Search Results (273)

This paper examines the philosophy of language in The Platform Sutra of the Sixth Patriarch (六祖壇經), demonstrating its centrality to Zen Buddhism and Buddhist sinicization. The sutra emphasizes the ineffability of ultimate truth (至道無言) and the principle that words falter in encapsulating the Dao (言語道斷), framing language as a provisional “raft” (筏) that must be instrumentalized yet transcended through a dialectic of employing and abandoning (用離辯證). It ontologically grounds this view in Buddha-nature’s (佛性) pre-linguistic essence, advocating transcending reliance on words and letters (不假文字) while strategically deploying language to dismantle its own authority. Historically, this constituted a revolt against Tang scholasticism’s textual fetishism. The text adopts a dynamic dialectic, neither clinging to nor rejecting language, exemplified by Huineng’s awakening through the Diamond Sutra, where recitation catalyzes internal insight. Operationally, it utilizes negational discourse, the “Two Paths Mutually Condition” method (二道相因) embedded in the “Twelve Pairs of Dharmic Forms” (法相語言十二對) in particular, to systematically deconstruct dualisms, while promoting embodied unity of speech, mind, and action (口念心行) to critique empty recitation. Ultimately, the sutra orchestrates language as a self-subverting medium: balancing acknowledgment of its limitations with pragmatic instrumentality, it presents an Eastern paradigm where language actively disrupts conceptual fetters to facilitate direct insight into Buddha-nature, reframing it as a dynamic catalyst for “illuminating the mind and seeing one’s nature” (明心見性). Full article

When scholars view characters in King Lear through a Machiavellian lens, they read Edmund, Goneril, and Regan as stock Machiavels. In contrast, they often perceive Cordelia, Kent, and Edgar as selfless, apolitical characters. This essay argues that the latter characters are more complicated and politically adroit than they are often judged to be. They are Machiavellian as well, but Shakespeare conceives them within a more appreciative view of the concept of realpolitik. This essay explains the characters’ strategies by relating them to Machiavelli’s tenets of achieving and maintaining political power. The central quandary of the play is the lack of a male heir to the throne. Cordelia attempts to solve the problem by marrying the King of France for political reasons. She has an alliance with Kent, who helps her to justify her invasion of her homeland with French forces. Once the plans for a surprise attack go awry, Cordelia does not follow Machiavellian strategies and is consequently killed. Ironically, Edgar is as ambitious as Edmund, whom he lets plot against his father and bring about Gloucester’s slow decline so as to inherit his father’s fortune while Edmund incurs the blame for his father’s demise. Like Kent, he enlists a disguise for self-advancement. The most adroit Machiavellian characters—Edgar, Kent, and the King of France—all survive through chicanery and cunning. Shakespeare illustrates that secular methods of governorship defeat the old world of divine politics. Full article

Background/Objectives: Breast cancer tumors possess intratumoral heterogeneity (ITH), which is associated with therapeutic resistance. Tumors with high ITH exhibit human epidermal growth factor receptor 2 (HER2) heterogeneity, affecting the effectiveness of HER2-targeted therapies. Our recent study identified HER2 ITH as an independent prognostic factor for poor outcomes in HER2-positive breast cancer. We here investigated the association between HER2 ITH and anti-HER2 neoadjuvant chemotherapy (NAC) resistance. Methods: This study included 97 patients with primary HER2-positive breast cancer treated with anti-HER2 NAC. Breast tumor samples were obtained from vacuum-assisted breast biopsy before NAC. HER2 gene amplification was assessed using fluorescence in situ hybridization (FISH), and HER2 gene copy number histograms were generated. Using the Gaussian mixture model, histogram data were analyzed and categorized into the high (HH) and low HER2 heterogeneity (LH) groups. The association between HER2 ITH and treatment response was evaluated using the pathological complete response (pCR) rate. Results: Of the 97 patients, 18 (18.6%) and 79 (81.4%) were classified into the HH and LH groups, respectively. The pCR rate in the HH group was significantly lower at 28% (5/18) than that in the LH group at 65% (51/79) (p < 0.01). Multivariate analysis of pathological parameters revealed that the most significant predictor of pCR rate was HER2 ITH (p = 0.02). Conclusions: HER2 ITH assessment may be valuable in predicting therapeutic outcomes in HER2-positive breast cancer. Our novel approach of the HER2 ITH method using FISH histograms could serve as a useful tool for predicting anti-HER2 NAC resistance. Full article

The hypercube $Q_n$ is a well-known and efficient interconnection network. Ruskey and Savage posed the following question: does every matching in a hypercube $Q_n$ for $n\ge 2$ extend to a Hamiltonian cycle? Fink addressed this by proving that every perfect matching extends to a Hamiltonian cycle in $Q_n$, thereby resolving Kreweras’ conjecture. Ruskey and Savage’s problem is still open and has been proven only for small matchings. An edge of $Q_n$ is an i-edge when the binary representations of its endpoints differ at the ith coordinate. In this paper, we consider $Q_n$ for $n\ge 3$ and show that any matching consisting of edges of at most six types, which does not cover every pair of vertices at a distance of 3, extends to a Hamiltonian cycle. Full article

The amount of space provided to laying hens has been an animal welfare topic of concern from consumers, special interest groups, and lawmakers. The freedom to perform normal behaviors is one component of animal welfare, and, therefore, the objective of this study was to assess behavior at different stocking densities. Shaver White laying hens were housed in colony cages at five stocking densities. Video recordings of three cages/treatment were taken at 30, 46, and 62 weeks of age in the morning, afternoon, and night. At each age, a 20 min segment of video from each time of day was analyzed. Every minute was annotated to identify the behavior that hens spent the majority of their time performing. Data were averaged to calculate the percentage of hens engaged in each behavior per cage. The total count of aggressive bouts was recorded across the 20 min period. Data were analyzed with a general linear model utilizing the variables time of day, density, age, and the full factorial of interactions. Intermediate stocking densities displayed the lowest percentage of crouching (p = 0.009) and aggressive acts per hen (p < 0.0001). Hens stocked at 1341.93 cm² walked the most (p < 0.0001). Hens were seen standing and preening (p < 0.0001) more in the morning, crouching and sham dust bathing (p < 0.0001) more in the afternoon, stretching less while feeding and drinking, and being more aggressive at night (p < 0.0001). Finally, as hens aged, they began to stand and crouch more (p < 0.0001) and preen (p = 0.013), walk (p < 0.0001), and demonstrate aggressive behaviors (p = 0.007) less. In conclusion, the majority of behaviors assessed were not influenced by stocking density. However, the different amounts of aggression between the treatments could indicate higher stress and frustration, which warrants more investigation. Full article

Tumor diseases are characterized by high interindividual and intratumoral heterogeneity (ITH). The development and progression of neoplasms outline complex networks of extracellular and cellular signals that have yet to be fully elucidated. This narrative review provides a comprehensive overview of the literature related to the cellular and molecular mechanisms underlying the heterogeneity of the tumor mass. Furthermore, it examines the possible role of the tumor microenvironment in the development and support of the neoplasm, in order to highlight its potential in the construction of a diagnostic–therapeutic approach to precision medicine. Many authors underline the importance of the tumor microenvironment (TME) as it actively takes part in the growth of the neoplastic mass and in the formation of metastases and in the acquisition of resistance to anticancer drugs. In specific body districts, the ideal conditions occur for the TME establishment, particularly the inflammatory state, the recruitment of cell types, the release of specific cytokines and growth factors, hypoxic conditions. These components actively intervene by enabling tumor progression and construction of physical barriers shaped by the extracellular matrix that contribute to forming peripheral tolerance by intervention of myeloid precursors and the polarization of M2 macrophages. In recent years, ITH and the TME have assumed an important position in cancer research and pharmacology as they enable understanding the dense network of communication existing between the neoplasm and the surrounding environment, and to monitor and deepen the effects of drugs with a view to develop increasingly precise and effective therapies. In the last decade, knowledge of TME has been exploited to produce targeted molecular agents (inhibitory small molecules, monoclonal antibodies, gene therapy). Nonetheless, the bibliography shows the need to study ITH through new prognostic and predictive biomarkers (e.g., ctDNA and CTCs) and to increase its basic biology knowledge. Precision medicine is a new opportunity in the treatment of oncological diseases that is transforming the development of new drug approaches and their clinical use. Biology and biotechnologies are providing the bases for this revolution. Full article

Meme studies that evaluate specific media characters are growing in popularity, and with the twenty-fifth anniversary of The Mummy (1999) in 2024, the scholarly gap involving memes related to The Mummy narratives became apparent. This article, therefore, focuses on memes depicting the character of Evelyn “Evie” Carnahan, who has been played by Rachel Weisz and Maria Bello. Through the analysis, which takes librarianship and gender perspectives due to Evie’s character, four meme categories emerge: (1) general librarian stereotypes, (2) the ‘dangerous/harmful book’ trope, (3) gender issues, and (4) the choosing of the ’real’ (better) Evie. This study finds that the professional and personal issues experienced by Evie in the films—and in the memes—are the same ones that remain problematic for women, librarians, and female librarians in the contemporary world. Moreover, rather than trying to choose between Evies, it is more useful to interpret Weisz’s and Bello’s renderings as critical parts of a whole—a complete woman, librarian, scholar, and adventurer—especially since both iterations of the character face stereotypes involving gender, maternal status, and career aspects. Full article

This study examines the symbolic ambiguity of Buddhist robes in the Heian period, focusing particularly on their representation in The Tale of Genji. While Buddhist monastic garments traditionally signify religious renunciation, they also functioned as fashion items regulated by strict social norms. Through an analysis of Heian-era dress codes and deviations from them, as well as literary portrayals of robes associated with ordination scenes, this study reveals that robes embodied not only religious aspirations but also worldly attachments. Literary depictions highlight the tension between formal religious identity and persistent human desires, demonstrating how Buddhist robes served not only as religious symbols but also as mediators between spiritual ideals and secular emotions. By examining robes as visual and emotional media within a broader cultural and historical framework, this paper argues that Buddhist robes during the Heian period symbolized the complex intersection of salvation and desire. Ultimately, this study sheds light on how religious symbols, rather than representing pure spiritual transcendence, reveal the enduring contradictions inherent in human nature. Full article

In the period between 2021 and 2022 immediately following the COVID-19 lockdowns, there were 37 professional or academic productions of The Tempest in the United States. The play was by far the most produced of Shakespeare’s works in this timespan, and those 37 productions represent a 280% increase compared to 2019, in which there were 13 such productions. Considering The Tempest’s hyper-popularity within the context of the Black Lives Matter Movement and the birth of We See You White American Theatre’s calls for reform in 2020, this paper seeks to understand anew the way in which Shakespeare constructs blackness in the play. Indeed for all of its beauty and magic, The Tempest stages a violent anti-blackness in its treatment of Caliban. In particular, I argue an unexplored connection between The Tempest and Ben Jonson’s 1605 court masque, The Masque of Blackness, itself an exploration of the construction of race for a particular early modern audience. My exploration here began as a partial answer to a question posed by Robin Alfriend Kello: “how do you balance [an] attraction to the richness of Shakespearian verse against these layered histories of racial violence and exclusion?” A deeper understanding of Shakespeare’s version of blackness may grant insights into areas of intervention for those theaters reaching for The Tempest amidst national calls for anti-racist theatrical work. Full article

Novels, which take shape in imaginary worlds, are closely connected to life and reality. Psychiatric disorders also belong to life and reality and are part of the content of literary works. Authors sometimes make use of mental disorders to tell a story or to give depth to fiction. Such disorders, which started to be seen in Turkish literature in the novels of the Tanzimat period, play particularly dramatic roles in texts produced after the 1960–1970s. Psychological disorders include dissociative disorders, one type of which is multiple personality disorder. The person experiencing this type of dissociation develops two or more independent personality systems in response to feelings of anxiety. One of the most important works of recent Turkish literature, Nermin Yıldırım’s Saklı Bahçeler Haritası (The Hidden Gardens Map), first published in 2013, is a novel in which multiple personality disorder plays a significant role. This study attempts to determine how the defining criteria and symptoms of multiple personality disorder are exhibited in the aforementioned novel and how its effects and related issues are conveyed to the reader. Full article

This article proposes a close reading of Rivers Solomon’s 2019 novella The Deep, a recent eco-story about water, memory, and survival. Solomon’s work is inspired by a song called “The Deep” from experimental hip-hop group clipping, a dark science fiction tale about the underwater-dwelling descendants of African women thrown off slave ships during the Middle Passage. This imaginative alternate history, or counter-mythology, was invented by the Detroit techno band Drexciya, which, in a series of releases between 1992 and 2002, tells us the story of an underwater realm in the mid-Atlantic, where merpeople and their descendants establish a utopian society in the sea, free from the war and racism on the surface. My analysis uses Saidiya Hartman’s “critical fabulation” to make productive sense of the gaps in the archive of trans-Atlantic slavery that silence the voices of enslaved women, listening to the voices of water to imagine not only what was but also what could be. Moreover, this article examines The Deep through a trajectory that moves from the ocean as a space that reproduces death only to the ocean as a generative force for posthuman and multispecies kinship. Using Black hydrocriticism, hydrofeminism, and econarratology, I will argue that this transition is made possible by the “despatialization” of the ocean—a concept introduced by Erin James—where the ocean is conceived not as a fixed or stable environment, but as a space in constant flux, defying stability, and the subsequent immersion in its waters. Full article

Literary works of contemporary Australian Aboriginal writers are widely read for their engagement with expressions of resilience and resistance against colonial supremacy. But these works have a greater significance in modern times, as they carry forward the Aboriginal cultural traditions of caring for the country (an Aboriginal concept that comprises people, their culture, and all living and non-living entities in a place, including the land) and in vocalising the concerns that arise from grief for the loss of the natural environment. This paper investigates how Alexis Wright, in her postmillennial novels Carpentaria (2006) and The Swan Book (2013), redefines dominant ethical and aesthetic frameworks and tries to delineate ecoethics in these novels through a critical analysis of the representation of relationality and interconnectedness between Aboriginal people and their natural environment. By exploring the Aboriginal belief system as represented in the texts and its role in shaping Aboriginal environmental values, this paper argues that Carpentaria and The Swan Book embody ecoethics and offer a reimagining of deep ecological perspectives in contemporary literature. Full article

It is necessary for the allocation of resources to be more efficient, and making more adequate operational strategies to realize productivity change is contributed to by the kind of output sources in the hotel’s production process. This study tries to propose hotel productivity change models from overall and disaggregate perspectives by using the Luenberger productivity index based on directional distance function. Empirical findings briefly show that the overall productivity change of ITHs in Taiwan has a growing trend and is driven from a technical change rather than an efficiency change. Moreover, the disaggregate hotel productivity growth comes from the service of hotel facilities, but improving the performance of the catering service is more important to a hotel’s overall performance. Individual ITHs can grasp the contribution of disaggregate hotel productivity growth on the overall productivity change, maintaining or developing competitive advantages in the hotel’s operation and management. Therefore, the viewpoint of this study can not only be used to examine the hotel issues but also be applied to other issues in the hospitality and tourism industry that target overall and disaggregate productivity growth. Full article

The Help, winner of the 2009 Exclusive Books Boeke Prize, is the debut novel of American author Kathryn Stockett. Taking Jacques Derrida’s “Politics of Friendship” as the major theoretical framework, this research examines the transformation from the white community and the Black community to the trans-racial community through the emotional interaction between white mistresses and Black maids. The distinctively exclusive white community perpetuates racial discrimination and confronts Black others with hostility, while the racially injured Black people can only seek mutual refuge and friendly affection in the Black community. On the surface, the white community and the Black community are antagonistic. However, the racist system has entangled the emotions and fates of the three protagonists with different identities. In the book, when the Black people open their hearts to tell their stories and gain support and trust within the community, white people not only witness social injustice, but also unconditionally assume responsibility for the “other” when facing Black “others”. Based on the “law of unconditional love”, the novel breaks through the inherent limitations based on race, class, geography, etc., and calls for the advent of the politics of friendship and the formation of trans-racial communities. Full article

This study examines how the Japanese writer Furui Yoshikichi engages with Western mystical experiences, particularly through his reading of Martin Buber’s Ecstatic Confessions and his broader engagement with Meister Eckhart and medieval German mysticism. Furui’s literary inquiry revolves around the inherent tension between the ineffability of mystical experiences and their articulation through language. He critically engages with the paradox of verbalization, recognizing that while mystical experiences transcend linguistic and temporal boundaries, they nevertheless achieve resonance through written and spoken expressions. His reflections converge with Buddhist notions of Sūnyatā, underscoring intersections between Eastern and Western spiritual traditions. Drawing upon his background as a translator of German literature, Furui mediates mystical experiences within a comparative framework, navigating cultural and linguistic boundaries. His approach elucidates the concept of the multiplicity of qualities in mystical experiences, demonstrating particularity and universality simultaneously. By analyzing Furui’s interpretation of mystical texts, this study contributes to broader discussions on the limitations of language in conveying transcendence and the role of literary imagination in rendering the ineffable. Full article