Search Results (32)

Fascination with the unknown has always characterized humanity. This includes creation of mythical creatures that are believed to exist even though fully unproven. Fabricating monsters began to peak in early modern Europe. Sixteenth-century monsters were among the earliest documented, often with printed leaflets that displayed such creatures. This monster tradition began to flourish, both in scientific and popular form including human, animal and hybrid monsters. One of the most famous products of the time was the Monster of Ravenna, inspired by a malformed human birth in 1512, Italy. Due to a lack of understanding of teratology, animal and, indeed, even human birth defects were mischaracterized and used as tools to support the validity of monsters for political agendas. Animals have been an ongoing part of these and other mythical conceptualizations, sometimes of the divine, sometimes of the demonic. This article considers appearance of human- and animal-based fictional monsters in early modern Europe with some later repercussions. Full article

This paper provides a comprehensive review of the structural features and biomechanical functions of modern passive and semi-active knee prostheses, followed by comparative analysis. Based on findings from scientific literature and engineering practice, a new conceptual knee prosthesis was developed using a modular design approach. The proposed structure was modeled in SolidWorks, and its kinematic behavior and structural integrity were quantitatively evaluated through finite element analysis (FEA). The knee module was specifically designed to integrate with previously developed ankle and foot prosthetic components via an adapter interface. This modular approach allows the prosthesis to be configured according to the individual clinical needs of the patient. Simulation results confirmed that the proposed design meets the requirements for motion accuracy and structural reliability. In future work, the physical prototype will be manufactured using 3D printing with PLA plastic as an initial test material, followed by fabrication with high-strength engineering plastics or metal alloys. This study represents a critical early step toward the development of a fully functional, adaptive lower-limb prosthetic system. Full article

Early printed books, particularly incunabula, are invaluable archives of the beginnings of modern educational systems. However, their complex layouts, antique typefaces, and page degradation caused by bleed-through and ink fading pose significant challenges for automatic transcription. In this work, we present a modular pipeline that addresses these problems by combining modern layout analysis and language modeling techniques. The pipeline begins with historical layout-aware text segmentation using Kraken, a neural network-based tool tailored for early typographic structures. Initial optical character recognition (OCR) is then performed with Kraken’s recognition engine, followed by post-correction using a fine-tuned ByT5 transformer model trained on manually aligned line-level data. By learning to map noisy OCR outputs to verified transcriptions, the model substantially improves recognition quality. The pipeline also integrates a preprocessing stage based on our previous work on bleed-through removal using robust statistical filters, including non-local means, Gaussian mixtures, biweight estimation, and Gaussian blur. This step enhances the legibility of degraded pages prior to OCR. The entire solution is open, modular, and scalable, supporting long-term preservation and improved accessibility of cultural heritage materials. Experimental results on 15th-century incunabula show a reduction in the Character Error Rate (CER) from around 38% to around 15% and an increase in the Bilingual Evaluation Understudy (BLEU) score from 22 to 44, confirming the effectiveness of our approach. This work demonstrates the potential of integrating transformer-based correction with layout-aware segmentation to enhance OCR accuracy in digital humanities applications. Full article

This paper investigates how the layout strategies of Xuanying’s Yiqiejing yinyi (mid-7th c.), the earliest surviving Chinese Buddhist glossary, evolved across manuscripts, Buddhist Canon editions, and Qing-era scholarly reprints from the 7th to 19th centuries. While Xuanying’s work serves as the central case due to its breadth of preservation and representativeness, this study also references Huiyuan’s glossary (early-8th c.) to highlight broader patterns of reception and adaptation, particularly in late imperial China. Through a usability–production efficiency framework, the study identifies a continuum from the flexible manuscript layouts to the standardized double-line format used in Buddhist woodblock printing, and later to Qing-era adaptations that integrated Buddhist glossaries into evidential studies. It argues that layout decisions were influenced not merely by practical considerations of use and production but also by changing conceptions of textual function and authority. It also highlights the unintended effects of layout standardization, which at times introduced new interpretive complexities. By demonstrating how layout actively influenced the reproduction and reception of Buddhist glossaries, this study offers a new perspective on the intersection of materiality, textual transmission, and reading practices in pre-modern China. Full article

Artificial Intelligence (AI) is rapidly transforming orthodontic care by providing personalized treatment plans that enhance precision and efficiency. This narrative review explores the current applications of AI in orthodontics, particularly its role in predicting tooth movement, fabricating custom aligners, optimizing treatment times, and offering real-time patient monitoring. AI’s ability to analyze large datasets of dental records, X-rays, and 3D scans allows for highly individualized treatment plans, improving both clinical outcomes and patient satisfaction. AI-driven aligners and braces are designed to apply optimal forces to teeth, reducing treatment time and discomfort. Additionally, AI-powered remote monitoring tools enable patients to check their progress from home, decreasing the need for in-person visits and making orthodontic care more accessible. The review also highlights future prospects, such as the integration of AI with robotics for performing orthodontic procedures, predictive orthodontics for early intervention, and the use of 3D printing technologies to fabricate orthodontic devices in real-time. While AI offers tremendous potential, challenges remain in areas such as data privacy, algorithmic bias, and the cost of adopting AI technologies. However, as AI continues to evolve, its capacity to revolutionize orthodontic care will likely lead to more streamlined, patient-centered, and effective treatments. This review underscores the transformative role of AI in modern orthodontics and its promising future in advancing dental care. Full article

Recent development of methodologies based on digital twins through 3D scanning and 3D printing has increased over the past decade, offering new possibilities in manufacturing, production and scaling of models’ applications. However, there are few examples of the application of model digitization technologies for the restoration of ceramic-built heritage by means of 3D modelling. That is why this research focuses on the application of these advanced methodologies to the recovery of architectural ceramic ornamental objects in heritage buildings. Deteriorated ceramic pieces are selected and scanned during field campaigns using 3D scanning technology in early 20th century heritage sites in Seville (Spain). The aim is to create accurate replicas of these damaged objects by 3D printing with clay using non-invasive techniques. The study stands out for its practical approach and its implications for the conservation of built cultural heritage. The results proved effective for replacing lost or damaged elements in a heritage context. Once the investment in the necessary equipment and technologies has been made, the use of clay as a material for 3D printing not only proves feasible but also offers advantages in terms of cost and time savings for repairs compared to traditional restoration techniques. In the present investigation the production time of similar pieces using 3D printing took 6.3–10.9 h while traditional methods take over a week. The application of these technologies represents an advancement in integrating modern methods into cultural heritage conservation, opening new possibilities for the preservation of history and art worldwide. Full article

Early-stage knee osteoarthritis is often suitable for treatment with high tibial osteotomy (HTO). This is an effective joint-preserving treatment, resulting in good postoperative outcomes. To overcome the limitations of traditional HTO, the surgical technique and correction accuracy can be enhanced by personalised procedures using three-dimensional digital planning and metal additive manufacturing, The purpose of this clinical trial study was to evaluate the three-dimensional accuracy of a new personalised HTO procedure, using modern imaging techniques, 3D modelling, and distance map analysis (DMA). Twenty-five patients were treated with the personalised HTO procedure. Before surgery and after 6 months, they underwent clinical evaluation scoring, radiographic imaging, and computed-tomography scanning to generate morphological models. Specifically, preoperative tibia models were used to plan the tibia correction and the design and position of the fixation plate. Preoperative, planned, and postoperative models were imported in computer-aided and designing software (Geomagic ControlTM 2014, 3D Systems, Rock Hill, SC, USA) for DMA implementation to assess geometrical differences between model surfaces. A very good reproduction of the planned tibia morphology was achieved postoperatively (average differences between −0.9 mm and 1.4 mm). DMA values associated with fixation-plate deformation were less than 1 mm, similar to those for plate-to-tibia surface-contour matching. Overall, personalised digitally planned HTO utilising three-dimensional printed surgical guides and plates enables accurate planned correction and plate placement. Full article

Fabrication aspects of PdO thin films and coatings are reviewed here. The work provides and organizes the up-to-date information on the methods to obtain the films. In recent years, the interest in Pd oxide for different applications has increased. Since Pd can be converted into PdO, it is instructive to pay attention to the preparation of the pure and the alloyed Pd films, heterostructures, and nanoparticles synthesized on different substrates. The development of PdO films is presented from the early reports on coatings’ formation by oxidation of Pd foils and wires to present technologies. Modern synthesis/growth routes are gathered into chemical and physical categories. Chemical methods include hydrothermal, electrochemical, electroless deposition, and coating methods, such as impregnation, precipitation, screen printing, ink jet printing, spin or dip coating, chemical vapor deposition (CVD), and atomic layer deposition (ALD), while the physical ones include sputtering and cathodic arc deposition, laser ablation, ion or electron beam-induced deposition, evaporation, and supersonic cluster beam deposition. Analysis of publications indicates that many as-deposited Pd or Pd-oxide films are granular, with a high variety of morphologies and properties targeting very different applications, and they are grown on different substrates. We note that a comparative assessment of the challenges and quality among different films for a specific application is generally missing and, in some cases, it is difficult to make a distinction between a film and a randomly oriented, powder-like (granular), thin compact material. Textured or epitaxial films of Pd or PdO are rare and, if orientation is observed, in most cases, it is obtained accidentally. Some practical details and challenges of Pd oxidation toward PdO and some specific issues concerning application of films are also presented. Full article

This article examines the life, theological career, exegetical development, and posthumous biographies of Johannes Oecolampadius as illustrative examples of the fact that the Swiss Reformation, with all its religious movements, was far from a uniform concept in terms of its origins, purposes, and methodologies. The article explains through Oecolampadius’s example an approach to reform that was ‘in progress’, traversing the nexuses of disparate methods and exegetical priorities. Oecolampadius’s experience occupied a position at the intersection between the authority of Patristics and the principle of sola scriptura, exemplifying a balance between the past and the present of Christian tradition. The path that led Oecolampadius to become a Protestant Reformer is characterised by a gradual transition, not abrupt, not radical. His example demonstrates the methodological and ideological diversity of the Reformation, which can be observed through the prism of a single life and its intellectual periods. His conversion offers insight into how these varied approaches shaped personal engagements with Scripture, and challenges the notion of an immediate or singular evangelical ‘calling’ or ‘conviction’. This article examines a specific phase within the broader and varied trajectory of the Swiss Reformation by analysing the transformation of Oecolampadius from a biblical scholar to a preacher, and eventually to a Reformer. This case study illustrates how disparate methodologies, whether rooted in humanism or Patristics, contributed to gradual and personal evolution, ultimately giving rise to distinctive individual stances on reform. This article presents a synthesis of three distinct perspectives on the question. The first part approaches the question through the lens of church history and intellectual history; the second one utilises the history of exegesis and New Testament scholarship; and the third draws upon the perspectives of Protestant historiography, from the standpoint of social history and the history of biographies in Early Modern times. Full article

In 1606 Henry Garnet, provincial of the English Jesuits and purported co-conspirator in the Gunpowder Plot against James I, was executed at St. Paul’s Cathedral in London. Following his death, accounts of miracles occurring at his execution began to spread throughout England, including an account of a relic bearing his miraculous image. While Catholic writers promoted these accounts as evidence of Garnet’s innocence, Protestant contemporaries argued that Garnet was an illegitimate martyr and that his commemoration was evidence of Catholic support for regicide. This article demonstrates how London Protestant writers and publishers utilized anti-hagiographical arguments to intervene in attempts to promote Garnet’s sainthood, counter claims about the veracity of his relic, and shape his legacy in the decades following his execution. Full article

This study provides a brief discussion of the major nanopharmaceuticals formulations as well as the impact of nanotechnology on the future of pharmaceuticals. Effective and eco-friendly strategies of biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) are outlined. This paper discusses the need to use natural resources for the “green” design of new nanoformulations with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, and the preparation of nanomaterials must be carefully considered. Therefore, safety and long-term effects of pharmaceutical nanoformulations must not be overlooked. The testing of nanopharmaceuticals represents an essential point in their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent a valuable, bioinspired model for nanopharmaceutical testing that avoids using animals. Nanoformulations are critical in various fields, especially in pharmacy, medicine, agriculture, and material science, due to their unique properties and advantages over conventional formulations that allows improved solubility, bioavailability, targeted drug delivery, controlled release, and reduced toxicity. Nanopharmaceuticals have transitioned from experimental stages to being a vital component of clinical practice, significantly improving outcomes in medical fields for cancer treatment, infectious diseases, neurological disorders, personalized medicine, and advanced diagnostics. Here are the key points highlighting their importance. The significant challenges, opportunities, and future directions are mentioned in the final section. Full article

Virtual reality (VR) technology has attracted the attention of architectural practitioners due to its ability to allow people to interact with proposed design elements through unique and immersive experiences. This study aims at providing a bottom-up decision-making approach, using VR technology for inhabitant engagement in the design process of historic urban district renovation to preserve local culture, improve community interaction, and replace printed paper use for review. The study focuses on the Tangzixiang district in the Anhui province, providing Scheme 1 with a traditional architectural style and Scheme 2 with a modern architectural style for the renovation. The schemes are developed in a VR environment in both smooth movement mode and node-based movement mode. A total of 62 inhabitants and 10 architecture practitioners finished the VR experience, and the survey-based results indicate that VR quality can satisfy the requirements of practitioners in a professional review. In the inhabitants’ view, Scheme 1, with a traditional architectural style, is identified as being more effective in preserving local culture. The scheme is improved by the design studio after the survey, based on the questionnaire results and comments. Notably, 56 participants scored five, indicating their agreement with the notion that VR enhances their engagement in the design stage. The effectiveness of the VR technology in the bottom-up decision-making process has proven to offer inhabitants opportunities to participate. This study demonstrates how this level of immersive experience in VR environments has the potential to be applied in more projects, aiding clients in better understanding design intent and helping them make more informed decisions early in the design process. Full article

Mastering a colour—as such, its ‘domestication’—involves a weft of technological and symbolic relationships encompassed in the human ability to reproduce a visible colour using the techniques of textile dyeing. The Regimento dos panos or Regimento dos trapeiros (‘regulation of fabrics’ or ‘regulation of drapers’), published in 1573 and expanded in 1690, is a document made up of 107 chapters aiming to standardise the various stages of the production chain of woollen goods in Portugal. In the sections relating to the finishing of fabrics, the regulation carefully details the dyeing of the colour black. The main aim of this text is to discuss the four recipes presented in that document. The system presupposed a phase exogenous to the rules, since the fabrics had to be previously dyed blue (‘celestial blues’) by means of successive immersions of the cloth in a vat with indigo. The dyeing itself was achieved by mixing mordants and auxiliaries (alum, tartar, iron sulphate, and tannins) with a red dye (madder). The main conclusion is that the formulae presented do not constitute, in their general principles, a characteristic Portuguese methodology. In addition, the article includes an inventory of the raw materials used for dyeing in the Early Modern Age, produced, through a qualitative method, through cross-reference with other manuscript and printed sources, as well as an interpretation of their social and economic importance, and a systematisation of the types of Portuguese wools. Full article

(1) Background: Polymeric heart valves are prostheses constructed out of flexible, synthetic materials to combine the advantageous hemodynamics of biological valves with the longevity of mechanical valves. This idea from the early days of heart valve prosthetics has experienced a renaissance in recent years due to advances in polymer science. Here, we present progress on a novel, 3D-printable aortic valve prosthesis, the TIPI valve, removing the foldable metal leaflet restrictor structure in its center. Our aim is to create a competitive alternative to current valve prostheses made from flexible polymers. (2) Methods: Three-dimensional (3D) prototypes were designed and subsequently printed in silicone. Hemodynamic performance was measured with an HKP 2.0 hemodynamic testing device using an aortic valve bioprosthesis (BP), a mechanical prosthesis (MP), and the previously published prototype (TIPI 2.2) as benchmarks. (3) Results: The latest prototype (TIPI 3.4) showed improved performance in terms of regurgitation fraction (TIPI 3.4: 15.2 ± 3.7%, TIPI 2.2: 36.6 ± 5.0%, BP: 8.8 ± 0.3%, MP: 13.2 ± 0.7%), systolic pressure gradient (TIPI 3.4: 11.0 ± 2.7 mmHg, TIPI 2.2: 12.8 ± 2.2 mmHg, BP: 8.2 ± 0.9 mmHg, MP: 10.5 ± 0.6 mmHg), and effective orifice area (EOA, TIPI 3.4: 1.39 cm², TIPI 2.2: 1.28 cm², BP: 1.58 cm², MP: 1.38 cm²), which was equivalent to currently used aortic valve prostheses. (4) Conclusions: Removal of the central restrictor structure alleviated previous concerns about its potential thrombogenicity and significantly increased the area of unobstructed opening. The prototypes showed unidirectional leaflet movement and very promising performance characteristics within our testing setup. The resulting simplicity of the shape compared to other approaches for polymeric heart valves could be suitable not only for 3D printing, but also for fast and easy mass production using molds and modern, highly biocompatible polymers. Full article

Cultural heritage objects present a special set of challenges for chemical analysis. Often micro-sampling or even contacting the object is deemed an unacceptable risk to the object. This study examined if specular reflection FTIR, a non-sampling and non-contact analytical technique, can provide insight into chemical composition of the layered coatings on Frédéric Flachéron’s paper negatives (1848–1852) in the Harrison D. Horblit Collection of Early Photography, in Houghton Library, at Harvard University. Specular reflection FTIR data confirmed the identification of beeswax and sandarac as the transparentizing media on Flachéron’s paper negatives, as previously published by Lee Ann Daffner. However, specular reflection FTIR analysis also indicated that some negatives had additional localized coatings of orange shellac in specific areas of the images. To understand why Flachéron retouched his negatives with orange shellac, modern experimental replications of the paper negative process were performed. Through modern experimentation with the paper negative technique, it was found that Flachéron’s coatings of shellac served as an integral part of his image-altering technique. The color of the orange shellac subtly alters contrast and density, but it does not mask an area the way an opaque watercolor or highly pigmented paint might. The fine adjustments to the negatives with orange shellac were an attempt to perfect the contrast in the print, and better render depth and detail. These discoveries add to a growing body of recent research that points to the historic and art historic importance of negatives and coatings in photography. The specificity with which specular reflection FTIR was able to nondestructively identify the chemical composition of the local coating, and specifically target the analysis on the areas in which it appeared, allowed for an understanding of Flachéron’s use of local coatings as a retouching method rather than a protective coating. Full article