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Search Results (5)

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Keywords = Pinnigorgia

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13 pages, 3590 KiB  
Article
The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling
by Liang-Mou Kuo, Po-Jen Chen, Ping-Jyun Sung, Yu-Chia Chang, Chun-Ting Ho, Yi-Hsiu Wu and Tsong-Long Hwang
Mar. Drugs 2018, 16(1), 19; https://doi.org/10.3390/md16010019 - 9 Jan 2018
Cited by 44 | Viewed by 6202
Abstract
The activation of hepatic stellate cells (HSCs) is a significant phenomenon during the pathogenesis of liver disorders, including liver cirrhosis and fibrosis. Here, we identified that the extract from a gorgonian coral Pinnigorgia sp. (Pin) induced apoptosis of HSC-T6 cells. Pin inhibited the [...] Read more.
The activation of hepatic stellate cells (HSCs) is a significant phenomenon during the pathogenesis of liver disorders, including liver cirrhosis and fibrosis. Here, we identified that the extract from a gorgonian coral Pinnigorgia sp. (Pin) induced apoptosis of HSC-T6 cells. Pin inhibited the viability of HSC-T6 cells and increased their subG1 population, DNA fragmentation, caspase-3 activation, and reactive oxygen species (ROS) production in a concentration-dependent manner. The Pin-induced ROS generation and apoptotic effects were significantly reversed by a thiol antioxidant, N-acetylcysteine (NAC). Additionally, Pin induced ERK/JNK phosphorylation and pharmacological inhibition of ERK/JNK rescued the Pin-induced cell death. Pin-activated ERK/JNK were significantly reduced after the administration of NAC; however, the inhibition of ERK/JNK failed to change the Pin-induced ROS production. Similarly, pinnigorgiol A, a pure compound isolated from Pin, elicited ROS production and apoptosis in HSC-T6 cells. The pinnigorgiol A-induced apoptosis was retrained by NAC. Together, it appears that Pin leads to apoptosis in HSC-T6 cells through ROS-mediated ERK/JNK signaling and caspase-3 activation. Pinnigorgiol A serves as a bioactive compound of Pin and may exhibit therapeutic potential by clearance of HSCs. Full article
(This article belongs to the Special Issue Development and Application of Herbal Medicine from Marine Origin)
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8 pages, 854 KiB  
Article
New Marine Sterols from a Gorgonian Pinnigorgia sp.
by Yu-Chia Chang, Tsong-Long Hwang, Chih-Hua Chao and Ping-Jyun Sung
Molecules 2017, 22(3), 393; https://doi.org/10.3390/molecules22030393 - 3 Mar 2017
Cited by 10 | Viewed by 5266
Abstract
Continuous chemical investigation of the gorgonian coral Pinnigorgia sp. resulted in the isolation of two new sterols, 5α,6α-epoxy-(22E,24R)-3β,11-dihydroxy-9,11-secoergosta-7-en-9-one (1) and (22R)-acetoxy-(24ξ)-ergosta-5-en-3β,25-diol (2). The structures of sterols 1 and 2 were elucidated [...] Read more.
Continuous chemical investigation of the gorgonian coral Pinnigorgia sp. resulted in the isolation of two new sterols, 5α,6α-epoxy-(22E,24R)-3β,11-dihydroxy-9,11-secoergosta-7-en-9-one (1) and (22R)-acetoxy-(24ξ)-ergosta-5-en-3β,25-diol (2). The structures of sterols 1 and 2 were elucidated using spectroscopic methods. Sterol 1 displayed inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils with IC50 values of 8.65 and 5.86 μM, respectively. The structure of a known metabolite, pubinernoid A (3), is revised as (+)-loliolide (4). Full article
(This article belongs to the Section Natural Products Chemistry)
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11 pages, 1790 KiB  
Article
Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)
by Yu-Chia Chang, Tsong-Long Hwang, Liang-Mou Kuo and Ping-Jyun Sung
Mar. Drugs 2017, 15(1), 11; https://doi.org/10.3390/md15010011 - 6 Jan 2017
Cited by 17 | Viewed by 5231
Abstract
Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D–J (1–7), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 1–7 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol [...] Read more.
Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D–J (1–7), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 1–7 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1 treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC50 value of 3.93 μM; and secosterols 2, 5, and 7 reduced elastase enzyme release, and 3, 5, and 7 decreased the production of superoxide anions from human neutrophils. Full article
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7 pages, 1160 KiB  
Article
New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.
by Yu-Chia Chang, Tsong-Long Hwang, Jyh-Horng Sheu, Yang-Chang Wu and Ping-Jyun Sung
Mar. Drugs 2016, 14(12), 218; https://doi.org/10.3390/md14120218 - 26 Nov 2016
Cited by 22 | Viewed by 5722
Abstract
Pinnigorgiols D (1) and E (2), two new 9,11-secosterols with a rearranged carbon skeleton, were isolated from a Taiwan gorgonian Pinnigorgia sp. The structures of these two compounds were elucidated on the basis of spectroscopic methods and were proven [...] Read more.
Pinnigorgiols D (1) and E (2), two new 9,11-secosterols with a rearranged carbon skeleton, were isolated from a Taiwan gorgonian Pinnigorgia sp. The structures of these two compounds were elucidated on the basis of spectroscopic methods and were proven to possess a tricyclo[5,2,1,1]decane ring. The new secosterols 1 and 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils. Full article
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9 pages, 1037 KiB  
Article
Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.
by Yu-Chia Chang, Liang-Mou Kuo, Tsong-Long Hwang, Jessica Yeh, Zhi-Hong Wen, Lee-Shing Fang, Yang-Chang Wu, Chan-Shing Lin, Jyh-Horng Sheu and Ping-Jyun Sung
Mar. Drugs 2016, 14(1), 12; https://doi.org/10.3390/md14010012 - 7 Jan 2016
Cited by 18 | Viewed by 5780
Abstract
Three new 9,11-secosterols, pinnisterols A–C (1–3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 [...] Read more.
Three new 9,11-secosterols, pinnisterols A–C (1–3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs). Full article
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