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Keywords = orphanage

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14 pages, 237 KiB  
Article
Child Maltreatment and the Mediating Effects of Bullying Victimization on School Engagement Among South Korean Youth in Orphanages and a National Sample
by Sunghwan Cho, Seon Kim, Hollee A. McGinnis and Traci L. Wike
Children 2025, 12(7), 829; https://doi.org/10.3390/children12070829 - 23 Jun 2025
Viewed by 288
Abstract
Background: Peer bullying is a global problem affecting youth around the world that can impact youth development including school engagement. The relationship between child maltreatment and school bullying victimization and perpetration is well known. However, few studies have explored the extent of bullying [...] Read more.
Background: Peer bullying is a global problem affecting youth around the world that can impact youth development including school engagement. The relationship between child maltreatment and school bullying victimization and perpetration is well known. However, few studies have explored the extent of bullying among vulnerable groups of adolescents. Youth in orphanage care may be at higher risk of both maltreatment and bullying because of the circumstances and stigma that brought them into care. This study aimed to examine peer bullying victimization among adolescents residing in orphanage care compared to a national sample of adolescents in South Korea, and to investigate the mediating effect of bullying victimization on the relationship between child maltreatment and school engagement. This comparison allowed for an examination of how caregiving contexts may differentially influence the impact of maltreatment and bullying on school engagement. Methods: Data from the national Korean Welfare Panel Study (KoWePS) 7th wave (n = 521) and a study of 153 South Korean adolescents in orphanage care were merged into one dataset (n = 675). Analysis included descriptive and bivariate statistics, two simple mediation analyses, and multiple regression analysis to verify mediation effects using PROCESS Macro. Results: Adolescents in orphanage care reported significantly higher bullying victimization and lower school engagement than the national sample. Negative correlations were identified between child maltreatment, bullying victimization, and school engagement among adolescents in orphanage care. Importantly, bullying victimization significantly mediated the relationship between child maltreatment and school engagement within this group. Conclusions: These findings highlight the complex relationship between maltreatment and bullying victimization, emphasizing the need for comprehensive interventions addressing both maltreatment and peer bullying to enhance school engagement among vulnerable youth. Full article
(This article belongs to the Section Pediatric Mental Health)
12 pages, 440 KiB  
Article
Institutional Accreditation and Its Impact on Children’s Health in Orphanages: A Systematic Literature Review on Learning Organizations and Quality Assurance
by Dewi Kartikawati, Binahayati Rusyidi, Nurliana Cipta Apsari and Sri Sulastri
Soc. Sci. 2025, 14(5), 307; https://doi.org/10.3390/socsci14050307 - 15 May 2025
Viewed by 691
Abstract
The process of institutional accreditation establishes crucial mechanisms that lead to better quality childcare in orphanages through the development of organizational stability and trained staff, in addition to healthcare improvements. The assessment of accreditation effects on children’s health draws from learning organizations and [...] Read more.
The process of institutional accreditation establishes crucial mechanisms that lead to better quality childcare in orphanages through the development of organizational stability and trained staff, in addition to healthcare improvements. The assessment of accreditation effects on children’s health draws from learning organizations and quality assurance frameworks in this systematic review. A systematic database review yielded 35 peer-reviewed publications that followed PRISMA analysis procedures. Research evidence shows that accredited orphanages attain better results when it comes to hygiene practices, as well as nutrition standards, healthcare access, mental healthcare support. Accreditation enables institutions to learn continuously because the process promotes service delivery improvements. The advantages of accreditation in orphanages are clear, but accreditation faces the barriers of monetary constraints, employee reluctance towards external inspections, and erratic policy execution, which reduce its widespread adoption. Accreditation efforts in orphanages require purposeful funding alongside built-up staff competencies and stronger regulatory policies to achieve their maximum potential benefit. Full article
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14 pages, 346 KiB  
Perspective
Revisiting One of the Oldest Orphanages, Asylums, and Indigenous Residential Boarding Schools: The Thomas Indian School at Seneca Nation
by Hayden Haynes, Theresa McCarthy, Corinne Abrams, Melissa E. Lewis and Rodney C. Haring
Int. J. Environ. Res. Public Health 2024, 21(9), 1120; https://doi.org/10.3390/ijerph21091120 - 25 Aug 2024
Cited by 1 | Viewed by 4881
Abstract
For Indigenous populations, one of the most recognized acts of historical trauma has come from boarding schools. These institutions were established by federal and state governments to forcibly assimilate Indigenous children into foreign cultures through spiritual, physical, and sexual abuse and through the [...] Read more.
For Indigenous populations, one of the most recognized acts of historical trauma has come from boarding schools. These institutions were established by federal and state governments to forcibly assimilate Indigenous children into foreign cultures through spiritual, physical, and sexual abuse and through the destruction of critical connections to land, family, and tribal community. This literature review focuses on the impact of one of the oldest orphanages, asylums, and Indigenous residential boarding schools in the United States. The paper shares perspectives on national and international parallels of residential schools, land, truth and reconciliation, social justice, and the reconnection of resiliency-based Indigenous Knowledge towards ancestral strength, reclamation, survivorship, and cultural continuance. Full article
26 pages, 3717 KiB  
Article
Lingering Effects of Early Institutional Rearing and Cytomegalovirus Infection on the Natural Killer Cell Repertoire of Adopted Adolescents
by Elizabeth K. Wood, Brie M. Reid, Dagna S. Sheerar, Bonny Donzella, Megan R. Gunnar and Christopher L. Coe
Biomolecules 2024, 14(4), 456; https://doi.org/10.3390/biom14040456 - 9 Apr 2024
Cited by 1 | Viewed by 1961
Abstract
Adversity during infancy can affect neurobehavioral development and perturb the maturation of physiological systems. Dysregulated immune and inflammatory responses contribute to many of the later effects on health. Whether normalization can occur following a transition to more nurturing, benevolent conditions is unclear. To [...] Read more.
Adversity during infancy can affect neurobehavioral development and perturb the maturation of physiological systems. Dysregulated immune and inflammatory responses contribute to many of the later effects on health. Whether normalization can occur following a transition to more nurturing, benevolent conditions is unclear. To assess the potential for recovery, blood samples were obtained from 45 adolescents adopted by supportive families after impoverished infancies in institutional settings (post-institutionalized, PI). Their immune profiles were compared to 39 age-matched controls raised by their biological parents (non-adopted, NA). Leukocytes were immunophenotyped, and this analysis focuses on natural killer (NK) cell populations in circulation. Cytomegalovirus (CMV) seropositivity was evaluated to determine if early infection contributed to the impact of an atypical rearing. Associations with tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ), two cytokines released by activated NK cells, were examined. Compared to the NA controls, PI adolescents had a lower percent of CD56bright NK cells in circulation, higher TNF-α levels, and were more likely to be infected with CMV. PI adolescents who were latent carriers of CMV expressed NKG2C and CD57 surface markers on more NK cells, including CD56dim lineages. The NK cell repertoire revealed lingering immune effects of early rearing while still maintaining an overall integrity and resilience. Full article
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15 pages, 432 KiB  
Article
Brothers Home and the Production of Vanished Lives
by Eli Park Sorensen
Genealogy 2023, 7(4), 101; https://doi.org/10.3390/genealogy7040101 - 18 Dec 2023
Cited by 1 | Viewed by 41335
Abstract
This article delves into the history of one of the most infamous internment facilities in Korea’s recent past—Hyungje Bokjiwon (형제복지원), or Brothers Home. The article outlines the history of Brothers Home, its biopolitical production of ‘vanished lives’, and what enabled it to come [...] Read more.
This article delves into the history of one of the most infamous internment facilities in Korea’s recent past—Hyungje Bokjiwon (형제복지원), or Brothers Home. The article outlines the history of Brothers Home, its biopolitical production of ‘vanished lives’, and what enabled it to come into existence—arguing that this is an essential context for understanding the history of international adoption from Korea. Located in Busan, South Korea, Brothers Home began as an orphanage in the early 1960s but developed into a ‘social welfare institution’ in the early 1970s. The events that transpired from the early 1970s until the facility shut down in the late 1980s—a period which aligns with the height of international adoption from Korea—have led to some referring to this place as Korea’s ‘concentration camp’. Inmates died in the hundreds, predominantly due to malnutrition and illness, while many suffered brutal deaths through physical abuse and torture. Some of the children from Brothers Home were relocated to Western nations for adoption. The history of Brothers Home embodies the biopolitical process of bodies and lives simultaneously enveloped in and, at the same time, kept outside socio-legal frameworks to invalidate those lives or render them insignificant or invisible; to erase them from any meaningful, socio-legal context and thereby reducing those lives to bare life. The article will focus on three main areas: the history of Brothers Home, the biopolitical production of vanished lives, and how the latter resonates with specific instances depicted in testimonies written by people returning to Korea to uncover details about their adoption circumstances, that is, moments encapsulating this ‘production of vanished lives’. The central concern here is less to draw a direct line between international adoption and the events at Brothers Home, but rather to outline a crucial biopolitical context—epitomized in the history of Brothers Home—that precedes the adoption process and thus constitutes its condition of possibility. By juxtaposing this biopolitical context with autobiographical testimonies of people searching for information about the circumstances of their adoption, the article seeks to understand what it means to bear witness to the existence of a life whose desubjectivization—or disappearance—at the same time constitutes the witnessing subject’s condition of possibility. Full article
(This article belongs to the Special Issue Transnational and/or Transracial Adoption and Life Narratives)
15 pages, 953 KiB  
Article
Feasibility of Developing Audiovisual Material for Training Needs in a Vietnam Orphanage: A Mixed-Method Design
by Patricia Jovellar-Isiegas, Carolina Jiménez-Sánchez, Almudena Buesa-Estéllez, Pilar Gómez-Barreiro, Inés Alonso-Langa, Sandra Calvo and Marina Francín-Gallego
Int. J. Environ. Res. Public Health 2023, 20(4), 3118; https://doi.org/10.3390/ijerph20043118 - 10 Feb 2023
Viewed by 2186
Abstract
Disabled children living in orphanages in low-income countries may not have access to the therapy they need. The COVID-19 pandemic has complicated the situation dramatically, making online training activities a possible innovative option to meet the real needs of local staff. This study [...] Read more.
Disabled children living in orphanages in low-income countries may not have access to the therapy they need. The COVID-19 pandemic has complicated the situation dramatically, making online training activities a possible innovative option to meet the real needs of local staff. This study aimed to detect the training needs of the local staff of an orphanage in Vietnam, as well as develop an audiovisual training material and measure its feasibility. Training needs were identified through a focus group carried out by the volunteers of Fisios Mundi, a nongovernmental organization. The audiovisual training material was developed to meet these specific needs. Lastly, its feasibility was evaluated, in terms of both content and format, through an ad hoc questionnaire. Nine volunteers participated in the project. Twenty-four videos were created and structured around five themes. This study expands the body of knowledge on how an international cooperation project can be developed in a pandemic situation. The audiovisual training material content and format created in this project was considered by the volunteers as very feasible and useful for training the staff of a Vietnamese orphanage. Full article
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12 pages, 339 KiB  
Article
Association of Residence Type on Smoking in South Korean Adolescents during the COVID-19 Pandemic: Findings from a National Survey
by Mi Young Kwon and Myoung Sun Cho
Int. J. Environ. Res. Public Health 2022, 19(19), 12886; https://doi.org/10.3390/ijerph191912886 - 8 Oct 2022
Cited by 1 | Viewed by 1767
Abstract
The closure of schools due to the COVID-19 pandemic has forced adolescents to stay home. These disruptions, as well as a significant decrease in social access, have impacted smoking behavior. This study identified the association between the adolescents’ type of residence and tobacco [...] Read more.
The closure of schools due to the COVID-19 pandemic has forced adolescents to stay home. These disruptions, as well as a significant decrease in social access, have impacted smoking behavior. This study identified the association between the adolescents’ type of residence and tobacco product use. A cross-sectional study (using data from the Korea Youth Risk Behavior Web-based Survey) examined 3774 students in 2019 (pre-pandemic) and 2575 students in 2020 (during the pandemic). The participants were South Korean middle and high school students aged 13–19 years. Using multinomial logistic regression, it was shown that adolescents who lived alone or in a boarding house had a higher risk of being an e-cigarette smoker compared with those who lived with family or relatives (OR = 6.49, CI = 2.06–20.45). Living in a dormitory or orphanage also increased the risk of dual tobacco use compared with living with family (OR = 2.09, 95% CI = 1.13–3.84). With the advent and continuation of the COVID-19 pandemic, this effect became more significant in 2020 than in 2019. Our findings support the theory that residential differences affect adolescent smoking behavior and highlight the importance of integrated smoking bans and educational programs to control adolescent smoking. Full article
(This article belongs to the Special Issue E-cigarette Use among Youth)
23 pages, 470 KiB  
Article
The Sexual Economies of Clericalism: Women Religious and Gendered Violence in the Catholic Church
by Kathleen McPhillips and Tracy McEwan
Religions 2022, 13(10), 916; https://doi.org/10.3390/rel13100916 - 30 Sep 2022
Cited by 9 | Viewed by 6885
Abstract
As the sexual abuse crisis continues to plague the Catholic Church across the world, the focus on men as both perpetrators of sexual violence, and victims of child sexual abuse has been at the forefront of media and academic analysis. However, evidence from [...] Read more.
As the sexual abuse crisis continues to plague the Catholic Church across the world, the focus on men as both perpetrators of sexual violence, and victims of child sexual abuse has been at the forefront of media and academic analysis. However, evidence from public inquiries, criminal investigations, academic research and survivor testaments identifies women religious as both perpetrators of sexual and physical violence against children and victims of clerical sexual violence. This indicates that women religious, colloquially known as nuns, belong to a very unsettled landscape in religious gender politics in that they have been both victims of male clerical abuse and perpetrators of child abuse. This article considers these two contested realities by examining and analysing the evidence from research studies and public inquiries. We found that nuns were not only perpetrators of physical and sexual violence against children, but they were also engaged in herding children into the pathways of organised clerical paedophiles, particularly in children’s homes and orphanages where children were considered sexual commodities. Simultaneously, the sexual abuse of nuns has recently become a major concern for religious communities and the wider Church. We argue that by bringing these two realities together through a new discourse—the sexual economies of clericalism—new understandings of the agency of nuns can be explored in a wider theoretical and methodological framework. Full article
7 pages, 12653 KiB  
Article
Echocardiographic Screening for Rheumatic Heart Disease in a Ugandan Orphanage: Feasibility and Outcomes
by Massimo Mapelli, Paola Zagni, Valeria Calbi, Laura Fusini, Aliku Twalib, Roberto Ferrara, Irene Mattavelli, Laura Alberghina, Elisabetta Salvioni, Cyprian Opira, Jackson Kansiime, Gloria Tamborini, Mauro Pepi and Piergiuseppe Agostoni
Children 2022, 9(10), 1451; https://doi.org/10.3390/children9101451 - 23 Sep 2022
Cited by 2 | Viewed by 2066
Abstract
Background: Rheumatic heart disease (RHD) is a major cause of cardiovascular disease in developing nations, leading to more than 230,000 deaths annually. Most patients seek medical care only when long-term structural and hemodynamic complications have already occurred. Echocardiographic screenings ensure the early detection [...] Read more.
Background: Rheumatic heart disease (RHD) is a major cause of cardiovascular disease in developing nations, leading to more than 230,000 deaths annually. Most patients seek medical care only when long-term structural and hemodynamic complications have already occurred. Echocardiographic screenings ensure the early detection of asymptomatic subjects who could benefit from prophylaxis, monitoring and intervention, when appropriate. The aim of this study is to assess the feasibility of a screening program and the prevalence of RHD in a Ugandan orphanage. Methods: We performed an RHD-focused echocardiogram on all the children (5–14 years old) living in a north Ugandan orphanage. Exams were performed with a portable machine (GE Vivid-I). All the time intervals were recorded (minutes). Results: A total of 163 asymptomatic children were screened over 8 days (medium age 9.1; 46% male; 17% affected by severe motor impairment). The feasibility rate was 99.4%. An average of 20.4 exams were performed per day, with an average of 15.5 images collected per subject. Pathological mitral regurgitation (MR) was found in 5.5% of subjects, while at least two morphological features of RHD were found in 4.3%, leading to 1 “definite RHD” (0.6%) case and 13 “borderline RHD” cases (8.1%). Six congenital heart defects were also noted (3.7%): four atrial septal defects, one coronary artery fistula and one Patent Ductus Arteriosus. Conclusions: We demonstrated the feasibility of an echocardiographic screening for RHD in an orphanage in Uganda. A few factors, such as good clinical and hygienic care, the availability of antibiotics and closeness to a big hospital, may account for the low prevalence of the disease in our population. Full article
(This article belongs to the Section Pediatric Cardiology)
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14 pages, 474 KiB  
Article
Effects of Play in an Upright Position on Intra-Individual Variability of Gross Motor and Language Development in Institutionalized Infants
by Sunanta Prommin, Wantana Siritaratiwat, Surussawadi Bennett, Lugkana Mato, Orawan Keeratisiroj and Worawan Kamruecha
Int. J. Environ. Res. Public Health 2022, 19(18), 11804; https://doi.org/10.3390/ijerph191811804 - 19 Sep 2022
Cited by 3 | Viewed by 2376
Abstract
(1) Objective: To investigate the effects of play in an upright position on intra-individual variability and to examine the relationship between the variability of gross motor and language development in institutionalized infants aged six to ten months. (2) Methods: Thirty infants were conveniently [...] Read more.
(1) Objective: To investigate the effects of play in an upright position on intra-individual variability and to examine the relationship between the variability of gross motor and language development in institutionalized infants aged six to ten months. (2) Methods: Thirty infants were conveniently enrolled in either the experimental or control groups. The Alberta Infant Motor Scale (AIMS) and the Communication and Symbolic Behavior Scales Developmental Profile (CSBS-DP) Infant/Toddler Checklist were tested pre and post each monthly intervention for three months. Sixteen infants in the experimental group received an additional program of 45 min play in an upright position three times a week for a 3-month period. (3) Results: There were significant between-group differences in intra-individual variability of the AIMS percentiles (p-value = 0.042). In addition, there was a significant difference in the intra-individual variability of the language percentile between groups (p-value = 0.009). The intra-individual variability of gross motor development was significantly correlated (rs = 0.541; p = 0.03) with language development. (4) Conclusions: Play in an upright position could be applied to improve intra-individual variability in gross motor and language development percentiles in institutionalized infants. Full article
(This article belongs to the Section Children's Health)
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12 pages, 268 KiB  
Perspective
Can Suboptimal Visual Environments Negatively Affect Children’s Cognitive Development?
by Alexandros A. Lavdas and Nikos A. Salingaros
Challenges 2021, 12(2), 28; https://doi.org/10.3390/challe12020028 - 9 Nov 2021
Cited by 6 | Viewed by 4744
Abstract
There are indications that children born during the period of COVID-19 lockdown have cognitive development issues, without having been affected by the virus. We discuss here the idea that environmental deprivation—and, especially, the lack of appropriate visual stimulation—might be one source of these [...] Read more.
There are indications that children born during the period of COVID-19 lockdown have cognitive development issues, without having been affected by the virus. We discuss here the idea that environmental deprivation—and, especially, the lack of appropriate visual stimulation—might be one source of these defects. This thought is in line with previous findings in children brought up in orphanages with poor environmental stimulation, hypothesizing that the minimalist architectural style prevailing for the last several decades is among the potential contributing factors. The process of eliminating organized complexity characteristic of organic forms may prove to be detrimental for humanity’s future, providing suboptimal environmental stimulation and opportunities for interaction during the critical stages of brain development. Full article
19 pages, 7468 KiB  
Article
Safe Haven—Bath House and Library by the Burmese Border
by Anett Mizsei and Péter György Horváth
Heritage 2021, 4(3), 2105-2123; https://doi.org/10.3390/heritage4030119 - 2 Sep 2021
Cited by 2 | Viewed by 3624
Abstract
This study gives an overview of contemporary vernacular tendencies in Thai architecture. The research includes ecological, economical, ergonomic and cultural aspects, and the aim is to find a possible future direction for architectural design that is able to incorporate local features and follow [...] Read more.
This study gives an overview of contemporary vernacular tendencies in Thai architecture. The research includes ecological, economical, ergonomic and cultural aspects, and the aim is to find a possible future direction for architectural design that is able to incorporate local features and follow traditions yet apply them in a contemporary way. As an example, a case study was carried out about a project realized in Safe Haven Orphanage in Thailand. It consists of two small-scale buildings designed and constructed by TYIN Tegnestue Architects, Sami Rintala and Hans Skotte, together with volunteers and the local community, and they are great examples of a community building “healing architecture”. Due to their aesthetics, their ecological and sustainable approach and their structures, they can provide cultural continuity, which is key for the organic evaluation of regional architecture. Full article
(This article belongs to the Special Issue Heritage Patterns—Representative Models)
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12 pages, 733 KiB  
Article
Prevalence of Fetal Alcohol Spectrum Disorders (FASD) among Children Adopted from Eastern European Countries: Russia and Ukraine
by Joan Colom, Lidia Segura-García, Adriana Bastons-Compta, Marta Astals, Vicente Andreu-Fernandez, Natalia Barcons, Raquel Vidal, Ana I. Ibar, Vicky Fumadó, Nuria Gómez, Agnés Russiñol and Oscar Garcia-Algar
Int. J. Environ. Res. Public Health 2021, 18(4), 1388; https://doi.org/10.3390/ijerph18041388 - 3 Feb 2021
Cited by 16 | Viewed by 8587
Abstract
Fetal alcohol spectrum disorder (FASD) is a leading cause of neurodevelopmental disorders. Children adopted internationally from countries where alcohol consumption during pregnancy is very high are at greater risk for FASD. Lack of expertise in diagnosing FASD and mixed neurodevelopmental and behavioral signs [...] Read more.
Fetal alcohol spectrum disorder (FASD) is a leading cause of neurodevelopmental disorders. Children adopted internationally from countries where alcohol consumption during pregnancy is very high are at greater risk for FASD. Lack of expertise in diagnosing FASD and mixed neurodevelopmental and behavioral signs due to abandonment complicate a timely diagnosis. The aim of this study was to determine the prevalence of FASD in adopted children. Children between the ages of 8 and 24 adopted from Russia and Ukraine were evaluated for clinical and historical features of FASD. Of the 162 children evaluated, 81 (50%) met FASD diagnostic criteria. Thirty-three (20.4%) children had fetal alcohol syndrome (FAS), 28 (17.2%) had partial FAS, 2 (1.2%) had alcohol-related birth defects (ARBD) and 18 (11.1%) had alcohol-related neurodevelopmental disorder (ARND). Of the 81 children in which fetal alcohol exposure could not be confirmed, many had manifestations that would have established a diagnosis of FASD if a history of maternal alcohol consumption was confirmed. In a population of children with a high risk of prenatal alcohol exposure (adoptees from Eastern European countries), at least 50% showed manifestations associated with FASD. The reported prevalence in this study is in line with the results obtained in a previous study as well as in orphanages of origin. Full article
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7 pages, 231 KiB  
Article
Anthropometric Assessment of Nepali Children Institutionalized in Orphanages
by Lucía Fernández, Ana Rubini, Jose M. Soriano, Joaquín Aldás-Manzano and Jesús Blesa
Children 2020, 7(11), 217; https://doi.org/10.3390/children7110217 - 7 Nov 2020
Cited by 2 | Viewed by 3196
Abstract
Nepal is among the world’s poorest countries, and it is the third-poorest country in the South Asian region. Asia has the largest number of orphans in the world; in Nepal there are around 13,281 orphan children. The objective of this study is to [...] Read more.
Nepal is among the world’s poorest countries, and it is the third-poorest country in the South Asian region. Asia has the largest number of orphans in the world; in Nepal there are around 13,281 orphan children. The objective of this study is to evaluate the growth status of institutionalized children in Nepal through the analyses of anthropometric measures. The sample was Nepalese children aged 4 to 17, obtained from two different orphanages: in the first one, children with physical and mental disabilities coexist with children without any conditions. In the second one, there were no subjects with disabilities. Significant evidence of an association between mental and physical disability in institutionalized children and undernutrition (wasting and stunting) was found in this study. There is also weak but significant evidence of a relationship between underweight and being male. The study could help reaching a better understanding of growth status of institutionalized children in Nepal. Full article
(This article belongs to the Special Issue Childhood Malnutrition)
14 pages, 425 KiB  
Article
Case of Poliomyelitis Caused by Significantly Diverged Derivative of the Poliovirus Type 3 Vaccine Sabin Strain Circulating in the Orphanage
by Ekaterina A. Korotkova, Maria A. Prostova, Anatoly P. Gmyl, Liubov I. Kozlovskaya, Tatiana P. Eremeeva, Olga Y. Baikova, Alexandr Y. Krasota, Nadezhda S. Morozova and Olga E. Ivanova
Viruses 2020, 12(9), 970; https://doi.org/10.3390/v12090970 - 1 Sep 2020
Cited by 8 | Viewed by 3565
Abstract
Significantly divergent polioviruses (VDPV) derived from the oral poliovirus vaccine (OPV) from Sabin strains, like wild polioviruses, are capable of prolonged transmission and neuropathology. This is mainly shown for VDPV type 2. Here we describe a molecular-epidemiological investigation of a case of VDPV [...] Read more.
Significantly divergent polioviruses (VDPV) derived from the oral poliovirus vaccine (OPV) from Sabin strains, like wild polioviruses, are capable of prolonged transmission and neuropathology. This is mainly shown for VDPV type 2. Here we describe a molecular-epidemiological investigation of a case of VDPV type 3 circulation leading to paralytic poliomyelitis in a child in an orphanage, where OPV has not been used. Samples of feces and blood serum from the patient and 52 contacts from the same orphanage were collected twice and investigated. The complete genome sequencing was performed for five polioviruses isolated from the patient and three contact children. The level of divergence of the genomes of the isolates corresponded to approximately 9–10 months of evolution. The presence of 61 common substitutions in all isolates indicated a common intermediate progenitor. The possibility of VDPV3 transmission from the excretor to susceptible recipients (unvaccinated against polio or vaccinated with inactivated poliovirus vaccine, IPV) with subsequent circulation in a closed children’s group was demonstrated. The study of the blood sera of orphanage residents at least twice vaccinated with IPV revealed the absence of neutralizing antibodies against at least two poliovirus serotypes in almost 20% of children. Therefore, a complete rejection of OPV vaccination can lead to a critical decrease in collective immunity level. The development of new poliovirus vaccines that create mucosal immunity for the adequate replacement of OPV from Sabin strains is necessary. Full article
(This article belongs to the Section Animal Viruses)
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