Search Results (48)

The individual marathon optimal pacing sparring the runner to hit the “wall” after 2 h of running remain unclear. In the current study we examined to what extent Deep neural Network contributes to identify the individual optimal pacing training a Variational Auto Encoder (VAE) with a small dataset of nine runners. This last one has been constructed from an original one that contains the values of multiple physiological variables for 10 different runners during a marathon. We plot the Lyapunov exponent/Time graph on these variables for each runner showing that the marathon wall could be anticipated. The pacing strategy that this innovative technique sheds light on is to predict and delay the moment when the runner empties his reserves and ’hits the wall’ while considering the individual physical capabilities of each athlete. Our data suggest that given that a further increase of marathon runner using a cardio-GPS could benefit of their pacing run for optimizing their performance if AI would be used for learning how to self-pace his marathon race for avoiding hitting the wall. Full article

Multitarget drugs are molecules with the ability to act simultaneously on different targets at the same time, and they have been evaluated in the last decade as a powerful tool in the development of promising therapeutics for neurodegenerative diseases. This is very useful for multifactorial diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, a group of neurological disorders that induce neurodegeneration and neuroinflammation. Successful drug design for multifactorial diseases depends on an interdisciplinary and collaborative approach. The complexity of the above pathologies has clearly demonstrated that such single-target drugs are inadequate to achieve a successful therapeutic result. Furthermore, molecules hitting more than one biological target exhibit also a safer profile. In this review, we present a comprehensive knowledge of recent research on multitarget synthetic approaches to confront Alzheimer’s, Parkinson’s, and Huntington’s neurodegenerative diseases. Full article

Background: Schizophrenia is classified by the World Health Organization (WHO) as one of the top ten diseases contributing to the global medical economic burden. Some studies have pointed out that exercise is effective for physical and mental health, as well as cognition. We hypothesized that participation in pickleball intervention would lead to improved self-esteem and reduced psychiatric symptoms in schizophrenia patients. Method: We recruited participants with schizophrenia from a long-term care facility and a regional hospital, dividing them into two groups based on the institutions. The experimental group underwent a nine-week pickleball exercise intervention, with sessions three times a week, each lasting 90 min, and a Dink ball test was conducted weekly. Questionnaires on self-esteem and the short-form health survey were collected both before and after the intervention. Result: This trial included 30 patients, divided equally into the experimental group (n = 15) and the control group (n = 15). After the nine-week pickleball intervention, there were no significant differences between the experimental and control groups in the Rosenberg Self-Esteem Scale (RSES) (p = 0.153) or the Brief Symptom Rating Scale (BSRS-5) (p = 0.289). However, the Dink test scores in the experimental group showed significant improvements in physical activity capabilities and attention over time, with average hit counts increasing from 5.3 ± 1.5 to 10.7 ± 2.3 (p < 0.01). Conclusions: Although the pickleball intervention did not yield significant differences in self-esteem and symptom measures between groups, the improvements observed in physical performance and attention in the experimental group suggest that exercise remains a feasible complementary approach for managing schizophrenia symptoms. Further research with larger sample sizes is recommended. Full article

Background/Objectives: Fibromyalgia (FM) is a chronic condition characterized by widespread musculoskeletal pain, fatigue, and impaired motor performance. This study aimed to investigate the effects of transcranial direct current stimulation (tDCS) during virtual reality (VR) tasks on the motor performance of women with FM. Methods: Participants were divided into two groups: Group A received active tDCS for 10 days followed by sham tDCS for 10 days, while Group B received the opposite sequence. Both groups performed VR tasks using MoveHero software (v. 2.4) during the tDCS sessions. Motor performance was assessed by the number of hits (movement with correct timing to reach the targets) and absolute (accuracy measure) and variable (precision measure) errors during VR tasks. Participants were 21 women, aged 30–50 years, and diagnosed with FM. Results: Group A, which received active tDCS first, presented significant improvements in motor performance (number of hits and absolute and variable errors). The benefits of active tDCS persisted into the sham phase, suggesting a lasting neuroplastic effect. Conclusions: tDCS during VR tasks significantly improved motor performance in women with FM, particularly in complex, extensive movements. These findings indicate that tDCS enhances neuroplasticity, leading to sustained motor improvements, making it a promising therapeutic tool in FM rehabilitation. Full article

Background and Aims: Over the last few decades, rampant nitrogen fertilization has exacerbated soil acidification in agricultural ecosystems. To counteract this, liming has become an essential technique for rehabilitating fertility in acid-degraded agricultural soils. Our research aimed to shed light on the response of ammonia oxidizers to liming in acidic soils within a controlled rice paddy experiment. We conducted a pot experiment with rice, featuring three different treatments: a control with only soil, a low dolomite dose (LD), and a high dolomite dose (HD). Various soil properties were investigated throughout the study. Under flooding, soil pH values rose across the treatments, from 5.4 in the control to 6.8 in HD. Ammonium and nitrate levels peaked in the HD treatment, reaching 30 and 22 mg kg⁻¹, respectively. Similarly, dissolved organic carbon and microbial biomass carbon surged at mid-season aeration, hitting highs of 101 and 30 mg kg⁻¹, respectively, in the HD treatment. Ammonia-oxidizing bacteria (AOB) and archaea (AOA) were responsive to dolomite-lime application, with distinct reactions; AOB abundance and potential nitrification rates were positively affected by higher lime doses, whereas AOA numbers decreased over time and with dolomite application. Additionally, soil enzymes such as urease, catalase, invertase, phenol oxidase, and phosphatase also increased progressively, mirroring the rise in soil pH. This study identified increased soil pH as the critical factor influencing various soil parameters, especially the balance between AOA and AOB populations. Both AOB and AOA were sensitive to liming; AOA decreased while liming stimulated AOB abundance. Full article

This study aimed to determine the distributions of number of shots per point, point duration, point pace and technical actions during the match in professional men and women padel players. A total of 35,145 hits (3239 points; men = 1602 and women = 1637) were analyzed in 20 matches corresponding to quarterfinal, semifinal and final matches of the World Padel Tour 2020 season. The observations were conducted through systematic observation and involved a total of 32 players (16 men and 16 women). Men’s points lasted 13.5–14.8 s, comprising 10–11 hits, resulting in a ratio of 0.80 shots per second, with no differences between sets. Women’s points lasted longer than men’s (14.4 to 16.2 s, p = 0.011) but included a similar number of shots per point, resulting in a lower rhythm of play (0.73–0.75 shots per second, p < 0.001), particularly in the third set (p = 0.004). Volleys, lobs and directs were used in >60% of the points, with a frequency of one to three times per point. Bandejas were used in 50–60% of the points, with a frequency of one to two times per point. Backwalls and flat smashes were used at least once in 30–48% of the points. Selective actions had a greater frequency of use in the third set (i.e., flat smash and smash x3 in women; forehand/backhand volleys and side-wall forehand in men), suggesting occasional changes in the style of play, but likely explained by the onset of fatigue. In conclusion, game volumes, intensity and actions remained broadly similar throughout professional padel matches. Full article

On 28 December 2020, the area of the city of Petrinja was hit by two strong earthquakes of magnitudes 5.0 and 4.7 on the Richter scale, and the following day, 29 December 2020, the same area was hit by an even stronger earthquake of magnitude 6.2. It was one of the two strongest instrumentally recorded earthquakes that hit the territory of the Republic of Croatia in the last hundred years, and the strongest earthquake in the Banovina area after the great earthquake in 1909. Increased seismic activity in this area is caused by two vertical strike–slip faults, Pokupski and Petrinjski. This article aims to determine the displacements of the Earth’s crust caused by seismic activity in this area using GNSS measurements and InSAR techniques and comparing their results. Our study showed that horizontal coseismic displacements of 20 cm and more were limited to a radius of 20 km from the epicenter, with a maximum displacement of around half a meter. Considering the original plate tectonic movements of the region and the time elapsed since the previous earthquake of similar magnitude, the geodynamic movements of the Dinarides area are in substantial part sudden displacements associated with earthquakes. Full article

Thunderstorms endanger life and infrastructure. The accurate and precise prediction of thunderstorms is therefore helpful to enable protection measures and to reduce the risks. This manuscript presents the latest developments to improve thunderstorm forecasting in the first few hours. This includes the description and discussion of a new Julia-based method (JuliaTSnow) for the temporal extrapolation of thunderstorms and the blending of this method with the numerical weather prediction model (NWP) ICON. The combination of ICON and JuliaTSnow attempts to overcome the limitations associated with the pure extrapolation of observations with atmospheric motion vectors (AMVs) and thus increase the prediction horizon. For the blending, the operational ICON-D2 is used, but also the experimental ICON-RUC, which is implemented with a faster data assimilation update cycle. The blended products are evaluated against lightning data. The critical success index (CSI) for the blended RUC product is higher for all forecast time steps. This is mainly due to the higher resolution of the AMVs (prediction hours 0–2) and the rapid update cycle of ICON-RUC (prediction hours 2–6). The results demonstrate the potential of the rapid update cycle to improve the short-term forecasts of thunderstorms. Moreover, the transition between AMV-driven nowcasting to NWP is much smoother in the blended RUC product, which points to the advantages of fast data assimilation for seamless predictions. The CSI is well above the critical value of 0.5 for the 0–2 h forecasts. Values below 0.5 mean that the number of hits (correct informations) is lower than the number of failures, which results from the missed cells plus false alarms. The product is then no longer useful in forecasting thunderstorms with a spatial accuracy of 0.3 degrees. Unfortunately, with RUC, the CSI also drops below 0.5 when the last forecast is more than 3 h away from the last data assimilation, indicating the lack of model physics to accurately predict thunderstorms. This lack is simply a result of chaos theory. Within this context, the role of NWP in comparison with artificial intelligence (AI) is discussed, and it is concluded that AI could replace physical short-term forecasts in the near future. Full article

Hereditary spastic paraplegias (HSPs) comprise a family of degenerative diseases mostly hitting descending axons of corticospinal neurons. Depending on the gene and mutation involved, the disease could present as a pure form with limb spasticity, or a complex form associated with cerebellar and/or cortical signs such as ataxia, dysarthria, epilepsy, and intellectual disability. The progressive nature of HSPs invariably leads patients to require walking canes or wheelchairs over time. Despite several attempts to ameliorate the life quality of patients that have been tested, current therapeutical approaches are just symptomatic, as no cure is available. Progress in research in the last two decades has identified a vast number of genes involved in HSP etiology, using cellular and animal models generated on purpose. Although unanimously considered invaluable tools for basic research, those systems are rarely predictive for the establishment of a therapeutic approach. The advent of induced pluripotent stem (iPS) cells allowed instead the direct study of morphological and molecular properties of the patient’s affected neurons generated upon in vitro differentiation. In this review, we revisited all the present literature recently published regarding the use of iPS cells to differentiate HSP patient-specific neurons. Most studies have defined patient-derived neurons as a reliable model to faithfully mimic HSP in vitro, discovering original findings through immunological and –omics approaches, and providing a platform to screen novel or repurposed drugs. Thereby, one of the biggest hopes of current HSP research regards the use of patient-derived iPS cells to expand basic knowledge on the disease, while simultaneously establishing new therapeutic treatments for both generalized and personalized approaches in daily medical practice. Full article

The recent pandemic has been identified as a driver of one of the most severe socio-economic crises over the last few decades. While some sectors have experienced an expansion, others have struggled with a changed business environment. The aim of this research is to simultaneously examine the financial performance and sustainability of the e-commerce and hospitality industries, applying asset and debt ratio analysis to the top five companies in the world from each sector in the time period from 2017 to 2022. The results indicate that the assessed companies demonstrated the ability to successfully manage some of their assets. The debt ratio analysis implies that the assessed companies in the hotel industry have reshaped their capital structure, increasing their reliance on debt in 2020 and 2021 to finance their assets. On the contrary, the selected e-commerce companies were found on average to rely less on debt to finance assets. In accordance with expectations, the differences across the examined sectors and companies that have been observed are mostly in regard to the lower scale of utilization of fixed assets to generate turnover, and in terms of the increased share of debts used to finance assets in the hotel industry, which was among the first and hardest hit by the pandemic. Consequently, the study allows policy makers to identify distinctive strategies for each area of economic activity. Full article

Candidiasis is one of the most frequent nosocomial infections affecting an increasing number of at-risk patients. Candida albicans remains the most frequent causative agent of candidiasis, but, in the last decade, C. auris has emerged as a formidable multi-drug-resistant pathogen. Both species are fully capable of forming biofilms, which contribute to resistance, increasing the urgency for new effective antifungal therapies. Repurposing existing drugs could significantly accelerate the development of novel therapies against candidiasis. Here, we have screened the Repurposing Hub library from the Broad Institute, containing over 6000 compounds, in search for inhibitors of C. albicans and C. auris biofilm formation. The primary screen identified 57 initial hits against C. albicans and 33 against C. auris. Confirmatory concentration-dependent assays were used to validate the activity of the initial hits and, at the same time, establish their anti-biofilm potency. Based on these results, ebselen, temsirolimus, and compound BAY 11-7082 emerged as the leading repositionable compounds. Subsequent experiments established their spectrum of antifungal activity against yeasts and filamentous fungi. In addition, their in vivo activity was examined in the murine models of hematogenously disseminated C. albicans and C. auris infections. Although promising, further in vitro and in vivo studies are needed to confirm their potential use for the therapy of candidiasis and possibly other fungal infections. Full article

Urbanization in flood-prone areas is a critical issue worldwide. The historical floods, the urban expansion in terms of building footprint, the extent and construction period of inundated buildings with reference to two representative floods (5–6 November 1994 and 24–25 November 2016), and the ground effects and dynamics of these events were investigated in the cities of Garessio, Ceva, and Clavesana, along the Tanaro River (NW Italy). An integrated approach based on historical data analysis, photograph interpretation, field surveys, and GIS investigations was adopted, and novel metrics for quantitative analysis of urbanization and flood exposure at the individual-building scale were introduced. The considered cities were hit by damaging floods several times over the last centuries and experienced an increase in built-up surface after the mid-19th century, especially between the 1930s and 1994. The 1994 and 2016 high-magnitude floods highlighted that urban expansion largely occurred in flood-prone areas, and anthropogenic structures conditioned flood propagation. One of the rare Italian cases of the relocation of elements exposed to floods is documented. This research aims to emphasize the relevance of information on past floods and urbanization processes for land planning and land management and the need for land use planning for flood control to forbid new urban expansion in potentially floodable areas. The outcomes represent an essential knowledge base to define effective and sustainable management measures to mitigate hydrogeomorphic risk. Full article

The Covid-19 pandemic has had a significant impact on many economic sectors. The most severe immediate financial effects of Covid-19 include job losses and decreased hiring, and we can expect generalized lower economic growth in the long term. While such phenomena are there for all to see, measuring their scope is complex. In this work, we performed a massive analysis of job postings (ads) taken from LinkUp, a popular job search web platform, to better understand the occupational trends in IT. We analyzed about nine million ads for computer and mathematical experts to measure the impact of the virus on the IT job market. We also extended our investigations to almost 109 million advertisements (about 300 GB of data) for all kinds of positions to overview the effects of Covid-19 on the job market at large. The results show that the Covid-19 crisis hit the job market during the first two quarters of 2020, causing the number of job advertisements to drop across all sectors (except one). Specifically, the IT sector lost between 15% and 48% of the ads, depending on the specific professional figure. Since the last quarter of 2020, the ad numbers have recovered for some sectors, and by the first 2021 quarter, all of them have more job ads than in the last five years. Finally, we used text analysis to understand the trends of interest in teleworking. We found that in the second quarter of 2020, the number of ads explicitly mentioning telework was almost three times the average of the previous quarters. Full article

Three facts characterise the hailstorm of 30 August 2022 in the Catalan village of La Bisbal d’Empordà and its surroundings: first, the most dramatic, the death of a child hit by a hailstone; second, the damage to most of the roofs and cars in the town; finally, the highest recorded amount of hail (more than 10 cm) in Catalonia in at least the last 30 years. This research focuses on the radar field comparison and the observations provided by an electronic survey of the study area. The results reveal that weather radar underestimated the hail size because of different factors. Conversely, some reporters provided an inaccurate hour. The difference of three months between the hail event and the electronic survey is the probable cause of this mistake in the time estimation. However, the survey delay helped to avoid answers with larger hail sizes than those provided by the official spotters. Full article

Mechanical damage resulting from excessive impact force during handling and other postharvest operations from harvesting to consumption is a critical quality problem in fresh produce marketing. The study investigates the impact of bruise damage, storage temperature, and storage period on the physiological responses of Omani pomegranate fruit cultivar ‘Helow’. Fruits were subjected to low (45°; 1.18 J) and high (65°; 2.29 J) impact levels using a pendulum test by hitting the fruit on the cheek side. Bruised and non-bruised fruit were stored at 5 and 22 °C for 28 days. Bruise measurements, water loss per unit mass, water loss per surface area, firmness, fruit size measurements, geometric mean diameter, surface area, fruit volume, color parameters, respiration rate, and ethylene production rate were evaluated. Bruise area, bruise volume, and bruise susceptibility of damaged pomegranate fruit were increased as impact level, storage duration, and storage temperature increased. Pomegranates damaged at a high impact level and conditioned at 22 °C showed 20.39% weight loss on the last day of storage compared to the control and low-impact-bruised fruit. Firmness and geometric mean diameter were significantly (p < 0.05) reduced by bruising at a high impact level. Impact bruising level and storage temperature decreased lightness, yellowness, browning index, and increased redness over time. Furthermore, the respiration rate was five times higher in the non-bruised and low- and high-impact-injured fruit stored at 22 °C than that stored at 5 °C. The ethylene production rate recorded its highest value on day 21 in high-level-impact-bruised pomegranate fruit. The bruise susceptibility was strongly correlated with the majority of the studied parameters. This study can confirm that bruising can affect not only the visual quality characteristics but also the physiological attributes of pomegranate fruit; therefore, much care is required to preserve fresh produce and avoid any mechanical damage and losses during postharvest handling. Full article