Search Results (12,401)

Background: During the COVID-19 pandemic, analgesic use increased significantly, primarily due to self-medication for symptom relief. In Brazil, metamizole (dipyrone) is widely used despite international restrictions, highlighting the importance of evaluating its consumption patterns. Objective: To assess analgesic use during the COVID-19 pandemic. Methods: This cross-sectional study was conducted via a household survey in Alegre, Espírito Santo, Brazil. Structured questionnaires were used to collect data on sociodemographic characteristics, clinical conditions, and medication use. Descriptive statistics included frequency distributions, medians, and interquartile ranges. Factors associated with analgesic use were analyzed using Poisson regression with robust variance. Results: Among 694 participants, 31.6% reported using analgesics, with metamizole being the most frequently used (87.2%), followed by acetaminophen (paracetamol) (24.7%). Analgesic use was more common among individuals with polypharmacy, lower self-reported quality of life, better self-perceived health, and recent dental appointments. Conclusions: A high prevalence of analgesic use was identified, particularly of metamizole. Given its over-the-counter availability and growing evidence of risks such as liver injury and other adverse events, ongoing monitoring is essential. These findings underscore the need for public health strategies and pharmacist involvement to promote the rational and safe use of analgesics. Full article

Background: Cultural sensitivity during intrapartum care is a critical determinant of maternal satisfaction and quality of care, particularly in multicultural settings. In Saudi Arabia, the diversity of birthing women underscores the need for midwives to provide culturally competent, respectful, and individualized care. Objective: To assess women’s perceptions of midwives’ cultural sensitivity during intrapartum care in Riyadh, Saudi Arabia, and identify demographic factors influencing these perceptions. Methods: A quantitative cross-sectional study was conducted using a validated cultural sensitivity questionnaire. Data were collected online through purposive sampling from women who had given birth in the past 12 months. Descriptive statistics summarized participant characteristics and perception scores, while inferential tests examined associations between perceptions and demographic variables. Results: women reported moderate to high perceptions of cultural sensitivity. Age and nationality significantly influenced perception scores (p < 0.05). While communication and respect for religious practices scored highest, areas such as shared decision making and language-concordant support were identified as needing improvement. Conclusions: Women in Riyadh often perceive midwives as culturally sensitive; however, gaps remain in communication and involvement in decision making. Training programs that strengthen midwives’ cultural competence—especially in language services and patient engagement—could enhance the intrapartum experience. Full article

Objectives: To analyze, across the periods before, during, and after the implementation of Social Isolation and Distancing Measures (IMDIS): (a) changes in the prevalence of non-communicable chronic diseases (NCDs), stratified by age group in the Brazilian population; and (b) the association between physical inactivity (PI), insufficient moderate-to-vigorous physical activity (MVPA), and sedentary behavior (SB) with the occurrence of these conditions. This cross-sectional study used data from VIGITEL (Brazil’s Surveillance System of Risk and Protective Factors for Chronic Diseases by Telephone Survey), an annual population-based telephone survey conducted across the country. Data were collected in 2019, 2021, and 2023, with a total sample size of 101,226 participants. Arterial hypertension (AH) and diabetes mellitus (DM) were self-reported, and obesity (OB) was diagnosed using body mass index. PI, insufficient MVPA, and SB were identified via VIGITEL indicators. Chi-square tests assessed differences in prevalence overall and by age group. Logistic regression models estimated odds ratios (ORs) for associations between demographic variables, behavioral factors, and the studied periods. The prevalence of AH and DM was highest among individuals over 60 years, reaching 61% after IMDIS, a period when OB also peaked across all age groups. Individuals aged 30–59 and those over 60 had higher odds of AH, DM, and OB across all periods. Female participants had higher ORs for AH and DM both before and after IMDIS. PI and insufficient MVPA were associated with increased odds of AH, DM, and OB in all periods, while SB significantly elevated the OR for OB at all time points. After IMDIS, there was an increase in the prevalence of AH, DM, and OB among older adults and younger individuals. PI, insufficient MVPA, SB, and advanced age were all associated with a greater likelihood of NCDs at every stage of the study. The high post-IMDIS rates of AH, DM, and OB highlight the need for urgent public health strategies. Low-cost programs, such as live videos and online group sessions, should be included in national physical activity guidelines. These initiatives are affordable, aligned with WHO goals, and reduce PI in IMDIS scenarios. Incorporating them into Academia da Saúde and Agita Brasil strengthens NCD prevention and increases the resilience of the health system for future health crises. Full article

Introduction: Understanding adolescent maturational development and its impact on physical and psychological well-being is essential for supporting the academic and professional growth of undergraduate students in Health Sciences programs (Psychology, Medicine, and Nursing). This study aimed to assess and compare self-concept, self-perception, physical activity, and lifestyle among first-year Health Sciences students. Methods: A descriptive cross-sectional study was conducted with first-year students at the University of La Laguna, Tenerife, Spain. Data were collected using the Rosenberg Self-Esteem Scale (RSES), General Health Questionnaire (GHQ-12), Physical Activity Questionnaire for Adolescents (PAQ-A), and Health Behaviour in School-aged Children (HBSC). Variables included sex, age, study program, and body mass index (BMI). Statistical analyses included descriptive statistics, reliability assessment (Cronbach’s alpha), distribution tests, and chi-squared tests. Results: Among 190 participants, the RSES showed generally positive self-esteem, although 75% of students reported low self-confidence. Male Psychology students all scored in the fair range on self-perception. Physical activity was low, particularly among female students, with 20% classified as sedentary. HBSC results indicated the need for lifestyle improvements. SOC-13 scores showed that 80.5% of students had fair levels of sense of coherence. Conclusions: Health Sciences students exhibited low self-concept, emotional distress, sedentary habits, and inadequate lifestyle behaviors. Male Nursing students and female Psychology students had the poorest self-concept scores. The findings emphasize the need for interventions promoting healthy habits and emotional well-being among students entering health-related academic programs. Full article

Accurate prediction of slab temperature during the continuous casting and rolling process is essential for optimizing reheating furnace scheduling and achieving energy savings and emission reductions in steel production. However, because of the dynamic boundary conditions caused by the complex transport processes, obtaining precise temperature data for slabs remains challenging. These difficulties lead to issues such as low hot charging rates, mixing of hot and cold slabs in reheating furnaces, and excessive heat loss from slabs after cutting. To address these challenges, this study develops a mathematical model to calculate slab temperatures during the continuous casting and rolling process, providing a foundation for production scheduling optimization. The model accounts for the coupled heat transfer effects induced by dynamic slab stacking and the stacking heat transfer effects resulting from slabs with varying cross-sectional dimensions. Validation against experimental data demonstrated the model’s accuracy and reliability. Key findings highlighted that neglecting dynamic stacking effects or simplifying slab dimensions introduces errors. These results enhance slab temperature tracking in complex processes and advance related theoretical understanding. Full article

Smallholder irrigation farmers play a vital role in sustaining rural communities in South Africa. However, the performance of smallholder irrigators, both as income generators and job creators, has come under scrutiny in recent years. In Limpopo province, a study was conducted in the Vhembe District using cross-sectional data from 95 independent and 165 public smallholder irrigators, which are privately established farmers and users of government-supported and managed irrigation systems, respectively. Qualitative data were collected through questionnaires, key informant interviews, and group discussions. Quantitative data were analyzed by SPSS version 30 using themes and codes, employing inferential statistical methods such as chi-square and t-tests to assess variables related to agrifood systems, crop selection, and market access. The study found that smallholders predominantly favor the production of grains, vegetables, and horticultural crops, with a statistically significant (p < 0.05) similarity between independent and public irrigators. Public irrigators dominate within irrigation schemes at 64% of the total, with X² of 22.7 with 0.001 p-value. Amongst the groups, the income distribution shows a statistically significant difference in earnings between independent and public irrigators (χ² = 25.83, p < 0.001). Informal and formal markets are accessible and available to 59% of independent irrigators, but 30% of public irrigators only access the informal market (p < 0.001). The major identified challenge across all smallholders is the lack of food value addition and commercial packaging. The study recommends the development of food value addition initiatives, adoption of climate-smart practices, maintenance of infrastructure, and improvement of market access to enhance productivity and sustainability. Full article

Background and Objective: Thyroid cancer (TC) represents the most common group of endocrine tumors, and its incidence has increased over the last four decades. The imbalance of trace elements, such as zinc (Zn), has been investigated due to the thyroid’s sensitivity to these elements. Zn is essential for thyroid hormone action and may be involved in the pathogenesis of TC. This systematic review and meta-analysis aim to contribute to the discussion on the association between low serum Zn concentrations and the occurrence of TC. Materials and Methods: The search was carried out in the PubMed/MEDLINE, Scopus, Embase, LILACS and Web of Science databases, including observational studies published until December 2024. The primary outcome was low serum Zn concentration and the occurrence of TC. Three independent reviewers selected the studies and extracted the data from the original publications. The risk of bias was assessed using the Newcastle–Ottawa Quality Assessment Scale. Data analysis was performed using R software (V.4.3.1), and heterogeneity was calculated using the I² statistic, with results based on random effects models. Results: A total of 10 studies (n = 7 case–control and n = 3 cross-sectional) with sample sizes ranging from 44 to 294 individuals were included. The results indicated that serum Zn levels were not significantly lower in patients with TC compared with healthy controls (mean difference: −251.77; 95% confidence interval: −699.09, 195.54; I² = 100%, very low certainty). Conclusions: Further investigations, including rigorously designed observational studies with representative samples and improved control of potential confounding variables are indispensable. Full article

Although the relationship between risk factors and disease patterns still remains poorly understood, arterial hypertension in climacteric women is a substantial risk factor for multimorbidity. This cross-sectional study analyzed data from 1003 women aged ≥40 years attending Brazilian Basic Health Units to assess multimorbidity (≥2 chronic conditions) and its patterns (cardiometabolic, musculoskeletal, and neuropsychological). An adjusted logistic regression revealed that postmenopausal status (OR: 2.17; 95% CI: 1.05–4.48) and an age of ≥70 years (OR: 2.85; 95% CI: 1.16–6.99) were key risk factors for multimorbidity. Notably, 86% of hypertensive women had multimorbidity, most frequently dyslipidemia (50%), type 2 diabetes (37%), and thyroid disorders (18%). The cardiometabolic pattern (86% prevalence) was strongly associated with hypertension, especially among women aged ≥50 years (OR: 2.10; 95% CI: 1.10–3.98) and those with obesity grade I+ (OR: 2.30; 95% CI: 1.36–3.89). Musculoskeletal disorders were associated with postmenopausal status (OR: 2.41; 95% CI: 1.05–5.51) and obesity (OR: 1.92; 95% CI: 1.08–3.43), while neuropsychological diseases showed no significant associations. These findings highlight that hypertensive climacteric women—especially postmenopausal, older, or those with obesity—face elevated risks of cardiometabolic and musculoskeletal multimorbidity, underscoring the need for targeted preventive strategies in this population. Full article

Background and Aims: Anaphylaxis is a severe allergic reaction that can lead to life-threatening consequences. Despite growing awareness of food allergies, schools in Saudi Arabia remain underprepared to manage allergic reactions. This study aimed to evaluate the preparedness of primary schools in Rabigh, Saudi Arabia, in managing allergic reactions, with a focus on their policies and training practices to prevent food-related anaphylaxis. Methods: A cross-sectional survey was conducted involving all 24 primary schools in Rabigh. We used a previously published questionnaire that was translated into Arabic and contextually adapted; however, no formal psychometric validation was performed. The questionnaire assessed school preparedness to manage allergic reactions and existing protocols for allergy management. Data were analysed using IBM SPSS Statistics version 25 to examine associations between preparedness level and the presence of pupils with food allergy or anaphylaxis. Results: Nineteen schools (79%) completed the survey. Most schools (95%) had emergency communication systems, and 74% designated a staff member to manage allergic reactions. However, only 58% were aware of pupils with food allergies. Preventive measures such as food-handling guidance and a no-nut policy were present in most schools. Still, policies against food sharing and closer supervision of high-risk pupils were inconsistently implemented. A comparison between schools with and without pupils with allergies revealed that schools with such pupils were more likely to identify allergy risks and provide closer supervision during mealtimes (p = 0.042). Conclusions: While some primary schools in Rabigh reported strengths such as designated staff and emergency communication systems, substantial gaps were observed in preventive measures, including mealtime supervision and food-sharing policies. Preparedness varied across schools, with those without known allergic pupils less likely to implement preventive practices. These findings underscore the importance of standardised policies and regular staff training to ensure readiness for allergic emergencies in all schools. Full article

The lower melt strength of biodegradable materials in comparison to low density polyethylenes raises serious issues regarding their processability via blown film molding. Thus, reliable rheological characterization is a viable option for assessing their efficient flow performance. The blends of poly (lactic acid) (PLA) and poly (butylene adipate-co-terephthalate) (PBAT) modified with four chain-extending cross-linkers (CECLs) undergo shearing during extrusion and are subjected to extensional deformation during the subsequent film blowing. The shear viscosity data obtained with a capillary rheometer corresponded well to the molecular weights obtained by gel permeation chromatography, while an evaluation of elongational viscosity using a Sentmanat Extensional Rheometer failed due to sample sagging during the process of temperature setting and an unacceptable deviation from the theoretically supposed exponential decrease of sample cross-sections. Therefore, the response of the PBAT/PLA blends to elongation was determined via changes in the duration of time intervals corresponding to the rupture of elongated samples. An increased consistency of the PBAT/PLA blends with CECL, as previously indicated by dynamic mechanical analysis, differential scanning calorimetry, and scanning electron microscopy, was evaluated in this way. Full article

Numerical simulation of metal forming processes is finding increasingly wide applications in advanced industry for the optimization of material processing conditions and prediction of process parameters, finally delivering a reduction of production costs. This work presents a comparison between simulation results of radial shear rolling (RSR) of VT3-1 titanium alloy (Ti-Al-Mo-Cr-Fe-Si) and results of experimental RSR at 1060 °C, 980 °C, and 900 °C in one, three, and five passes, respectively. The digital model (DM) demonstrates a high convergence of the calculation results (calculation error of less than 5%) with the actual geometric parameters of the experimental bars, their surface temperature, and rolling time during the experiment, which indicates a good potential for its application in the selection of deformation modes. Based on the simulation and experimental data, the conditions providing for the formation of differently sized grains in the bar cross-section have been identified. All of the as-rolled bars exhibit a gradient distribution of macrostructure grain size number (GSN), from the smallest one at the bar surface (2–4) to the greatest one in the center (4–6). The macrostructure GSN correlates with the workpiece temperature, which is the highest in the axial zone of the bars, and with the experimentally observed high plastic strain figures in the surface layers. It was found that, depending on the temperature conditions and reduction ratio per pass, any minor change in the values of process parameters can lead to the formation of macrostructures with different grain size numbers. Full article

Background: Smoking is a major public health concern in Saudi Arabia, with significant gender differences influencing smoking behavior and cessation. Aim: This study aimed to investigate smoking abstinence self-efficacy (ASE), decisional balance (DB), quitting desire, and their predictors among adult male and female smokers in Saudi Arabia. Methods: A cross-sectional study was conducted using a convenience sample of 375 male and 220 female adult smokers recruited via social media. Data were collected through an online survey assessing personal health, smoking behavior, desire to quit, ASE, and DB. Logistic regression was used to identify predictors of earnest quitting desire, high ASE, and negative DB. Results: Males were more likely to smoke for 10 or more years (70.7% vs. 29.1%), maintain regular smoking patterns (86.9% vs. 54.1%), and exhibit high nicotine dependence (29.3% vs. 6.4%) compared to females. A higher proportion of females (76.8%) than males (66.9%) expressed a strong desire to quit. ASE was generally higher in males, with 49.6% showing average levels, while 46.4% of females had low ASE, particularly in social and positive mood contexts. Females displayed a higher prevalence of negative DB (73.6% vs. 58.1%), indicating greater awareness of smoking’s drawbacks. Both genders acknowledged the cons of smoking, though males perceived fewer pros. Conclusions: A complex interplay of factors influences smoking behavior and cessation among adult smokers. Gender differences also play a crucial role in smoking cessation factors among Saudi adults. Tailored cessation strategies addressing self-efficacy and motivation are recommended to enhance quitting success. Full article

This study examines the evolution of willingness to accept the monkeypox (Mpox) vaccine in Romania between 2022 and 2025. It explores key sociodemographic and behavioral predictors of vaccine acceptance and investigates how public perceptions—particularly concerning disease severity and conspiracy beliefs—have shifted across two independent cross-sectional samples. Two nationally distributed surveys were conducted in July 2022 (n = 820) and January–February 2025 (n = 1029), targeting Romanian residents aged 18 and above. Data were analyzed using descriptive statistics, Chi-square tests, Kolmogorov–Smirnov tests, and a Random Forest classification model to assess the relative importance of predictors of vaccine acceptance. Between 2022 and 2025, vaccine acceptance increased modestly, particularly among individuals aged 36–65 and those with prior experience of voluntary or COVID-19 vaccination. Random Forest analysis identified behavioral factors as the strongest predictors of acceptance in both years, while the influence of education and gender varied over time. Belief in conspiracy theories slightly declined and lost predictive relevance by 2025. Perceptions of pandemic potential and fear of infection also decreased, suggesting reduced risk salience and possible pandemic fatigue. Despite a slight upward trend, overall Mpox vaccine acceptance in Romania remains among the lowest in Europe. These findings highlight the need for targeted public health communication, particularly toward skeptical or demographically vulnerable groups. Prior vaccination behavior emerged as a key driver of acceptance, indicating that trust-building strategies should capitalize on existing pro-vaccination habits. Future research should adopt qualitative and longitudinal approaches to better capture the evolving psychosocial dynamics of vaccine hesitancy. Full article

Background/Objectives: During kidney failure, chronic hemodialysis therapy (HD) is required to replace lost renal function, and patients on regular HD frequently report xerostomia. This systematic review and meta-analysis aims to compare salivary flow rates between patients with kidney failure on HD and healthy controls and to evaluate acute changes in salivary secretion before and after a dialysis session. Methods: A systematic review was conducted in accordance with PRISMA guidelines. PubMed, Web of Science, and Embase were searched for observational studies quantifying salivary flow rates in adult patients with kidney failure on chronic hemodialysis versus healthy controls or pre- versus post-dialysis. Data on salivary flow rates were extracted and stratified by subtype (whole or gland-specific) and condition (stimulated or unstimulated), along with key study characteristics including participant demographics, saliva collection methods, and dialysis duration. Study quality was appraised using NHLBI tools and categorized as poor, fair, or good. Where ≥2 homogeneous datasets existed, random-effects meta-analyses (α = 0.05) were performed to estimate mean differences (95% CI) for each salivary parameter; heterogeneity was evaluated via I². Results: A total of 20 studies (13 cross-sectional, 7 before-after) met inclusion, of which 17 studies (with a total of 1224 HD patients and 548 controls) were meta-analyzed. Compared with controls, HD patients showed lower secretion rates of unstimulated whole saliva (UWS: MD −0.11 mL/min; 95% CI −0.20 to −0.02; I² = 94%) and stimulated whole saliva (SWS: MD −0.77 mL/min; 95% CI −0.94 to −0.60; I² = 92%), whereas stimulated parotid saliva (SPS) did not differ significantly (MD −0.08 mL/min; 95% CI −0.77 to 0.60; I² = 96%). In before-after analyses, both UWS (MD +0.15 mL/min; 95% CI 0.02–0.28; I² = 90%) and SWS (MD +0.20 mL/min; 95% CI 0.14–0.26; I² = 0%) increased immediately post-HD. Conclusions: Despite methodological challenges and population heterogeneity, the evidence indicates salivary hypofunction in HD patients and improvement after hemodialysis. The magnitude of these effects seems influenced by underlying comorbidities (notably diabetes), HD duration, and methodological factors. Since saliva is of major importance to maintaining good oral health, recognizing and managing dry mouth should therefore be part of the comprehensive care of patients with kidney failure. Full article

Background/Objectives: Childhood obesity is a growing public health concern globally, with significant physical and psychological implications. While numerous studies have linked obesity to poor mental health outcomes, cultural differences may influence this relationship. This study examines the association between childhood obesity and psychological well-being among Saudi children aged 8–12 years. Methods: A cross-sectional case-control study was conducted in Al-Hofuf, Saudi Arabia. A total of 128 children were recruited, divided into a high-body-weight group (n = 64) and a healthy-weight group (n = 64). Psychological well-being was assessed using the Psychological Well-being Scale for Children (PWSC) and the Stirling Children’s Well-being Scale (SCWS). Anthropometric measurements were recorded, and parental body mass index (kg/m²) data were included. Data analysis was performed using SPSS 2023, employing chi-square tests and t-tests. Results: No statistically significant differences were found between the children’s body mass index (kg/m²) groups across most psychological well-being dimensions. However, a significant association was observed between maternal body mass index (kg/m²) and children’s PWSC scores (χ² = 6.217, p = 0.045), suggesting a potential influence of parental weight on child well-being. Additionally, a significant sex difference in SCWS scores was noted, with males displaying higher well-being levels than females (χ² = 7.798, p = 0.041). Family income and school grade showed no significant associations with psychological well-being. Conclusions: Contrary to findings from Western studies, childhood obesity did not significantly impact psychological well-being in this Saudi sample. Cultural factors, parental influence, and age-related differences may contribute to these results. Further longitudinal and qualitative research is needed to explore these associations in greater depth. Full article