Search Results (5)

Floods, exacerbated by climate change, necessitate timely and accurate situational awareness to support effective disaster response. While electro-optical (EO) satellite imagery has been widely employed for flood assessment, its utility is significantly limited under conditions such as cloud cover or nighttime. Synthetic Aperture Radar (SAR) provides consistent imaging regardless of weather or lighting conditions but it remains challenging for human analysts to interpret. To bridge this modality gap, we present diffusion-based SAR-to-EO image translation (DSE), a novel framework designed specifically for enhancing the interpretability of SAR imagery in flood scenarios. Unlike conventional GAN-based approaches, our DSE leverages the Brownian Bridge Diffusion Model to achieve stable and high-fidelity EO synthesis. Furthermore, it integrates a self-supervised SAR denoising module to effectively suppress SAR-specific speckle noise, thereby improving the quality of the translated outputs. Quantitative experiments on the SEN12-FLOOD dataset show that our method improves PSNR by 3.23 dB and SSIM by 0.10 over conventional SAR-to-EO baselines. Additionally, a user study with SAR experts revealed that flood segmentation performance using synthetic EO (SynEO) paired with SAR was nearly equivalent to using true EO–SAR pairs, with only a 0.0068 IoU difference. These results confirm the practicality of the DSE framework as an effective solution for EO image synthesis and flood interpretation in SAR-only environments. Full article

In applications such as environmental monitoring, algorithms and deep learning-based methods using synthetic aperture radar (SAR) and electro-optical (EO) data have been proposed with promising results. These results have been achieved using already cleaned datasets for training data. However, in real-world data collection, data are often collected regardless of environmental noises (clouds, night, missing data, etc.). Without cleaning the data with these noises, the trained model has a critical problem of poor performance. To address these issues, we propose the Clean Collector Algorithm (CCA). First, we use a pixel-based approach to clean the QA60 mask and outliers. Secondly, we remove missing data and night-time data that can act as noise in the training process. Finally, we use a feature-based refinement method to clean the cloud images using FID. We demonstrate its effectiveness by winning first place in the SAR-to-EO translation track of the MultiEarth 2023 challenge. We also highlight the performance and robustness of the CCA on other cloud datasets, SEN12MS-CR-TS and Scotland&India. Full article

Essential oils (Eos) have demonstrated antiviral activity, but their toxicity can hinder their use as therapeutic agents. Recently, some essential oil components have been used within safe levels of acceptable daily intake limits without causing toxicity. The “ImmunoDefender,” a novel antiviral compound made from a well-known mixture of essential oils, is considered highly effective in treating SARS-CoV-2 infections. The components and doses were chosen based on existing information about their structure and toxicity. Blocking the main protease (Mpro) of SARS-CoV-2 with high affinity and capacity is critical for inhibiting the virus’s pathogenesis and transmission. In silico studies were conducted to examine the molecular interactions between the main essential oil components in “ImmunoDefender” and SARS-CoV-2 Mpro. The screening results showed that six key components of ImmunoDefender formed stable complexes with Mpro via its active catalytic site with binding energies ranging from −8.75 to −10.30 kcal/mol, respectively for Cinnamtannin B1, Cinnamtannin B2, Pavetannin C1, Syzyginin B, Procyanidin C1, and Tenuifolin. Furthermore, three essential oil bioactive inhibitors, Cinnamtannin B1, Cinnamtannin B2, and Pavetannin C, had significant ability to bind to the allosteric site of the main protease with binding energies of −11.12, −10.74, and −10.79 kcal/mol; these results suggest that these essential oil bioactive compounds may play a role in preventing the attachment of the translated polyprotein to Mpro, inhibiting the virus’s pathogenesis and transmission. These components also had drug-like characteristics similar to approved and effective drugs, suggesting that further pre-clinical and clinical studies are needed to confirm the generated in silico outcomes. Full article

Synthetic aperture radar (SAR) provides an all-weather and all-time imaging platform, which is more reliable than electro-optical (EO) remote sensing imagery under extreme weather/lighting conditions. While many large-scale EO-based remote sensing datasets have been released for computer vision tasks, there are few publicly available SAR image datasets due to the high costs associated with acquisition and labeling. Recent works have applied deep learning methods for image translation between SAR and EO. However, the effectiveness of those techniques on high-resolution images has been hindered by a common limitation. Non-linear geometric distortions, induced by different imaging principles of optical and radar sensors, have caused insufficient pixel-wise correspondence between an EO-SAR patch pair. Such a phenomenon is not prominent in low-resolution EO-SAR datasets, e.g., SEN1-2, one of the most frequently used datasets, and thus has been seldom discussed. To address this issue, a new dataset SN6-SAROPT with sub-meter resolution is introduced, and a novel image translation algorithm designed to tackle geometric distortions adaptively is proposed in this paper. Extensive experiments have been conducted to evaluate the proposed algorithm, and the results have validated its superiority over other methods for both SAR to EO (S2E) and EO to SAR (E2S) tasks, especially for urban areas in high-resolution images. Full article

The COVID-19 pandemic has posed a significant challenge to global public health. In response, the search for specific antiviral drugs that can effectively treat the disease caused by the SARS-CoV-2 virus has become a priority. While significant progress has been made in this regard, much work remains to address this ongoing crisis effectively. Favipiravir is an antiviral drug initially developed for the treatment of influenza and has received approval for emergency use for COVID-19 in many countries. A better understanding of the biodistribution and pharmacokinetics of Favipiravir in vivo would facilitate the development and translation of clinical antiviral drugs for COVID-19. Herein, we report the evaluation of [¹⁸F]Favipiravir in naive mice, transgenic mice models of Alzheimer’s disease, and nonhuman primates (NHP) with positron emission tomography (PET). The [¹⁸F]Favipiravir was obtained in an overall decay-corrected radiochemical yield of 29% with a molar activity of 25 GBq/µmol at the end of synthesis (EOS). PET imaging in naive mice, transgenic mice models of Alzheimer’s disease, and nonhuman primates revealed a low initial brain uptake, followed by a slow washout of [¹⁸F]Favipiravir in vivo. The [¹⁸F]Favipiravir was eliminated by a combination of hepatobiliary and urinary excretion. The low brain uptake was probably attributed to the low lipophilicity and low passive permeability of the drug. We hope this proof-of-concept study will provide a unique feature to study antiviral drugs using their corresponding isotopologues by PET. Full article