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30 pages, 930 KB  
Article
The Horizon Scandal as Socio-Technical Failure: A Systematic Analysis Through Cyber Security and Digital Forensics Frameworks
by Harjinder Singh Lallie
J. Cybersecur. Priv. 2026, 6(5), 144; https://doi.org/10.3390/jcp6050144 - 25 Aug 2026
Abstract
The Post Office Horizon scandal represents one of the most severe miscarriages of justice in modern British legal history, rooted in the deployment of a defective IT system and the institutional suppression of evidence that exposed its unreliability. This paper provides a systematic [...] Read more.
The Post Office Horizon scandal represents one of the most severe miscarriages of justice in modern British legal history, rooted in the deployment of a defective IT system and the institutional suppression of evidence that exposed its unreliability. This paper provides a systematic analysis of the scandal through the combined lenses of cyber security, digital forensics, and IT governance, drawing directly on the Post Office Horizon Public Inquiry dataset—including witness testimony, technical documentation, audit records, and internal communications spanning more than two decades. While many of the technical and procedural failures discussed have been documented in prior scholarship, the paper’s principal contribution is the systematic mapping of those failures against recognised governance frameworks and the Legally Accountable Digital Systems (LADS) proposal this mapping motivates. We identify and analyse five interconnected failure categories: software defects and poor system design; deficient patch governance; inadequate audit logging and compromised evidence integrity; investigative failures and prosecutorial conflict of interest; and a systemic absence of technical expertise and independent oversight. Each category is mapped against nine governance framework documents, including ISO/IEC 27001, NIST SP 800-53 Rev. 5, NIST SP 800-218 (SSDF), COBIT 2019, ISO/IEC 27035, NIST SP 800-61, and ISO/IEC 27036, with ISO/IEC 27037 applied additionally to evidential handling failures and NIST SP 800-92 to log management failures. A counterfactual analysis indicates that compliance with these frameworks could plausibly have detected, exposed, or substantially reduced most of the documented failures, though this claim is necessarily inferential and conditional on good-faith implementation. The scandal was therefore not caused primarily by the absence of adequate frameworks but by their wholesale non-application and by institutional incentives, examined later in the paper, that can undermine even fully compliant controls. However, the analysis also surfaces a governance gap that no existing framework addresses: the institutional failure mode in which the organisation responsible for system integrity holds active incentives to suppress evidence of failure rather than remediate it. To address this gap, we propose the concept of Legally Accountable Digital Systems (LADS)—a governance category for systems whose outputs are used as evidence in legal proceedings—and outline three supplementary pillars: technical independence, institutional independence, and forensic admissibility governance. We draw a parallel with the Sarbanes–Oxley Act of 2002, arguing that the Horizon Inquiry dataset provides an equivalent empirical foundation for the statutory reform of digital evidence governance. Finally, we outline the substantial research opportunities the Inquiry dataset presents across IT systems analysis, cyber security, forensic accounting, social network analysis, and legal informatics—a resource comparable in significance to the Enron materials that shaped a generation of corporate governance reform. Full article
(This article belongs to the Special Issue Building Community of Good Practice in Cybersecurity—2nd Edition)
21 pages, 1194 KB  
Article
Design of a Compact Ultra-Wideband Bio-Inspired Antenna Based on the Antennal Structure of Allomyrina dichotoma
by Xu Zheng, Chaobo Li and Chenxi Gao
Biomimetics 2026, 11(9), 606; https://doi.org/10.3390/biomimetics11090606 - 25 Aug 2026
Abstract
Grounded in structural biomimetics, this study extracts the multi-segmented tapered geometry from the 10-segmented lamellate antenna of Allomyrina dichotoma and maps it to microwave antenna design. Through biological characterization and parametric modeling, key geometric features—multi-segmented configuration, irregular contour, and bilateral symmetry—were extracted. Along [...] Read more.
Grounded in structural biomimetics, this study extracts the multi-segmented tapered geometry from the 10-segmented lamellate antenna of Allomyrina dichotoma and maps it to microwave antenna design. Through biological characterization and parametric modeling, key geometric features—multi-segmented configuration, irregular contour, and bilateral symmetry—were extracted. Along the 2D pathway, a 10 × 10 × 1 mm3 PCB microstrip antenna was designed and fabricated, achieving 111% fractional bandwidth from 4.86 to 17.05 GHz with a peak gain of 2.15 dBi and a radiation efficiency of 67–72% across the operating band, plus two additional bands at 24.76–28.58 GHz and 32.66–37.73 GHz. The multiple resonance valleys on S11 curves and frequency-dependent surface current evolution indicate that multi-mode resonant coupling, perimeter increment, and symmetric aperture efficiency together underpin the ultra-wideband performance. Along the 3D pathway, a dipole antenna replicated via metallic 3D printing attains an electrical length of 0.17λ, with 66% bandwidth and 1.45 dBi gain, confirming the same geometric principle in a shape-preserving form. The 2D route favors planar integration and bandwidth, while the 3D route offers extreme miniaturization. This work provides experimental validation of cross-domain geometric mapping from biology to electromagnetics within structural biomimetics, and offers engineering evidence for the intrinsic versatility of this morphology across physical domains. Full article
(This article belongs to the Section Biomimetic Design, Constructions and Devices)
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31 pages, 13323 KB  
Article
Probing the Capsid: pH-Driven Gating at the AAV 5-Fold Pore and Its Role in Peptide Ligand Binding
by Arianna Minzoni, Benjamin Bobay, Shriarjun Shastry, Eduardo Barbieri, Brandon Brino, Crystal Collazo, Shizuo Kamita, Danni Wang, Ciera Khuu, Alexander Polgar, Joseph Siino, Sushmita Koley, Peyton Russelburg, Mark Snyder, Christopher Belisle, Michael Daniele and Stefano Menegatti
Pharmaceutics 2026, 18(9), 1053; https://doi.org/10.3390/pharmaceutics18091053 - 25 Aug 2026
Abstract
Background/Objectives: Adeno-associated virus (AAV) capsids undergo pH-dependent conformational gating at the 5-fold symmetry pore, but how these structural dynamics shape serotype-specific behavior and affinity-ligand recognition remains unclear, particularly for the clinically important serotypes AAV8 and AAV9. This study aimed to establish a pH-resolved [...] Read more.
Background/Objectives: Adeno-associated virus (AAV) capsids undergo pH-dependent conformational gating at the 5-fold symmetry pore, but how these structural dynamics shape serotype-specific behavior and affinity-ligand recognition remains unclear, particularly for the clinically important serotypes AAV8 and AAV9. This study aimed to establish a pH-resolved structural framework linking 5-fold pore dynamics to peptide-ligand recognition and to translate this framework into sequence-based design principles for affinity capture of gene therapy vectors. Methods: AAV8 and AAV9 5-fold capsid assemblies were subjected to 500 ns molecular dynamics simulations under acidic (pH 5), neutral (pH 7), and basic (pH 9) conditions, with analysis of pore volume, inter-residue contact networks, electrostatic potential, and solvent-accessible surface area. In parallel, affinity chromatography using three mixed-mode peptide ligands (RVVAVYRI, TTFRAHHI, and TYHHHHII) was performed on clarified HEK293 lysates containing AAV8 or AAV9, with capsid yield, host-cell-protein clearance, and transduction activity assessed by ELISA, SEC-HPLC, and flow-cytometry-based transduction assays. Results: AAV8 displayed a heterogeneous, bimodal pore conformational landscape at pH 7, whereas AAV9 exhibited a discrete gate-like transition with maximal pore constriction at physiological pH; both serotypes showed pore-proximal contact remodeling with distinct network topologies. Experimentally, TYHHHHII achieved the highest selectivity for genome-containing capsids at pH 7, with transduction activity enrichment factors of 2.82 (AAV8) and 5.61 (AAV9), while TTFRAHHI provided the broadest operational pH range for bulk capsid recovery. Conclusions: These findings establish a structural framework linking pH-dependent pore dynamics to affinity ligand recognition and suggest practical sequence-design rules for ligand engineering: clustered histidines for neutral-pH selectivity, Arg-containing motifs for broad-pH robustness, and aromatic or hydrophobic residues for reinforcement of capsid binding. Full article
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35 pages, 4536 KB  
Article
Electromechanical Coupling Modeling and LQG Active Vibration Control of CFRP Cantilever Plates Using MFCs
by Dongyang Song, Pengyue Na, Yulai Zhao, Dong Yang, Mohammed Meiirbekov and Haitao Luo
Modelling 2026, 7(5), 177; https://doi.org/10.3390/modelling7050177 - 25 Aug 2026
Abstract
This study addresses the inherently low damping and vibration susceptibility of carbon fiber reinforced polymer (CFRP) laminated cantilever plates by developing a comprehensive dynamic modeling and active vibration control framework. An electromechanical coupling model incorporating macro-fiber composite (MFC) actuators and sensors is established [...] Read more.
This study addresses the inherently low damping and vibration susceptibility of carbon fiber reinforced polymer (CFRP) laminated cantilever plates by developing a comprehensive dynamic modeling and active vibration control framework. An electromechanical coupling model incorporating macro-fiber composite (MFC) actuators and sensors is established using the first-order shear deformation theory (FSDT) and the assumed mode method, with virtual springs introduced to account for non-ideal clamped boundary conditions. A reduced-order state-space model is then derived through model reduction, and a linear quadratic Gaussian (LQG) controller is designed for optimal state estimation and feedback control. The theoretical model is systematically validated via convergence analysis, ANSYS finite element simulations, and LMS impact hammer testing. The results demonstrate that, with the relative errors of the first four natural frequencies controlled within 2%, the theoretical mode shapes are highly consistent with those obtained from ANSYS simulations. An active vibration control experimental platform is established, and the effectiveness of the control strategy is verified under dual-spectrum harmonic and impact excitations. The results show that the designed LQG controller can effectively suppress multi-modal vibrations, substantially attenuating the response amplitudes of dominant modes and significantly accelerating the transient vibration convergence. This study addresses the challenge of precisely characterizing actual non-ideal clamped boundary conditions. Through model order reduction and closed-loop LQG control experiments, it provides a comprehensive set of theoretical methodologies, numerical solution strategies, and engineering-oriented experimental schemes for the electromechanical coupling dynamic modeling and optimal vibration suppression of CFRP thin-walled composite structures. Full article
(This article belongs to the Special Issue Advanced Modelling, Design and Testing of Composite Materials)
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20 pages, 7187 KB  
Article
Design and Experimental Investigation of a Compact Traveling-Wave Piezoelectric Angular Motion Motor
by Laurynas Šišovas and Andrius Čeponis
Micromachines 2026, 17(9), 1000; https://doi.org/10.3390/mi17091000 - 24 Aug 2026
Abstract
This paper presents the design, numerical analysis, and experimental investigation of a compact traveling-wave piezoelectric motor for continuous and incremental angular motion. The key advancement of the proposed design is a compact coaxial direct-drive architecture that combines a single ring-shaped piezoelectric stator with [...] Read more.
This paper presents the design, numerical analysis, and experimental investigation of a compact traveling-wave piezoelectric motor for continuous and incremental angular motion. The key advancement of the proposed design is a compact coaxial direct-drive architecture that combines a single ring-shaped piezoelectric stator with four independently excited electrode sections, three discrete spherical contact elements, a cone-shaped rotor, and an adjustable spring-based preload mechanism. In contrast to conventional traveling-wave motors employing continuous annular or toothed contact interfaces, the proposed configuration localizes the stator–rotor interaction at three predefined contact points while allowing both continuous bidirectional rotation and incremental angular positioning within the same actuator. Numerical analysis identified the operating mode at 39.95 kHz and confirmed the formation of elliptical displacement trajectories at the spherical contact elements. The calculated resonance frequency and effective electromechanical coupling coefficient were 39.93 kHz and 4.36%, respectively. Experimental measurements showed resonance of 39.94 kHz with an effective coupling coefficient of 4.47%. The motor achieved a maximum rotational speed of 87 ± 2.2 RPM at 180 Vp-p. The maximum stall torque reached approximately 8.3 N·mm and 8.4 N·mm for clockwise (CW) and counterclockwise (CCW), respectively, at 180 Vp-p. Depending on the excitation amplitude, the angular step varied from 0.082 ± 0.015° to 3.038 ± 0.120°. The results confirm that the proposed compact motor can provide controllable continuous rotation and incremental angular positioning. Full article
(This article belongs to the Special Issue Piezoelectric Sensors, Actuators, Transducers, and Energy Harvesters)
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13 pages, 1279 KB  
Article
The Effect of Different Surface Treatments and Thermocycling on Repair Bond Strength of a 3D-Printed Permanent Crown Resin
by Merve Yılmaz and Nihan Gönülol
Appl. Sci. 2026, 16(17), 8350; https://doi.org/10.3390/app16178350 - 22 Aug 2026
Viewed by 117
Abstract
The aim of this study was to investigate the effects of surface treatments and thermocycling on the shear bond strength of a 3D-printed permanent crown resin. A total of 120 disc-shaped specimens (10 × 3 mm) were fabricated using a 3D printer and [...] Read more.
The aim of this study was to investigate the effects of surface treatments and thermocycling on the shear bond strength of a 3D-printed permanent crown resin. A total of 120 disc-shaped specimens (10 × 3 mm) were fabricated using a 3D printer and randomly assigned to four groups according to surface repair protocols: airborne-particle abrasion with Al2O3, bur roughening, 37% orthophosphoric acid etching, and a control group with no surface treatment. All specimens received a silane coupling agent followed by an adhesive resin application, and repair was performed using a highly filled flowable composite. Each group was divided into three subgroups and subjected to 1000, 5000, or 15,000 thermal cycles. Shear bond strength was measured, failure modes were analyzed, and data were evaluated using two-way ANOVA and Tukey’s post hoc test (p < 0.05). The sandblasting group exhibited the highest bond strength (18.7 ± 5.0 MPa), which was significantly higher than the control (12.6 ± 3.7 MPa) and acid-etching (14.2 ± 3.8 MPa) groups (p < 0.05). Aging periods had no significant effect on bond strength (p > 0.05). Additionally, the interaction between surface treatment and thermocycling had no significant effect (p = 0.823). Under the tested conditions, airborne-particle abrasion resulted in the highest shear bond strength of 3D-printed permanent crown resin. Full article
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44 pages, 4014 KB  
Systematic Review
A Systematic Review of Cybersecurity Testbeds for Smart Environments: Architectures, Attack Coverage, and Defensive Evidence
by Vyron Kampourakis, Konstantinos E. Kampourakis, Michail Takaronis and Vasileios Gkioulos
Future Internet 2026, 18(9), 445; https://doi.org/10.3390/fi18090445 - 22 Aug 2026
Viewed by 65
Abstract
Smart-environment cybersecurity increasingly depends on experimental platforms that can reproduce attacks against buildings, homes, and cities under realistic conditions. However, the literature remains fragmented across testbed design, attack demonstration, and defensive validation. This makes it particularly difficult to judge what kind of security [...] Read more.
Smart-environment cybersecurity increasingly depends on experimental platforms that can reproduce attacks against buildings, homes, and cities under realistic conditions. However, the literature remains fragmented across testbed design, attack demonstration, and defensive validation. This makes it particularly difficult to judge what kind of security evidence each study actually provides. This review systematically analyses 28 experimentally grounded studies published from 2020 onwards, focusing on how testbed realism, cyber–physical coupling, and evaluation mode shape the strength of the resulting claims. The corpus spans physical, hybrid, emulated, and dataset-driven environments across smart buildings, smart homes, and smart cities. Through our investigation, we discern a clear asymmetry in the field. Detection-oriented studies dominate, especially those based on emulation or public datasets, while live evidence for prevention, response, containment, and recovery is comparatively scarce. Availability and integrity/control attacks are the most frequently exercised, whereas authentication compromise and software exploitation remain rare because they are harder to stage on real hardware. Moreover, an important observation we arrive at is that physical and hardware-in-the-loop platforms support the strongest cyber–physical evidence, but emulated and replayed environments remain valuable for scale and reproducibility. At the same time, public datasets and offline classification results do not by themselves establish operational resilience in a live smart environment. To make these distinctions explicit, we introduce a cross-domain taxonomy of testbed architectures, attack families, and defensive control coverage, and map the evidence strength of reported mitigations using NIST cybersecurity framework-derived operational functions. Last, we identify open challenges, including weak recovery evaluation, limited reuse of reference testbeds, and the need for live, context-aware datasets, outlining promising future directions. Full article
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27 pages, 19421 KB  
Article
Modal Analysis of an Additively Manufactured AlSi10Mg Thick-Walled Cylinder: Finite Element Simulation, Experimental Validation, and Non-Conservative Damping Characterization
by Mazahir Hussain Shah, Shaheer Ul Hassan and Luděk Pešek
Appl. Mech. 2026, 7(3), 72; https://doi.org/10.3390/applmech7030072 - 21 Aug 2026
Viewed by 139
Abstract
This paper presents a systematic experimental and computational investigation of the free-vibration characteristics of a Laser Powder Bed Fusion (LPBF) AlSi10Mg thick-walled cylinder, a geometry relevant to electric-machine housings, hydraulic sleeves, and pressure-carrying components exposed to resonance-critical service loads. The specimen has an [...] Read more.
This paper presents a systematic experimental and computational investigation of the free-vibration characteristics of a Laser Powder Bed Fusion (LPBF) AlSi10Mg thick-walled cylinder, a geometry relevant to electric-machine housings, hydraulic sleeves, and pressure-carrying components exposed to resonance-critical service loads. The specimen has an outer diameter of 94 mm, an inner diameter of 64 mm, a wall thickness of 15 mm, and a height of 90 mm, placing it firmly in the thick-walled regime (d/D=0.68). A three-dimensional finite element model comprising 23,864 total elements (23,236 SOLID186 solid elements and 628 surface/contact elements) and 106,015 nodes was constructed in Ansys Mechanical using the AlSi10Mg material database entry (E = 75 GPa, ρ = 2670 kg/m3, ν = 0.33) and solved with the Block Lanczos eigensolver under free–free boundary conditions. Experimental modal analysis (EMA) was conducted using Brüel & Kjær software with an impact hammer with a 260-node measurement grid covering the outer surface and both end rings; frequency response functions were acquired over 0–22,500 Hz. Fourteen flexible modes were identified in simulation; nine corresponding experimental modes were resolved with frequency deviations ranging from 0.13% to 1.10%. In addition to frequency correlation, this paper introduces a non-conservative damping characterization framework comprising: (i) Rayleigh (proportional) damping coefficient extraction from EMA data and assessment of its frequency-domain validity; (ii) a viscoelastic complex-modulus model relating the real storage modulus E and imaginary loss modulus E to the modal loss factor η and damping ratio ζ; and (iii) a practical design workflow for resonance mitigation of future AM structures including electric machine frames. Experimental damping ratios (ζ=0.0130.311%) are converted to per-mode E values and loss factors, revealing that energy dissipation in LPBF AlSi10Mg is strongly mode-shape-dependent and cannot be accurately represented by a single Rayleigh model. Full article
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27 pages, 45917 KB  
Article
Numerical Simulation Research on Unloading and Fracturing Characteristics of Immediate Roof Rock in Underground Coal Mining
by Yan Qin, Nengxiong Xu, Zhenyu Zou, Liang Chen and Jiayu Qin
Fractal Fract. 2026, 10(8), 584; https://doi.org/10.3390/fractalfract10080584 - 21 Aug 2026
Viewed by 136
Abstract
Underground coal mining can induce deformation and failure of overlying strata and ground surface, which seriously endangers the safety of human life and property. During mining, the immediate roof rock successively experiences initial caving (fixed support on four sides) and periodic caving (fixed [...] Read more.
Underground coal mining can induce deformation and failure of overlying strata and ground surface, which seriously endangers the safety of human life and property. During mining, the immediate roof rock successively experiences initial caving (fixed support on four sides) and periodic caving (fixed support on three sides and free on one side). Different boundary conditions alter the unloading and deformation processes such as cracking and fracturing of immediate roof rock, thereby affecting its subsequent mechanical behavior of compaction and deformation, and resulting in differences in the movement law of overlying strata. In this paper, the numerical simulation method is adopted to investigate the variation laws of unloading and fracturing characteristics of immediate roof rock under initial caving and periodic caving with thickness-width ratio (t/w), length-width ratio (l/w), unloading stress (σu) and specimen strength (σc), and the corresponding action mechanism is revealed. The fractal evolution law of fractured immediate roof rock obtained from this study can quantitatively evaluate the compaction characteristics of caved rock, provide refined parameter support for surface subsidence prediction and possess guiding significance for stope surrounding rock control engineering. The results show that the fragments formed after the failure of immediate roof rock are mainly block-strip shaped under both first caving and periodic caving conditions. With the increase in the thickness-width ratio, the flexural rigidity of immediate roof rock increases and crack propagation is restrained, so that the particle-size–mass fractal dimension of fragments increases first and then decreases for the two caving modes. The increase in length-width ratio weakens the propagation of secondary fractures and raises the particle size of fragments, while the overall variation in particle-size–mass fractal dimension is small under the two working conditions. As the unloading stress continuously rises, the coupled tension-shear effect inside the rock gradually intensifies, and the failure mode changes from tension-shear failure to global shear failure. Accordingly, both the particle-size–mass fractal dimension and fractal dimension of crack distribution increase first and then decrease under first caving and periodic caving conditions. The increase in the strength of immediate roof rock raises the energy consumption during rock failure, and large-size fragments are more likely to be generated, which reduces the particle-size–mass fractal dimension and increases the particle size of fragments under both caving modes. Meanwhile, internal micro-fractures continuously initiate and propagate with the growth of rock strength. For specimens with relatively high strength, crack propagation is inhibited and the development of secondary fractures is weakened, leading to an evolution trend that the fractal dimension of crack distribution increases first and then decreases. Under identical parameter conditions, the particle-size distribution and crack complexity for first caving are mainly affected by geometric parameters; the particle size of fragments is primarily controlled by specimen strength; and the unloading stress threshold governs the transition of failure mode. For periodic caving, the crack-initiation location is first determined by asymmetric boundary constraints. The thickness-width ratio dominates the particle-size distribution of fragments, and unloading stress as well as specimen strength further regulate the complexity of cracks. Full article
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26 pages, 5322 KB  
Article
N-Acetylcysteine-Functionalized Mixed Micelles Overcome Multiple Intestinal Barriers to Improve Oral Bioavailability and Antioxidant Protection of Imperatorin
by Yu Zhang, Jian Guo, Haonan Qiu, Jiale Liu, Chi Zhang, Lutan Zhou, Chunfei Wang, Lihua Li and Xuefeng Hou
Pharmaceutics 2026, 18(8), 1036; https://doi.org/10.3390/pharmaceutics18081036 - 20 Aug 2026
Viewed by 188
Abstract
Background: Imperatorin (IPT) is a natural furanocoumarin featuring robust anti-inflammatory, antifibrotic and antioxidant activities. However, poor aqueous solubility and insufficient oral bioavailability restrict its clinical application. Multiple gastrointestinal barriers, including the mucus barrier, limited epithelial penetration and P-glycoprotein-triggered drug efflux, are major [...] Read more.
Background: Imperatorin (IPT) is a natural furanocoumarin featuring robust anti-inflammatory, antifibrotic and antioxidant activities. However, poor aqueous solubility and insufficient oral bioavailability restrict its clinical application. Multiple gastrointestinal barriers, including the mucus barrier, limited epithelial penetration and P-glycoprotein-triggered drug efflux, are major obstacles hindering IPT oral absorption. Methods: N-acetylcysteine (NAC)-functionalized TPGS conjugates were synthesized first. Using Pluronic® F108 and Lipoid® S-100 as a matrix, imperatorin@N-acetylcysteine-TPGS/Pluronic® F108/Lipoid® S-100 (IPT@NAC-TFS) micelles were fabricated. We characterized their physicochemical features and in vitro release behavior. The Caco-2/HT29-MTX-E12 co-culture cell model was adopted to explore mucus permeation, cellular uptake and transepithelial transport mechanisms. In vivo intestinal distribution and pharmacokinetic tests in rats were carried out to confirm the oral absorption-enhancing effect of micelles. Results: Optimized micelles displayed a uniform shape and favorable encapsulation efficiency. Low CMC maintained structural stability upon gastrointestinal dilution. NAC modification conferred mucus-penetrating capacity on micelles. TPGS simultaneously improved epithelial barrier permeability and inhibited drug efflux, switching IPT transport mode. The micelles effectively cleared intracellular ROS, recovered SOD activity and lowered MDA levels in BLM-impaired MLg fibroblasts. In vivo results revealed enhanced intestinal drug accumulation, with the relative oral bioavailability of IPT increased by 6.07-fold. Conclusions: IPT@NAC-TFS micelles overcome multiple gastrointestinal barriers for oral IPT delivery. Combining mucus penetration, efflux suppression and antioxidative capacity, this system offers a promising strategy to develop oral formulations of poorly soluble antifibrotic natural products. Full article
(This article belongs to the Section Drug Delivery and Controlled Release)
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13 pages, 2440 KB  
Article
Ternary CBe4S32−/− Clusters: Fan-Shaped Global Minima with Planar Tetracoordinate Carbon
by Ting Zhang, Ya-Xuan Cheng, Mesías Orozco-Ic and Jin-Chang Guo
Chemistry 2026, 8(8), 113; https://doi.org/10.3390/chemistry8080113 - 20 Aug 2026
Viewed by 194
Abstract
“Altering the auxiliary atoms” is an effective approach for expanding the planar tetracoordinate carbon (ptC) family. The ternary CBe4S32− cluster has been designed by using the “isoelectronic replacement of auxiliary bridges” strategy, based on previously reported ptC CBe4 [...] Read more.
“Altering the auxiliary atoms” is an effective approach for expanding the planar tetracoordinate carbon (ptC) family. The ternary CBe4S32− cluster has been designed by using the “isoelectronic replacement of auxiliary bridges” strategy, based on previously reported ptC CBe4Cl3+. It possesses a fan-shaped structure, containing one ptC center, an arc-shaped Be4 ligand chain, and three auxiliary S bridges. The extensive search and high-level quantum chemistry calculations indicate that both ptC CBe4S32− and its derivative CBe4S3 are global minima structures on their potential energy surfaces. Born–Oppenheimer molecular dynamics simulations suggest that they also possess good dynamical stability. Chemical bonding analyses indicate that the ptC center in CBe4S32− is stabilized by one delocalized π bond and three delocalized σ bonds within the CBe4 core, while magnetically induced current density analysis reveals localized diatropic circulations without exhibiting a ring current. The current contribution introduces two new members to the ptC family, expanding the ptC bonding modes and design strategies. Full article
(This article belongs to the Topic Aromatic Inorganic and Metallic Compounds II)
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10 pages, 1836 KB  
Article
A Retrospective Study of Ultrasonographic Features of Hepatic Metastases Following Adrenal Cortical Carcinoma Resection
by Rongchen Wang and Yang Chen
J. Clin. Med. 2026, 15(16), 6442; https://doi.org/10.3390/jcm15166442 - 20 Aug 2026
Viewed by 126
Abstract
Background/Objectives: Liver metastasis after surgery for adrenocortical carcinoma (ACC) is a critical factor affecting patient prognosis; however, relevant ultrasound imaging features remain poorly characterized. This retrospective study aims to systematically describe the conventional ultrasound and contrast-enhanced ultrasound (CEUS) features of post-surgical hepatic [...] Read more.
Background/Objectives: Liver metastasis after surgery for adrenocortical carcinoma (ACC) is a critical factor affecting patient prognosis; however, relevant ultrasound imaging features remain poorly characterized. This retrospective study aims to systematically describe the conventional ultrasound and contrast-enhanced ultrasound (CEUS) features of post-surgical hepatic metastases from ACC and to evaluate the clinical utility of ultrasonography in the diagnosis and follow-up. Methods: A total of 10 patients with post-surgical ACC liver metastases via ultrasound-guided liver biopsy between January 2000 and June 2026 at West China Hospital of Sichuan University were retrospectively enrolled. All patients underwent conventional ultrasound (B-mode and color Doppler flow imaging, CDFI) and CEUS. Given the small sample size, only descriptive statistics were performed, and all findings should be interpreted as exploratory. Results: All 10 patients were female (age range: 38–56 years), 70% had multiple lesions. On B-mode ultrasound, 80% of lesions appeared hypoechoic, 100% exhibited heterogeneous internal echotexture, 80% had irregular shapes, and 60% displayed well-defined margins. CDFI detected internal or perilesional blood flow signals in 90% of lesions, predominantly perilesional (50%). CEUS demonstrated arterial-phase hyperenhancement in all cases (50% heterogeneous hyperenhancement, 30% peripheral-dominant enhancement, and 20% ring-like nodular hyperenhancement), followed by rapid wash-out during the portal venous or delayed phases, with 100% of lesions showing hypoenhancement at 180 s. Conclusions: These exploratory findings suggest that post-surgical ACC liver metastases typically manifest on conventional ultrasound as hypoechoic, heterogeneous solid masses with variable margins and predominant perilesional blood flow. CEUS reveals a characteristic “fast-in, fast-out” malignant enhancement pattern. CEUS may serve as a useful adjunct to conventional imaging within a multimodal surveillance strategy, but larger prospective studies are needed to confirm its diagnostic value. Full article
(This article belongs to the Section Nuclear Medicine & Radiology)
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24 pages, 1766 KB  
Article
An Analytical Model for Low-Frequency Vibration Energy Harvesting in a Cantilever Beam with a Piezoelectric Patch: Development and Qualification Using Experimental Data
by Jorge Enrique Herrera Arroyave, Diego Fernando Arias Mateus, Milton Humberto Medina Barreto, Jorge Alfredo Ferrer Pérez and Christian Vanhille
Appl. Sci. 2026, 16(16), 8267; https://doi.org/10.3390/app16168267 - 19 Aug 2026
Viewed by 239
Abstract
Vibration-based piezoelectric energy harvesting provides a potential power source for low-consumption devices; however, its prediction requires a consistent representation of localized structural properties and experimentally identified modal behavior. This study presents the structural and modal qualification of an analytical electromechanical model for a [...] Read more.
Vibration-based piezoelectric energy harvesting provides a potential power source for low-consumption devices; however, its prediction requires a consistent representation of localized structural properties and experimentally identified modal behavior. This study presents the structural and modal qualification of an analytical electromechanical model for a 6061-T6 aluminum cantilever beam carrying a finite one-sided PZT-5J piezoelectric patch, with unequal beam and patch widths, under base excitation. The specific contribution is the traceable integration of local neutral-axis relocation, spatially varying mass and flexural rigidity, a finite-patch indicator function, d31 electromechanical coupling, multimodal projection, and mode-specific reduced-order equations. Two beam lengths, 275 and 250 mm, were investigated using broadband shaker excitation, accelerometry, and scanning laser vibrometry. The measured first and second bending frequencies were 16.56 and 110.31 Hz for the 275 mm beam and 19.14 and 125.00 Hz for the 250 mm beam. Experimental damping ratios obtained from the frequency-response functions ranged from 6.54×103 to 1.55×102. The analytical formulation reproduced the increase in modal frequencies produced by reducing the beam length and captured the measured transverse mode-shape trends. Experimentally identified frequencies, base accelerations, and damping ratios were subsequently introduced into the reduced model to obtain experimentally parameterized model outputs. The largest calculated peak voltage and estimated average electrical power were 155.99 mV and 1.22 μW, respectively, for the first mode of the 275 mm beam across a reference 10 kΩ resistive load. The reported qualification is restricted to the structural and modal response of the two tested configurations; the electrical quantities are calculated outputs rather than independent electrical measurements. Full article
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36 pages, 1594 KB  
Article
Sustainable Land Transport Infrastructure System Composition and Urban–Rural Income Inequality: Evidence from Chinese Prefecture-Level Cities
by Yaojun Qi, Fauzan Mohd Jakarni, Nur Ainina Mustafa and Nur ’Atirah Muhadi
Sustainability 2026, 18(16), 8509; https://doi.org/10.3390/su18168509 - 19 Aug 2026
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Abstract
Land transport infrastructure (LTI) is a core component of sustainable transport systems, shaping mobility, efficiency, and the spatial distribution of development gains. Existing studies of urban–rural income inequality mainly focus on individual transport modes or aggregate infrastructure scale, with limited attention to transport-system [...] Read more.
Land transport infrastructure (LTI) is a core component of sustainable transport systems, shaping mobility, efficiency, and the spatial distribution of development gains. Existing studies of urban–rural income inequality mainly focus on individual transport modes or aggregate infrastructure scale, with limited attention to transport-system composition and its contextual dependence. This study addresses this gap by conceptualizing LTI as a layered system and examining how its internal composition is associated with urban–rural income inequality across different levels of urbanization and economic development. Using a balanced panel of 286 prefecture-level cities from 2013 to 2023, the study constructs ratio-based indicators of compositional shifts within road systems, within rail systems, and between rail and road infrastructure. Two-way fixed-effects models incorporate interactions with urbanization and economic development. Conditional marginal-effect maps are then used to identify how these associations change across development contexts. The results reveal a clear stage-dependent pattern. Urbanization generally attenuates the inequality-widening association of mobility-oriented upgrading, whereas economic development influences whether such upgrading reinforces spatial polarization or supports wider diffusion. When urbanization and development are both sufficiently advanced, the marginal association may shift toward inequality reduction. At earlier stages, accessibility-oriented roads and conventional rail tend to show stronger equalizing associations. Mobility-oriented roads and high-speed rail are more likely to be associated with narrower inequality in more advanced settings. Mechanism-oriented analyses yield evidence consistent with two potential channels: the agricultural–non-agricultural labor-productivity gap and the non-agricultural employment share. The extended analyses and robustness checks broadly support the main findings. These findings indicate that transport infrastructure upgrading should be evaluated not only in terms of efficiency, but also according to whether the resulting infrastructure mix broadens access to opportunities, improves resource allocation, and supports inclusive regional development. Full article
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17 pages, 28027 KB  
Article
Root-Inspired Bio-Interlocking Structure Design and Its Mechanism on Enhancing the Interfacial Bonding of NiTi/Ti6Al4V Fabricated by MM-LPBF
by Jingyu Xu, Honglei Ge, Zhenyu Niu, Jiakun Shi, Shuitao Zhou, Juzhao Chen, Xuehao Gao, Haida Chen and Fenggang Liu
Materials 2026, 19(16), 3516; https://doi.org/10.3390/ma19163516 - 19 Aug 2026
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Abstract
The dissimilar combination of NiTi shape memory alloy and Ti6Al4V titanium alloy offers superelasticity, biocompatibility and high specific strength, showing broad application prospects in aerospace and medical fields. However, when fabricating NiTi/Ti6Al4V composite components by multi-material laser powder bed fusion (MM-LPBF), brittle cracks [...] Read more.
The dissimilar combination of NiTi shape memory alloy and Ti6Al4V titanium alloy offers superelasticity, biocompatibility and high specific strength, showing broad application prospects in aerospace and medical fields. However, when fabricating NiTi/Ti6Al4V composite components by multi-material laser powder bed fusion (MM-LPBF), brittle cracks or even complete delamination easily occur at the interface. In this paper, without relying on intermediate interlayer materials, we innovatively propose a root-inspired three-dimensional bio-interlocking interface structure. By means of macroscopic three-dimensional geometric interlocking, the crack propagation path and load transfer mode are forced to change. Using the branching angle (45°, 60°) and the structural size multiplier (1.2, 1.5) as variables, the influence of the bio-inspired geometric parameters on the interfacial forming quality, microstructure and mechanical properties was systematically investigated. The results show that the branching angle is the primary factor determining the performance. The 45° low-angle branched specimens exhibit overall brittle delamination along the flat metallurgical reaction interface under shear loading, with an average shear strength of only 17.47 MPa. In contrast, the 60° high-angle branched specimens, owing to their larger normal embedding depth, exhibit a failure mode transitioning to a mixed mode that includes crack deflection, branch shearing and plastic tearing of the Ti6Al4V matrix. Although TEM confirms that a continuous Ti2Ni brittle phase still exists at the interface, the optimised 60–1.5 structure increases the average shear strength to 128.37 MPa, which is more than six times higher than that of the 45–1.2 group (17.47 MPa). This “geometrical constraint toughening” strategy provides a new paradigm for the interfacial strengthening of dissimilar metals without relying on metallurgical modification. Full article
(This article belongs to the Special Issue Additive Manufacturing of Structural Materials and Their Composites)
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