Open AccessArticle
Effects of Ethanolic and Aqueous Extracts of Garcinia gardneriana Leaves in an In Vivo Experimental Model Induced by a Hyperlipidic Diet
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Bruna Larissa Spontoni do Espirito Santo, Lidiani Figueiredo Santana, Wilson Hino Kato Junior, Felipe de Oliveira de Araújo, Mariana Bento Tatara, Júlio Croda, Danielle Bogo, Karine de Cássia Freitas, Rita de Cássia Avellaneda Guimarães, Priscila Aiko Hiane, Arnildo Pott, Wander Fernando de Oliveira Filiú, Bernardo Bacelar de Faria, Patrícia de Oliveira Figueiredo, Valter Aragão do Nascimento, Frederico Louveira Ayres and Paulo Roberto Haidamus de Oliveira Bastos
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Abstract
The study of medicinal plants, such as the genus
Garcinia (Clusiaceae), in the treatment of non-communicable chronic diseases has aroused the interest of researchers. However, there are no studies in the literature that have investigated the effects of
Garcinia gardneriana in experimental models
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The study of medicinal plants, such as the genus
Garcinia (Clusiaceae), in the treatment of non-communicable chronic diseases has aroused the interest of researchers. However, there are no studies in the literature that have investigated the effects of
Garcinia gardneriana in experimental models of obesity for possible metabolic alterations. Swiss mice receiving a high-fat diet were supplemented with aqueous or ethanolic extract of
G. gardneriana at doses of 200 or 400 mg/kg/day. It was found that there was a reduction in food consumption in experimental groups compared with the control groups, and the group supplemented with aqueous extract at a dose of 200 mg/kg/daydisplayed a reduction in weight. The results showed an increase in the values of high density lipoprotein (HDL-c), total cholesterol, triglycerides and fasting blood glucose.
G. gardneriana did not protect against insulin resistance, and caused in an increase in monocyte chemoattractant protein-1 (MCP-1) concentrations and a reduction in interleukin 10 (IL-10). In addition, hepatic steatosis and microvesicular steatosis were indicated. It was revealed that, under the experimental conditions in the study,
G. gardneriana did not prevent weight gain or comorbidities; that is, a different behavior was obtained from that described in the literature with regard to the medicinal potential of the
Garcinia species, which is probably related to the phytochemical properties.
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(This article belongs to the Section
Lipids)
