Search Results (87)

We introduce a novel Bayesian approach for feature (variable) selection using Gaussian process regression, which is crucial for enhancing interpretability and model regularization. Our method employs nearest neighbor Gaussian processes as scalable approximations to classical Gaussian processes. Feature selection is performed by conditioning the process mean and covariance function on a random set representing the indices of relevant variables. A priori beliefs regarding this set control the feature selection, while reference priors are assigned to the remaining model parameters, ensuring numerical robustness in the process covariance matrix. For model inference, we propose a Metropolis-within-Gibbs algorithm. The effectiveness of the proposed feature selection approach is demonstrated through evaluation on simulated data, a computer experiment approximation, and two real-world data sets. Full article

Background and Objectives: Chronic low back pain (CLBP) is a prevalent condition that impairs quality of life, functionality, and work productivity. While most acute episodes of back pain resolve, 4–25% become chronic due to factors such as high pain intensity, psychological distress, and maladaptive behaviors. Nonspecific CLBP is best understood through the biopsychosocial model, encompassing biological, psychological, and social influences, including kinesiophobia. Management relies on physical activity, pain education, and psychological interventions, with therapist knowledge and attitudes affecting outcomes. This study aimed to assess the prevalence of CLBP among healthcare workers, examine their knowledge of pain neurophysiology, evaluate kinesiophobia, and explore how personal experience with CLBP influences their beliefs, attitudes, and interactions with patients. Materials and Methods: A cross-sectional observational study was conducted from January to May 2025 among healthcare professionals. A total of 50 participants completed an online questionnaire, of which 42 were valid and included in the analysis. The questionnaire collected demographic and professional data, determined the presence of CLBP, and included three standardized instruments: the Revised Neurophysiology of Pain Questionnaire (rNPQ) to assess knowledge of pain mechanisms, the Health Care Providers’ Pain and Impairment Relationship Scale (HC-PAIRS) to evaluate beliefs about pain and disability, and the Tampa Scale of Kinesiophobia (TSK-11) to measure fear of movement. Data were analyzed using SPSS and Microsoft Excel. Results: Among the 42 participants, 11 demonstrated low, 28 moderate, and 3 high knowledge of pain neurophysiology (rNPQ), with a mean score of 5.66. On the HC-PAIRS, the majority (30 participants) scored above 60, indicating beliefs that pain leads to disability, while 12 scored below 60, reflecting a biopsychosocial perspective; gender did not significantly affect HC-PAIRS scores (p = 0.213). As for kinesiophobia (TSK-11), 24 participants had low, 17 moderate, and 1 clinically significant fear of movement. Correlation analysis revealed that younger participants had higher rNPQ scores (r = −0.358, p = 0.020) and lower TSK-11 scores (r = −0.389, p = 0.011). TSK-11 scores increased with age (r = 0.432, p = 0.004), while HC-PAIRS scores showed no significant correlations. Conclusions: Healthcare professionals, particularly physiotherapists, show gaps in knowledge of pain neurophysiology and a tendency toward biomedical beliefs regarding chronic low back pain. This cross-sectional study indicates that a greater understanding of pain mechanisms is associated with lower kinesiophobia, emphasizing the importance of education. Integrating the biopsychosocial model into undergraduate and continuing professional training, through interdisciplinary and practical modules, may improve knowledge, reduce maladaptive fear-avoidance behaviors, and enhance patient care. Future studies should include larger, more diverse samples and assess the long-term impact of educational interventions on clinical practice. Full article

This article examines how the Ahiska Turks—deported from Georgia’s Meskheti region to Central Asia in 1944—sustained their religious belonging under shifting Soviet and post-Soviet political and social conditions, and how this religious continuity became intertwined with processes of collective memory formation. Drawing on published archival materials, existing scholarship, and a long-term ethnographic corpus composed of fourteen life-history oral interviews conducted between 2006 and 2025 in Turkey and Kazakhstan, the study traces the multigenerational trajectories of ritual practice. The findings show that funeral ceremonies, mevlid gatherings, Ramadan practices, and domestic prayer circles function as “sites of memory” through which the trauma of displacement is reinterpreted and intergenerational belonging is continually reconstituted. These ritual forms generate a meaningful sense of continuity and communal resilience in the face of prolonged experiences of loss, uncertainty, and “placelessness.” Situated at the intersection of the anthropology of religion, cultural trauma theory, and Soviet/post-Soviet diaspora studies, the article conceptualizes Islam as more than a realm of belief: for the Ahiska Turks, it operates as a core cultural infrastructure that anchors post-displacement resilience, social organization, and collective memory. The study contributes to the literature by offering an integrated analytical framework that places the Ahiska community within broader debates on religion, memory, and forced migration; by examining rituals not only as emotional practices but also as institutional and cultural scaffolding; and by foregrounding the understudied post-traumatic religious experiences of Muslim diasporas. Full article

Purpose: The aim of this review is to provide an overview of the effects of commonly used dietary supplements on soccer performance and to bridge the gap between scientific evidence and their practical application by practitioners working with elite soccer players. Methods: Relevant literature involving dietary supplement use in soccer players was identified through searches of PubMed, EMBASE, Scopus, and Web of Science. Additionally, insights were gathered from a cross-sectional online questionnaire completed by practitioners (nutritionists, physicians, sport scientists, strength and conditioning coaches, and heads of performance) working with first-division men’s teams across five European leagues. Eligible respondents were over 18 years old with >2 years of experience in elite sport. The 20-question survey, designed on Qualtrics and pilot-tested for content validity, covered practitioner background, beliefs about supplementation, and real-world practices. The study was approved by the Ethical Independent Committee in Genoa, Italy (Ref. 2020/12). Results: Among performance-enhancing supplements, caffeine has been shown to improve endurance, sprint performance, power, and cognitive function, while creatine consistently enhances short-duration, high-intensity efforts. Beta-alanine and sodium bicarbonate help reduce the buildup of acidity in muscles during repeated high-intensity exercise, supporting repeated sprint performance. For hydration and endurance support, dietary nitrates improve blood flow and oxygen delivery to muscles, and glycerol enhances fluid retention in hot environments and during compressed match schedules, where players compete in multiple matches within a short recovery window. Regarding recovery aids, protein and tart cherry supplementation have been shown to accelerate recovery, reduce muscle damage, and support training adaptations. Field insights revealed that creatine and caffeine were widely adopted by practitioners (>90%), with protein powders also commonly recommended (>80%). In contrast, beta-alanine, tart cherry, and dietary nitrates were only partially integrated into daily practice (30%, 32%, and 48.5%, respectively), while sodium bicarbonate (24%) and glycerol (10.5%) were used by a minority. Conclusions: Although scientific evidence provides a strong foundation for the efficacy of dietary supplements, their translation into elite soccer practice is shaped by a range of practical factors, including cultural resistance, taste preferences, gastrointestinal side effects, established team routines, and individual player preferences. These findings highlight the importance of targeted education for players and staff, individualized supplementation plans, and close collaboration between nutritionists, coaches, and medical teams. However, our survey did not directly assess reasons for non-implementation. In addition to practical barriers reported by practitioners, unfamiliarity with current evidence likely contributes to this evidence–practice gap. Full article

Objectives: The central nervous system plays a fundamental role in chronic pain; however, its behavior in this condition remains unclear, especially when associated with interventions such as kinesiotaping (KT). This study aimed to analyze the effects of KT on the somatosensory cortex of women with chronic low back pain. Methods: This case series involved 15 women with chronic low back pain. Participants underwent a progressive-tension KT protocol for 8 weeks, and electroencephalogram recordings were performed in two positions, namely sitting and standing while load bearing (10% of body weight), in the first and eighth weeks. The following instruments were employed: Oswestry lumbar disability index, fear avoidance beliefs questionnaire, and the numerical pain intensity scale. Results: All participants showed significant pain improvement and a reduction in Oswestry disability index scores from moderate to minimal. Additionally, activity in the alpha band within the somatosensory cortex and insula (central region—represented by the electrode Cz) decreased. This was confirmed by reduced power spectral density, indicating diminished cortical activity in these regions. Conclusions: KT positively affects women with chronic low back pain, providing pain reduction and improved functional capacity, as indicated by the fear avoidance beliefs questionnaire and numerical pain intensity scale. Moreover, KT reduces cortical activity in the somatosensory cortex, which is related to the progression of painful sensations, described above after the intervention. Full article

Background: Functional Neurological Disorder (FND) encompasses conditions with neurological symptoms inconsistent with structural pathology, arising instead from complex interactions between psychological, biological, and social factors. Despite growing research, the etiological and risk factor landscape remains only partially understood, complicating diagnosis and treatment. Objective: This systematic review maps risk factors for major FND subtypes such as functional seizures (psychogenic non-epileptic seizures or PNES), functional cognitive disorder (FCD), functional movement disorders (FMD), functional weakness and sensory disturbances, functional visual symptoms, and functional gait abnormalities by categorizing predisposing, precipitating, and perpetuating influences. Methods: A systematic search of PubMed, PsycINFO, Scopus, and Web of Science initially identified 245 records. After removal of 64 duplicates, 181 studies were screened by title and abstract. Of these, 96 full texts were examined in detail, and finally 23 studies met the predefined inclusion criteria. Data were extracted and analyzed thematically within a biopsychosocial framework, with results summarized in subtype-specific profiles. Results: Childhood adversity, especially emotional, physical, or sexual abuse, emerged as a robust and consistent predisposing factor across PNES cohorts. Psychiatric history (notably anxiety, depression, and PTSD), neurodevelopmental traits (more frequent in FCD), and personality patterns such as alexithymia and somatization also contributed to vulnerability. Precipitating influences included acute psychological stress, intrapersonal conflict, or concurrent medical illness. Perpetuating factors comprise maladaptive illness beliefs, avoidance behaviors, insufficient explanation or validation by healthcare providers, and secondary gains related to disability. While several risk factors were shared across subtypes, others appeared subtype-specific (trauma was especially associated with PNES, whereas neurodevelopmental traits were more characteristic of FCD). Conclusions: FND arises from a dynamic interplay of predisposing, precipitating, and perpetuating factors, with both shared and subtype-specific influences. Recognizing this heterogeneity can enhance diagnostic precision, guide tailored intervention, and inform future research into the neurobiological and psychosocial mechanisms underlying FND. Full article

Diesel engines serve as critical power sources across transportation and industrial fields, and their fault diagnosis is essential for ensuring operational safety and system reliability. However, acquiring sufficient and effective operational data remains a significant challenge due to the high complexity of the systems. As a modeling method that incorporates expert knowledge, the belief rule base (BRB) demonstrates strong potential in resolving such challenges. Nevertheless, the reliance on expert knowledge constrains its practical application, particularly in complex engineering scenarios. To overcome this limitation, this study proposes a reliability fault diagnosis method for diesel engines based on the belief rule base with data-driven initialization (DI-BRB-R), which aims to improve modeling capability under conditions of limited expert knowledge. Specifically, the approach first employs fuzzy c-means clustering with the Davies–Bouldin index (DBI-FCM) to initialize attribute reference values. Then, a Gaussian membership function with Laplace smoothing (LS-GMF) is developed to initialize the rule belief degrees. Furthermore, to guarantee the reliability of the model optimization process, a group of reliability guidelines is introduced. Finally, the effectiveness of the proposed method is validated through an example of fault diagnosis of the WD615 diesel engine. Full article

Chronic neck pain is a multifactorial condition involving physical, psychological, and neurological dimensions. This case report describes the clinical course of a 25-year-old female with chronic neck pain and recurrent headaches who underwent a 6-week integrative intervention consisting of manual therapy and pain neuroscience-based sensorimotor retraining, administered three times per week. Outcome measures included the Headache Impact Test-6 (HIT-6), Neck Pain and Disability Scale (NPDS), Pain Catastrophizing Scale (PCS), Fear-Avoidance Beliefs Questionnaire (FABQ), pressure pain threshold (PPT), cervical range of motion (CROM), and functional near-infrared spectroscopy (fNIRS) to assess brain activity. Following the intervention, the patient demonstrated marked reductions in pain and psychological distress: HIT-6 decreased from 63 to 24 (61.9%), NPDS from 31 to 4 (87.1%), FABQ from 24 to 0 (100%), and PCS from 19 to 2 (89.5%). Improvements in PPT and CROM were also observed. fNIRS revealed decreased dorsolateral prefrontal cortex (DLPFC) activation during pain stimulation and movement tasks, suggesting a possible reduction in central sensitization burden. These findings illustrate that an integrative approach targeting biopsychosocial pain mechanisms may be beneficial in managing chronic neck pain, improving function, and modulating cortical responses. This report provides preliminary evidence in support of the clinical relevance of combining manual therapy with neurocognitive retraining in similar patients. Full article

Background/Objectives: Obsessive–compulsive disorder (OCD) is a complex psychiatric condition often associated with alterations in cognitive processes, including memory. Although memory dysfunction has been proposed as a contributing factor to the onset and maintenance of OCD symptoms, it remains debated whether these deficits reflect genuine cognitive impairments or maladaptive metacognitive processes, such as pathological doubt and memory distrust. This review aims to synthesize current findings on memory functioning in OCD, focusing on distinct memory systems and the role of metacognition. Methods: A comprehensive literature search was conducted across five databases (PubMed, Scopus, Embase, PsycINFO, and Google Scholar), covering studies up to April 2025. Search terms included “Obsessive-compulsive disorder”; “OCD”; “Memory dysfunction”; “Episodic memory”; “Working memory impairment”; “Prospective memory deficits”; “Checking compulsions”; “Memory confidence”; “Cognitive biases”. Results: Short-term memory appears generally preserved in OCD. Working memory deficits are consistently reported, especially in the visuospatial domain, and they are associated with difficulties in updating and clearing irrelevant information. Episodic memory impairments are common and often linked to inefficient encoding strategies and heightened cognitive self-consciousness. Prospective memory is frequently compromised under neutral conditions. Individuals with checking symptoms tend to show intact objective memory performance, despite reporting low memory confidence, supporting the concept of memory distrust. Conclusions: Memory dysfunction in OCD is multifaceted, involving both cognitive and metacognitive alterations. The evidence supports a model in which executive dysfunctions and memory-related beliefs contribute to compulsive behaviors more than objective memory failure. These insights highlight the need for integrative assessment protocols and personalized interventions targeting both cognitive performance and metacognitive appraisals. Full article

Artificial intelligence has significantly transformed educational practices across disciplines. This study investigated the cognitive–behavioral mechanisms underpinning mathematics teachers’ engagement with AI teaching tools through an extended technology acceptance model. Utilizing structural equation modeling with data from 500 mathematics educators, we delineated psychological pathways connecting perceptual variables to technology engagement and pedagogical outcomes. Results revealed that perceived usefulness functioned as the primary determinant of AI engagement, while perceived ease of use operated exclusively through sequential mediational pathways, challenging conventional technology acceptance paradigms. Domain-specific factors, such as teacher AI literacy and mathematics teaching beliefs, emerged as significant mediators that conditioned technology-related behavioral responses. The mediators in this study illustrated differential attitudinal mechanisms through which perceptual variables transformed into engagement behaviors. These findings extended technology acceptance theories in educational contexts by demonstrating how domain-specific cognitive structures modulated perception–behavior relationships in professional technology adoption in mathematics education. Full article

Hepatocellular carcinoma (HCC) is a leading cause of cancer death globally, with the majority of cases detected at advanced stages when curative options are limited. Current systemic therapies, including immune checkpoint inhibitors, demonstrate limited efficacy with durable responses in only 15–20% of patients. This poor response is largely attributed to HCC’s immunosuppressive microenvironment, which blunts effective T-cell responses. By illustrating that innate immune cells can acquire memory-like characteristics through a process known as trained immunity, recent evidence has challenged the conventional belief that innate immunity is devoid of memory. This review investigates the potential of trained immunity, which is defined by the long-term functional reprogramming of innate immune cells through epigenetic, transcriptomic, and metabolic changes, to provide new therapeutic opportunities for HCC. We discuss mechanisms by which trained immunity can transform the HCC microenvironment, including enhanced inflammatory cytokine production, repolarization of tumor-associated macrophages toward anti-tumor phenotypes, increased immune cell infiltration, and improved bridging to adaptive immunity. We further evaluate emerging therapeutic strategies leveraging trained immunity principles, including BCG vaccination, β-glucan administration, cytokine-trained NK cell therapy, and innovative combination approaches. Finally, we address potential resistance mechanisms and future directions for clinical application. By integrating trained immunity into conventional immunotherapeutic regimens, we may significantly improve outcomes for HCC patients, potentially transforming advanced disease into a more manageable condition. Full article

The Anthropocene is a concept that highlights the profound changes humans have made to nearly every aspect of the Earth. It serves as a compelling narrative that challenges us to examine public perceptions and interests regarding human–nature interactions in an integrated way. These interactions are widespread but can vary significantly over time, across cultures and under different economic conditions, making them difficult to monitor effectively on a large scale. Recent advancements in digital technology, such as the ability to track online searches through tools, like Google Trends-Glimpse, and the near real-time monitoring of news broadcasts via the GDELT Project, present new opportunities. These tools can analyze data in multiple languages around the world, encouraging innovative approaches to integrate the diverse and complex information generated within this multi-language, multi-concept, and varied time-scale environment of human activity and beliefs. We propose a transformed version of Markowitz’s multi-asset optimization theory that encompasses over 5.5 billion people, several languages, and concepts since 2004. This approach is a functional ensemble where ecology and economics intersect, at least mechanistically. Our findings indicate that while there is a general increase in people’s interest in Anthropocene-related issues, significant differences exist across cultures. We also identify several sources of data noise and evidence that interfere with the overall methodology. Addressing these issues in future research will help to extend the validity of our approach, especially if it increases interest in conservation culturomics. Full article

Stigma and discrimination remain significant challenges to the quality of life and social integration of individuals with chronic mental disorders, particularly schizophrenia, one of the most stigmatized conditions. The paradox of insight, in which greater awareness of illness correlates with poorer psychosocial outcomes in the presence of high internalized stigma, provides a critical framework for understanding these challenges. This study examined the moderation between insight and internalized stigma and its influence on psychosocial outcomes in 83 male participants diagnosed with psychotic spectrum disorders. Using K-means clustering, three distinct profiles emerged: (1) good insight and minimal stigma, (2) poor insight and mild stigma, and (3) good insight and severe stigma. These profiles showed significant differences in depression, quality of life, and global functioning. Findings confirmed that internalized stigma moderates the relationship between insight and psychosocial well-being, exacerbating the negative influence of insight on quality of life and psychological health when stigma levels are high. The results emphasize the need for psychoeducational interventions to normalize experiences of psychosis, family and community engagement to reduce stigma, and cognitive-behavioral therapies to address stigma-related beliefs. These strategies are essential for improving psychosocial well-being and supporting recovery in this population. Full article

Background and Objectives: Theory of mind (ToM) deficits in children with ADHD are closely related to social difficulties and problems in interpersonal interactions. Evidence suggests that these cognitive deficits negatively affect the ability to understand and respond to others’ emotions and intentions, thus contributing to social isolation and a lower quality of life. However, the findings across studies vary, indicating that ADHD subtype and comorbidities, such as anxiety and mood disorders, can significantly influence sociocognitive deficits, modulating the extent of social problems. Materials and Methods: This review examines the relationship among ADHD, ToM, and empathy, analyzing studies comparing children with ADHD with peers with typical development or other neurodevelopmental conditions. A search in PubMed, Scopus, and the Cochrane Library prior to January 10, without time restrictions, using “ADHD”, “Cognitive Empathy”, and “Theory of Mind” identified relevant studies assessing these abilities through neuropsychological tests or questionnaires. Results: Of the initial 243 studies, 23 studies met the inclusion criteria. Children with ADHD exhibited significant impairments in ToM and empathy, affecting social cognition and interpersonal understanding. Various assessment tools revealed difficulties in understanding beliefs, emotions, and intentions, with executive function deficits playing a crucial role in shaping these social challenges. Conclusions: This review highlights the need for targeted therapeutic interventions that not only address cognitive deficits but consider emotional and metacognitive aspects, such as emotion regulation and self-awareness. Future research should focus on integrating executive function training with approaches that develop metacognitive and emotional skills, thus providing more comprehensive support. Full article

Background: Vulnerability to stress is associated with susceptibility to react to certain events, taking into account individual factors, beliefs, and available resources. Workplace bullying increases stress, absenteeism, and turnover among nurses, creating a toxic environment. This negatively impacts their well-being and compromises the quality of nursing care. As a result, patient safety and healthcare outcomes may be affected. Objectives: To assess the prevalence of vulnerability to stress in Portuguese nurses and its relationship with the experience of workplace bullying. Methodology: This study used a descriptive–correlational approach with a cross-sectional design. The data collection instrument used was a questionnaire consisting of a sociodemographic component and a scale assessing vulnerability to stress (QVS-23) and workplace bullying (NAQ-R). The total sample consisted of 2015 nurses working in healthcare institutions. Results: Nurses who perceived themselves as victims of workplace bullying were shown to be more vulnerable to stress, with a higher mean value for perfectionism and dramatization of existence, inhibition and functional dependence, lack of support and deprivation of affection, intolerance of frustration and rejection, and adverse living conditions. Conclusions: Organizations must create a healthy, respectful, and productive working environment by identifying the various factors that make them vulnerable to stress in the workplace. They must also act to prevent workplace bullying, thus protecting the health of nurses and promoting positive relationships and a harmonious work culture. Full article