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Keywords = image and diagnosis medical security

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35 pages, 4940 KiB  
Article
A Novel Lightweight Facial Expression Recognition Network Based on Deep Shallow Network Fusion and Attention Mechanism
by Qiaohe Yang, Yueshun He, Hongmao Chen, Youyong Wu and Zhihua Rao
Algorithms 2025, 18(8), 473; https://doi.org/10.3390/a18080473 - 30 Jul 2025
Viewed by 315
Abstract
Facial expression recognition (FER) is a critical research direction in artificial intelligence, which is widely used in intelligent interaction, medical diagnosis, security monitoring, and other domains. These applications highlight its considerable practical value and social significance. Face expression recognition models often need to [...] Read more.
Facial expression recognition (FER) is a critical research direction in artificial intelligence, which is widely used in intelligent interaction, medical diagnosis, security monitoring, and other domains. These applications highlight its considerable practical value and social significance. Face expression recognition models often need to run efficiently on mobile devices or edge devices, so the research on lightweight face expression recognition is particularly important. However, feature extraction and classification methods of lightweight convolutional neural network expression recognition algorithms mostly used at present are not specifically and fully optimized for the characteristics of facial expression images, yet fail to make full use of the feature information in face expression images. To address the lack of facial expression recognition models that are both lightweight and effectively optimized for expression-specific feature extraction, this study proposes a novel network design tailored to the characteristics of facial expressions. In this paper, we refer to the backbone architecture of MobileNet V2 network, and redesign LightExNet, a lightweight convolutional neural network based on the fusion of deep and shallow layers, attention mechanism, and joint loss function, according to the characteristics of the facial expression features. In the network architecture of LightExNet, firstly, deep and shallow features are fused in order to fully extract the shallow features in the original image, reduce the loss of information, alleviate the problem of gradient disappearance when the number of convolutional layers increases, and achieve the effect of multi-scale feature fusion. The MobileNet V2 architecture has also been streamlined to seamlessly integrate deep and shallow networks. Secondly, by combining the own characteristics of face expression features, a new channel and spatial attention mechanism is proposed to obtain the feature information of different expression regions as much as possible for encoding. Thus improve the accuracy of expression recognition effectively. Finally, the improved center loss function is superimposed to further improve the accuracy of face expression classification results, and corresponding measures are taken to significantly reduce the computational volume of the joint loss function. In this paper, LightExNet is tested on the three mainstream face expression datasets: Fer2013, CK+ and RAF-DB, respectively, and the experimental results show that LightExNet has 3.27 M Parameters and 298.27 M Flops, and the accuracy on the three datasets is 69.17%, 97.37%, and 85.97%, respectively. The comprehensive performance of LightExNet is better than the current mainstream lightweight expression recognition algorithms such as MobileNet V2, IE-DBN, Self-Cure Net, Improved MobileViT, MFN, Ada-CM, Parallel CNN(Convolutional Neural Network), etc. Experimental results confirm that LightExNet effectively improves recognition accuracy and computational efficiency while reducing energy consumption and enhancing deployment flexibility. These advantages underscore its strong potential for real-world applications in lightweight facial expression recognition. Full article
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25 pages, 2887 KiB  
Article
Federated Learning Based on an Internet of Medical Things Framework for a Secure Brain Tumor Diagnostic System: A Capsule Networks Application
by Roman Rodriguez-Aguilar, Jose-Antonio Marmolejo-Saucedo and Utku Köse
Mathematics 2025, 13(15), 2393; https://doi.org/10.3390/math13152393 - 25 Jul 2025
Viewed by 241
Abstract
Artificial intelligence (AI) has already played a significant role in the healthcare sector, particularly in image-based medical diagnosis. Deep learning models have produced satisfactory and useful results for accurate decision-making. Among the various types of medical images, magnetic resonance imaging (MRI) is frequently [...] Read more.
Artificial intelligence (AI) has already played a significant role in the healthcare sector, particularly in image-based medical diagnosis. Deep learning models have produced satisfactory and useful results for accurate decision-making. Among the various types of medical images, magnetic resonance imaging (MRI) is frequently utilized in deep learning applications to analyze detailed structures and organs in the body, using advanced intelligent software. However, challenges related to performance and data privacy often arise when using medical data from patients and healthcare institutions. To address these issues, new approaches have emerged, such as federated learning. This technique ensures the secure exchange of sensitive patient and institutional data. It enables machine learning or deep learning algorithms to establish a client–server relationship, whereby specific parameters are securely shared between models while maintaining the integrity of the learning tasks being executed. Federated learning has been successfully applied in medical settings, including diagnostic applications involving medical images such as MRI data. This research introduces an analytical intelligence system based on an Internet of Medical Things (IoMT) framework that employs federated learning to provide a safe and effective diagnostic solution for brain tumor identification. By utilizing specific brain MRI datasets, the model enables multiple local capsule networks (CapsNet) to achieve improved classification results. The average accuracy rate of the CapsNet model exceeds 97%. The precision rate indicates that the CapsNet model performs well in accurately predicting true classes. Additionally, the recall findings suggest that this model is effective in detecting the target classes of meningiomas, pituitary tumors, and gliomas. The integration of these components into an analytical intelligence system that supports the work of healthcare personnel is the main contribution of this work. Evaluations have shown that this approach is effective for diagnosing brain tumors while ensuring data privacy and security. Moreover, it represents a valuable tool for enhancing the efficiency of the medical diagnostic process. Full article
(This article belongs to the Special Issue Innovations in Optimization and Operations Research)
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26 pages, 654 KiB  
Review
Advances in Neural Network-Based Image, Thermal, Infrared, and X-Ray Technologies
by Jacek Wilk-Jakubowski, Łukasz Pawlik, Leszek Ciopiński and Grzegorz Wilk-Jakubowski
Appl. Sci. 2025, 15(13), 7198; https://doi.org/10.3390/app15137198 - 26 Jun 2025
Viewed by 415
Abstract
With the dynamic development of imaging technologies and increasing demands in various industrial fields, neural networks are playing a crucial role in advanced design, monitoring, and analysis techniques. This review article presents the latest research advancements in neural network-based imaging, thermal, infrared, and [...] Read more.
With the dynamic development of imaging technologies and increasing demands in various industrial fields, neural networks are playing a crucial role in advanced design, monitoring, and analysis techniques. This review article presents the latest research advancements in neural network-based imaging, thermal, infrared, and X-ray technologies from 2005 to 2024. It focuses on two main research categories: ‘Technology’ and ‘Application’. The ‘Technology’ category includes neural network-enhanced image sensors, thermal imaging, infrared detectors, and X-ray technologies, while the ‘Application’ category is divided into image processing, robotics and design, object recognition, medical imaging, and security systems. In image processing, significant progress has been made in classification, segmentation, digital image storage, and information classification using neural networks. Robotics and design have seen advancements in mobile robots, navigation, and machine design through neural network integration. Object recognition technologies include neural network-based object detection, face recognition, and pattern recognition. Medical imaging has benefited from innovations in diagnosis, imaging techniques, and disease detection using neural networks. Security systems have improved in terms of monitoring and efficiency through neural network applications. This review aims to provide a comprehensive understanding of the current state and future directions of neural network-based imaging, thermal, infrared, and X-ray technologies. Full article
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13 pages, 1228 KiB  
Article
Medical Photography in Dermatology: Quality and Safety in the Referral Process to Secondary Healthcare
by Eduarda Castro Almeida, João Rocha-Neves, Ana Filipa Pedrosa and José Paulo Andrade
Diagnostics 2025, 15(12), 1518; https://doi.org/10.3390/diagnostics15121518 - 14 Jun 2025
Viewed by 458
Abstract
Background: Medical photography is widely used in dermatology referrals to secondary healthcare, yet concerns exist regarding image quality and data security. This study aimed to evaluate the quality of clinical photographs used in dermatology referrals, to identify discrepancies between specialties’ perceptions, and to [...] Read more.
Background: Medical photography is widely used in dermatology referrals to secondary healthcare, yet concerns exist regarding image quality and data security. This study aimed to evaluate the quality of clinical photographs used in dermatology referrals, to identify discrepancies between specialties’ perceptions, and to determine the general awareness of proper storage and security of clinical photographs. Methods: A 43-question survey, based on previously validated questionnaires, was administered to general and family medicine (GFM) doctors and to dermatologists at an academic referral hospital in Porto, Portugal. The survey assessed demographics, photo-taking habits, perceived photo quality, adequacy of clinical information, and opinions on the role of photography in the referral process. Quantitative statistical methods were used to analyze questionnaire responses. Results: A total of 65 physicians participated (18 dermatologists and 47 GFM doctors). Significant differences were observed between the two groups. While 36.2% of GFMs rated their submitted photos as high- or very-high-quality, none of the dermatologists rated the received photos as high-quality, with 83.3% rating them as average (p = 0.012). Regarding clinical information, 46.8% of GFMs reported consistently sending enough information, while no dermatologists reported always receiving sufficient information (p < 0.001). Most respondents (76.9%) agreed that the quality of photographs is important in diagnosis and treatment. Conclusions: The findings reveal a discrepancy between GFM doctors’ and dermatologists’ perceptions of photograph quality and information sufficiency in dermatology referrals. Standardized guidelines and educational interventions are necessary to improve the quality and consistency of clinical photographs, thereby enhancing communication between healthcare providers and ensuring patient data privacy and security. Full article
(This article belongs to the Section Medical Imaging and Theranostics)
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10 pages, 905 KiB  
Article
Impact of Testicular Cancer on the Socio-Economic Health, Sexual Health, and Fertility of Survivors—A Questionnaire Based Survey
by M. Raheel Khan, Patrice Kearney Sheehan, Ashley Bazin, Christine Leonard, Lynda Corrigan and Ray McDermott
Cancers 2025, 17(11), 1826; https://doi.org/10.3390/cancers17111826 - 30 May 2025
Cited by 1 | Viewed by 509
Abstract
Introduction: Testicular cancer (TC) is diagnosed at a young age and carries a remarkably high cure rate. Hence, there is a sizeable population living in the survivorship phase. Many studies have highlighted the plight of TC survivors as a result of the [...] Read more.
Introduction: Testicular cancer (TC) is diagnosed at a young age and carries a remarkably high cure rate. Hence, there is a sizeable population living in the survivorship phase. Many studies have highlighted the plight of TC survivors as a result of the late side-effects of the different therapeutic modalities used for the treatment of TC. This is the first study in Ireland to highlight the impact of TC on socio-economic health, sexual health, and fertility in survivors. Method: We performed a questionnaire-based survey, which was fully anonymised to encourage participation. Questionnaires were designed to measure the self-reported impact on social, sexual, and economic health on a five-point Likert scale (ranging from no effect to very significant effect), whereas any effect on fertility was investigated with questions regarding biological children before and after cancer with or without medical assistance. Results: A total of 83 TC survivors participated in the study. Almost half of our respondents revealed some effect on their performance at work and personal finances. Around one-third suffered an impact on career choice, job security, and their relationship with their partner. Regarding sexual health, the worst repercussions were noted on sex drive and body image perception, where close to half of the respondents reported at least some deterioration. Ejaculation and erectile function were affected in 30% of the participants. Of all participants, 17% reported issues with fertility, and the same proportion reported seeking medical help to conceive after diagnosis or treatment of TC. Conclusions: In conclusion, some TC survivors experience significant impact on their socio-economic and sexual health. Full article
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16 pages, 5441 KiB  
Article
Secure Retrieval of Brain Tumor Images Using Perceptual Encryption in Cloud-Assisted Scenario
by Ijaz Ahmad, Md Shahriar Uzzal and Seokjoo Shin
Electronics 2025, 14(9), 1759; https://doi.org/10.3390/electronics14091759 - 25 Apr 2025
Viewed by 296
Abstract
Scarcity of data is one of the major challenges in developing automatic computer-aided diagnosis systems, training radiologists and supporting medical research. One solution toward this is community cloud storage, which can be utilized by organizations with a common interest as a shared data [...] Read more.
Scarcity of data is one of the major challenges in developing automatic computer-aided diagnosis systems, training radiologists and supporting medical research. One solution toward this is community cloud storage, which can be utilized by organizations with a common interest as a shared data repository for joint projects and collaboration. In this large database, relevant images are often searched by an image retrieval system, for which the computation and storage capabilities of a cloud server can bring the benefits of high scalability and availability. However, the main limitation in availing third party-provided services comes from the associated privacy concerns during data transmission, storage and computation. To ensure privacy, this study implements a content-based image retrieval application for finding different types of brain tumors in the encrypted domain. In this framework, we propose a perceptual encryption technique to protect images in such a way that the features necessary for high-dimensional representation can still be extracted from the cipher images. Also, it allows data protection on the client side; therefore, the server stores and receives images in an encrypted form and has no access to the secret key information. Experimental results show that compared with conventional secure techniques, our proposed system reduced the difference in non-secure and secure retrieval performance by up to 3%. Full article
(This article belongs to the Special Issue Security and Privacy in Networks)
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40 pages, 4320 KiB  
Review
Federated Learning in Smart Healthcare: A Survey of Applications, Challenges, and Future Directions
by Mohammad Nasajpour, Seyedamin Pouriyeh, Reza M. Parizi, Meng Han, Fatemeh Mosaiyebzadeh, Liyuan Liu, Yixin Xie and Daniel Macêdo Batista
Electronics 2025, 14(9), 1750; https://doi.org/10.3390/electronics14091750 - 25 Apr 2025
Viewed by 2001
Abstract
In recent years, novel technologies in smart healthcare systems have opened significant opportunities for diagnosis and treatment across various medical fields. Federated Learning (FL), a decentralized machine learning approach, trains shared models using local data from devices like wearables and hospital systems without [...] Read more.
In recent years, novel technologies in smart healthcare systems have opened significant opportunities for diagnosis and treatment across various medical fields. Federated Learning (FL), a decentralized machine learning approach, trains shared models using local data from devices like wearables and hospital systems without transferring sensitive information, offering a promising solution to privacy challenges in areas such as cancer prediction, COVID-19 detection, drug discovery, and medical image processing. This literature survey reviews FL architectures (e.g., FedHealth, PerFit), applications, and recent advancements, demonstrating their impact on healthcare through enhanced predictive models for patient care. Key findings include improved accuracy in wearable-based diagnostics and secure multi-institutional collaboration, though limitations persist. We also highlight open challenges, such as security risks, communication costs, and data heterogeneity, which require further research attention. Full article
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9 pages, 2881 KiB  
Article
Compact Near-Infrared Imaging Device Based on a Large-Aperture All-Si Metalens
by Zhixi Li, Wei Liu, Yubing Zhang, Feng Tang, Liming Yang and Xin Ye
Nanomaterials 2025, 15(6), 453; https://doi.org/10.3390/nano15060453 - 17 Mar 2025
Viewed by 770
Abstract
Near-infrared imaging devices are extensively used in medical diagnosis, night vision, and security monitoring. However, existing traditional imaging devices rely on a bunch of refracting lenses, resulting in large, bulky imaging systems that restrict their broader utility. The emergence of flat meta-optics offers [...] Read more.
Near-infrared imaging devices are extensively used in medical diagnosis, night vision, and security monitoring. However, existing traditional imaging devices rely on a bunch of refracting lenses, resulting in large, bulky imaging systems that restrict their broader utility. The emergence of flat meta-optics offers a potential solution to these limitations, but existing research on compact integrated devices based on near-infrared meta-optics is insufficient. In this study, we propose an integrated NIR imaging camera that utilizes large-size metalens with a silicon nanostructure with high transmission efficiency. Through the detection of target and animal and plant tissue samples, the ability to capture biological structures and their imaging performance was verified. Through further integration of the NIR imaging device, the device significantly reduces the size and weight of the system and optimizes the aperture to achieve excellent image brightness and contrast. Additionally, venous imaging of human skin shows the potential of the device for biomedical applications. This research has an important role in promoting the miniaturization and lightweight of near-infrared optical imaging devices, which is expected to be applied to medical testing and night vision imaging. Full article
(This article belongs to the Special Issue The Interaction of Electron Phenomena on the Mesoscopic Scale)
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17 pages, 6079 KiB  
Article
Secure Hybrid Deep Learning for MRI-Based Brain Tumor Detection in Smart Medical IoT Systems
by Nermeen Gamal Rezk, Samah Alshathri, Amged Sayed, Ezz El-Din Hemdan and Heba El-Behery
Diagnostics 2025, 15(5), 639; https://doi.org/10.3390/diagnostics15050639 - 6 Mar 2025
Cited by 1 | Viewed by 1278
Abstract
Background/Objectives: Brain tumors are among the most aggressive diseases, significantly contributing to human mortality. Typically, the classification of brain tumors is performed through a biopsy, which is often delayed until brain surgery is necessary. An automated image classification technique is crucial for [...] Read more.
Background/Objectives: Brain tumors are among the most aggressive diseases, significantly contributing to human mortality. Typically, the classification of brain tumors is performed through a biopsy, which is often delayed until brain surgery is necessary. An automated image classification technique is crucial for accelerating diagnosis, reducing the need for invasive procedures and minimizing the risk of manual diagnostic errors being made by radiologists. Additionally, the security of sensitive MRI images remains a major concern, with robust encryption methods required to protect patient data from unauthorized access and breaches in Medical Internet of Things (MIoT) systems. Methods: This study proposes a secure and automated MRI image classification system that integrates chaotic and Arnold encryption techniques with hybrid deep learning models using VGG16 and a deep neural network (DNN). The methodology ensures MRI image confidentiality while enabling the accurate classification of brain tumors and not compromising performance. Results: The proposed system demonstrated a high classification performance under both encryption scenarios. For chaotic encryption, it achieved an accuracy of 93.75%, precision of 94.38%, recall of 93.75%, and an F-score of 93.67%. For Arnold encryption, the model attained an accuracy of 94.1%, precision of 96.9%, recall of 94.1%, and an F-score of 96.6%. These results indicate that encrypted images can still be effectively classified, ensuring both security and diagnostic accuracy. Conclusions: The proposed hybrid deep learning approach provides a secure, accurate, and efficient solution for brain tumor detection in MIoT-based healthcare applications. By encrypting MRI images before classification, the system ensures patient data confidentiality while maintaining high diagnostic performance. This approach can empower radiologists and healthcare professionals worldwide, enabling early and secure brain tumor diagnosis without the need for invasive procedures. Full article
(This article belongs to the Special Issue Artificial Intelligence in Brain Diseases)
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24 pages, 6478 KiB  
Article
The Data Heterogeneity Issue Regarding COVID-19 Lung Imaging in Federated Learning: An Experimental Study
by Fatimah Alhafiz and Abdullah Basuhail
Big Data Cogn. Comput. 2025, 9(1), 11; https://doi.org/10.3390/bdcc9010011 - 14 Jan 2025
Cited by 3 | Viewed by 875
Abstract
Federated learning (FL) has emerged as a transformative framework for collaborative learning, offering robust model training across institutions while ensuring data privacy. In the context of making a COVID-19 diagnosis using lung imaging, FL enables institutions to collaboratively train a global model without [...] Read more.
Federated learning (FL) has emerged as a transformative framework for collaborative learning, offering robust model training across institutions while ensuring data privacy. In the context of making a COVID-19 diagnosis using lung imaging, FL enables institutions to collaboratively train a global model without sharing sensitive patient data. A central manager aggregates local model updates to compute global updates, ensuring secure and effective integration. The global model’s generalization capability is evaluated using centralized testing data before dissemination to participating nodes, where local assessments facilitate personalized adaptations tailored to diverse datasets. Addressing data heterogeneity, a critical challenge in medical imaging, is essential for improving both global performance and local personalization in FL systems. This study emphasizes the importance of recognizing real-world data variability before proposing solutions to tackle non-independent and non-identically distributed (non-IID) data. We investigate the impact of data heterogeneity on FL performance in COVID-19 lung imaging across seven distinct heterogeneity settings. By comprehensively evaluating models using generalization and personalization metrics, we highlight challenges and opportunities for optimizing FL frameworks. The findings provide valuable insights that can guide future research toward achieving a balance between global generalization and local adaptation, ultimately enhancing diagnostic accuracy and patient outcomes in COVID-19 lung imaging. Full article
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32 pages, 3661 KiB  
Systematic Review
Explainable AI in Diagnostic Radiology for Neurological Disorders: A Systematic Review, and What Doctors Think About It
by Yasir Hafeez, Khuhed Memon, Maged S. AL-Quraishi, Norashikin Yahya, Sami Elferik and Syed Saad Azhar Ali
Diagnostics 2025, 15(2), 168; https://doi.org/10.3390/diagnostics15020168 - 13 Jan 2025
Cited by 6 | Viewed by 5270
Abstract
Background: Artificial intelligence (AI) has recently made unprecedented contributions in every walk of life, but it has not been able to work its way into diagnostic medicine and standard clinical practice yet. Although data scientists, researchers, and medical experts have been working in [...] Read more.
Background: Artificial intelligence (AI) has recently made unprecedented contributions in every walk of life, but it has not been able to work its way into diagnostic medicine and standard clinical practice yet. Although data scientists, researchers, and medical experts have been working in the direction of designing and developing computer aided diagnosis (CAD) tools to serve as assistants to doctors, their large-scale adoption and integration into the healthcare system still seems far-fetched. Diagnostic radiology is no exception. Imagining techniques like magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) scans have been widely and very effectively employed by radiologists and neurologists for the differential diagnoses of neurological disorders for decades, yet no AI-powered systems to analyze such scans have been incorporated into the standard operating procedures of healthcare systems. Why? It is absolutely understandable that in diagnostic medicine, precious human lives are on the line, and hence there is no room even for the tiniest of mistakes. Nevertheless, with the advent of explainable artificial intelligence (XAI), the old-school black boxes of deep learning (DL) systems have been unraveled. Would XAI be the turning point for medical experts to finally embrace AI in diagnostic radiology? This review is a humble endeavor to find the answers to these questions. Methods: In this review, we present the journey and contributions of AI in developing systems to recognize, preprocess, and analyze brain MRI scans for differential diagnoses of various neurological disorders, with special emphasis on CAD systems embedded with explainability. A comprehensive review of the literature from 2017 to 2024 was conducted using host databases. We also present medical domain experts’ opinions and summarize the challenges up ahead that need to be addressed in order to fully exploit the tremendous potential of XAI in its application to medical diagnostics and serve humanity. Results: Forty-seven studies were summarized and tabulated with information about the XAI technology and datasets employed, along with performance accuracies. The strengths and weaknesses of the studies have also been discussed. In addition, the opinions of seven medical experts from around the world have been presented to guide engineers and data scientists in developing such CAD tools. Conclusions: Current CAD research was observed to be focused on the enhancement of the performance accuracies of the DL regimens, with less attention being paid to the authenticity and usefulness of explanations. A shortage of ground truth data for explainability was also observed. Visual explanation methods were found to dominate; however, they might not be enough, and more thorough and human professor-like explanations would be required to build the trust of healthcare professionals. Special attention to these factors along with the legal, ethical, safety, and security issues can bridge the current gap between XAI and routine clinical practice. Full article
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37 pages, 7190 KiB  
Article
An Evolutionary Federated Learning Approach to Diagnose Alzheimer’s Disease Under Uncertainty
by Nanziba Basnin, Tanjim Mahmud, Raihan Ul Islam and Karl Andersson
Diagnostics 2025, 15(1), 80; https://doi.org/10.3390/diagnostics15010080 - 1 Jan 2025
Cited by 12 | Viewed by 1545
Abstract
Background: Alzheimer’s disease (AD) leads to severe cognitive impairment and functional decline in patients, and its exact cause remains unknown. Early diagnosis of AD is imperative to enable timely interventions that can slow the progression of the disease. This research tackles the complexity [...] Read more.
Background: Alzheimer’s disease (AD) leads to severe cognitive impairment and functional decline in patients, and its exact cause remains unknown. Early diagnosis of AD is imperative to enable timely interventions that can slow the progression of the disease. This research tackles the complexity and uncertainty of AD by employing a multimodal approach that integrates medical imaging and demographic data. Methods: To scale this system to larger environments, such as hospital settings, and to ensure the sustainability, security, and privacy of sensitive data, this research employs both deep learning and federated learning frameworks. MRI images are pre-processed and fed into a convolutional neural network (CNN), which generates a prediction file. This prediction file is then combined with demographic data and distributed among clients for local training. Training is conducted both locally and globally using a belief rule base (BRB), which effectively integrates various data sources into a comprehensive diagnostic model. Results: The aggregated data values from local training are collected on a central server. Various aggregation methods are evaluated to assess the performance of the federated learning model, with results indicating that FedAvg outperforms other methods, achieving a global accuracy of 99.9%. Conclusions: The BRB effectively manages the uncertainty associated with AD data, providing a robust framework for integrating and analyzing diverse information. This research not only advances AD diagnostics by integrating multimodal data but also underscores the potential of federated learning for scalable, privacy-preserving healthcare solutions. Full article
(This article belongs to the Special Issue Artificial Intelligence in Alzheimer’s Disease Diagnosis)
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18 pages, 3638 KiB  
Systematic Review
Systematic Literature Review of Epaxial Paraspinal Schwannomas: Differential Diagnosis and Treatment Approaches
by Wassim Khalil, Roula Khalil, Alexandre Meynard, Alexandre Perani, Elodie Chaudruc, Mathilde Duchesne, Karine Durand, François Caire and Henri Salle
Therapeutics 2024, 1(2), 106-123; https://doi.org/10.3390/therapeutics1020010 - 14 Dec 2024
Viewed by 1014
Abstract
Background: Schwannomas, predominantly benign nerve sheath tumors, are typically found within the intradural extramedullary space of the spinal cord with potential extradural expansion. Other typical localizations are the upper limbs and neck area. Pure epaxial paraspinal schwannomas are very rare, often asymptomatic, and [...] Read more.
Background: Schwannomas, predominantly benign nerve sheath tumors, are typically found within the intradural extramedullary space of the spinal cord with potential extradural expansion. Other typical localizations are the upper limbs and neck area. Pure epaxial paraspinal schwannomas are very rare, often asymptomatic, and predominantly occur in the thoracic region, with only a handful of cases reported globally. The range of differential diagnoses for paraspinal lesions is extensive, emphasizing the importance of accurate diagnosis to ensure optimal therapy and avoid unnecessary treatments. Method: We conducted a systematic literature review searching for published recommendations for paraspinal lesion management in addition to examining the case of a 49-year-old male patient who presented with a history of persistent back pain. A thorough medical history and physical examination were followed by ultrasound and MRI, revealing a well-defined paravertebral mass spanning from T7 to T9. A secure ultrasound-guided biopsy was performed, leading to a preliminary diagnosis of paraspinal schwannoma. Subsequently, complete surgical resection was performed. Results: pathological reports confirmed the initial diagnosis of paraspinal schwannoma. Further investigation using FMI and RNA sequencing did not detect any specific genetic anomalies aside from an NF2 gene mutation. A follow-up MRI conducted six months later showed no signs of recurrence. Conclusions: The broad spectrum of differential diagnoses for paraspinal lesions necessitates a multidisciplinary approach to ensure accurate diagnosis and tailored treatment. This approach involves meticulous imaging interpretation followed by a secure biopsy procedure to obtain preliminary pathology results, ultimately leading to the implementation of the most suitable surgical treatment. Full article
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25 pages, 5211 KiB  
Article
A Novel Grammar-Based Approach for Patients’ Symptom and Disease Diagnosis Information Dissemination to Maintain Confidentiality and Information Integrity
by Sanjay Nag, Nabanita Basu, Payal Bose and Samir Kumar Bandyopadhyay
Bioengineering 2024, 11(12), 1265; https://doi.org/10.3390/bioengineering11121265 - 13 Dec 2024
Viewed by 1151
Abstract
Disease prediction using computer-based methods is now an established area of research. The importance of technological intervention is necessary for the better management of disease, as well as to optimize use of limited resources. Various AI-based methods for disease prediction have been documented [...] Read more.
Disease prediction using computer-based methods is now an established area of research. The importance of technological intervention is necessary for the better management of disease, as well as to optimize use of limited resources. Various AI-based methods for disease prediction have been documented in the literature. Validated AI-based systems support diagnoses and decision making by doctors/medical practitioners. The resource-efficient dissemination of the symptoms identified and the diagnoses undertaken is the requirement of the present-day scenario to support paperless, yet seamless, information sharing. The representation of symptoms using grammar provides a novel way for the resource-efficient encoding of disease diagnoses. Initially, symptoms are represented as strings, and, in terms of grammar, this is called a sentence. Moreover, the conversion of the generated string containing the symptoms and the diagnostic outcome to a QR code post encryption makes it portable. The code can be stored in a mobile application, in a secure manner, and can be scanned wherever required, universally. The patient can carry the medical condition and the diagnosis in the form of the QR code for medical consultations. This research work presents a case study based on two diseases, influenza and coronavirus, to highlight the proposed methodology. Both diseases have some common and overlapping symptoms. The proposed system can be implemented for any kind of disease detection, including clinical and diagnostic imaging. Full article
(This article belongs to the Section Biosignal Processing)
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17 pages, 955 KiB  
Review
Software as a Medical Device (SaMD) in Digestive Healthcare: Regulatory Challenges and Ethical Implications
by Miguel Mascarenhas, Miguel Martins, Tiago Ribeiro, João Afonso, Pedro Cardoso, Francisco Mendes, Hélder Cardoso, Rute Almeida, João Ferreira, João Fonseca and Guilherme Macedo
Diagnostics 2024, 14(18), 2100; https://doi.org/10.3390/diagnostics14182100 - 23 Sep 2024
Cited by 6 | Viewed by 2903
Abstract
The growing integration of software in healthcare, particularly the rise of standalone software as a medical device (SaMD), is transforming digestive medicine, a field heavily reliant on medical imaging for both diagnosis and therapeutic interventions. This narrative review aims to explore the impact [...] Read more.
The growing integration of software in healthcare, particularly the rise of standalone software as a medical device (SaMD), is transforming digestive medicine, a field heavily reliant on medical imaging for both diagnosis and therapeutic interventions. This narrative review aims to explore the impact of SaMD on digestive healthcare, focusing on the evolution of these tools and their regulatory and ethical challenges. Our analysis highlights the exponential growth of SaMD in digestive healthcare, driven by the need for precise diagnostic tools and personalized treatment strategies. This rapid advancement, however, necessitates the parallel development of a robust regulatory framework to ensure SaMDs are transparent and deliver universal clinical benefits without the introduction of bias or harm. In addition, the discussion highlights the importance of adherence to the FAIR principles for data management—findability, accessibility, interoperability, and reusability. However, enhanced accessibility and interoperability require rigorous protocols to ensure compliance with data protection guidelines and adequate data security, both of which are crucial for effective integration of SaMDs into clinical workflows. In conclusion, while SaMDs hold significant promise for improving patients’ outcomes in digestive medicine, their successful integration into clinical workflow depends on rigorous data protection protocols and clinical validation. Future directions include the need for adequate clinical and real-world studies to demonstrate that these devices are safe and well-suited to healthcare settings. Full article
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