailty Assessment Tools in Predicting Postoperative Outcomes After Revision Total Hip and Knee Arthroplasty: A Systematic Review
by Ruben David Braescu, Jenel Marian Pătrașcu, Jenel Marian Pătrașcu and Dan Grigore Cojocaru
J. Clin. Med. 2026, 15(12), 4489; https://doi.org/10.3390/jcm15124489 - 10 Jun 2026
Viewed by 149
Abstract
Background/Objectives: Frailty has emerged as a relevant marker of biological vulnerability in patients undergoing complex orthopedic procedures, yet its specific prognostic value in revision total hip and knee arthroplasty remains incompletely synthesized. This systematic review evaluated whether validated preoperative frailty assessment tools are [...] Read more.
Background/Objectives: Frailty has emerged as a relevant marker of biological vulnerability in patients undergoing complex orthopedic procedures, yet its specific prognostic value in revision total hip and knee arthroplasty remains incompletely synthesized. This systematic review evaluated whether validated preoperative frailty assessment tools are associated with adverse postoperative outcomes after revision total joint arthroplasty and whether available studies allow comparison of prediction performance across instruments. Methods: A systematic search of PubMed/MEDLINE, Embase, the Cochrane Library, Web of Science, Scopus, citation lists, and selected gray-literature sources was performed from inception through January 2026. Gray-literature records and conference abstracts were used only for citation tracking; the synthesis included only full-length peer-reviewed original research articles involving adult patients undergoing revision total hip arthroplasty, revision total knee arthroplasty, or both, with quantitative outcomes according to a validated frailty measure. Because of heterogeneity in frailty tools, outcome definitions, revision indications, and adjustment strategies, findings were synthesized narratively and certainty was assessed by outcome domain. Results: Eleven full-length studies were included, with cohorts ranging from 117 patients to 576,920 admissions, and most were retrospective database analyses. Higher frailty burden was consistently associated with worse short-term outcomes, including complications, prolonged hospital stay, readmission, non-home discharge, resource use, and mortality-related risk stratification. Representative findings included 30-day readmission of 23.8% versus 9.9%, surgical complications of 28.6% versus 7.8%, and odds ratios of up to 10.79 for complications across escalating frailty strata. Prediction studies suggested stronger discrimination for revision-specific or broader models, such as CARDE-B, RAI-rev, and machine-learning approaches, than for simpler generic frailty indices. Conclusions: Frailty is a consistent preoperative marker of elevated short-term perioperative risk after revision arthroplasty. The available evidence supports incorporating frailty assessment into preoperative risk stratification and counseling, but it remains insufficient to establish one universally preferred tool or to prove that frailty screening alone improves outcomes without targeted intervention. Full article
(This article belongs to the Section Orthopedics)
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13 pages, 1737 KB  
Article
Effect of Sagittal TTTG on Graft Failure After Anterior Cruciate Ligament Reconstruction
by Sebastian Schmidt, Chilan B. G. Leite, Domenico Franco, Ali Darwich, Cale A. Jacobs and Christian Lattermann
Surgeries 2026, 7(2), 68; https://doi.org/10.3390/surgeries7020068 - 9 Jun 2026
Viewed by 221
Abstract
Background: Anterior cruciate ligament reconstruction (ACLR) is a common orthopedic procedure with generally favorable outcomes, yet graft failure remains a significant challenge, particularly in young and active patients. While various anatomical and biomechanical risk factors for graft failure have been proposed, the influence [...] Read more.
Background: Anterior cruciate ligament reconstruction (ACLR) is a common orthopedic procedure with generally favorable outcomes, yet graft failure remains a significant challenge, particularly in young and active patients. While various anatomical and biomechanical risk factors for graft failure have been proposed, the influence of the sagittal tibial tubercle–trochlear groove (sTTTG) distance, representing anterior–posterior alignment of the tibial tubercle, has not been sufficiently explored. This study aimed to evaluate the association between sTTTG and ACL graft failure and assess contributing biomechanical variables, including tibiofemoral rotation (TFR), posterior tibial slope (PTS), and knee flexion angle. Methods: For this secondary analysis, a retrospective matched case–control study was conducted, involving 151 patients with ACL graft failure who underwent revision ACLR and 151 controls with intact grafts after a minimum 2-year follow-up period. sTTTG was measured on axial MRI as the anteroposterior distance from the trochlear groove to the tibial tubercle, perpendicular to the posterior femoral condylar axis. Secondary measurements included TT-TG, TFR, medial and lateral PTS, and knee flexion angle. Group differences as well as factors predictive of sTTTG were analyzed. Results: The ACLR failure group demonstrated a significantly lower sTTTG distance compared to controls (0.5 ± 4.6 mm vs. 2.4 ± 4.8 mm, p = 0.001). Logistic regression analysis revealed that a 1 mm increase in sTTTG was associated with an 8% reduction in revision risk (OR = 0.93 per 1 mm increase; 95% CI, 0.88–0.97; p = 0.003), although the predictive accuracy was low (AUC = 0.6). Multivariable analysis identified lateral PTS and knee flexion as significant independent predictors of sTTTG. Conclusions: A decreased sTTTG distance was significantly associated with ACL graft failure, underscoring the relevance of sagittal tibial tubercle positioning in ACL biomechanics. While not an independent clinical decision-making tool, sTTTG appears relevant to graft failure and may be considered in future risk assessment strategies. Full article
(This article belongs to the Section Minimally Invasive and Robotic Surgery Group)
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10 pages, 1459 KB  
Article
Mid-Term Outcomes of a Next-Generation Modular Acetabular System in Primary and Revision Total Hip Arthroplasty
by Garrett Ruff, Laith Bahlouli, Anzar Sarfraz, Farouk Khury, Diren Arsoy, Claudette Lajam and Vinay K. Aggarwal
J. Clin. Med. 2026, 15(11), 4258; https://doi.org/10.3390/jcm15114258 - 31 May 2026
Viewed by 315
Abstract
Background/Objectives: Total hip arthroplasty (THA) is a common orthopedic procedure, and with projected growth in both primary and revision surgical volumes, robust implant performance data is necessary to inform surgical decision-making. To ensure successful outcomes in primary THA (pTHA) and revision THA [...] Read more.
Background/Objectives: Total hip arthroplasty (THA) is a common orthopedic procedure, and with projected growth in both primary and revision surgical volumes, robust implant performance data is necessary to inform surgical decision-making. To ensure successful outcomes in primary THA (pTHA) and revision THA (rTHA), surgeons need versatile implant systems that can address patient-specific surgical challenges. This study aimed to evaluate the outcomes of a next-generation acetabular system used for various indications in both pTHA and rTHA. Methods: We retrospectively reviewed 319 patients who underwent either pTHA or rTHA using a modern acetabular system at a single urban academic center between 2014 and 2023 with at least 18 months of follow-up. Baseline characteristics and the patient-reported Hip Disability and Osteoarthritis Outcome Score, Joint Replacement (HOOS, JR) were collected. A total of 284 patients who underwent pTHA and 35 patients who underwent rTHA were included. Median follow-up was 2.6 years (range: 1.5–8.4 years). Results: The most common indication was osteoarthritis (90%) for pTHA and instability (46%) for rTHA. Most rTHAs utilized a dual-mobility construct (74%), compared to pTHAs (22%). There were ten all-cause acetabular revisions in the entire cohort (eight in pTHA, two in rTHA), four of which were aseptic (three in pTHA, one in rTHA). All-cause and aseptic acetabular survivorship of the pTHA cohort was 97.2% and 98.7%, respectively, and of the rTHA cohort was 94.3% and 97.1%, respectively. Improvement in the median HOOS, JR score was 21.5 points at one year and 25.5 points at two years among pTHAs. Conclusions: The findings with this system support adequate mid-term acetabular component survivorship in pTHA and rTHA, along with clinically meaningful functional improvement following pTHA. Given the retrospective, observational nature of this study, further prospective research with extended follow-up and larger sample sizes, particularly in the rTHA cohort, is needed to better assess long-term outcomes. Full article
(This article belongs to the Section Orthopedics)
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17 pages, 31462 KB  
Review
Orthodontic Treatment in Idiopathic Root Resorption: A Narrative Review and a Clinical Case Report
by Marta Karolczuk, Ilona Radej, Irena Grodzka, Antonino Lo Giudice and Izabela Szarmach
J. Clin. Med. 2026, 15(11), 4074; https://doi.org/10.3390/jcm15114074 - 25 May 2026
Viewed by 351
Abstract
Idiopathic root resorption is diagnosed when external root resorption occurs in the absence of an identifiable etiological factor. Two main forms are described in the literature: apical and cervical. Owing to the rarity of this condition and the limited number of published reports, [...] Read more.
Idiopathic root resorption is diagnosed when external root resorption occurs in the absence of an identifiable etiological factor. Two main forms are described in the literature: apical and cervical. Owing to the rarity of this condition and the limited number of published reports, evidence-based recommendations for orthodontic management are currently lacking. The aim of this study was to provide a narrative overview of published case reports describing orthodontic procedures performed in patients with idiopathic root resorption and to supplement the available literature with a detailed clinical case. A case of a 7-year-7-month-old female patient presenting with generalized idiopathic root resorption and a concomitant skeletal Class III malocclusion is described. In this patient, skeletal anchorage was used to support maxillary protraction in an attempt to obtain an orthopedic effect. The literature review had a narrative character and was based on a structured search of the PubMed, Scopus, and Web of Science databases covering the period from January 2010 to December 2025. Only English-language case reports meeting strict eligibility criteria were considered. Of 47 records initially identified, two fulfilled the inclusion criteria; an additional two case reports were retrieved through manual searching. Conclusions: Given that the available evidence is limited to isolated case reports and a single clinical observation, the present findings do not allow for reliable conclusions regarding the safety, effectiveness, or general applicability of orthodontic treatment in patients with idiopathic root resorption. Clinical management should therefore be individualized, with careful documentation and close radiological follow-up. Further well-documented clinical reports are required to better characterize treatment-related risks in this patient group. Full article
(This article belongs to the Special Issue Orthodontics: Current Advances and Future Options)
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14 pages, 1725 KB  
Article
Intra-Individual Variability of Vancomycin Trough Concentrations Before and After Implementation of a Standardized Operating Procedure in Orthopedic Inpatients
by Moritz Diers, Laura Isabell Werneburg, Alexander Zeh, Natalia Gutteck, Karl-Stefan Delank and Felix Werneburg
Antibiotics 2026, 15(5), 517; https://doi.org/10.3390/antibiotics15050517 - 20 May 2026
Viewed by 318
Abstract
Background: Standardized operating procedures (SOPs) for intravenous vancomycin therapy have been shown to improve population-level trough target attainment and to reduce nephrotoxicity in orthopedic inpatients. However, mean target attainment on a population level does not capture how stably an individual patient remains within [...] Read more.
Background: Standardized operating procedures (SOPs) for intravenous vancomycin therapy have been shown to improve population-level trough target attainment and to reduce nephrotoxicity in orthopedic inpatients. However, mean target attainment on a population level does not capture how stably an individual patient remains within the therapeutic window. Intra-individual variability of vancomycin trough concentrations has remained underreported as a patient-level quality indicator in the orthopedic stewardship literature, despite its direct clinical relevance, as alternating sub- and supratherapeutic phases compromise both efficacy and safety independently of the mean exposure. Methods: We conducted a secondary analysis of the prospectively and retrospectively collected data of the Halle Vancomycin SOP cohort. Pre-SOP (n = 58) and post-SOP (n = 23) patient cohorts were compared with respect to patient-level variability metrics, including the coefficient of variation (CV%), swing index, mean absolute successive difference (MSSD), range of trough values, zone-transition frequencies, and the proportion of “stable” patients defined as CV% below 20%. First-order Markov transition matrices were computed to characterize the directionality of trough movements between subtherapeutic, target, and supratherapeutic zones. The primary analysis was restricted to patients with at least three documented trough measurements. Results: The median CV% decreased from 43.5% (IQR 33.5–51.5) pre-SOP to 32.5% (IQR 21.9–38.6) post-SOP (Mann–Whitney U, p = 0.011). The swing index decreased from 1.09 to 0.75 (p = 0.002), and the median range of individual trough concentrations shrank from 19.1 mg/L to 13.2 mg/L (p = 0.029). The absolute number of zone transitions per patient did not differ significantly between cohorts, but their directionality differed substantially: target-zone persistence increased from 37.8% to 57.6%. Across all 403 measurements, subtherapeutic values declined from 38.5% to 26.6%, while target-zone measurements rose from 28.5% to 44.7%. In the post-SOP cohort, longer therapy duration was associated with lower CV% (Spearman ρ = −0.52, p = 0.032). Conclusions: In addition to improvements in population-level target attainment, implementation of the SOP was associated with stabilization of the individual exposure profile of orthopedic inpatients receiving intravenous vancomycin. Intra-individual variability was lower in the post-SOP cohort, and transitions between zones were more often oriented toward the target range. These findings, derived from a single-centre secondary analysis with a small post-SOP cohort, support patient-level variability metrics as a complementary quality indicator in protocolized vancomycin management and warrant prospective multicentre validation. Full article
(This article belongs to the Section Antibiotics Use and Antimicrobial Stewardship)
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19 pages, 2704 KB  
Review
Pediatric Extremity Vascular Malformations: Diagnosis, Referral, and Limb Management from a Pediatric Orthopedic Perspective
by Taichun Li, Jingmiao Wang, Hai Li and Ziming Zhang
J. Clin. Med. 2026, 15(10), 3833; https://doi.org/10.3390/jcm15103833 - 15 May 2026
Viewed by 371
Abstract
Extremity vascular malformations in children and adolescents are congenital vascular developmental abnormalities that often present to pediatric orthopedic surgeons with pain, swelling, restricted motion, contracture, gait disturbance, limb asymmetry, and growth-related deformity rather than with an obvious vascular phenotype. The orthopedic importance of [...] Read more.
Extremity vascular malformations in children and adolescents are congenital vascular developmental abnormalities that often present to pediatric orthopedic surgeons with pain, swelling, restricted motion, contracture, gait disturbance, limb asymmetry, and growth-related deformity rather than with an obvious vascular phenotype. The orthopedic importance of these lesions lies less in surface appearance than in their potential to affect muscle balance, joint integrity, osseous development, and peri-procedural safety. This review translates contemporary vascular anomaly classification and multidisciplinary management pathways into a practical orthopedic framework for diagnosis, referral, and longitudinal limb management. The most useful first step is to distinguish low-flow from high-flow lesions and then define lesion depth, periarticular or osseous involvement, coagulopathy risk, and syndromic overgrowth phenotype. Ultrasound is usually the first-line imaging modality for flow characterization, whereas magnetic resonance imaging is the cornerstone for defining extent and planning treatment. Plain radiographs remain highly relevant for identifying phleboliths, osseous remodeling, arthropathy, contracture-related deformity, and limb-length discrepancy. Venous malformations generally warrant pathway-based coagulation assessment, especially D-dimer and fibrinogen, because localized intravascular coagulopathy has direct implications for intervention and surgery. Arteriovenous malformations are best managed within specialist multidisciplinary teams. Fibro-adipose vascular anomaly and syndromic overgrowth phenotypes warrant particular attention because they frequently drive pain, contracture, and progressive limb imbalance. Outcome assessment in this field should extend beyond lesion size and incorporate pain, function, quality of life, and growth-related consequences. For pediatric orthopedic surgeons, management should move from late deformity correction toward early classification, early referral, longitudinal surveillance of joint and growth-related complications, and careful integration of local, surgical, and systemic therapies. Full article
(This article belongs to the Section Orthopedics)
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39 pages, 6701 KB  
Article
Multi-Velocity Ceiling Diffuser for Orthopedic Procedures or Ventilation: An Integrated CFD, Performance Assessment, and Surrogate Modeling Framework
by Hasan Mhd Nazha, Hanan Mukhaiber, Mhd Ayham Darwich and Marah Salamie
Buildings 2026, 16(10), 1937; https://doi.org/10.3390/buildings16101937 - 13 May 2026
Viewed by 1407
Abstract
Operating room ventilation is a key engineering factor in maintaining clean air environments. This study presents an integrated three-part methodology combining Computational Fluid Dynamics parametric analysis, performance assessment with effect size analysis and multi-criteria decision analysis using quantitative engineering metrics, and surrogate modeling [...] Read more.
Operating room ventilation is a key engineering factor in maintaining clean air environments. This study presents an integrated three-part methodology combining Computational Fluid Dynamics parametric analysis, performance assessment with effect size analysis and multi-criteria decision analysis using quantitative engineering metrics, and surrogate modeling for thermal effect propagation in an orthopedic operating room. Simulations were conducted in ANSYS Fluent 2020 R2, benchmarking an existing local operating room against an ASHRAE 170-2021 compliant model, followed by parametric evaluation of four ceiling inlet configurations. The existing system exhibited critically low velocities (0.05–0.10 m/s) with a coefficient of variation of 0.73, indicating severe flow non-uniformity. The proposed Multi-Velocity Ceiling Diffuser—featuring a high-velocity core (0.40 m/s) over the surgical area and a low-velocity peripheral frame (0.20 m/s)—achieved 85% coverage of the ASHRAE-recommended velocity range (0.20–0.30 m/s), a coefficient of variation of 0.14 (81% improvement), and 62 air changes per hour, representing an 86% reduction in supply airflow compared to a full-ceiling system. Effect size analysis confirmed that MVCD performance shows large practical differences from smaller inlet designs (Cohen’s d ≥ 0.41) and negligible difference from full-ceiling systems (Cohen’s d = 0.05). Multi-criteria decision analysis—with feasibility and cost quantified using engineering estimates (ductwork area, downtime days, standardized cost data)—ranked MVCD as optimal under the modeled assumptions (composite score = 0.84), outperforming the existing system (0.59) and full-ceiling design (0.51). To address the isothermal assumption limitation, a Random Forest surrogate model was implemented as a differentiable approximation strategy for parametric uncertainty propagation. Under non-isothermal conditions, the MVCD is predicted to maintain a spatial median velocity of 0.19 m/s (5th–95th percentile range: 0.17–0.21 m/s) and 71% ASHRAE compliance (parameter sampling range across literature-derived distributions: 63–78%). Achieving ASHRAE velocity criteria is an engineering surrogate for ventilation effectiveness; the relationship between these metrics and clinical infection outcomes depends on multiple factors beyond airflow, including surgical technique, patient factors, and antimicrobial prophylaxis. No clinical inference is permitted from the present results. Experimental measurement in a physical MVCD-equipped operating room is required to validate these predictions prior to clinical implementation. Full article
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19 pages, 1936 KB  
Article
Radiographic Healing and Observed Complications Following Light-Cured Polymer Immobilization: A Retrospective Cohort Study of 108 Patients
by Onix Reyes Martínez, James Stavitz, Kenielle Olmeda-Mercado, Viviana Negrón-Rodríguez and Ryan Porcelli
J. Clin. Med. 2026, 15(10), 3709; https://doi.org/10.3390/jcm15103709 - 12 May 2026
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Abstract
Purpose: Traditional plaster and fiberglass casts remain widely used for fracture immobilization but are associated with recognized challenges, including skin irritation, hygiene limitations, and distress during cast removal, particularly in pediatric populations. Light-cured polymer immobilization (LCPI) systems have been introduced as an alternative [...] Read more.
Purpose: Traditional plaster and fiberglass casts remain widely used for fracture immobilization but are associated with recognized challenges, including skin irritation, hygiene limitations, and distress during cast removal, particularly in pediatric populations. Light-cured polymer immobilization (LCPI) systems have been introduced as an alternative method of fracture support. The primary objective of this study was to describe radiographic healing and alignment outcomes among patients treated with an LCPI system. Secondary objectives were to document skin- and device-related events and to identify any unplanned removals or subsequent re-interventions. Methods: A 6-month retrospective cohort study was conducted involving 108 consecutive patients treated with an LCPI system between January and June 2025 at a single orthopaedic clinic. Clinical and radiographic records were reviewed to extract demographic information, injury characteristics, treatment details, immobilization duration, healing outcomes, alignment status, and recorded adverse events. Outcomes were summarized using descriptive statistics. Results: Immobilization was applied for 104 fractures (96.3%), three sprains (2.8%), and one elbow dislocation (0.9%). The cohort (76 males, 32 females; mean age: 13.4 years; range: 4–53) demonstrated radiographic union or progression toward union among fracture cases with available follow-up imaging. Mean immobilization duration was 29.2 days (SD: 6.2; range: 10–48). Alignment at device removal was documented as anatomic or near-anatomic in 103 of 104 fractures (99.1%) based on treating clinician assessment (99.1%). Device breakage was documented in 12 cases (11.1%), of which 3 required additional immobilization. Two patients (1.9%) experienced mild cutaneous reactions that resolved with conservative management. No severe device-related complications were documented. Conclusions: Healing outcomes and recorded adverse events were consistent with expected clinical patterns for this patient population in this descriptive retrospective cohort of patients treated with an LCPI system. These findings provide descriptive real-world data regarding clinical utilization and short-term outcomes in selected patients. Prospective comparative studies are needed to further define effectiveness, safety, cost considerations, and broader applicability across diverse fracture populations. Full article
(This article belongs to the Section Orthopedics)
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14 pages, 261 KB  
Article
Examining the Relationships and Differences of Satisfaction, Kinesiophobia, and Pain Between Rehabilitation Phases in Patients After Total Knee Replacement
by Anna Christakou, Danai Georgitsi, Manolis Papadopoulos, Nikolaos Zacharakis and Panayiotis Papagelopoulos
Surgeries 2026, 7(2), 57; https://doi.org/10.3390/surgeries7020057 - 5 May 2026
Viewed by 907
Abstract
Background/objectives: Total knee arthroplasty is one of the most commonly performed orthopedic procedures of the lower extremities, primarily for patients with osteoarthritis or rheumatoid arthritis. Despite its widespread use, evidence remains limited regarding the association between patient satisfaction, kinesiophobia, and pain during the [...] Read more.
Background/objectives: Total knee arthroplasty is one of the most commonly performed orthopedic procedures of the lower extremities, primarily for patients with osteoarthritis or rheumatoid arthritis. Despite its widespread use, evidence remains limited regarding the association between patient satisfaction, kinesiophobia, and pain during the early postoperative period. The purpose of the present study was to examine the relationships and differences among satisfaction, kinesiophobia, and pain in hospitalized patients following total knee arthroplasty, as well as to compare these variables across four postoperative time points. Methods: A total of 41 patients, aged 65–85 years, participated in this study. Patient satisfaction was assessed using a structured satisfaction questionnaire, kinesiophobia was assessed using the Greek version of Tampa Scale of Kinesiophobia, and pain was assessed using the Visual Analogue Scale. Measurements were obtained on the first postoperative day, on the day of hospital discharge, fifteen days after discharge, and four weeks after discharge. Normality was assessed using the Shapiro–Wilk test, indicating non-normally distributed data. The relationship between the variables were examined using Spearman’s correlation coefficient. Comparisons between the four postoperative time points were conducted using the Friedman test with Kendall’s W for effect size estimation, followed by Wilcoxon post hoc analyses with Bonferroni corrections. Results: The results showed that a significant negative correlation between satisfaction and kinesiophobia was observed at the fourth phase (r = −0.41, p = 0.04). Satisfaction was also negatively correlated with pain from the third to the fourth phase (r = −0.41, p = 0.008), whereas kinesiophobia demonstrated a significant positive correlation with pain from the second to the fourth phase (r = 0.47–0.56, p = 0.002). Friedman test comparisons revealed a significant increase in satisfaction over time (χ2 (3) = 13.88, p = 0.003), a significant progressive decrease in kinesiophobia with a moderate effect size (χ2 (3) = 76.40, p < 0.001; Kendall’s W = 0.62), and a significant progressive reduction in pain with a large effect size (χ2 (3) = 89.60, p < 0.001; Kendall’s W = 0.73). Conclusions: These findings indicate that satisfaction, kinesiophobia, and pain are significantly interrelated during the early postoperative period following total knee arthroplasty. Further studies with larger samples and longer follow-up periods are required to confirm these associations and support the development of targeted rehabilitation strategies. Full article
(This article belongs to the Special Issue Advances in Total Hip and Knee Arthroplasty)
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