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Keywords = heteromeric TRP assemblies

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20 pages, 1619 KB  
Review
Heteromeric TRP Channels in Lung Inflammation
by Meryam Zergane, Wolfgang M. Kuebler and Laura Michalick
Cells 2021, 10(7), 1654; https://doi.org/10.3390/cells10071654 - 1 Jul 2021
Cited by 25 | Viewed by 5059
Abstract
Activation of Transient Receptor Potential (TRP) channels can disrupt endothelial barrier function, as their mediated Ca2+ influx activates the CaM (calmodulin)/MLCK (myosin light chain kinase)-signaling pathway, and thereby rearranges the cytoskeleton, increases endothelial permeability and thus can facilitate activation of inflammatory cells [...] Read more.
Activation of Transient Receptor Potential (TRP) channels can disrupt endothelial barrier function, as their mediated Ca2+ influx activates the CaM (calmodulin)/MLCK (myosin light chain kinase)-signaling pathway, and thereby rearranges the cytoskeleton, increases endothelial permeability and thus can facilitate activation of inflammatory cells and formation of pulmonary edema. Interestingly, TRP channel subunits can build heterotetramers, whereas heteromeric TRPC1/4, TRPC3/6 and TRPV1/4 are expressed in the lung endothelium and could be targeted as a protective strategy to reduce endothelial permeability in pulmonary inflammation. An update on TRP heteromers and their role in lung inflammation will be provided with this review. Full article
(This article belongs to the Collection The Endothelial Cell in Lung Inflammation)
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