Search Results (3)

The aim of this article review is to analyze some models and clinical issues related to the implementation of accelerated diagnostic protocols based on specific cardiac biomarkers in patients admitted to the emergency department (ED) with symptoms compatible with acute cardiac disorders. Four specific clinical issues will be discussed in detail: (a) pathophysiological and clinical interpretations of circulating hs-cTnI and hs-cTnT levels; (b) the clinical relevance and estimation of the biological variation of biomarkers in patients admitted to the ED with acute and severe diseases; (c) the role and advantages of the point-of-care testing (POCT) methods for cardiac-specific biomarkers in pre-hospital and hospital clinical practice; and (d) the clinical role of specific cardiac biomarkers in patients with acute heart failure (AHF). In order to balance the risk between a hasty discharge versus the potential harms caused by a cardiac assessment in patients admitted to the ED with suspected acute cardiovascular disease, the measurement of specific cardiac biomarkers is essential for the early identification of the presence of myocardial dysfunction and/or injury and to significantly reduce the length and costs of hospitalization. Moreover, specific cardiac biomarkers (especially hs-cTnI and hs-cTnT) are useful predictors of mortality and major adverse cardiovascular events (MACE) in patients admitted to the ED with suspected acute cardiovascular disease. To guide the implementation of the most rapid algorithms for the diagnosis of Non-ST-Elevation Myocardial Infarction (NSTEMI) into routine clinical practice, clinical scientific societies and laboratory medicine societies should promote collaborative studies specifically designed for the evaluation of the analytical performance and, especially, the cost/benefit ratio resulting from the use of these clinical protocols and POCT methods in the ED clinical practice. Full article

The objective of the present paper is to develop a methodology that could allow the representation of the analytical hyporheic flux equation model (AHF) in a numerical model done in MODFLOW. Therefore, the scope of the research is to show the viability of the methodology suggested in a real case (Biebrza river, Poland, Europe). Considering that the model requires extensive manipulation in the creation of the packages, a test phase through the seepage package of MODFLOW is carried out with the aim of representing the river package of MODFLOW. FloPy is the tool chosen to develop this implementation due to the versatility of manipulating the packages available in MODFLOW through coding. The obtained results showed a correct implementation of the AHF model using the example of the Biebrza River. The results obtained will enable a better understanding regarding the modelling of the interaction between the river and the aquifer, considering streams with specific geometries where the depth is dimensionally higher than the width. Full article

Modelling of water flow in the hyporheic zone and calculations of water exchange between groundwater and surface waters are important issues in modern environmental research. The article presents the Analytical Hyporheic Flux approach (AHF) permitting calculation of the amount of water exchange in the hyporheic zone, including vertical water seepage through the streambed and horizontal seepage through river banks. The outcome of the model, namely water fluxes, is compared with the corresponding results from the numerical model SEEP2D and simple Darcy-type model. The errors of the AHF model, in a range of 11–16%, depend on the aspect ratio of water depth to river width, and the direction of the river–aquifer water exchange, i.e., drainage or infiltration. The AHF model errors are significantly lower compared to the often-used model based on vertical water seepage through the streambed described by Darcy’s law. Full article