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Keywords = muscle dysmorphia

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23 pages, 869 KiB  
Article
Cognitive Behavioral Therapy for Muscle Dysmorphia and Anabolic Steroid-Related Psychopathology: A Randomized Controlled Trial
by Metin Çınaroğlu, Eda Yılmazer, Selami Varol Ülker and Gökben Hızlı Sayar
Pharmaceuticals 2025, 18(8), 1081; https://doi.org/10.3390/ph18081081 - 22 Jul 2025
Viewed by 412
Abstract
Background/Objectives: Muscle dysmorphia (MD), a subtype of body dysmorphic disorder, is prevalent among males who engage in the non-medical use of anabolic–androgenic steroids (AASs) and performance-enhancing drugs (PEDs). These individuals often experience severe psychopathology, including mood instability, compulsivity, and a distorted body [...] Read more.
Background/Objectives: Muscle dysmorphia (MD), a subtype of body dysmorphic disorder, is prevalent among males who engage in the non-medical use of anabolic–androgenic steroids (AASs) and performance-enhancing drugs (PEDs). These individuals often experience severe psychopathology, including mood instability, compulsivity, and a distorted body image. Despite its clinical severity, no randomized controlled trials (RCTs) have evaluated structured psychological treatments in this subgroup. This study aimed to assess the efficacy of a manualized cognitive behavioral therapy (CBT) protocol in reducing MD symptoms and associated psychological distress among male steroid users. Results: Participants in the CBT group showed significant reductions in MD symptoms from the baseline to post-treatment (MDDI: p < 0.001, d = 1.12), with gains sustained at follow-up. Large effect sizes were also observed in secondary outcomes including depressive symptoms (PHQ-9: d = 0.98), psychological distress (K10: d = 0.93), disordered eating (EDE-Q: d = 0.74), and exercise addiction (EAI: d = 1.07). No significant changes were observed in the control group. Significant group × time interactions were found for all outcomes (all p < 0.01), indicating CBT’s specific efficacy. Discussion: This study provides the first RCT evidence that CBT significantly reduces both core MD symptoms and steroid-related psychopathology in men engaged in AAS/PED misuse. Improvements extended to mood, body image perception, and compulsive exercise behaviors. These findings support CBT’s transdiagnostic applicability in addressing both the cognitive–behavioral and affective dimensions of MD. Materials and Methods: In this parallel-group, open-label RCT, 59 male gym-goers with DSM-5-TR diagnoses of MD and a history of AAS/PED use were randomized to either a 12-week CBT intervention (n = 30) or a waitlist control group (n = 29). CBT sessions were delivered weekly online and targeted distorted muscularity beliefs, compulsive behaviors, and emotional dysregulation. Primary and secondary outcomes—Muscle Dysmorphic Disorder Inventory (MDDI), PHQ-9, K10, EDE-Q, EAI, and BIG—were assessed at the baseline, post-treatment, and 3-month follow-up. A repeated-measures ANOVA and paired t-tests were used to analyze time × group interactions. Conclusions: CBT offers an effective, scalable intervention for individuals with muscle dysmorphia complicated by anabolic steroid use. It promotes broad psychological improvement and may serve as a first-line treatment option in high-risk male fitness populations. Future studies should examine long-term outcomes and investigate implementation in diverse clinical and cultural contexts. Full article
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13 pages, 2400 KiB  
Article
Social Media Exposure and Muscle Dysmorphia Risk in Young German Athletes: A Cross-Sectional Survey with Machine-Learning Insights Using the MDDI-1
by Maria Fueth, Sonja Verena Schmidt, Felix Reinkemeier, Marius Drysch, Yonca Steubing, Simon Bausen, Flemming Puscz, Marcus Lehnhardt and Christoph Wallner
Healthcare 2025, 13(14), 1695; https://doi.org/10.3390/healthcare13141695 - 15 Jul 2025
Viewed by 391
Abstract
Background and Objectives: Excessive social media use is repeatedly linked to negative body image outcomes, yet its association with muscle dysmorphia, especially in athletic youth, remains underexplored. We investigated how social media exposure, comparison behavior, and platform engagement relate to muscle dysmorphia symptomatology [...] Read more.
Background and Objectives: Excessive social media use is repeatedly linked to negative body image outcomes, yet its association with muscle dysmorphia, especially in athletic youth, remains underexplored. We investigated how social media exposure, comparison behavior, and platform engagement relate to muscle dysmorphia symptomatology in young German athletes. Materials and Methods: An anonymous, web-based cross-sectional survey was conducted (July–October 2024) of 540 individuals (45% female; mean age = 24.6 ± 5.3 years; 79% ≥ 3 h sport/week) recruited via Instagram. The questionnaire comprised demographics, sport type, detailed social media usage metrics, and the validated German Muscle Dysmorphic Disorder Inventory (MDDI-1, 15 items). Correlations (Spearman’s ρ, Kendall’s τ) were calculated; multivariate importance was probed with classification-and-regression trees and CatBoost gradient boosting, interpreted via SHAP values. Results: Median daily social media time was 76 min (IQR 55–110). Participants who spent ≥ 60 min per day on social media showed higher MDDI scores (mean 38 ± 7 vs. 35 ± 6; p = 0.010). The strongest bivariate link emerged between perceived social media-induced body dissatisfaction and felt pressure to attain a specific body composition (Spearman ρ = 0.748, Kendall τ = 0.672, p < 0.001). A CatBoost gradient-boosting model out-performed linear regression in predicting elevated MDDI. The three most influential features (via SHAP values) were daily social media time, frequency of comparison with fitness influencers, and frequency of “likes”-seeking behavior. Conclusions: Intensive social media exposure substantially heightens muscle dysmorphia risk in young German athletes. Machine-learning interpretation corroborates time on social media and influencer comparisons as primary drivers. Interventions should combine social media literacy training with sport-specific psychoeducation to mitigate maladaptive comparison cycles and prevent downstream eating disorder pathology. Longitudinal research is warranted to clarify causal pathways and to test targeted digital media interventions. Full article
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15 pages, 258 KiB  
Article
#BodyPositivity: The Role of Body Appreciation and Body Mass Index for Muscle Dysmorphia, Body Attitudes and Exercise Motives Among Men
by Kamila Czepczor-Bernat, Adriana Modrzejewska and Justyna Modrzejewska
Nutrients 2025, 17(7), 1177; https://doi.org/10.3390/nu17071177 - 28 Mar 2025
Cited by 1 | Viewed by 1003
Abstract
Objectives: The main aim of this study was to investigate the hypothesis that men with high body appreciation and healthy (normal) weight would have significantly lower levels of muscle dysmorphia and the non-adaptive (negative) multiple dimensions of body attitudes, as well as [...] Read more.
Objectives: The main aim of this study was to investigate the hypothesis that men with high body appreciation and healthy (normal) weight would have significantly lower levels of muscle dysmorphia and the non-adaptive (negative) multiple dimensions of body attitudes, as well as higher levels of the selected pro-health and adaptive exercise motives, than those men with low body appreciation and excess body weight. Methods: A total of 374 Polish men (Mage = 28.96 ± 8.52) completed the following questionnaires: (a) the Body Appreciation Scale-2, (b) the Muscle Dysmorphic Disorder Inventory, (c) the Male Body Attitude Scale, and (d) the Exercise Motivations Inventory-2. Results: By analyzing the most important findings, it was discovered, as hypothesized, that significant differences (in terms of most of the assessed scale/subscales) were found between men who had high body appreciation and healthy weight (Cluster 4), and men with low body appreciation and excess body weight (Cluster 3). Cluster 4 (vs. Cluster 3) was characterized as follows: (a) considering muscle dysmorphia, these participants had lower levels in terms of the total score and subscale of appearance intolerance; (b) they had fewer non-adaptive (negative) body attitudes, with lower total scores and lower scores on two subscales (body fat and height); (c) for the selected pro-health and adaptive exercise motives, Cluster 4 had higher levels on all subscales. Conclusions: Our results show that holding views in line with positive body image is also beneficial for the functioning of adult men. However, further research needs to be conducted in this area to determine whether the content in the interventions and prevention activities for both sexes should be the same and what factors should be taken into account in order to influence excessive fixation on a muscularity. Full article
(This article belongs to the Special Issue Eating and Mental Health Disorders)
18 pages, 659 KiB  
Article
Interaction Between Social Support and Muscle Dysmorphia: The Role of Self-Efficacy and Social Media Use
by Fiorenza Giordano, Danilo Calaresi, Loriana Castellani, Valeria Verrastro, Tommaso Feraco and Valeria Saladino
Behav. Sci. 2025, 15(2), 122; https://doi.org/10.3390/bs15020122 - 24 Jan 2025
Cited by 3 | Viewed by 2055
Abstract
Muscle dysmorphia (MD) consists of a type of body dysmorphic disorder and involves a distorted perception of one’s muscles, strict diets, and workouts. Mostly, studies focus on adult male athletes, especially bodybuilders, while research on adolescents and women is limited. Our study aims [...] Read more.
Muscle dysmorphia (MD) consists of a type of body dysmorphic disorder and involves a distorted perception of one’s muscles, strict diets, and workouts. Mostly, studies focus on adult male athletes, especially bodybuilders, while research on adolescents and women is limited. Our study aims to explore potential protective or risk factors influencing MD, using a mediation model calculated through Structural Equation Modeling (SEM) and at the same time help to involve female individuals in the exploration of a distress traditionally and predominantly analyzed only in male individuals. The model examines whether problematic social media use (PSMU) and generalized self-efficacy (GSE) are potential first- and second-level mediators, respectively, in the relationship between perceived social support (PSS) and MD. The sample consisted of 2325 individuals of both sexes aged 14–29 years. Structural equation models were used to assess effect sizes, regressions, and direct and indirect effects of perceived social support on muscle dysmorphia and general self-efficacy both on problematic social media use and muscle dysmorphia. Our results suggest that inadequate perceived social support may reduce individuals’ perceived effectiveness in managing daily challenges, potentially leading to problematic use of social media, which may contribute to muscle dysmorphia symptoms. Future interventions could promote a healthier perception of one’s body, improving confidence in individuals’ coping strategies and strengthening the social environment of reference. Full article
(This article belongs to the Special Issue Psychological Well-Being and Mental Health)
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20 pages, 363 KiB  
Review
Eating- and Weight-Related Disorders in the Armed Forces
by Hubertus Himmerich, Davide Gravina, Inga Schalinski, Gerd-Dieter Willmund, Peter Lutz Zimmermann, Johanna Louise Keeler and Janet Treasure
Metabolites 2024, 14(12), 667; https://doi.org/10.3390/metabo14120667 - 1 Dec 2024
Cited by 1 | Viewed by 2183
Abstract
Background/Objectives: Like in the general population, the prevalences of eating- and weight-related health issues in the armed forces are increasing. Relevant medical conditions include the eating disorders (EDs) anorexia nervosa, bulimia nervosa, binge eating disorder, and avoidant restrictive food intake disorder (ARFID), as [...] Read more.
Background/Objectives: Like in the general population, the prevalences of eating- and weight-related health issues in the armed forces are increasing. Relevant medical conditions include the eating disorders (EDs) anorexia nervosa, bulimia nervosa, binge eating disorder, and avoidant restrictive food intake disorder (ARFID), as well as body dysmorphic disorder, muscle dysmorphia, and the relative energy deficiency in sport (RED-S) syndrome. Methods: We performed a narrative literature review on eating- and weight-related disorders in the armed forces. Results: Entry standards might exclude people with obesity, with EDs, or at high risk for EDs from entering the armed forces for military reasons and to protect the individual’s health. Relevant potential risk factors of eating- and weight-related disorders in the military are the emphasis on appearance and fitness in the military, high levels of stress, military sexual trauma, post-traumatic stress disorder, deployment, relocation, long commutes, consumption of ultra-processed foods and beverages, limitations on food selection and physical exercise, and intensive combat training and field exercises. Eating- and weight-related disorders negatively impact professional military appearance and lead to problems with cardiorespiratory and neuromuscular fitness; daytime sleepiness; and a higher risk of musculoskeletal injuries, and other physical and mental health problems. Current and potential future therapeutic options include occupational health measures, psychosocial therapies, neuromodulation, and drug treatments. Conclusions: Even though randomized controlled trials (RCTs) have been performed to test treatments for obesity in the armed forces, RCTs for the treatment of EDs, body dysmorphic disorder, muscle dysmorphia, and RED-S syndrome are lacking in the military context. Full article
14 pages, 651 KiB  
Review
At the Crossroads between Eating Disorders and Body Dysmorphic Disorders—The Case of Bigorexia Nervosa
by Octavian Vasiliu
Brain Sci. 2023, 13(9), 1234; https://doi.org/10.3390/brainsci13091234 - 24 Aug 2023
Cited by 6 | Viewed by 7525
Abstract
Bigorexia nervosa (BN) is a controversial nosological entity, considered either a feeding/eating disorder (FED) or a subtype of body dysmorphic disorder (BDD). This rapid review aims to explore the characteristic features of BN and identify evidence-based therapeutic interventions for this condition. Three electronic [...] Read more.
Bigorexia nervosa (BN) is a controversial nosological entity, considered either a feeding/eating disorder (FED) or a subtype of body dysmorphic disorder (BDD). This rapid review aims to explore the characteristic features of BN and identify evidence-based therapeutic interventions for this condition. Three electronic databases (PubMed, Cochrane, and Google Scholar) were searched for relevant information about BN, and 26 reports were reviewed in detail. The results showed that bodybuilders, weightlifters, and other populations involved in athletic activities are the most vulnerable to the onset of this disorder. Patients with BN should also be screened for physical and psychiatric comorbidities and complications, such as anabolic steroid use disorder, physical exercise addiction, and depressive or anxiety disorders. The main differential diagnoses for BN are schizophrenia spectrum disorders, depressive disorders, anxiety disorders, bodily distress disorder, and obsessive–compulsive disorders. Using validated screening instruments is considered very important from a clinical perspective, with the aim of providing early identification of this disorder. Therapeutic interventions for patients with BN are still in the early phases of development, and no specific pharmacological treatment has yet been identified. Since it is similar to the obsessive–compulsive spectrum, cognitive behavioral therapy has been suggested as a useful intervention; however, it has not yet been validated in large-scale clinical trials. In conclusion, based on the reviewed data, clarifying the concept of BN is of practical importance for constructing adequate prevention strategies and validating proper therapeutic interventions. Full article
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15 pages, 441 KiB  
Article
Psychometric Evaluation of the Drive for Muscularity Scale and the Muscle Dysmorphic Disorder Inventory among Brazilian Cisgender Gay and Bisexual Adult Men
by Cleonaldo Gonçalves Santos, Maurício Almeida, Mauro Lúcio de Oliveira Júnior, Tiffany A. Brown and Pedro Henrique Berbert de Carvalho
Int. J. Environ. Res. Public Health 2023, 20(2), 989; https://doi.org/10.3390/ijerph20020989 - 5 Jan 2023
Cited by 5 | Viewed by 2426
Abstract
Despite high levels of muscularity concerns among sexual-minority men, most of the existing literature on the drive for muscularity and muscle dysmorphia focuses on heterosexual men and has mainly been conducted in Western and English-speaking regions. The present study aimed to evaluate the [...] Read more.
Despite high levels of muscularity concerns among sexual-minority men, most of the existing literature on the drive for muscularity and muscle dysmorphia focuses on heterosexual men and has mainly been conducted in Western and English-speaking regions. The present study aimed to evaluate the psychometric properties of the Drive for Muscularity Scale (DMS) and the Muscle Dysmorphic Disorder Inventory (MDDI) in Brazilian cisgender gay and bisexual adult men who were 18–50 years old. We evaluated the factor structure of both measures using a two-step, split-sample exploratory (EFA; n = 704) and confirmatory (CFA; n = 705) factor-analytic approach, which supported the original three-factor structure of the MDDI and resulted in a reduced two-factor solution with 13 items for the DMS. Convergent validity was supported through associations of the DMS and the MDDI with eating disorder symptoms, body-ideal internalization, self-objectification beliefs and behaviors, and body appreciation measures. Additionally, we found good internal consistency, and test–retest reliability of both measures. Results support the validity and reliability of the DMS and the MDDI in Brazilian cisgender gay and bisexual adult men and will support future studies exploring these constructs in Brazilian sexual-minority men. Full article
(This article belongs to the Special Issue Eating Disorders: Challenges, Advances and Public Health Insight)
12 pages, 482 KiB  
Article
Sports Supplements User Profile Based on Demographic, Sports, and Psychological Variables: A Cross-Sectional Study
by Leticia Mera-Zouain, José Luis Carballo and Mercedes Guilabert Mora
Nutrients 2022, 14(21), 4481; https://doi.org/10.3390/nu14214481 - 26 Oct 2022
Viewed by 2504
Abstract
Despite the high prevalence of sports supplement (SS) use, efforts to profile users have not been conclusive. Studies report that 30–95% of recreational exercisers and elite athletes use SS. Research found has mostly focused on demographic and sports variables to profile SS users, [...] Read more.
Despite the high prevalence of sports supplement (SS) use, efforts to profile users have not been conclusive. Studies report that 30–95% of recreational exercisers and elite athletes use SS. Research found has mostly focused on demographic and sports variables to profile SS users, but little research has studied the psychological factors that may influence the use of SS. The purpose of this investigation was to classify, describe, and differentiate the profile of users and non-users of SS, considering demographic, sports, and psychological variables. A total of 554 participants completed the questionnaire. Overall, 45% of recreational exercisers and elite athletes reported using supplements. There were significant differences found regarding the use of SS between men and women (51% vs. 49%, p = 0.002; OR = 1.799), and when training 4 or more days per week (p ≤ 0.001; OR = 1.526). Findings regarding the psychological variables have been found in the Adonis Complex. These results indicate that participants with greater concerns regarding physical appearance, tend to be SS users (p = 0.001; OR = 1.200). The results of this study fill a gap in previous research, and provide an approximate profile, including demographic, sports, and psychological variables of SS users. Full article
(This article belongs to the Special Issue Nutrition in Brain, Cognitive and Psychological Health)
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14 pages, 570 KiB  
Article
Validation of the Muscle Dysmorphic Disorder Inventory (MDDI) among Italian Women Practicing Bodybuilding and Powerlifting and in Women Practicing Physical Exercise
by Silvia Cerea, Matteo Giraldo, Corrado Caudek, Gioia Bottesi, Antonio Paoli and Marta Ghisi
Int. J. Environ. Res. Public Health 2022, 19(15), 9487; https://doi.org/10.3390/ijerph19159487 - 2 Aug 2022
Cited by 7 | Viewed by 3523
Abstract
Studies pertaining to muscle dysmorphia (MD) have concentrated the most on males. However, a new body ideal for women is emerging: a very toned, athletic body with flat, smooth muscles. The emphasis on the level of muscularity represents a contribution to the growth [...] Read more.
Studies pertaining to muscle dysmorphia (MD) have concentrated the most on males. However, a new body ideal for women is emerging: a very toned, athletic body with flat, smooth muscles. The emphasis on the level of muscularity represents a contribution to the growth of MD symptoms in women. The aim of this study was to evaluate the factorial structure and psychometric properties of the muscle dysmorphic disorder inventory (MDDI) in two samples of physically active Italian women. One-hundred and sixty-five women practicing non-competing bodybuilding/powerlifting and 353 women practicing physical exercise completed the MDDI and measures of features associated with MD. Findings of the confirmatory factor analysis showed a three-factor structure with acceptable fit and invariant across groups. Omega coefficients revealed adequate internal consistency for all the scales and for the total score of the MDDI. Furthermore, convergent and divergent validity as well as retest reliability emerged to be good. MDDI represents a reliable measure of MD symptoms in physically active Italian women. Full article
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12 pages, 3132 KiB  
Article
mRNA Quantification of NIPBL Isoforms A and B in Adult and Fetal Human Tissues, and a Potentially Pathological Variant Affecting Only Isoform A in Two Patients with Cornelia de Lange Syndrome
by Beatriz Puisac, María-Esperanza Teresa-Rodrigo, María Hernández-Marcos, Carolina Baquero-Montoya, María-Concepción Gil-Rodríguez, Torkild Visnes, Christopher Bot, Paulino Gómez-Puertas, Frank J. Kaiser, Feliciano J. Ramos, Lena Ström and Juan Pié
Int. J. Mol. Sci. 2017, 18(3), 481; https://doi.org/10.3390/ijms18030481 - 23 Feb 2017
Cited by 2 | Viewed by 5412
Abstract
Cornelia de Lange syndrome (CdLS) is a congenital developmental disorder characterized by craniofacial dysmorphia, growth retardation, limb malformations, and intellectual disability. Approximately 60% of patients with CdLS carry a recognizable pathological variant in the NIPBL gene, of which two isoforms, A and B, [...] Read more.
Cornelia de Lange syndrome (CdLS) is a congenital developmental disorder characterized by craniofacial dysmorphia, growth retardation, limb malformations, and intellectual disability. Approximately 60% of patients with CdLS carry a recognizable pathological variant in the NIPBL gene, of which two isoforms, A and B, have been identified, and which only differ in the C-terminal segment. In this work, we describe the distribution pattern of the isoforms A and B mRNAs in tissues of adult and fetal origin, by qPCR (quantitative polymerase chain reaction). Our results show a higher gene expression of the isoform A, even though both seem to have the same tissue distribution. Interestingly, the expression in fetal tissues is higher than that of adults, especially in brain and skeletal muscle. Curiously, the study of fibroblasts of two siblings with a mild CdLS phenotype and a pathological variant specific of the isoform A of NIPBL (c.8387A > G; P.Tyr2796Cys), showed a similar reduction in both isoforms, and a normal sensitivity to DNA damage. Overall, these results suggest that the position of the pathological variant at the 3´ end of the NIPBL gene affecting only isoform A, is likely to be the cause of the atypical mild phenotype of the two brothers. Full article
(This article belongs to the Special Issue Pre-mRNA Splicing 2016)
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