Search Results (56)

Augustine of Hippo (354–430), one of the most influential theologians of Late Antiquity, spent nearly a decade in the Manichaean sect before becoming a central figure in the shaping of Western “orthodox” Christianity. While his major works such as the Confessiones and De civitate Dei have been extensively studied for their treatment of Manichaeism, the vast collection of his ca. 300 preserved letters (Epistulae) remains an understudied source for understanding this aspect of his intellectual and theological development. This article addresses that gap by proposing a methodology to identify both anti- and crypto-Manichaean themes in his letters. Drawing on phenomenological openness, hermeneutical perspective, and close reading, the study also incorporates genuine Manichaean sources and anti-Manichaean polemics to contextualise Augustine’s rhetorical strategies. The Epistulae, unpolished and situated in specific communicative contexts, offer a unique view of Augustine’s doctrinal positioning after his conversion. Traces of his Manichaean past re-emerge in vocabulary, argumentation, and theological emphasis. This is exemplified in Epistula 137 to Volusianus (411–412), which, without naming the sect, covertly critiques key Manichaean doctrines such as Docetism and materialism. These critiques align with extant Manichaean sources and may reflect Augustine’s awareness of latent Manichaean influence in Christian communities. By bringing the Epistulae into the broader discussion of Augustine’s anti-Manichaean engagement, this study highlights their value as a window into his theological evolution and pastoral strategy in a religiously contested environment. Full article

The Draw-A-Person Intellectual Ability test for children, adolescents, and adults is a widely used tool in psychology for assessing intellectual ability. This test relies on human drawings for initial raw scoring, with the subsequent conversion of data into IQ ranges through manual procedures. However, this manual scoring and IQ assessment process can be time-consuming, particularly for busy psychologists dealing with a high caseload of children and adolescents. Presently, DAP-IQ screening continues to be a manual endeavor conducted by psychologists. The primary objective of our research is to streamline the IQ screening process for psychologists by leveraging deep learning algorithms. In this study, we utilized the DAP-IQ manual to derive IQ measurements and categorized the entire dataset into seven distinct classes: Very Superior, Superior, High Average, Average, Below Average, Significantly Impaired, and Mildly Impaired. The dataset for IQ screening was sourced from primary to high school students aged from 8 to 17, comprising over 1100 sketches, which were subsequently manually classified under the DAP-IQ manual. Subsequently, the manual classified dataset was converted into digital images. To develop the artificial intelligence-based models, various deep learning algorithms were employed, including Convolutional Neural Network (CNN) and state-of-the-art CNN (Transfer Learning) models such as Mobile-Net, Xception, InceptionResNetV2, and InceptionV3. The Mobile-Net model demonstrated remarkable performance, achieving a classification accuracy of 98.68%, surpassing the capabilities of existing methodologies. This research represents a significant step towards expediting and enhancing the IQ screening for psychologists working with diverse age groups. Full article

Background/Objectives: Malan syndrome (MALNS) is an ultra-rare genetic disorder caused by aberrations in the NFIX gene, located at chromosome 19p13.2. Key features of MALNS include general overgrowth, a typical facial gestalt, muscle–skeletal abnormalities, speech difficulties and intellectual disability. Additionally, MALNS frequently presents with autism-like behaviour and social challenges. However, characterisation of the cognitive profile of MALNS, including social perception skills, is limited. Methods: Six children and adolescents with MALNS, whose clinical and emotional–behavioural features had been described in previous studies, were assessed by means of a single, co-normed neuropsychological battery covering multiple cognitive domains. Results: Consistent with their intellectual disability, performance was generally weak across all neuropsychological subtests. Nonetheless, memory for faces, visual attention and contextual (non-verbal) theory of mind emerged as relative strengths of the profile, both at group and individual levels. Conversely, tasks requiring verbal reasoning and language comprehension, such as comprehension of instructions and verbal theory of mind, represented weaknesses for all participants. Conclusions: These findings provide a further characterisation of cognitive and social functioning in MALNS, which can inform future research as well as clinical practice and rehabilitation Full article

Leisure education has the potential to improve the quality of life and prepare students for social participation after graduation. This study elucidates the perspectives of special education teachers on leisure instruction. The study surveyed 129 teachers from 10 special needs schools for students with intellectual disabilities in Prefecture A, a rural area of Japan. An online survey was conducted from 21 October to 17 November 2023. The survey items were based on 13 aspects of leisure instruction identified from a literature review related to leisure instruction in Japan and a qualitative analysis of interviews with high school teachers in special needs schools for students with intellectual disabilities. The results showed that “The ability to pass time during brief periods of free time”, “Various activity experiences that lead to leisure”, and “Knowing one’s strengths and weaknesses in activities” were significantly more important during school. Conversely, “understanding the psychological importance of leisure”, “connecting with organizations that support leisure activities”, and “finding places to engage in leisure activities” were significantly more important after graduation. The results of this study can be used to identify the gaps in perception between special education teachers and vocational rehabilitation practitioners responsible for post-social participation support. Full article

Older adults with intellectual disabilities are not adequately prepared for ageing and show anxiety and uncertainty regarding the future. Therefore, the two-year educational intervention “Good Life in Old Age” was implemented to improve their understanding of ageing and enhance their well-being. This study aimed to explore the meaning of ageing during and after the intervention from the perspective of older adults with mild intellectual disability. The ethnographic design included participant observations, field notes, group interviews, and individual follow-up interviews with 20 adults aged 44–75 (mean 63.2) with intellectual disabilities. The main findings are expressed in four themes; Awareness of ageing with intellectual disabilities, Strengthened as a person through empowering community, Awareness of vulnerability as an older adult, and The educational intervention as a resource to manage vulnerability. The education programme created a social network for healthy ageing with an atmosphere of mutual support fostering greater mental strength and self-confidence. Individual retirement plans should be created to foster socialisation, involving adapted activities and conversations about bereavement and death. There is a need to disseminate and continue developing promising education programmes for older adults with intellectual disabilities to reduce their anxiety about retirement and loneliness and facilitate healthy ageing. Full article

The objective was to investigate the effects of auditory environments on postural balance during cognitive tasks. Nineteen individuals with intellectual disabilities, aged between 15 and 19, participated in the study. The assessment involved center of pressure (CoP) measurements on both firm and foam surfaces under open-eye (OE) and closed-eye (CE) conditions. During these assessments, participants were exposed to nature sounds and noise sounds while performing counting and verbal fluency tasks. The results showed that nature sounds on a firm surface under OE conditions during counting demonstrated a significant decrease in CoP values (p = 0.037), indicating improved postural balance. However, noise sounds on foam surfaces during counting and verbal fluency showed increased CoP values, reflecting impaired postural balance (p < 0.05). In conclusion, nature sounds on a firm surface with OE during counting improved postural balance. Conversely, noise sounds on foam surfaces during counting and verbal fluency tasks impaired postural balance. Full article

Background/Objectives: The evolution of digital technology enhances the broadening of a person’s intellectual growth. Research points out that implementing innovative applications of the digital world improves human social, cognitive, and metacognitive behavior. Artificial intelligence chatbots are yet another innovative human-made construct. These are forms of software that simulate human conversation, understand and process user input, and provide personalized responses. Executive function includes a set of higher mental processes necessary for formulating, planning, and achieving a goal. The present study aims to investigate executive function reinforcement through artificial intelligence chatbots, outlining potentials, limitations, and future research suggestions. Specifically, the study examined three research questions: the use of conversational chatbots in executive functioning training, their impact on executive-cognitive skills, and the duration of any improvements. Methods: The assessment of the existing literature was implemented using the systematic review method, according to the PRISMA 2020 Principles. The avalanche search method was employed to conduct a source search in the following databases: Scopus, Web of Science, PubMed, and complementary Google Scholar. This systematic review included studies from 2021 to the present using experimental, observational, or mixed methods. It included studies using AI-based chatbots or conversationalists to support executive functions, such as anxiety, stress, depression, memory, attention, cognitive load, and behavioral changes. In addition, this study included general populations with specific neurological conditions, all peer-reviewed, written in English, and with full-text access. However, the study excluded studies before 2021, the literature reviews, systematic reviews, non-AI-based chatbots or conversationalists, studies not targeting the range of executive skills and abilities, studies not written in English, and studies without open access. The criteria aligned with the study objectives, ensuring a focus on AI chatbots and the impact of conversational agents on executive function. The initial collection totaled n = 115 articles; however, the eligibility requirements led to the final selection of n = 10 studies. Results: The findings of the studies suggested positive effects of using AI chatbots to enhance and improve executive skills. Although, several limitations were identified, making it still difficult to generalize and reproduce their effects. Conclusions: AI chatbots are an innovative artificial intelligence tool that can function as a digital assistant for learning and expanding executive skills, contributing to the cognitive, metacognitive, and social development of the individual. However, its use in executive skills training is at a primary stage. The findings highlighted the need for a unified framework for reference and future studies, better study designs, diverse populations, larger sample sizes of participants, and longitudinal studies that observe the long-term effects of their use. Full article

This article explores the relatively theoretical question of what contribution academic theology is making to the synodal process and how this interaction might deepen in the years to come. It stresses the importance of what it calls foundational theological questions, employing the thought of the Jesuit philosopher and theologian Bernard Lonergan to define this term. It traces how a slow awareness of the importance of such questions, and an explicit attention to the question of theological method that is related to this, began emerging in the Second Vatican Council. It then suggests that such questions have come closer to the center of attention in the synodal process launched by Pope Francis. It proposes that the synodal process in the future will benefit by making further use of the thought of Lonergan. It leaves to a further study the question of how clarifying foundational and methodological questions in theology might have consequences for Catholic education in general. Full article

Alzheimer’s disease (AD) is a complex neurodegenerative disorder influenced by various genetic factors. In addition to the well-established amyloid precursor protein (APP), Presenilin-1 (PSEN1), Presenilin-2 (PSEN2), and apolipoprotein E (APOE), several other genes such as Sortilin-related receptor 1 (SORL1), Phospholipid-transporting ATPase ABCA7 (ABCA7), Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), Phosphatidylinositol-binding clathrin assembly protein (PICALM), and clusterin (CLU) were implicated. These genes contribute to neurodegeneration through both gain-of-function and loss-of-function mechanisms. While it was traditionally thought that heterozygosity in autosomal recessive mutations does not lead to disease, haploinsufficiency was linked to several conditions, including cancer, autism, and intellectual disabilities, indicating that a single functional gene copy may be insufficient for normal cellular functions. In AD, the haploinsufficiency of genes such as ABCA7 and SORL1 may play significant yet under-explored roles. Paradoxically, heterozygous knockouts of PSEN1 or PSEN2 can impair synaptic plasticity and alter the expression of genes involved in oxidative phosphorylation and cell adhesion. Animal studies examining haploinsufficient AD risk genes, such as vacuolar protein sorting-associated protein 35 (VPS35), sirtuin-3 (SIRT3), and PICALM, have shown that their knockout can exacerbate neurodegenerative processes by promoting amyloid production, accumulation, and inflammation. Conversely, haploinsufficiency in APOE, beta-secretase 1 (BACE1), and transmembrane protein 59 (TMEM59) was reported to confer neuroprotection by potentially slowing amyloid deposition and reducing microglial activation. Given its implications for other neurodegenerative diseases, the role of haploinsufficiency in AD requires further exploration. Modeling the mechanisms of gene knockout and monitoring their expression patterns is a promising approach to uncover AD-related pathways. However, challenges such as identifying susceptible genes, gene–environment interactions, phenotypic variability, and biomarker analysis must be addressed. Enhancing model systems through humanized animal or cell models, utilizing advanced research technologies, and integrating multi-omics data will be crucial for understanding disease pathways and developing new therapeutic strategies. Full article

This study highlights how middle schoolers discuss the benefits and drawbacks of AI-driven conversational agents in learning. Using thematic analysis of focus groups, we identified five themes in students’ views of AI applications in education. Students recognized the benefits of AI in making learning more engaging and providing personalized, adaptable scaffolding. They emphasized that AI use in education needs to be safe and equitable. Students identified the potential of AI in supporting teachers and noted that AI educational agents fall short when compared to emotionally and intellectually complex humans. Overall, we argue that even without technical expertise, middle schoolers can articulate deep, multifaceted understandings of the possibilities and pitfalls of AI in education. Centering student voices in AI design can also provide learners with much-desired agency over their future learning experiences. Full article

Background: The human gut environment undergoes substantial changes as a host ages. This investigation centered on the gut microbiome diversity among patients with severe motor and intellectual disabilities (SMID), examining the association between the gut microbiome composition and physical characteristics with varying levels of diversity. Methods: Fourteen subjects were investigated, with physical and defecation status, blood biochemical test, gut microbiome profiling, and fecal metabolites used to divide the patients into a high-diversity group (HD, eight patients) and a low-diversity group (LD, six patients). Results: Findings indicated that the microbiome of the LD group showed delayed maturation reminiscent of neonates and lactating infants. Analysis of the fecal bile acids (BAs) revealed a markedly diminished proportion of deoxycholic acid in the secondary BAs in the LD group, suggestive of inadequate conversion from primary to secondary BAs. Furthermore, the LD group presented with loose stools. The LD group exhibited a higher degree of physical severity, with all patients bedridden and fed via gastrostomy with only enteral formula received. Conclusions: The composition of the gut microbiome and BAs in the LD group was found to differ from those of healthy individuals and the HD group, indicating a potentially immature gut environment for these individuals. Full article

This article discusses an inclusive research program where colleagues and co-researchers (with intellectual disability) guide and inform future research practice to ensure research is targeted to areas of significance and relevance to them. The research program is about sites of former disability institutions. Many people with intellectual disability in Australia were segregated and forced to live in disability institutions until deinstitutionalisation efforts became mainstream in the late 20th Century. We are a team of four people based in New South Wales, Australia. Our team includes disability advocates and researchers who have contributed to a program of research exploring connections between sites of former disability institutions and contemporary disability rights. In this article, we reflect on conversations about our research undertaken so far and where the research goes from here. We explore five pillars of action informing how research relating to disability institutions can progress: 1. Current use: research exploring erasure of experiences of institutionalisation communicated through educational resources and maps about current use of sites of former disability institutions; 2. Reparative planning processes: research developing frameworks for alternative approaches to planning and heritage processes supporting alternative uses of former sites of disability institutions; 3. Official recognition and redress: research exploring perspectives on governments formally recognising and remedying experiences of people with disability who were institutionalised; 4. Community-led repair and remembrance: research identifying practices for both celebrating advocates with disability and reckoning with and repairing familial and social bonds broken through institutionalisation; 5. Community-inclusive practices: research exploring endurance of institutional practices in disability accommodation in community settings. These five pillars are underpinned by three foundational layers: advancing disability human rights; reckoning with intersections between disability institutions and settler colonialism, other dynamics of oppression, and eugenics; and using inclusive practices. Full article

This article examines the life, theological career, exegetical development, and posthumous biographies of Johannes Oecolampadius as illustrative examples of the fact that the Swiss Reformation, with all its religious movements, was far from a uniform concept in terms of its origins, purposes, and methodologies. The article explains through Oecolampadius’s example an approach to reform that was ‘in progress’, traversing the nexuses of disparate methods and exegetical priorities. Oecolampadius’s experience occupied a position at the intersection between the authority of Patristics and the principle of sola scriptura, exemplifying a balance between the past and the present of Christian tradition. The path that led Oecolampadius to become a Protestant Reformer is characterised by a gradual transition, not abrupt, not radical. His example demonstrates the methodological and ideological diversity of the Reformation, which can be observed through the prism of a single life and its intellectual periods. His conversion offers insight into how these varied approaches shaped personal engagements with Scripture, and challenges the notion of an immediate or singular evangelical ‘calling’ or ‘conviction’. This article examines a specific phase within the broader and varied trajectory of the Swiss Reformation by analysing the transformation of Oecolampadius from a biblical scholar to a preacher, and eventually to a Reformer. This case study illustrates how disparate methodologies, whether rooted in humanism or Patristics, contributed to gradual and personal evolution, ultimately giving rise to distinctive individual stances on reform. This article presents a synthesis of three distinct perspectives on the question. The first part approaches the question through the lens of church history and intellectual history; the second one utilises the history of exegesis and New Testament scholarship; and the third draws upon the perspectives of Protestant historiography, from the standpoint of social history and the history of biographies in Early Modern times. Full article

The interplay between intellectual property rights for new plant varieties and public interests, particularly farmers’ rights, is critically examined within the context of global agricultural practices and Sustainable Development Goals (SDGs). According to the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS), World Trade Organization (WTO) members shall establish a mechanism to grant effective protection to new plant varieties. There are two typical compliance mechanisms with TRIPS: the model developed by the International Convention for the Protection of New Varieties of Plants (UPOV Convention) and India’s sui generis system. A comparison from the sustainable development perspective is conducted through the textual analysis of the regulations of each model. The results show that the UPOV Convention cannot advance the achievement of Sustainable Development Goals and might have adverse effects. Conversely, India’s sui generis system represents a more balanced approach, addressing the needs of the farmers, the community, and environmental protection alongside those of breeders and benefitting sustainable development. The conclusion advocates for revising the UPOV Convention to incorporate broader concerns, including farmers’ rights and environmental sustainability, to ensure a more equitable approach to the protection of plant varieties. Full article

This paper examines the writings of European travelers, chaplains, and resident doctors on pandemics in the Mediterranean regions from the 16th to the 19th centuries. Using French comparative literary theory, the article highlights how Muslim communities in Egypt, Turkey, Aleppo, and Mecca were stereotyped based on their belief in predestination, their failure to avoid contamination, and their lack of social distancing during plague outbreaks. This paper argues that travelers were influenced by Renaissance humanism, Ars Apodemia, religious discourses, and texts, such as plague tracts, model town concepts, the book of orders, and tales, and that they essentialized Mediterranean Islamicate societies by depicting contamination motifs supposedly shaped by the absence of contagion theory in prophetic medicines. Regarding plague science, this paper concludes that Christian and Muslim intellectuals had similar approaches until the Black Death and that Arabs were eclectic since the Abbasid period. This paper further maintains that the travelers’ approaches fostered chauvinism and the cultural hegemony of the West over the Orient since the Renaissance and Enlightenment periods, driven by eschatology, conversion, and power structure narratives. Full article