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Feature Paper
Article

577 Views

12 Pages

Characterization of the Left Ventricular Myocardium in Systemic Sclerosis

Briella K. Egberts,
Rajiv Ananthakrishna,
Ranjit Shah,
Antony Chun Fai So,
Jennifer Walker,
Sivabaskari Pasupathy,
Susanna Proudman and
Joseph B. Selvanayagam

J. Clin. Med.2025, 14(16), 5627;https://doi.org/10.3390/jcm14165627

8 August 2025

Background/Objectives: Cardiac involvement in systemic sclerosis (SSc) ranges from subclinical to severe. While pulmonary artery hypertension (PAH) is well-documented, the mechanism of left ventricular (LV) ischemia remains unclear. Oxygen-sensitive...

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Article

8 Citations

4,021 Views

19 Pages

Higher Ventricular-Arterial Coupling Derived from Three-Dimensional Echocardiography Is Associated with a Worse Clinical Outcome in Systemic Sclerosis

Francesco Tona,
Elisabetta Zanatta,
Roberta Montisci,
Denisa Muraru,
Elena Beccegato,
Elena De Zorzi,
Francesco Benvenuti,
Giovanni Civieri,
Franco Cozzi and
Sabino Iliceto
+ 1 author

Pharmaceuticals2021, 14(7), 646;https://doi.org/10.3390/ph14070646

5 July 2021

Primary myocardial involvement is common in systemic sclerosis (SSc). Ventricular-arterial coupling (VAC) reflecting the interplay between ventricular performance and arterial load, is a key determinant of cardiovascular (CV) performance. We aimed to...

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Article

954 Views

11 Pages

The Effectiveness of Sacubitril/Valsartan in Systemic Sclerosis Patients with Heart Failure: A Retrospective Analysis

Nouran Eshak,
Mahmoud Abdelnabi,
Jaxon Quillen,
Micheal Pham,
Joseph Hentz and
Vivek Nagaraja

J. Clin. Med.2025, 14(12), 4054;https://doi.org/10.3390/jcm14124054

8 June 2025

Introduction: Cardiac involvement in patients with systemic sclerosis (SSc) can present variably from being asymptomatic to manifesting with heart failure, conduction abnormalities, pulmonary hypertension, and pericardial effusion. Symptomatic cardia...

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Review

1 Citations

2,916 Views

22 Pages

Insights into Pulmonary Arterial Hypertension in Connective Tissue Diseases

Bogna Grygiel-Górniak,
Mateusz Lucki,
Przemysław Daroszewski and
Ewa Lucka

J. Clin. Med.2025, 14(13), 4742;https://doi.org/10.3390/jcm14134742

4 July 2025

Pulmonary arterial hypertension (PAH) is a severe complication associated with connective tissue diseases (CTDs), which is characterized by a significant influence on the patient’s prognosis and mortality. The prevalence of PAH varies depending...

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Review

58 Citations

7,786 Views

13 Pages

Heart Involvement in Inflammatory Rheumatic Diseases: A Systematic Literature Review

Florina Buleu,
Elena Sirbu,
Alexandru Caraba and
Simona Dragan

Medicina2019, 55(6), 249;https://doi.org/10.3390/medicina55060249

6 June 2019

Introduction: Patients with inflammatory rheumatic diseases have an increased risk of developing cardiovascular manifestations. The high risk of cardiovascular pathology in these patients is not only due to traditional cardiovascular risk factors (ag...

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