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Keywords = nordaucane sesquiterpenoids

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Article
Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatus
by Yu-Qi Gao, Chun-Jun Guo, Qiang Zhang, Wen-Ming Zhou, Clay C. C. Wang and Jin-Ming Gao
Molecules 2015, 20(1), 325-334; https://doi.org/10.3390/molecules20010325 - 25 Dec 2014
Cited by 19 | Viewed by 8564
Abstract
Six sesquiterpenoids 16, including two new ones, an ent-daucane-type sesquiterpenoid, asperaculane A (1), and a nordaucane one, asperaculane B (2), and four known nordaucane derivatives, aculenes A–D 36, together with the known [...] Read more.
Six sesquiterpenoids 16, including two new ones, an ent-daucane-type sesquiterpenoid, asperaculane A (1), and a nordaucane one, asperaculane B (2), and four known nordaucane derivatives, aculenes A–D 36, together with the known secalonic acid D (7), were isolated from a fermentation culture of the fungus Aspergillus aculeatus. Their structures and absolute configurations were established by analyses of their spectroscopic data, including 1D and 2D-NMR spectra, HR-ESIMS, electronic circular dichroism (ECD) data, and quantum chemical calculations. These metabolites were evaluated for in vitro cytotoxic activity against two cell lines, human cancer cell lines (HeLa) and one normal hamster cell line (CHO). Full article
(This article belongs to the Collection Bioactive Compounds)
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