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Keywords = cor triatriatum dexter

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15 pages, 1918 KB  
Systematic Review
Cor Triatriatum Dexter: The Largest Comprehensive Review in the Field on 124 Worldwide Cases (1968–Now)
by Pier Paolo Bassareo, Erica Franco, Sophie Duignan, Massimo Chessa, Mariateresa Cascio, Colin Joseph McMahon, Kevin Patrick Walsh and Marco Alfonso Perrone
J. Cardiovasc. Dev. Dis. 2026, 13(2), 76; https://doi.org/10.3390/jcdd13020076 - 3 Feb 2026
Abstract
Background. Cor triatriatum dexter (CTD) is a rare congenital heart defect where a membrane divides the right atrium into two chambers, resulting from the incomplete regression of the right valve of the sinus venosus. Due to its rarity, only individual case reports and [...] Read more.
Background. Cor triatriatum dexter (CTD) is a rare congenital heart defect where a membrane divides the right atrium into two chambers, resulting from the incomplete regression of the right valve of the sinus venosus. Due to its rarity, only individual case reports and a limited number of case series have been published to date. This study constitutes the most extensive comprehensive review conducted in this area. Eight factors were evaluated: age at diagnosis, sex, clinical presentation, electrocardiographic findings, imaging (ultrasound, CT, or MRI), associated cardiac anomalies, and patient outcomes. Methods. The electronic databases PubMed and Scopus were searched from their inception until 30 October 2025. Only case reports and case series were considered for inclusion. Studies involving foetuses, autopsies, and animals were excluded. The collected data were primarily presented as percentages. Results. One hundred fourteen studies were found encompassing 124 patients. The mean age at diagnosis was 33.3 ± 9.4 years The most common clinical presentations were dyspnoea (44.3%) and cyanosis (29.5%). The most commonly encountered ECG changes were supraventricular tachycardia/atrial flutter/atrial fibrillation (33.3%) and right bundle branch block (22.6%). On chest X-ray, cardiomegaly was noted in 46.5%. CTD was suspected or diagnosed by echocardiography in 95.2% of cases. The diagnosis was confirmed by CT and/or MRI in 34.1% of cases. A concomitant congenital heart defect was found in 67.7%, especially in the form of all kinds of atrial septal defect (38.1%) and of right valvular and right ventricular involvement (20.1%). An outcome was reported in 97/124. Surgical correction was the treatment of choice in 51.6%. Since 1991, a percutaneous approach has been employed in selected cases (5.1%). Conservative management was the treatment of choice in 43.3%. The mortality rate was 8.2%. Discussion. The principal limitation of this systematic review lies in its reliance solely on case reports and small case series, reflecting the absence of large-scale studies on CTD. Nonetheless, it constitutes the most comprehensive analysis available to date. Full article
(This article belongs to the Section Pediatric Cardiology and Congenital Heart Disease)
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12 pages, 972 KB  
Review
Cor triatriatum dexter in Dogs: A Silent Bystander or a Potential Time Bomb? A Focused Literature Review from a Professional Perspective
by Michela Pugliese, Diego Antonio Sicuso, Giordana Merola, Bengü Bilgiç, Annalisa Previti, Mehmet Erman Or and Annamaria Passantino
Vet. Sci. 2025, 12(2), 175; https://doi.org/10.3390/vetsci12020175 - 14 Feb 2025
Viewed by 2186
Abstract
Congenital heart diseases (CHDs) are structural anomalies present at birth, resulting from aberrant embryonic development. In veterinary medicine, CHDs are an important reason for disease and death in both dogs and cats. Their prevalence varies across species and breeds, with certain defects being [...] Read more.
Congenital heart diseases (CHDs) are structural anomalies present at birth, resulting from aberrant embryonic development. In veterinary medicine, CHDs are an important reason for disease and death in both dogs and cats. Their prevalence varies across species and breeds, with certain defects being more common in specific breeds due to genetic predisposition. In this article, we will focus specifically on cor triatriatum dexter (CTD), an uncommon congenital defect that involves the division of the right atrium into two chambers by a fibromuscular membrane. This malformation can have serious consequences, depending on the severity of the obstruction created by the membrane, and the presence of the often-associated congenital anomalies. It can range from mild, clinically silent anomalies to severe defects that result in heart failure, cyanosis, or sudden death. The present review aims to (i) explore the pathophysiology of CTD in dogs; (ii) outline the clinical scenario underlying the increased interest in CHDs by overviewing the evolution of appropriate diagnostic techniques and the treatment options available; and (iii) provide a discussion from a medical–legal and ethical point of view. Full article
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8 pages, 2081 KB  
Case Report
Partial Venous Inflow Occlusion under Mild Hypothermia for Membranectomy in a Dog with Cor Triatriatum Dexter
by Chang-Hwan Moon, Kyung-Min Kim, Won-Jong Lee, Woo-Jin Kim, Seok-Min Lee, Ho-Jung Choi, Hae-Beom Lee, Seong-Mok Jeong and Dae-Hyun Kim
Animals 2023, 13(18), 2921; https://doi.org/10.3390/ani13182921 - 14 Sep 2023
Cited by 2 | Viewed by 1882
Abstract
Cor triatriatum dexter (CTD) is an uncommon congenital cardiac anomaly in dogs. This case report describes successful membranectomy for CTD via partial venous inflow occlusion under mild hypothermia in a dog. A 7-month-old intact male mixed-breed dog weighing 20.5 kg presented with a [...] Read more.
Cor triatriatum dexter (CTD) is an uncommon congenital cardiac anomaly in dogs. This case report describes successful membranectomy for CTD via partial venous inflow occlusion under mild hypothermia in a dog. A 7-month-old intact male mixed-breed dog weighing 20.5 kg presented with a history of abdominal distention, lethargy, and anorexia. Clinical examination, radiography, echocardiography, microbubble testing, and computed tomography revealed a remnant right atrium membrane obscuring the venous blood inflow from the vena cava. Considering the potential risk of re-stenosis following interventional treatment, curative resection involving surgical membranectomy via venous inflow occlusion was performed. By performing partial venous inflow occlusion under mild hypothermia (34.5 °C), sufficient time was obtained to explore the defect and resect the remnant membrane. The dog recovered without any complications, and the clinical signs were relieved. This case illustrates that partial venous inflow occlusion under mild hypothermia is feasible for achieving curative resection of cor triatriatum dexter in dogs. Full article
(This article belongs to the Special Issue Advances in Animals Cardiac Physiology)
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7 pages, 1843 KB  
Case Report
Cor Triatriatum Dexter Associated with an Ostium Primum Atrial Defect and Left-Sided Opening of the Coronary Sinus in a Stillborn Fetus
by Silvia Farkašová Iannaccone, David Sedmera, Alžbeta Ginelliová, Peter Bohuš, Lucia Mistríková and Daniel Farkaš
J. Cardiovasc. Dev. Dis. 2023, 10(9), 370; https://doi.org/10.3390/jcdd10090370 - 28 Aug 2023
Viewed by 2763
Abstract
Cor triatriatum is a very rare cardiac malformation characterized by the presence of an abnormal interatrial membrane separating either the left or right atrial chamber into two compartments. It can be associated with other cardiac defects and is often symptomatic in childhood. The [...] Read more.
Cor triatriatum is a very rare cardiac malformation characterized by the presence of an abnormal interatrial membrane separating either the left or right atrial chamber into two compartments. It can be associated with other cardiac defects and is often symptomatic in childhood. The signs depend on the size and position of the interatrial membrane and other associated malformations. Here we report a case of right-sided cor triatriatum associated with an ostium primum-type interatrial septum defect and left-sided opening of the coronary sinus in a fetus. The cause of intrauterine death was asphyxia due to total placental abruption. Full article
(This article belongs to the Section Pediatric Cardiology and Congenital Heart Disease)
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10 pages, 1022 KB  
Case Report
Percutaneous Balloon Dilation in Two Dogs with Cor Triatriatum Dexter
by Valentina Patata, Tommaso Vezzosi, Giulia Calogero, Marta Croce, Helena Broch, Federica Marchesotti, Martina Bini and Oriol Domenech
Vet. Sci. 2022, 9(8), 419; https://doi.org/10.3390/vetsci9080419 - 8 Aug 2022
Cited by 1 | Viewed by 3159
Abstract
Percutaneous balloon dilation was performed in a Rhodesian Ridgeback and in an American Staffordshire Terrier affected by cor triatriatum dexter (CTD). Both cases had ascites without jugular venous distension or pleural effusion. In both dogs the CTD presented a perforated membrane but with [...] Read more.
Percutaneous balloon dilation was performed in a Rhodesian Ridgeback and in an American Staffordshire Terrier affected by cor triatriatum dexter (CTD). Both cases had ascites without jugular venous distension or pleural effusion. In both dogs the CTD presented a perforated membrane but with different morphology: in one case the coronary sinus entered the caudal chamber of the CTD together with the caudal vena cava. In the other case, the coronary sinus communicated with the cranial chamber of the CTD together with the cranial vena cava. Percutaneous balloon dilation of the CTD was successfully performed, and both dogs had uneventful surgery recoveries. At two years of follow-up, the dogs were free from clinical signs and cardiac medication. Full article
(This article belongs to the Special Issue Advances in Right Heart Diseases in Veterinary Science)
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6 pages, 716 KB  
Case Report
Cor Triatriatum Dexter: Contrast Echocardiography Is Key to the Diagnosis of a Rare but Treatable Cause of Neonatal Persistent Cyanosis
by Irene Picciolli, Gaia Francescato, Anna Maria Colli, Alessia Cappelleri, Alessandra Mayer, Roberto Raschetti, Roberta Di Cosola, Marco Pisaniello, Giuseppe Alberto Annoni, Marco Papa, Mimoza Maldi, Guido Olivieri, Fabio Mosca and Stefano Marianeschi
Children 2022, 9(5), 676; https://doi.org/10.3390/children9050676 - 6 May 2022
Cited by 6 | Viewed by 3524
Abstract
Cor triatriatum dexter (CTD) is an extremely uncommon and underreported congenital cardiac anomaly in which the persistence of the embryonic right venous valve separates the right atrium into two chambers with varying degrees of obstruction to antegrade flow and variable degree of right [...] Read more.
Cor triatriatum dexter (CTD) is an extremely uncommon and underreported congenital cardiac anomaly in which the persistence of the embryonic right venous valve separates the right atrium into two chambers with varying degrees of obstruction to antegrade flow and variable degree of right to left shunt at atrial level. Depending on the size of the valves, clinical manifestations vary from absence of symptoms to severe hypoxia, requiring urgent surgical correction. We herein describe the diagnostic difficulties in a case of neonatal CTD, who developed increasingly severe and unresponsive cyanosis, first interpreted as postnatal maladjustment with pulmonary hypertension. The failure to respond to oxygen and pulmonary vasodilators led us to reconsider a different diagnosis. The use of contrast echocardiography improved the diagnostic performance of transthoracic echocardiogram (TTE) and revealed a massive right-to-left shunt secondary to the presence of an atrial membrane that required urgent surgery. Full article
(This article belongs to the Special Issue Research Progress of the Pediatric Cardiology)
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8 pages, 2117 KB  
Case Report
Percutaneous Edge-to-Edge Tricuspid Valve Repair in a Patient with Cor Triatriatum Dexter: A Case Report
by Fabian Barbieri, Mark Schröder, Niklas Beyhoff, Ulf Landmesser, Markus Reinthaler and Mario Kasner
J. Cardiovasc. Dev. Dis. 2021, 8(9), 111; https://doi.org/10.3390/jcdd8090111 - 14 Sep 2021
Cited by 2 | Viewed by 2421
Abstract
Background: Tricuspid regurgitation is gaining importance due to its high morbidity and mortality. Especially in the elderly, novel technologies in percutaneous therapies have become valuable options due to the commonly present high surgical risk. Case presentation: We report a case of a 78-year-old [...] Read more.
Background: Tricuspid regurgitation is gaining importance due to its high morbidity and mortality. Especially in the elderly, novel technologies in percutaneous therapies have become valuable options due to the commonly present high surgical risk. Case presentation: We report a case of a 78-year-old female suffering from massive tricuspid regurgitation with repetitive right-sided heart failure hospitalizations. As the patient was very frail and deemed as high surgical risk, we used the TriClip® system to improve her symptomatic status. During diagnostic work-up, an additional membrane separating the right atrium, consistent with the definition of a cor triatriatum dexter, was found. Although increasing the complexity of the procedure, implantation of 3 clips with reduction of tricuspid regurgitation to a mild-to-moderate degree was achieved without any notable complications. The patient was discharged with ameliorated symptoms on the fourth postoperative day. Conclusions: Our case highlights the feasibility of percutaneous edge-to-edge tricuspid valve repair in an elderly woman with cor triatriatum dexter. Accurate echocardiographic visualization is an absolute requirement to gain access to the tricuspid valve without interacting with prevailing additional membranes. Full article
(This article belongs to the Section Imaging)
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