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Keywords = cortical bone trajectory

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14 pages, 2034 KB  
Article
Accuracy of Three-Dimensionally Printed, Patient-Specific Drill Guides for Implant Placement in Canine Cervical Vertebrae: A Cadaveric Study
by Christopher J. Ponticello, Christopher L. Mariani, Joshua M. R. Carrillo, Joshua A. Zlotnick, Kristen Malinak Blodgett, Ashley Gavitt and Ola Harrysson
Vet. Sci. 2025, 12(12), 1190; https://doi.org/10.3390/vetsci12121190 - 12 Dec 2025
Viewed by 799
Abstract
The objective of this study was to assess the accuracy of autoclavable, three-dimensionally (3D) printed drill guides (3DPG) created with a rapid printing protocol and utilized by both an experienced and inexperienced surgeon in constraining the trajectory of drill tracts to intended corridors [...] Read more.
The objective of this study was to assess the accuracy of autoclavable, three-dimensionally (3D) printed drill guides (3DPG) created with a rapid printing protocol and utilized by both an experienced and inexperienced surgeon in constraining the trajectory of drill tracts to intended corridors within canine cervical vertebrae. The 3DPG were designed using computed tomographic (CT) images of six complete cadaveric canine cervical vertebral columns and used to create drill tracts in all vertebrae by both an experienced and a novice surgeon. Repeat CT imaging was used to assess the entry point (EPD) and angular deviation (AD) of the actual versus planned drill tracts. Unintended cortical bone violations were also assessed. A total of 80 3DPG were used to create 144 drill tracts in 42 vertebrae. The overall mean EPD was 1.1 mm (median 0.9 mm, range 0.1–5.1 mm) and the overall mean AD was 7.3° (median 5.2°, range 0.5–33.8°). There were no differences in overall EPD (p = 0.85) or AD (p = 0.20) between the inexperienced and novice surgeons. There were no unintended cortical bone breaches. These 3DPG allowed the creation of safe and accurate drill tracts within the canine cervical spine by both an experienced and an inexperienced surgeon. Full article
(This article belongs to the Section Veterinary Surgery)
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10 pages, 224 KB  
Brief Report
Hypothyroidism and Mandibular Cortical Alterations Evaluated on Panoramic Radiography: A Cross-Sectional Study in Women
by Vicente Vera-Rodríguez, María Pedrera-Canal, Olga Leal-Hernández, Juan Fabregat-Fernández, María Luz Canal-Macías, Fidel López-Espuela, Francisco M. García-Blazquez, Jose M. Moran and Raúl Roncero-Martín
Healthcare 2025, 13(19), 2529; https://doi.org/10.3390/healthcare13192529 - 7 Oct 2025
Viewed by 792
Abstract
Background/Objectives: Thyroid hormone deficiency may impair bone metabolism, but its mandibular impact remains uncertain. We aimed to compare the prevalence of altered Mandibular Cortical Index (MCI; C2–C3) and Panoramic Mandibular Index (PMI) on digital panoramic radiographs in adult women with primary hypothyroidism versus [...] Read more.
Background/Objectives: Thyroid hormone deficiency may impair bone metabolism, but its mandibular impact remains uncertain. We aimed to compare the prevalence of altered Mandibular Cortical Index (MCI; C2–C3) and Panoramic Mandibular Index (PMI) on digital panoramic radiographs in adult women with primary hypothyroidism versus euthyroid controls, considering age and key clinical covariates. To our knowledge, this is the first study out of Spain addressing this question. Methods: This is a cross-sectional study (September 2021–June 2024) of 179 white women recruited at a university clinic. Cases were on L-thyroxine for ≥6 months, with TSH > 4.5 mIU/L and normal FT4; controls were euthyroid and untreated. Demographics, reproductive history, and BMI were recorded. Panoramic radiographs (Ratograph EVO 3D; 72 kV, 6 mA, 14.4 s) were analysed; MCI was graded (Klemetti C1–C3) distal to the mental foramen; PMI and mandibular cortical width (MCW) were measured bilaterally. Results: Women with hypothyroidism showed higher BMI and a greater number of years since menopause; age was slightly higher, but the difference was not significant. MCI distribution did not differ between groups (C3 and C2–C3, both p > 0.45). PMI (left/right) was similar (p = 0.253/0.160). Left MCW was higher in hypothyroidism in a crude analysis (4.86 ± 0.98 vs. 4.46 ± 0.94 mm; p = 0.039), but lost significance after age adjustment (adjusted p = 0.191); right MCW showed no differences. Total tooth loss tended to be higher (p = 0.055) without conclusive evidence. Conclusions: In this cohort, primary hypothyroidism was not associated with a differential mandibular cortical pattern by MCI or PMI; the crude MCW difference was explained by age. These Spain-based data refine heterogeneous prior findings and indicate that, in women treated for hypothyroidism, mandibular cortical metrics largely resemble those of their euthyroid peers. Longitudinal and multicentre studies are warranted to clarify trajectories and enhance generalisability. Full article
11 pages, 948 KB  
Article
Finite Element Analysis of Stress Distribution in Canine Lumbar Fractures with Different Pedicle Screw Insertion Angles
by Ziyao Zhou, Xiaogang Shi, Jiahui Peng, Xiaoxiao Zhou, Liuqing Yang, Zhijun Zhong, Haifeng Liu, Guangneng Peng, Chengli Zheng and Ming Zhang
Vet. Sci. 2025, 12(7), 682; https://doi.org/10.3390/vetsci12070682 - 19 Jul 2025
Cited by 1 | Viewed by 1648
Abstract
Pedicle screw fixation is a critical technique for stabilizing lumbar fractures in canines, yet the biomechanical implications of insertion angles remain underexplored. This study aims to identify optimal screw trajectories by analyzing stress distribution and deformation patterns in beagle lumbar segments (L6-L7) using [...] Read more.
Pedicle screw fixation is a critical technique for stabilizing lumbar fractures in canines, yet the biomechanical implications of insertion angles remain underexplored. This study aims to identify optimal screw trajectories by analyzing stress distribution and deformation patterns in beagle lumbar segments (L6-L7) using finite element analysis (FEA). A 3D finite element model was reconstructed from CT scans of a healthy beagle, incorporating cortical/cancellous bone, intervertebral disks, and cartilage. Pedicle screws (2.4 mm diameter, 22 mm length) were virtually implanted at angles ranging from 45° to 65°. A 10 N vertical load simulated standing conditions. Equivalent stress and total deformation were evaluated under static loading. The equivalent stress occurred at screw–rod junctions, with maxima at 50° (11.73 MPa) and minima at 58° (3.25 MPa). Total deformation ranged from 0.0033 to 0.0064 mm, with the highest at 55° and the lowest at 54°. The 58° insertion angle demonstrated optimal biomechanical stability with minimal stress concentration, with 56–60° as a biomechanically favorable range for pedicle screw fixation in canine lumbar fractures, balancing stress distribution and deformation control. Future studies should validate these findings in multi-level models and clinical settings. Full article
(This article belongs to the Special Issue Advanced Therapy in Companion Animals—2nd Edition)
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11 pages, 9473 KB  
Communication
Minimally Invasive Postero-Inferior Sacroiliac Joint Fusion: Surgical Technique and Procedural Details
by Usman Latif, Paul J. Hubbell, Goran Tubic, Luis A. Guerrero, Ioannis M. Skaribas and Jon E. Block
J. Pers. Med. 2023, 13(7), 1136; https://doi.org/10.3390/jpm13071136 - 14 Jul 2023
Cited by 4 | Viewed by 4014
Abstract
(1) Background: Minimally invasive sacroiliac joint (SIJ) fusion is the preferred surgical intervention to treat chronically severe pain associated with SIJ degeneration and dysfunction. (2) Methods: This paper details the ten-step surgical procedure associated with the postero-inferior approach using the PsiF™ DNA Sacroiliac [...] Read more.
(1) Background: Minimally invasive sacroiliac joint (SIJ) fusion is the preferred surgical intervention to treat chronically severe pain associated with SIJ degeneration and dysfunction. (2) Methods: This paper details the ten-step surgical procedure associated with the postero-inferior approach using the PsiF™ DNA Sacroiliac Joint Fusion System. (3) Results: The posterior surgical approach with an inferior operative trajectory (postero-inferior) utilizes easily identifiable landmarks to provide the safest, most direct access to the articular joint space for transfixing device placement. Implanting the device through the subchondral bone provides maximum fixation and stabilization of the joint by utilizing an optimal amount of cortical bone–implant interface. Approaching the joint from the inferior trajectory also places the implant perpendicular to the S1 endplate at a “pivot point” near the sacral axis of rotation, which addresses the most significant motion of the joint. (4) Conclusions: Further observational data from real-world clinical use are encouraged to further validate this procedure as the surgical preference for minimally invasive SIJ fusion. Full article
(This article belongs to the Special Issue The Path to Personalized Pain Management)
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13 pages, 5758 KB  
Review
Minimally Invasive Spinal Treatment (MIST)—A New Concept in the Treatment of Spinal Diseases: A Narrative Review
by Ken Ishii, Goichi Watanabe, Takashi Tomita, Takuya Nikaido, Tomohiro Hikata, Akira Shinohara, Masato Nakano, Takanori Saito, Kazuo Nakanishi, Tadatsugu Morimoto, Norihiro Isogai, Haruki Funao, Masato Tanaka, Yoshihisa Kotani, Takeshi Arizono, Masahiro Hoshino and Koji Sato
Medicina 2022, 58(8), 1123; https://doi.org/10.3390/medicina58081123 - 18 Aug 2022
Cited by 14 | Viewed by 5713
Abstract
In the past two decades, minimally invasive spine surgery (MISS) techniques have been developed for spinal surgery. Historically, minimizing invasiveness in decompression surgery was initially reported as a MISS technique. In recent years, MISS techniques have also been applied for spinal stabilization techniques, [...] Read more.
In the past two decades, minimally invasive spine surgery (MISS) techniques have been developed for spinal surgery. Historically, minimizing invasiveness in decompression surgery was initially reported as a MISS technique. In recent years, MISS techniques have also been applied for spinal stabilization techniques, which were defined as minimally invasive spine stabilization (MISt), including percutaneous pedicle screws (PPS) fixation, lateral lumbar interbody fusion, balloon kyphoplasty, percutaneous vertebroplasty, cortical bone trajectory, and cervical total disc replacement. These MISS techniques typically provide many advantages such as preservation of paraspinal musculature, less blood loss, a shorter operative time, less postoperative pain, and a lower infection rate as well as being more cost-effective compared to traditional open techniques. However, even MISS techniques are associated with several limitations including technical difficulty, training opportunities, surgical cost, equipment cost, and radiation exposure. These downsides of surgical treatments make conservative treatments more feasible option. In the future, medicine must become “minimally invasive” in the broadest sense—for all patients, conventional surgeries, medical personnel, hospital management, nursing care, and the medical economy. As a new framework for the treatment of spinal diseases, the concept of minimally invasive spinal treatment (MIST) has been proposed. Full article
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20 pages, 7891 KB  
Article
Characterization of Porous Scaffolds Fabricated by Joining Stacking Based Laser Micro-Spot Welding (JS-LMSW) for Tissue Engineering Applications
by Luis D. Cedeño-Viveros, Ciro A. Rodriguez, Victor Segura-Ibarra, Elisa Vázquez and Erika García-López
Materials 2022, 15(1), 99; https://doi.org/10.3390/ma15010099 - 23 Dec 2021
Cited by 1 | Viewed by 3168
Abstract
A novel manufacturing approach was used to fabricate metallic scaffolds. A calibration of the laser cutting process was performed using the kerf width compensation in the calculations of the tool trajectory. Welding defects were studied through X-ray microtomography. Penetration depth and width resulted [...] Read more.
A novel manufacturing approach was used to fabricate metallic scaffolds. A calibration of the laser cutting process was performed using the kerf width compensation in the calculations of the tool trajectory. Welding defects were studied through X-ray microtomography. Penetration depth and width resulted in relative errors of 9.4%, 1.0%, respectively. Microhardness was also measured, and the microstructure was studied in the base material. The microhardness values obtained were 400 HV, 237 HV, and 215 HV for the base material, HAZ, and fusion zone, respectively. No significant difference was found between the microhardness measurement along with different height positions of the scaffold. The scaffolds’ dimensions and porosity were measured, their internal architecture was observed with micro-computed tomography. The results indicated that geometries with dimensions under 500 µm with different shapes resulted in relative errors of ~2.7%. The fabricated scaffolds presented an average compressive modulus ~13.15 GPa, which is close to cortical bone properties. The proposed methodology showed a promising future in bone tissue engineering applications. Full article
(This article belongs to the Special Issue Advances in Metal-Based Additive Manufacturing)
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16 pages, 7606 KB  
Article
Biomechanical Evaluation of Cortical Bone Trajectory Fixation with Traditional Pedicle Screw in the Lumbar Spine: A Finite Element Study
by Kuo-Chih Su, Kun-Hui Chen, Chien-Chou Pan and Cheng-Hung Lee
Appl. Sci. 2021, 11(22), 10583; https://doi.org/10.3390/app112210583 - 10 Nov 2021
Cited by 11 | Viewed by 7213
Abstract
Cortical bone trajectory (CBT) is increasingly used in spinal surgery. Although there are many biomechanical studies, the biomechanical effect of CBT in combination with traditional pedicle screws is not detailed. Therefore, the purpose of this study was to investigate the effects of the [...] Read more.
Cortical bone trajectory (CBT) is increasingly used in spinal surgery. Although there are many biomechanical studies, the biomechanical effect of CBT in combination with traditional pedicle screws is not detailed. Therefore, the purpose of this study was to investigate the effects of the traditional pedicle screw and CBT screw implantation on the lumbar spine using finite element methods. Based on the combination of the traditional pedicle screw and the CBT system implanted into the lumbar spine, four finite element spinal lumbar models were established. The models were given four different load conditions (flexion, extension, lateral bending, and axial rotation), and the deformation and stress distribution on the finite element model were observed. The results show that there was no significant difference in the structural stability of the lumbar spine model between the traditional pedicle screw system and the CBT system. In addition, CBT may reduce stress on the endplate. Different movements performed by the model may have significant biomechanical effects on the spine and screw system. Clinical spinal surgeons may also consider using the CBT system in revision spinal surgery, which may contribute to smaller wounds. Full article
(This article belongs to the Special Issue Design, Safety and Ergonomics of Biomedical Devices)
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8 pages, 1850 KB  
Article
Incidence of Screw Loosening in Cortical Bone Trajectory Fixation Technique between Single- and Dual-Threaded Screws
by Chao-Hsuan Chen, Chih-Hsiu Tu, Der-Cherng Chen, Hsiang-Ming Huang, Hao-Yu Chuang, Der-Yang Cho, Da-Tian Bau and Han-Chung Lee
Medicines 2021, 8(9), 50; https://doi.org/10.3390/medicines8090050 - 2 Sep 2021
Cited by 2 | Viewed by 3929
Abstract
Purpose: This study aims to elucidate the radiological outcome after Cortical bone trajectory (CBT) screw fixation and whether dual-threaded (DT) screws should be used in the fusion surgery. Methods: 159 patients with degenerative lumbar disorder who had undergone midline lumbar inter-body fusion surgery [...] Read more.
Purpose: This study aims to elucidate the radiological outcome after Cortical bone trajectory (CBT) screw fixation and whether dual-threaded (DT) screws should be used in the fusion surgery. Methods: 159 patients with degenerative lumbar disorder who had undergone midline lumbar inter-body fusion surgery by CBT screw-fixation technique (2014 to 2018). Patient subgroups were based on single-threaded (ST) or DT screw, fixation length, as well as whether fixation involved to sacrum level (S1). Serial dynamic plain films were reviewed and an appearance of a halo phenomenon between screw–bone interfaces was identified as a case of screw loosening. Results: 29 patients (39.7%) in ST group and 10 patients (11.6%) in DT group demonstrated a halo phenomenon (p < 0.0001 ****). After subgrouping with fixation length, the incidence rates of a halo phenomenon in each group were 11.1%:3% (ST-1L vs. DT-1L), 37%:13.8% (ST-2L vs. DT-2L), and 84.2%:23.5% (ST-3L vs. DT-3L). Among the 85 patients with a fixation involved in S1, 26 patients (52%) with single-threaded screw (STS group) and 8 patients (22.8%) with dual-threaded screw (DTS group) demonstrated a halo appearance (p = 0.0078 **). After subgrouping the fixation level, the incidence of a halo appearance in each group was 25%:0% (STS-1L vs. DTS-1L), 40.9%:26.3% (STS-2L vs. DTS-2L), and 87.5%: 30% (STS-3L vs. DTS-3L). Conclusion: Both fixation length and whether fixation involved to S1 contribute to the incidence of screw loosening, the data supports clinical evidence that DT screws had greater fixation strength with an increased fixative stability and lower incidence of screw loosening in CBT screw fixation compared with ST screws. Level of evidence: 2. Full article
(This article belongs to the Special Issue PROTAC—From Bench to Bed)
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11 pages, 341 KB  
Review
Diagnostic, Surgical, and Technical Considerations for Lumbar Interbody Fusion in Patients with Osteopenia and Osteoporosis: A Systematic Review
by Sauson Soldozy, Samuel R. Montgomery, Danyas Sarathy, Steven Young, Anthony Skaff, Bhargav Desai, Jennifer D. Sokolowski, Faheem A. Sandhu, Jean-Marc Voyadzis, Kaan Yağmurlu, Avery L. Buchholz, Mark E. Shaffrey and Hasan R. Syed
Brain Sci. 2021, 11(2), 241; https://doi.org/10.3390/brainsci11020241 - 14 Feb 2021
Cited by 15 | Viewed by 3720
Abstract
Objective: Osteoporosis is increasing in incidence as the ageing population continues to grow. Decreased bone mineral density poses a challenge for the spine surgeon. In patients requiring lumbar interbody fusion, differences in diagnostics and surgical approaches may be warranted. In this systematic review, [...] Read more.
Objective: Osteoporosis is increasing in incidence as the ageing population continues to grow. Decreased bone mineral density poses a challenge for the spine surgeon. In patients requiring lumbar interbody fusion, differences in diagnostics and surgical approaches may be warranted. In this systematic review, the authors examine studies performing lumbar interbody fusion in patients with osteopenia or osteoporosis and suggest avenues for future study. Methods: A systematic literature review of the PubMed and MEDLINE databases was performed for studies published between 1986 and 2020. Studies evaluating diagnostics, surgical approaches, and other technical considerations were included. Results: A total of 13 articles were ultimately selected for qualitative analysis. This includes studies demonstrating the utility of Hounsfield units in diagnosis, a survey of surgical approaches, as well as exploring the use of vertebral augmentation and cortical bone screw trajectory. Conclusions: This systematic review provides a summary of preliminary findings with respect to the use of Hounsfield units as a diagnostic tool, the benefit or lack thereof with respect to minimally invasive approaches, and the question of whether or not cement augmentation or cortical bone trajectory confers benefit in osteoporotic patients undergoing lumbar interbody fusion. While the findings of these studies are promising, the current state of the literature is limited in scope and, for this reason, definitive conclusions cannot be drawn from these data. The authors highlight gaps in the literature and the need for further exploration and study of lumbar interbody fusion in the osteoporotic spine. Full article
(This article belongs to the Special Issue Neurosurgery and Neuroanatomy)
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7 pages, 1554 KB  
Article
Cortical Bone Trajectory Instrumentation with Vertebroplasty for Osteoporotic Thoracolumbar Compression Fracture
by Wei-Lin Hsu, Yu-Hsiang Lin, Hao-Yu Chuang, Han-Chung Lee, Der-Cherng Chen, Yen-Tse Chu, Der-Yang Cho and Chao-Hsuan Chen
Medicina 2020, 56(2), 82; https://doi.org/10.3390/medicina56020082 - 17 Feb 2020
Cited by 6 | Viewed by 3536
Abstract
Background: Osteoporotic spinal fractures commonly occur in elderly patients with low bone mineral density. In these cases, percutaneous vertebroplasty or percutaneous kyphoplasty can provide significant pain relief and improve mobility. However, studies have reported both the recurrence of vertebral compression fractures at the [...] Read more.
Background: Osteoporotic spinal fractures commonly occur in elderly patients with low bone mineral density. In these cases, percutaneous vertebroplasty or percutaneous kyphoplasty can provide significant pain relief and improve mobility. However, studies have reported both the recurrence of vertebral compression fractures at the index level after vertebroplasty and the development of new vertebral fractures at the adjacent level that occur without any additional trauma. Pedicle screw fixation combined with percutaneous vertebroplasty has been proposed as an effective procedure for addressing osteoporotic thoracolumbar fractures. However, in osteoporotic populations, pedicle screws can loosen, pullout, or migrate. Currently, the efficacy of cortical bone trajectory screw fixation for osteoporotic fractures remains unclear. Thus, we assessed the effects of using cortical bone trajectory instrumentation with vertebroplasty on patient outcomes. Method: We retrospectively reviewed data from 12 consecutively sampled osteoporotic thoracolumbar fracture patients who underwent cortical bone trajectory instrumentation with vertebroplasty. Patients were enrolled beginning in October 2015 and were followed for >24 months. Result: The average age was 74 years, and the average dual-energy x-ray absorptiometry T-score was −3.6. The average visual analog scale pain scores improved from 8 to 2.5 after surgery. The average blood loss was 36.25 mL. All patients regained ambulation and experienced reduced pain post-surgery. No recurrent fractures or instrument failures were recorded during follow-up. Conclusions: Our findings suggest that cortical bone trajectory instrumentation combined with percutaneous vertebroplasty may be a good option for treating osteoporotic thoracolumbar fractures, as it can prevent recurrent vertebral fractures or related kyphosis in sagittal alignment. Full article
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