Search Results (11)

Immunotherapy has emerged as a transformative approach in gastrointestinal (GI) cancers, addressing historically poor survival rates in advanced-stage disease. Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis demonstrate remarkable efficacy in colorectal cancer with deficient mismatch repair (dMMR) or high microsatellite instability (MSI-H), exemplified by trials like NICHE-2 achieving exceptional pathological response rates. However, significant limitations persist, including resistance in some dMMR/MSI-H tumors, minimal efficacy in proficient mismatch repair (pMMR) tumors, and low overall response rates across most GI malignancies due to tumor heterogeneity and immune evasion mechanisms. Predictive biomarkers such as tumor mutational burden (TMB) and PD-L1 expression are crucial for optimizing patient selection, while hypermutated pMMR tumors with POLE mutations represent emerging therapeutic opportunities. In pancreatic adenocarcinoma, where survival remains dismal, combination strategies with chemotherapy and novel approaches like cancer vaccines show promise but lack transformative breakthroughs. Esophagogastric cancers benefit from ICIs combined with chemotherapy, particularly in MSI-H and HER2-positive tumors, while hepatocellular carcinoma has achieved significant progress with combinations like atezolizumab–bevacizumab and durvalumab–tremelimumab surpassing traditional therapies. Biliary tract cancers show modest improvements with durvalumab–chemotherapy combinations. Despite these advances, immunotherapy faces substantial challenges including immune-related adverse events, acquired resistance through cancer immunoediting, and the need for biomarker-driven approaches to overcome tumor microenvironment barriers. This review discusses key clinical trials, therapeutic progress, and emerging modalities including CAR T-cell therapies and combination strategies, emphasizing the critical need to address resistance mechanisms and refine precision medicine approaches to fully realize immunotherapy’s potential in GI malignancies. Full article

Live music can afford novel, transformative aesthetic interactions for individual audience members. Nevertheless, concert research tends to focus on shared experience. In this paper we offer an account of exploratory listening that foregrounds embodied–enactive engagement and affective resonance through close analysis of the music, physiological measurements, and reflections from interviews. Our analysis centres on data collected from two musician audience members about one specific piece out of a larger interdisciplinary project involving concerts given by the Stavanger Symphony Orchestra and The Norwegian Radio Orchestra in March and June of 2024. Through the combination of in-depth phenomenological interviews with musically skilled audience members and measurements of breathing and body motion, we explore aesthetic enactment beyond common patterns of ‘synchronised’ response, focusing on audience members’ experiences of Harald Sæverud’s ‘Kjempeviseslåtten’ (The Ballad of Revolt) (1943). We find forms of absorbed, both imaginative and embodied involvement, of listeners enacting meaningful contact with, and pathways through, the music that in some ways corroborate crowd patterns but also reveal exploratory expertise and idiosyncratic affective orientations. Full article

This article locates the clinic as a historically contingent space which faced cultural resistance and remained alien to the colonized population in India. It corroborates the socio-political tension in setting up a clinic within the colony and investigates how the Western clinic as a colonial apparatus was resituated as the “Indian clinic” per se. With the historical emergence of a new class of medical practitioners called “daktars” (a Bengali vernacularization of the term “doctor”), the health-seeking behaviour and public health model of colonial India witnessed a decolonial shift. Unlike their English counterparts, daktars did not enjoy a privileged position within the medical archives of colonial India. This archival gap within Indian medical history presents itself as a viable topic for discussion through the means of the literature of the colonized. Bengali writer Ashoke Mukhopadhyay’s novel Abiram Jwarer Roopkotha (2018), translated into English as A Ballad of Remittent Fever in 2020, remedies the colonial politics of the archive by reconstructing the lives of various daktars and their pursuit of self-reliance. The article takes a neo-historical approach towards understanding and assessing the past of daktari medicine and thereby offers comments on its traces in the contemporary public health of India. Full article

The Victorian bourgeois ballad is a distinctive genre that demonstrates the spirituality of religion transferred to the drawing room. This paper will examine in detail four examples of the genre—The Lost Chord, The Holy City, Arise O Sun and The Volunteer Organist to examine the spirituality of the genre in terms of the materials used, the musical construction, the value system underpinning it and the expressive character. It will interrogate their relationship to the spirituality of Victorian Anglicanism and the place of this spirituality in the lives of the people with whom they were popular and its role in their social life, drawing on the author’s own experience. It was also a genre in which women excelled and this and the notion of spirituality will be examined culturally, drawing on Foucault’s notion of subjugated knowing. Full article

To solve the problem that the common long-tailed classification method does not use the semantic features of the original label text of the image, and the difference between the classification accuracy of most classes and minority classes are large, the long-tailed image classification method based on enhanced contrast visual language trains the head class and tail class samples separately, uses text image to pre-train the information, and uses the enhanced momentum contrastive loss function and RandAugment enhancement to improve the learning of tail class samples. On the ImageNet-LT long-tailed dataset, the enhanced contrasting visual language-based long-tailed image classification method has improved all class accuracy, tail class accuracy, middle class accuracy, and the F₁ value by 3.4%, 7.6%, 3.5%, and 11.2%, respectively, compared to the BALLAD method. The difference in accuracy between the head class and tail class is reduced by 1.6% compared to the BALLAD method. The results of three comparative experiments indicate that the long-tailed image classification method based on enhanced contrastive visual language has improved the performance of tail classes and reduced the accuracy difference between the majority and minority classes. Full article

Ballads are often among the bestselling songs of heavy metal and hard rock bands. Within these genres, ballads represent a way to address emotions such as love that are not part of the primary self-understanding of those genres. Still, “genre ideals and style” often seem to be at odds with the sentimental aesthetics of the ballad and its emotional expression and experience. In this article, we take a close look at the sonic, textual, performative, visual, and emotional-somatic articulation of love and the generation of sentimentality in three selected metal ballads. Even if the term “power ballad,” which is often used in reference to hard rock and metal ballads, refers to the simultaneity of “heaviness” in the sound and the thematization of love in the lyrics, sentimental ballads in the stereotypically more masculine-connotated genres nevertheless create friction and skepticism in their discursive evaluation, as they generate aesthetic discrepancies between concrete songs and genre conventions. Their quantitative popularity contrasts with their qualitative evaluation. Therefore, in a second step, we analyze the reception of the selected ballads, in particular their discursive evaluations in music reviews, in order to point out the ways of argumentation through which frictions are established. As a result, we show that evaluations are related to how love is addressed in the songs and to the extent of proximity of the ballads to genre rules. Full article

Thomas Walton (known as Purser) and Clinton Atkinson (known as Clinton) were hanged for piracy in 1583. This article examines a range of texts relating to Purser and Clinton, including court depositions, plays and ballads, to consider the ways in which their lives and deaths were depicted and discover what this might tell us about contemporary attitudes towards piracy. Purser and Clinton were based in Dorset where the boundaries delineating piracy as an illegal activity were blurred and the local beneficiaries of piracy spanned the social hierarchy, reaching as high as nobility and the Admiralty. A wealth of textual evidence details the links between the maritime and littoral networks which sustained their activities, enabled their rise to prominence, and engineered their ultimate downfall. In reading together both official documents and popular printed texts this article reveals some of the complex networks which supported and were supported by piracy and, in doing so, locates the figure of the pirate within wider discourses of society, governance and mobility. Full article

In 1205, the Danish king Valdemar II married a Bohemian princess, known in her new country as Dagmar. Little contemporary information exists concerning this queen, who died only seven years after her arrival. Nonetheless, Dagmar is one of very few figures from medieval Danish history whose names are familiar to a general Danish public in the present. Over the centuries, a narrative of her life has emerged, based largely on a group of ballad texts first written down in the sixteenth century, that Queen Dagmar was so exceptionally beautiful and kind that Danes (particularly common people) remained devoted to her memory through the generations. Moreover, several texts, and a remarkable early twentieth-century painting in St Bendt’s Church in Ringsted posit her as an intercessor on behalf of Denmark, in ways that come very close to portraying her as a saint, so much that one twentieth-century ballad scholar concludes that the Benedictine monks of Ringsted launched a canonization process on her behalf. This article investigates the image of Queen Dagmar as it has developed over the centuries with a particular eye toward implications or claims of sanctity, toward Dagmar’s purported role as an intercessor during and after her lifetime, and her perceived (and at times seemingly prescribed) role in the constitution of Danish identity. Full article

Collective mourning is an expression of societal maturity, cohesion, and respect. The world is in grief, but in early January 2020, before nobody could even imagine that SARS-CoV-2 would turn into the COVID-19 pandemic, a music video version of a pop ballad about love and isolation was spread across a Chinese social network. The song ‘You Are Not Alone’ was adapted as a cover by young foreigners living in China to express their support to bereaved families and frontline workers and encourage the people of China, their second home. At that time, the rest of the world looked to distant China but could hardly expect to face the same adversity months later. The authors reported that the music video was a spontaneous artistic expression copying such traumatic events and the mourning process. The present work analyses how the music was blended with lyrics and images describing the outbreak in Wuhan to reach their goal. The original song and this shortened version for China were compared regarding musical and lyric structures and main characteristics. Additionally, an analysis of the two videos was done regarding cinemetric variables and non-verbal communication that emphasized the power of songs to express deep sorrow and sympathy but also to give hope. Psychological first aid, the five stages of the mourning process by Kübler-Ross, the dual-process model by Stroebe and Schut, and Taylor’s tend-to-befriend provided a better understanding of the translation from interpersonal to societal mourning. Finally, other memorable songs that society spontaneously chose to be performed alone or together to cope with sudden and dramatic situations, mitigate physical distancing, and alleviate human suffering are discussed. Music, lyrics, and artistic performance are playing a key role in building social and emotional ties during this pandemic, hampering individual and social pain and sorrow despite cultural barriers. Full article

In this paper, we explore a generative music method that can compose atonal and tonal music in different styles. One of the main differences between regular engineering problems and artistic expressions is that goals and constraints are usually ill-defined in the latter case; in fact the rules here could or should be transgressed more regularly. For this reason, our approach does not use a pre-existing dataset to imitate or extract rules from. Instead, it uses formal grammars as a representation method than can retain just the basic features, common to any form of music (e.g., the appearance of rhythmic patterns, the evolution of tone or dynamics during the composition, etc.). Exploring different musical spaces is the responsibility of a program interface that translates musical specifications into the fitness function of a genetic algorithm. This function guides the evolution of those basic features enabling the emergence of novel content. In this study, we then assess the outcome of a particular music specification (guitar ballad) in a controlled real-world setup. As a result, the generated music can be considered similar to human-composed music from a perceptual perspective. This endorses our approach to tackle arts algorithmically, as it is able to produce novel content that complies with human expectations. Full article

The four poets that provide the material for this chapter did not know each other and they probably did not know each other’s work. However, they had important formative experiences in common: They were all educated in Scotland and they all left Scotland after that early education. Yet, they all retained special, although different, ties to that country, to its history, and its writing. They were all “modern” in their poetry, sometimes bizarrely so: Of each of them it could be said, “There was no one like her.” This strangeness they also share, as they share a willingness, even desire, to shock, a muddling of contemporary and archaic, of real and legendary. Veronica Forrest-Thomson’s “Hold on to your seat-belt Persephone” is an indicative phrase. I aim to show that these serially inimitable modern writers have complicated and intertwined Scottish and international connections. Full article