Search Results (79)

We present the Virtual Beamline (VBL) application, an interactive web-based platform for visualizing high-intensity laser–matter interactions using particle-in-cell (PIC) simulations, with future potential for experimental data visualization. These interactions include ion acceleration, electron acceleration, $\gamma$-flash generation, electron–positron pair production, and attosecond and spiral pulse generation. Developed at the ELI Beamlines facility, VBL integrates a custom-built WebGL engine with WebXR-based Virtual Reality (VR) support, allowing users to explore complex plasma dynamics in non-VR mode on a computer screen or in fully immersive VR mode using a head-mounted display. The application runs directly in a standard web browser, ensuring broad accessibility. VBL enhances the visualization of PIC simulations by efficiently processing and rendering four main data types: point particles, 1D lines, 2D textures, and 3D volumes. By utilizing interactive 3D visualization, it overcomes the limitations of traditional 2D representations, offering enhanced spatial understanding and real-time manipulation of visualization parameters such as time steps, data layers, and colormaps. Users can interactively explore the visualized data by moving their body or using a controller for navigation, zooming, and rotation. These interactive capabilities improve data exploration and interpretation, making VBL a valuable tool for both scientific analysis and educational outreach. The visualizations are hosted online and freely accessible on our server, providing researchers, the general public, and broader audiences with an interactive tool to explore complex plasma physics simulations. By offering an intuitive and dynamic approach to large-scale datasets, VBL enhances both scientific research and knowledge dissemination in high-intensity laser–matter physics. Full article

Chinese herbal medicines have played a significant role in the development of new and effective drugs, but how to identify the active ingredients from complex extracts of traditional Chinese herbal medicines was a research difficulty. In recent years, few studies have focused on high-efficiency identification of small-molecule inhibitors of Programmed Death Ligand 1 with lower antigenicity and flexible structure tunability. In order to identify small molecule inhibitors of PD-L1 from complex Chinese herbal extracts, this study established a protein–ligand trapping system based on high-performance liquid chromatography coupled with a photo-diode array detector, ion trap/quadrupole time-of-flight tandem mass spectrometry, and a Programmed Death Ligand 1 affinity chromatography unit (ACPD-L1-HPLC-PDA-IT-TOF (Q-TOF)-MS) to rapidly screen and identify small-molecule inhibitors of Programmed Death Ligand 1 from Toddalia asiatica (L.) Lam. Fourteen components were then identified as PD-L1 binders, and surface plasmon resonance (SPR) validation results showed that six of them—magnoflorine (6), nitidine (22), chelerythrine (24), jatrorrhizine (13), toddaculin (68), and toddanol (45)—displayed PD-L1 binding activity. Laser scanning confocal microscopy results demonstrated that these compounds effectively inhibited the binding of PD-1 to PD-L1 in a dose-dependent manner. Additionally, flow cytometry analysis indicated they could promote human lung cancer cell line (A549) apoptosis when co-cultured with Peripheral Blood Mononuclear Cells (PBMCs). The system’s innovation lies in its first integration of dynamic protein–ligand trapping with multi-dimensional validation, coupled with high-throughput screening capacity for structurally diverse natural products. This workflow overcomes traditional phytochemical screening bottlenecks by preserving native protein conformations during affinity capture while maintaining chromatographic resolution, offering a transformative template for accelerating natural product-derived immunotherapeutics through the PD-1/PD-L1 pathway. Full article

Potassium dihydrogen phosphate (KDP) crystals, vital for high-power laser systems, pose significant machining challenges due to their brittleness, low hardness, and hygroscopic properties. Achieving crack-free, high-precision surfaces is essential but complex. Single-point diamond fly-cutting (SPDF) is the primary method, yet it exposes tools to high mechanical stress and heat, accelerating wear. In dry cutting, worn tools develop adhesive layers that detach, causing scratches and degrading surface quality. Traditional wet cutting improves surface finish but leaves residual fluids that contaminate the surface with metal ions, leading to optical degradation and fogging. To address these issues, this study explores mixed-fat-based minimum quantity lubrication (MQL) as a sustainable alternative, comparing two lubricants: biodegradable-base mixed ester lubrication (BBMEL) and hydrocarbon-based synthetic lubricant (HCBSL). A comprehensive evaluation method was developed to analyze surface roughness, tool wear, and subsurface damage under dry cutting, MQL-BBMEL, and MQL-HCBSL conditions. Experimental results show that MQL-BBMEL significantly enhances machining performance, reducing average surface roughness by 27.77% (Sa) and 44.77% (Sq) and decreasing tool wear by 25.16% compared to dry cutting, outperforming MQL-HCBSL. This improvement is attributed to BBMEL’s lower viscosity and higher proportion of polar functional groups, which form stable lubricating films, minimizing friction and thermal effects. Structural analyses confirm that MQL-BBMEL prevents KDP crystal deliquescence and surface fogging. These findings establish MQL-BBMEL as an eco-friendly, high-performance solution for machining brittle optical materials, offering significant advancements in precision machining for high-power laser systems. Full article

Yttrium oxide ceramic is an excellent optical material widely used in lasers, scintillators, and upconversion luminescence. In this study, LiF was employed as an additive to generate volatile gases (CF)_n to effectively inhibit carbon contamination and act as a sintering aid to accelerate densification during the spark plasma sintering (SPS) process. The effects of sintering temperature and annealing time on the transmittance of Y_1.8La_0.2O₃ transparent ceramics were systematically investigated. Results indicate that excessive LiF addition reduces the transmittance of Y_1.8La_0.2O₃ transparent ceramics due to the precipitation of F⁻ ions at grain boundaries, forming a secondary phase. For the Y_1.8La_0.2O₃ ceramics with 0.3 wt.% LiF, transmittance initially increases and then decreases with rising sintering temperature, reaching a maximum value of 78.10% in the UV region at 1550 °C. Under these conditions, the average particle size and relative density are 10–30 μm and 99.36%, respectively. Oxygen vacancies within the ceramics act as defects that degrade transmittance. Proper annealing in air reduces oxygen vacancy content, thereby improving transmittance. After annealing at 900 °C for 3 h, the maximum transmittance of Y_1.8La_0.2O₃ ceramics with 0.3 wt.% LiF increases to 82.67% in the UV region, accompanied by a 5.68% reduction in oxygen vacancy concentration. Full article

This review explores two main topics: the state-of-the-art and emerging capabilities of high-peak-power, ultrafast (picosecond and femtosecond) long-wave infrared (LWIR) laser technology based on CO₂ gas laser amplifiers, and the current and advanced scientific applications of this laser class. The discussion is grounded in expertise gained at the Accelerator Test Facility (ATF) of Brookhaven National Laboratory (BNL), a leading center for ultrafast, high-power CO₂ laser development and a National User Facility with a strong track record in high-intensity physics experiments. We begin by reviewing the status of 9–10 μm CO₂ laser technology and its applications, before exploring potential breakthroughs, including the realization of 100 terawatt femtosecond pulses. These advancements will drive ongoing research in electron and ion acceleration in plasma, along with applications in secondary radiation sources and atmospheric energy transport. Throughout the review, we highlight how wavelength scaling of physical effects enhances the capabilities of ultra-intense lasers in the LWIR spectrum, expanding the frontiers of both fundamental and applied science. Full article

Laser-driven ion acceleration is a new, rapidly developing field of research and one of the important applications of ultrafast high-peak-power lasers. In this acceleration method, extremely strong electric fields, induced by an ultrafast laser in the plasma generated by the laser–target interaction, enable the acceleration of ions to relativistic velocities on picosecond time scales and at sub-millimetre distances. This opens the prospect of constructing a fundamentally new type of high-energy ion accelerator—less complex, more compact, and cheaper than the ion accelerators operating today. This paper briefly discusses the basic mechanisms of heavy ion acceleration driven by an ultrafast high-peak-power laser and summarises the advances in experimental and numerical studies of laser-driven heavy ion acceleration. The main challenges facing this research and the prospects for the application of laser-accelerated heavy ion beams are outlined. Full article

The development of advanced detection systems for charged particles in laser-based accelerators and the need for precise time of flight measurements have led to the creation of detectors using ultra-thin plastic scintillators, indicating their use as transmission detectors with low energy loss and minimal dispersion for protons around a few MeV. This study introduces a new detection system designed by the Institute for Instrumentation in Molecular Imaging for time of flight and timing applications at the National Accelerator Center in Seville. The system includes an ultra-thin EJ-214 plastic scintillator coupled with a photomultiplier tube and shielded by aluminized mylar sheets. The prototype installation as an external trigger system at the ion beam nuclear microprobe of the aforementioned facility, along with its temporal performance and ion transmission, was thoroughly characterized. Additionally, the scintillator thickness and uniformity were analyzed using Rutherford backscattering spectrometry. Results showed that the experimental thickness of the EJ-214 sheet differs by approximately 46% from the supplier specifications. The detector response to MeV protons demonstrates a strong dependence on the impact position but remains mostly linear with the applied working bias. Finally, single ion detection was successfully achieved, demonstrating the applicability of this new system as a diagnostic tool. Full article

Recently, it has been experimentally shown that the sheath acceleration of protons from ultra-thin metal targets irradiated by sub-picosecond laser pulses of intensities above ${10}^{21}$ W/cm² is suppressed compared to well-established models. This detrimental effect has been attributed to a self-generation of gigagauss-level quasi-static magnetic fields in expanded plasmas on the rear side of a target. Here we present a set of numerical simulations which support this statement. Based on 2D full-scale PIC simulations, it is shown that the scaling of a cutoff energy of the accelerated protons with intensity deviates from a well-established Mora model for laser pulses with a duration exceeding 500 fs. This deviation is showed to be connected to effective magnetization of the hottest electrons producing at the maximum of the laser pulse intensity. We propose a modification of the Mora model which incorporates the effect of the possible electron magnetization. Comparing it to the simulation results shows that by appropriately choosing a single fitting parameter, the model produces results that quantitatively coincide with simulations. Full article

Neutrinoless double beta decay ($0\nu \beta \beta$) provides a way to probe physics beyond the Standard Model of particle physics. The upcoming nEXO experiment will search for $0\nu \beta \beta$ decay in ¹³⁶Xe with a projected half-life sensitivity exceeding ${10}^{28}$ years at the 90% confidence level using a liquid xenon (LXe) Time Projection Chamber (TPC) filled with 5 tonnes of Xe enriched to ∼90% in the $\beta \beta$-decaying isotope ¹³⁶Xe. In parallel, a potential future upgrade to nEXO is being investigated with the aim to further suppress radioactive backgrounds and to confirm $\beta \beta$-decay events. This technique, known as Ba-tagging, comprises extracting and identifying the $\beta \beta$-decay daughter ¹³⁶Ba ion. One tagging approach being pursued involves extracting a small volume of LXe in the vicinity of a potential $\beta \beta$-decay using a capillary tube and facilitating a liquid-to-gas phase transition by heating the capillary exit. The Ba ion is then separated from the accompanying Xe gas using a radio-frequency (RF) carpet and RF funnel, conclusively identifying the ion as ¹³⁶Ba via laser-fluorescence spectroscopy and mass spectrometry. Simultaneously, an accelerator-driven Ba ion source is being developed to validate and optimize this technique. The motivation for the project, the development of the different aspects, along with the current status and results, are discussed here. Full article

This study investigated the potential for efficient and resourceful utilization of phosphogypsum (PG) through the preparation of a High-volume Phosphogypsum Cement Stabilized Road Base (HPG-CSSB). The investigation analyzed the unconfined compressive strength (UCS), water stability, strength formation mechanism, microstructure, and pollutant curing mechanism of HPG-CSSB by laser diffraction methods (LD), X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and inductively coupled plasma-mass spectrometry (ICP-MS). The optimal mix ratio of HPG-CSSB was 4% cement, 1% CA2, 35% PG, and 60% graded crushed stone. The UCS reached 6.6 MPa, 9.3 MPa, and 11.3 MPa at 7, 28, and 60 d, respectively. The alkaline curing agent stimulated cement activity and accelerated the release of Ca²⁺ and SO₄²⁻ from the PG. This formed many C-S-H gels and ettringite (AFt). The curing agent converted Ca²⁺ to C-(A)-S-H gels due to high volcanic ash activity. The diverse hydration products strengthened HPG-CSSB. The HPG-CSSB exhibits favorable water stability, demonstrating a mere 7.6% reduction in strength following 28 d of immersion. The C-S-H gel and AFt generated in the system can carry out ion exchange and adsorption precipitation with F⁻ and PO₄³⁻ in PG, achieving the curing effect of toxic and hazardous substances. HPG-CSSB meets the Class A standard for integrated wastewater discharge. Full article

This work aimed to understand how the energy released by short laser pulses can produce different effects in carbon targets with different allotropic states. The IR pulse laser ablation, operating at 1064 nm wavelength, 3 ns pulse duration, and 100 mJ pulse energy, has been used to irradiate different types of carbon targets in a high vacuum. Graphite, highly oriented pyrolytic graphite, glassy carbon, active carbon, and vegetable carbon have exhibited different mass densities and have been laser irradiated. Time-of-flight (TOF) measurements have permitted the evince of the maximum carbon ion acceleration in the generated plasma (of about 200 eV per charge state) and the maximum yield emission (96 μg/pulse in the case of vegetal carbon) along the direction normal to the irradiated surface. The ion energy analyzer measured the carbon charge states (four) and their energy distributions. Further plasma investigations have been performed using a fast CCD camera image and surface profiles of the generated craters to calculate the angular emission and the ablation yield for each type of target. The effects as a function of the target carbon density and binding energy have been highlighted. Possible applications for the generation of thin films and carbon nanoparticles are discussed. Full article

We developed a versatile 100 Hz laser system based on negatively and positively chirped pulse amplification. The few-cycle output provides pulses with 7.1 fs and 0.25 mJ, while the power output supports 26 fs pulses with 50 mJ. The energy as well as the pulse duration stability of the system are below 1%, while the pointing stability is within 25% of the diffraction-limited spot size. We also show applications in high repetition rate target development and preparation for a laser-generated X-ray source for industrial CT imaging. Full article

An overview of the 200 TW Frascati Laser for Acceleration and Multidisciplinary Experiments (FLAME) at the SPARC_LAB Test Facility at the National Laboratories of Frascati (LNF-INFN) is presented. The FLAME laser is employed to investigate different laser–matter interaction schemes, i.e., electron acceleration and secondary radiation sources through Laser Wakefield Acceleration (LWFA) or ion and proton generation through Target Normal Sheath Acceleration (TNSA), for a wide range of scientific areas including the biomedical applications. Finally, recently performed experimental campaigns within the EuAPS and EuPRAXIA frameworks are reported. Full article

Skin damage is one of the most prevalent human injuries, which affects the health of human beings. However, skin damage is often accompanied by bacterial infection and wound microenvironment changes, causing damage to normal cells and inhibiting wound healing. Herein, we designed a thermal-responsive antibacterial hydrogel (GAG hydrogel) loaded with catalase (CAT)-like Au@Pt@MgSiO₃ nanoparticles (APM NPs) and gentamicin (GM) to promote wound healing. The GAG hydrogel was used in a photothermal therapy (PTT)/antibiotic combination to kill bacteria, reduce the use of antibiotics, improve the wound microenvironment, promote cell proliferation, and accelerate wound healing. Under near-infrared laser irradiation, APM NPs in the hydrogel generated local hyperthermia to kill bacteria. Meanwhile, the generated heat led to a change in the hydrogel’s morphology, enabling it to release GM and APM NPs to prevent the overuse of antibiotics. Subsequently, the CAT-like ability of the APM NPs decreased the oxidative stress caused by hydrogen peroxide (H₂O₂), thus remodeling the wound microenvironment. Then, the weakly acidic microenvironment of the wound caused the decomposition of the APM NPs and the release of magnesium ions (Mg²⁺), promoting the growth and migration of cells for wound healing. Therefore, the studied thermal-responsive antibacterial (GAG) hydrogel has potential in the field of wound healing. Full article

Progress in laser-driven proton acceleration requires increasing the proton maximum energy and laser-to-proton conversion efficiency while reducing the divergence of the proton beam. However, achieving all these qualities simultaneously has proven challenging experimentally, with the increase in beam energy often coming at the cost of beam quality. Numerical simulations suggest that coupling multi-PW laser pulses with ultrathin foils could offer a route for such simultaneous improvement. Yet, experimental investigations have been limited by the scarcity of such lasers and the need for very stringent temporal contrast conditions to prevent premature target expansion before the pulse maximum. Here, combining the newly commissioned Apollon laser facility that delivers high-power ultrashort (∼$24\mathrm{fs}$) pulses with a double plasma mirror scheme to enhance its temporal contrast, we demonstrate the generation of up to 35 MeV protons with only 5 J of laser energy. This approach also achieves improved laser-to-proton energy conversion efficiency, reduced beam divergence, and optimized spatial beam profile. Therefore, despite the laser energy losses induced by the plasma mirror, the proton beams produced by this method are enhanced on all accounts compared to those obtained under standard conditions. Particle-in-cell simulations reveal that this improvement mainly results from a better space–time synchronization of the maximum of the accelerating charge-separation field with the proton bunch. Full article