Two new C-glycoside angucyclines, marangucycline A (
1) and marangucycline B (
2), along with three known compounds, dehydroxyaquayamycin (
3), undecylprodigiosin (
4) and metacycloprodigiosin (
5), have been identified as products of the deep-sea sediment strain
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Two new C-glycoside angucyclines, marangucycline A (
1) and marangucycline B (
2), along with three known compounds, dehydroxyaquayamycin (
3), undecylprodigiosin (
4) and metacycloprodigiosin (
5), have been identified as products of the deep-sea sediment strain
Streptomyces sp. SCSIO 11594. New structures were elucidated on the basis of HRESIMS, 1D and 2D NMR analyses and comparisons to previously reported datasets. Compounds
2 and
4 displayed
in vitro cytotoxicity against four cancer cell lines A594, CNE2, HepG2, MCF-7 superior to those obtained with cisplatin, the positive control. Notably, compound
2 bearing a keto-sugar displayed significant cytotoxicity against cancer cell lines with IC
50 values ranging from 0.24 to 0.56 μM; An IC
50 value of 3.67 μM was found when using non-cancerous hepatic cell line HL7702, demonstrating the cancer cell selectivity of
2. Compounds
1–
3 were proved to have weak antibacterial activities against
Enterococcus faecalis ATCC29212 with an MIC value of 64.0 μg/mL. Moreover,
3 displayed selective antibacterial activity against methicillin-resistant
Staphylococcus epidermidis shhs-E1 with an MIC value of 16.0 μg/mL.
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