Search Results (15,156)

Objectives: Radial artery spasm (RAS) is a common complication of transradial coronary angiography that may adversely affect procedural success and patient comfort. This study aimed to evaluate clinical, procedural, and anthropometric factors associated with RAS in patients undergoing elective transradial coronary angiography, with a particular focus on the wrist circumference-to-body mass index (WC/BMI) ratio as a novel predictor. Methods: A total of 466 patients who underwent elective coronary angiography via the right radial artery between January 2024 and December 2024 were included. All procedures were performed using a 6 Fr introducer sheath according to a standardized protocol. Radial artery spasm was clinically defined as operator resistance during catheter manipulation accompanied by patient-reported pain or marked discomfort in the accessed arm. Wrist circumference and body mass index were measured before the procedure, and the WC/BMI ratio was calculated. Radial artery diameter was assessed using ultrasonography. Variables associated with RAS were evaluated using univariable and multivariable logistic regression analyses. Due to collinearity between WC/BMI and radial artery diameter, two separate multivariable models were constructed. Discriminative performance was assessed using receiver operating characteristic (ROC) curve analysis. Results: Radial artery spasm occurred in 51 patients (10.9%). Patients who developed RAS had significantly lower WC/BMI ratios and smaller radial artery diameters compared with those without spasm (both p ≤ 0.001). In multivariable analysis, a lower WC/BMI ratio was independently associated with an increased risk of RAS (odds ratio [OR] 0.51 per 0.1-unit increase; 95% confidence interval [CI] 0.34–0.78; p = 0.002). Similarly, smaller radial artery diameter remained an independent predictor of RAS (OR 0.83 per 0.1 mm increase; 95% CI 0.75–0.92; p < 0.001). The area under the curve (AUC) was 0.651 for WC/BMI and 0.636 for radial artery diameter. The combined model demonstrated improved discriminative ability (AUC 0.713). Conclusions: The WC/BMI ratio is a simple, practical, and readily obtainable anthropometric parameter that can predict the risk of radial artery spasm before transradial coronary angiography. When combined with radial artery diameter, it provides improved discrimination for identifying patients at higher risk of RAS. Full article

Background/Objectives: Surgery is the most effective treatment for early-stage lung cancer but imposes a greater physical burden than other therapies. We previously identified socioclinical factors associated with reduced perioperative health-related quality of life (HR-QOL) in patients undergoing anatomical pulmonary resection. This study aimed to evaluate the relationship between predictors of HR-QOL and long-term survival. Methods: In this prospective study, 87 patients undergoing anatomical pulmonary resection for non-small cell lung cancer at Shonan Kamakura General Hospital, Japan, were evaluated using the Short Form Health Survey 36. Multivariable analyses identified socioclinical factors associated with physical and mental QOL preoperatively and at 6 months postoperatively. Survival analyses were performed for factors showing differences in multivariable analysis and related trends in univariable analysis of HR-QOL. Results: Preoperatively, lower performance status (PS) and living alone were independently associated with poorer physical QOL (regression coefficient [95% CI]: −10.94 [−14.34–−7.54] and −9.86 [−13.89–−5.82], respectively; both p < 0.001) and mental QOL (−9.34 [−13.30–−5.37] and −10.33 [−15.30–−5.35]; both p < 0.001). At 6 months postoperatively, smoking cessation within 1 year, lower PS, and living alone predicted worse physical QOL, while smoking cessation and lower PS predicted worse mental QOL. Lower PS and higher comorbidity burden were also adverse prognostic factors for long-term survival (p < 0.001 and p = 0.015, respectively). Conclusions: Reduced physical activity and greater comorbidity are associated with poorer HR-QOL and survival after lung cancer surgery. These findings highlight the need for careful consideration of surgical indications in patients with these risk factors. Full article

Background: Ocular trauma is a significant cause of monocular visual impairment and potential psychological morbidity. This study aimed to determine the prevalence of anxiety, depression, and post-traumatic stress disorder (PTSD) in patients with mechanical ocular trauma and to investigate the predictive value of baseline clinical characteristics, specifically initial visual acuity. Methods: This retrospective study included 58 adult patients treated for mechanical ocular trauma. Sociodemographic data, injury mechanisms, and clinical variables, including initial visual acuity (LogMAR), ocular trauma score, and number of ocular surgeries, were analyzed. Psychological status was assessed using the Beck Depression Inventory, Beck Anxiety Inventory, and a PTSD checklist. Multivariate logistic regression and correlation analyses were performed to identify predictors of severe PTSD. Results: The cohort was predominantly male (86.2%) with a mean age of 42.5 years. Severe or very severe PTSD symptoms were identified in 35.1% of patients. Analysis revealed a significant positive correlation between initial visual acuity and PTSD scores (r = 0.273, p = 0.038). In the logistic regression model, initial visual acuity (LogMAR) demonstrated the highest odds ratio for severe PTSD in the multivariable model; however, this association did not reach statistical significance (OR = 2.164, 95% CI: 0.720–6.508, p = 0.169) and should therefore be interpreted as an exploratory trend rather than a confirmed predictor. Conclusions: Greater visual loss at the time of injury showed the strongest, although non-significant, association with subsequent PTSD symptom severity. These findings suggest that patients with severe initial visual impairment following ocular trauma may benefit from early psychological screening and timely mental health referral, warranting confirmation in larger prospective studies. Full article

Renal cell carcinoma (RCC) is a common and deadly urological cancer, for which there are no robust prognostic biomarkers or personalized treatment strategies. Paraptosis, a distinct form of regulated cell death marked by cytoplasmic vacuolization, is being increasingly recognized for its roles in tumorigenesis and therapy responses, yet its functional implications in RCC remain poorly defined. Transcriptomic profiles and corresponding clinical metadata from the TCGA-KIRC and GSE33371 datasets were systematically analyzed to characterize the paraptosis-related gene (PaRG) expression profile in renal cell carcinoma (RCC). Patients were categorized into two subtypes via consensus clustering, 574 overlapping differentially expressed genes (DEGs) were identified, and a four-gene (COL7A1, RNASE2, SLC10A2, and APOLD1) prognostic signature was constructed using LASSO and multivariate Cox regression. We analyzed the signature’s associations with tumor microenvironment (TME) features, cancer stem cell (CSC) indices, and tumor mutation burden (TMB), and validated the expression of the signature genes in RCC cell lines via qRT-PCR and Western blot. The four-gene signature showed robust prognostic performance (1-, 3-, and 5-year AUC: 0.751, 0.735, and 0.733 in the total cohort; 0.735, 0.731, and 0.767 in the training cohort), with high-risk patients having significantly poorer overall survival than the low-risk group. The low-risk group exhibited higher Stromal, Immune, and ESTIMATE scores (enriched immune/stromal infiltration), while the high-risk group had elevated CSC content and TMB, and the signature correlated with differential sensitivity to multiple chemotherapeutics. Both qRT-PCR and Western blot confirmed upregulation of COL7A1 and RNASE2 and downregulation of SLC10A2 and APOLD1 in RCC cell lines. Our study establishes a paraptosis-based two-subtype classification and four-gene prognostic signature for RCC that can reliably predicting patient survival, delineate TME characteristics, and guide personalized therapy, with COL7A1 emerging as a potential therapeutic target for advancing our understanding of paraptosis in RCC pathogenesis and optimizing treatment. Full article

Background: Dynamic visual acuity (DVA) is functionally distinct from static visual acuity (SVA), though SVA is often used clinically as a reference. Methods: To identify EEG biomarkers for DVA, we presented participants with a high-contrast checkerboard moving horizontally at speeds ranging from 4°/s to 30°/s, engaging motion-sensitive pathways while preserving spatial detail. Six EEG features—ERPs (N200 and P300), TRCA, Hjorth activity, mean curve length, and Tsallis entropy—were extracted from eight occipito-parietal channels and evaluated for speed sensitivity. Results: Hjorth activity and Tsallis entropy showed consistent monotonic trends with respect to speed. Hjorth activity exhibited the strongest univariate correlation (r = 0.88, p < 0.05). In a Lasso regression model using all speed-sensitive features, the predicted speed correlated with actual speed at r = 0.588, with TRCA-weighted features retained for their multivariate contribution. Notably, Hjorth activity peaked at PO7/PO8 (3.558 and 1.478 µV² at 30°/s), aligning with V5/MT+ activation. Conclusion: Given its high sensitivity, neuroanatomical plausibility, and simplicity, Hjorth activity is recommended as a primary candidate for EEG-based DVA biomarker development. This study provides a foundation for objective neurophysiological evaluation of dynamic vision. Full article

Background: Perivascular fat attenuation index (FAI) derived from coronary CT angiography (CCTA) has emerged as a quantitative biomarker of vascular inflammation, with potential to improve risk stratification in coronary artery disease (CAD) patients. This study aimed to evaluate plaque characteristics of coronary atherosclerotic lesions in patients with high (≥−70.1 HU) or low FAI of pericoronary adipose tissue. Methods: In a retrospective analysis, patients with suspected or confirmed CAD who underwent coronary CTA were included. Coronary lesions were classified into two groups based on their perivascular inflammation as assessed by CCTA: high perivascular FAI phenotype (≥−70.1 HU) versus low FAI phenotype (<−70.1 HU). Both groups were compared with respect to various patient- and lesion-specific characteristics. Results: A total of 247 coronary lesions were analyzed in this study. Of these, 36 (14.6%) lesions were associated with high perivascular inflammation (high FAI phenotpye) and 211 (85.4%) were associated with low perivascular inflammation (low FAI phenotype). Lesions with a high FAI phenotype demonstrated a significantly higher amount of non-calcified plaque volume (NCPV) compared to lesions with a low FAI phenotype [(111.8 mm³ (69.4–184.2) versus 87.7 mm³ (44.6–143.0), p < 0.003]. NCPV emerged as a consistent and significant predictor of fat attenuation positive plaque in both univariate (OR 1.030 [95% CI, 1.010–1.050], p = 0.003); and multivariate logistic regression analyses (OR 1.028 [95% CI, 1.008–1.050]. p = 0.007). Additionally, lesions with a high FAI phenotype less frequently exhibited homogeneous calcification than their low FAI phenotype counterparts (25% versus 46.9%, p = 0.014). Conclusions: Coronary lesions associated with a high FAI phenotype on coronary CCTA consist predominantly of non-calcified plaques. Conversely, lesions characterized by a low perivascular FAI phenotype are primarily calcified and seem to be more homogeneous by visual assessment. Further prospective studies are warranted to validate these associations and explore the underlying pathophysiological mechanisms. Full article

Background: Vesicourethral anastomotic stricture (VUAS) remains a clinically relevant complication following radical prostatectomy, with important implications for postoperative urinary function. Minimally invasive approaches may offer technical advantages; however, their impact on stricture formation in patients with microangiopathic risk factors remains incompletely defined. Objective: We aimed to compare the incidence of vesicourethral anastomotic stricture following open radical prostatectomy (ORP) and laparoscopic radical prostatectomy (LRP) in patients with microangiopathic comorbidities and to explore clinical and perioperative factors associated with stricture development. Materials and Methods: A retrospective two-centre cohort study was conducted including 115 patients who underwent radical prostatectomy for clinically localized prostate cancer between 2022 and 2024. All patients had at least one microangiopathic risk factor (diabetes mellitus, hypertension, or coronary artery disease). Seventy-two patients underwent ORP and forty-three underwent LRP. VUAS was defined by obstructive symptoms with endoscopic confirmation requiring intervention within 12 months postoperatively. Univariate analyses and exploratory logistic regression models were performed to assess factors associated with stricture formation. Results: Vesicourethral anastomotic stricture occurred in 21 patients (18.3%). The crude incidence of VUAS was lower after LRP compared with ORP (9.3% vs. 23.6%); however, this difference did not reach statistical significance. Patients who developed VUAS had a significantly higher body mass index, longer operative time, and greater intraoperative blood loss. In exploratory multivariable analyses, body mass index and operative duration were consistently associated with increased odds of stricture, whereas the effect of surgical approach was unstable and imprecise due to limited event numbers. Conclusions: In patients with microangiopathic risk factors, laparoscopic radical prostatectomy was associated with a lower crude incidence of vesicourethral anastomotic stricture compared with open surgery; however, this association was not robust after adjustment. Perioperative and technical factors appear to play a more prominent role in anastomotic healing than surgical approach alone. These findings highlight the importance of optimizing intraoperative conditions to reduce postoperative stricture risk. Full article

Background/Objectives: Physical activity (PA) is a modifiable determinant of health and quality of life (QoL) in kidney transplant recipients (KTRs). However, associations between PA, health-related QoL (HRQoL), inflammation, and clinical factors in KTRs remain incompletely defined. The aim was to evaluate PA levels in KTRs and explore their associations with HRQoL, clinical characteristics, and biochemical and inflammatory markers. Methods: We conducted a cross-sectional study of 32 stable KTRs (56% male; mean age 54.5 ± 14.2 years). PA was assessed using the International Physical Activity Questionnaire and classified as low (<700 MET-min/week) or high (≥700 MET-min/week) according to IPAQ categorical scoring. HRQoL was evaluated using the SF-36. Associations with demographic, clinical, biochemical (including potassium), and inflammatory markers—including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, and ferritin—were analyzed using multivariable binary logistic regression models. Results: Sixty-three percent of participants achieved high PA, which was associated with better physical functioning (78.8 vs. 58.3; p = 0.016), fewer emotional role limitations, younger age at transplantation, and preemptive transplantation or peritoneal dialysis. Active patients had modestly higher potassium levels (4.61 vs. 4.25 mmol/L; p = 0.041), a hypothesis-generating finding that should be interpreted cautiously. Inflammatory indices showed no significant associations. Conclusions: Although most KTRs achieved adequate PA levels, physical inactivity persisted in over one-third. Targeted strategies addressing HRQoL and clinical factors may support PA engagement after transplantation. Full article

Male pattern baldness (MPB) is a highly prevalent condition with a complex, poorly understood molecular basis that limits therapeutic innovation. This study aimed to bridge the gap between statistical genetic associations and biological function by identifying and prioritizing causal proteins and pathways involved in MPB. Using data from 24,069 men in the UK Biobank, we performed a proteome-wide association study of 2911 plasma proteins with self-reported MPB severity via multivariable ordinal logistic regression, adjusting for age, Body Mass Index (BMI), ethnicity, lifestyle, socioeconomic factors, and testosterone levels. Significant proteins underwent pathway enrichment analysis. Genetic integration included MAGMA for gene-level aggregation and tissue prioritization, transcriptome-wide association studies (TWAS) with GTEx models, conditional fine-mapping, and validation in an independent scalp biopsy transcriptomics dataset (GSE90594). Druggability and pleiotropy were evaluated using databases and phenome-wide association studies. Forty-seven proteins were significantly associated with MPB severity, enriched in pathways involving epidermis development, hair cycle regulation, and cell adhesion. Multi-omic integration prioritized five independent candidate genes: CD38, FGF5, TACSTD2, DPEP1, and PLB1. Transcriptomic validation confirmed differential expression in balding scalp for CD38 (upregulated) and TACSTD2, PLB1 (downregulated). CD38 was identified as druggable with low pleiotropic risks. This study elucidates the molecular architecture of MPB, revealing novel biological pathways beyond canonical androgen signaling. By prioritizing promising non-hormonal targets like CD38, our findings provide a robust, evidence-based framework to guide the development of future therapeutic interventions for this common condition. Full article

Background: Human cutaneous reactivity exhibits marked inter-individual variability, yet the contribution of constitutional pigmentation traits to short-term skin responses remains incompletely characterized. Fitzpatrick skin phototype reflects stable differences in pigmentation-related traits and may therefore act as a phenotypic modifier of early cutaneous reactivity following topical exposure. Methods: In this controlled human study, 239 healthy volunteers were stratified by Fitzpatrick skin phototype into three groups: I–II (n = 138), III (n = 72), and IV–V (n = 29). A standardized emulgel-based topical provocation model was applied under occlusion to the volar forearm, and cutaneous responses were assessed at 20 min (Test A), 24 h (Test B), and 96 h (Test C) using standardized visual scoring. Group comparisons, multivariable linear regression models adjusted for age, sex, country of origin, and experimental lot, and stratified analyses by country of origin, were performed. Results: Early and short-term cutaneous responses differed significantly across phototype groups. Participants with phototypes I–II exhibited higher response scores at both 20 min and 24 h compared with phototype III (p < 0.001). In adjusted models, phototype III remained independently associated with significantly lower reactivity relative to phototypes I–II at 20 min (β = −1.61, p < 0.001) and 24 h (β = −0.98, p < 0.001). Responses among phototypes IV–V were minimal to absent; however, this subgroup was underrepresented, and findings for IV–V are descriptive. Age was a significant positive predictor of response intensity, whereas sex showed no independent association. No persistent reactions were observed at 96 h in any phototype group. Stratified analyses confirmed that the reduced reactivity associated with phototype III was independent of country of origin. Conclusions: Fitzpatrick skin phototype is independently associated with early and short-term cutaneous reactivity following standardized topical provocation in humans. Lighter phototypes (I–II) demonstrate increased susceptibility to transient inflammatory responses, whereas phototype III shows markedly reduced reactivity. These findings support the role of skin phototype as a constitutional modifier of short-term cutaneous responses and highlight the importance of considering pigmentation-related phenotypes in the design and interpretation of dermatological testing, cosmetic tolerability studies, and safety assessments of topical formulations. Full article

Background/Objectives: The role of smoking in household SARS-CoV-2 transmission is controversial. The objective of this study was to analyze the impact of smoking on SARS-CoV-2 index cases and transmission to household contacts. Methods: Prospective cohort study of 227 index cases and 332 household contacts in Catalonia and Navarre (May 2022–December 2024). The primary outcome measure was SARS-CoV-2 infection in contacts, confirmed by rapid antigen and polymerase chain reaction testing. Adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the smoking-infection association were calculated using logistic regression, adjusting for age, vaccination, and previous infection. Results: The cumulative infection incidence in contacts was 38.6%, and was higher in people aged ≥65 years (60.6%) and in smokers (48.6%) vs. non-smokers (33.8%). In the multivariate analysis, index case vaccination (aOR = 0.27; 95%CI: 0.11–0.63) and previous contact infection (aOR = 0.49; 95%CI: 0.30–0.81) were associated with a lower probability of transmission, while smoking by household contacts (aOR = 2.09; 95%CI: 1.19–3.65) and age ≥ 65 years (aOR = 5.13; 95%CI: 2.18–12.09) were associated with an increased risk of infection. The index case smoking status was not statistically significant. Conclusions: Smoking by cohabitants and age ≥ 65 years increase the risk of SARS-CoV-2 infection. Index case vaccination and previous contact infection are associated with reduced intra-household transmission. Full article

Background/Objectives: Postoperative early hypocalcemia (PEH) is a key postoperative issue after parathyroidectomy in primary hyperparathyroidism. It often leads to long-lasting hypocalcemia, requiring more calcium and active vitamin D supplements. This study aimed to determine whether the extent of intraoperative parathyroid hormone (PTH) decline, measured 15 min after parathyroid tumor excision, could serve as a reliable intraoperative rule-out marker for PEH. Methods: We conducted a retrospective review of 88 adult patients who underwent surgical intervention for a solitary parathyroid tumor at a single institution. Postoperative early hypocalcemia (PEH) was defined as a total serum calcium level <8.5 mg/dL within the postoperative 6th hour or on postoperative day 1, requiring clinical calcium supplementation (oral and/or intravenous), with active vitamin D when appropriate. The percentage decrease in PTH at 15 min post-excision was calculated using morning-of-surgery preoperative PTH values alongside the 15-min post-excision levels. Additional variables assessed included preoperative alkaline phosphatase (ALP), parathyroid tumor weight, and serum concentrations of calcium, phosphate, magnesium, and 25-hydroxyvitamin D. Predictive factors were identified by logistic regression, and the diagnostic accuracy of the 15-min PTH decline was evaluated using receiver operating characteristic (ROC) curve analysis, optimizing cutoff selection with Youden’s index. Odds ratios were standardized per 10-unit increments for ALP and parathyroid tumor weight for interpretability. Results: Of the studied cohort, 10 patients (11.4%) developed PEH. The intraoperative 15-min PTH decline was notably greater in those who developed PEH compared to those who did not (81.2 ± 4.4% vs. 69.9 ± 8.3%; p < 0.001). Univariate logistic regression showed a significant association between the 15-min PTH decline and PEH (OR 1.22 per 1% increment; 95% CI 1.08–1.38). That said, when we added ALP and parathyroid tumor weight to the multivariate models, PTH decline no longer predicted independently. In contrast, ALP (OR 3.11 per 10 U/L; 95% CI 1.34–7.93; p = 0.011) and parathyroid tumor weight (OR 1.22 per 10 mg; 95% CI 1.10–1.48; p = 0.004) stayed significant. Thus, the incremental prognostic contribution of the 15-min PTH decline beyond ALP and parathyroid tumor weight appears limited. The ROC curve for the 15-min PTH decline produced an AUC of 0.883, with an optimal cutoff of 75% providing 100% sensitivity and 74.4% specificity. No patients with a PTH decline below 75% developed PEH. Conclusions: Preoperative ALP and parathyroid tumor weight showed the strongest independent associations with PEH following parathyroid tumor surgery. An intraoperative PTH decline of less than 75% at 15 min may serve as a practical rule-out tool for PEH, although further validation in larger patient populations is warranted. Full article

Background/Objectives: Periodontitis is a chronic inflammatory disease characterized by complex interactions between periodontal pathogens and the host immune response. Pro-inflammatory cytokines, particularly interleukins, may influence bacterial colonization and disease expression, but their association with specific periodontal pathogens remains unclear. This study investigated the associations between single-nucleotide polymorphisms in IL-1A, IL-1B, and TNFA and the presence of key periodontopathogenic bacteria in patients from Croatia. Methods: A cross-sectional study included 63 participants. Genotypes were determined, and subgingival plaque samples were analyzed for Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, and Treponema denticola using real-time PCR. Multivariable logistic regression models assessed associations between cytokine gene polymorphisms and periodontopathogenic bacteria presence, adjusting for age, gender, smoking status, and the presence of systemic diseases. Results: Among participants (median age 57.0 years, IQR 43.5–67.0; 58.7% female), P. intermedia (87.3%), T. forsythia (85.7%), and T. denticola (69.8%) were the most prevalent pathogens. The IL-1A CC genotype significantly increased the odds of P. gingivalis (OR = 5.54; p = 0.009) and T. denticola (OR = 3.77; p = 0.041) presence. The IL-1B CC genotype was independently associated with T. forsythia (OR = 8.48; p = 0.026). No significant associations were observed for TNFA polymorphism. Model performance ranged from moderate to good (AUC up to 0.89). Conclusions: Genetic variants in IL-1A and IL-1B may influence periodontal bacterial colonization, while demographic and lifestyle factors showed limited impact. Further studies in larger cohorts are warranted. Full article

Background/Objectives: This study investigated whether serum 25-hydroxyvitamin D (25(OH)D) modifies the association between meeting WHO aerobic physical activity guidelines and cardiometabolic risk clustering among rural older adults in South Korea. Methods: This cross-sectional study analyzed 2023 Korea National Health and Nutrition Examination Survey (KNHANES) data for rural-dwelling adults aged ≥65 years with complete data (n = 441). Cardiometabolic risk clustering (CMRC) was defined as the presence of ≥3 of five risk factors (abdominal obesity, elevated blood pressure, low HDL-cholesterol, elevated triglycerides, and hyperglycemia). Exposures were continuous serum 25-hydroxyvitamin D (25(OH)D) and adherence to the WHO aerobic physical activity guidelines (yes/no). Multivariable logistic regression models tested the 25(OH)D × physical activity interaction, adjusting for sex, age (≥75 vs. <75 years), education, household income, smoking status, alcohol use, and obesity (BMI ≥ 25 kg/m²). Conditional effects of physical activity were estimated at the 16th, 50th, and 84th percentiles of 25(OH)D. Results: A significant interaction between 25(OH)D and physical activity was observed (OR = 0.91, 95% CI: 0.85–0.97; p = 0.005). Physical activity was not associated with CMRC at low 25(OH)D (16th percentile, 17.08 ng/mL; OR = 1.64, 95% CI: 0.78–3.47), but it was associated with lower odds of CMRC at high 25(OH)D (84th percentile, 36.98 ng/mL; OR = 0.25, 95% CI: 0.10–0.62). Conclusions: Vitamin D status modified the association between aerobic physical activity and cardiometabolic risk clustering among rural older adults. Integrated prevention strategies addressing both physical activity and vitamin D insufficiency may be valuable in rural aging populations. Full article

In acidic tea soil, boron (B) adsorption and desorption processes are dominated by the complex relationship between soil acidity, mineralogy, and organic matter. This study investigated B adsorption–desorption behavior in five acidic tea soils (pH 3.8–5.6) collected from the Eastern Black Sea region of Türkiye and evaluated the potential of machine learning (ML) algorithms to predict B desorption. Laboratory batch experiments were conducted using five initial B concentrations, and adsorption data were interpreted using the Langmuir isotherm model. Adsorption experiments indicated that B interacted with Fe/Al-oxide-containing clay minerals, which had low but favorable binding affinity, as indicated by Langmuir maximum adsorption capacities (Qmax) ranging from 46.5 to 181.8 mg kg⁻¹. Desorption experiments revealed a high degree of reversibility, particularly in soils with lower adsorption capacities, ensuring potential B leaching. To capture the governing B desorption, six machine learning (ML) algorithms—Extreme Gradient Boosting (XGBoost), Random Forest (RF), Support Vector Regression (SVR), Gaussian Process Regression (GP), Elastic Net Regression (EN), and Multivariate Adaptive Regression Splines (MARS)—were trained on 75 data points. Among the tested models, Elastic Net showed the highest predictive accuracy (R² = 0.735). This model does not replace adsorption experiments. It offers a within-assay determination of desorption given measured adsorption, which may reduce the requirement for separate desorption equilibration and analyses. Permutation importance analysis identified B_ads as the dominant predictor of B desorption, with smaller contributions from pH_ads and EC_ads. The results demonstrate that integrating laboratory experiments with machine learning provides an effective framework for predicting B mobility in acidic tea soils, offering a parameterized experimental framework for describing boron desorption behavior in acidic tea soils. Full article