Search Results (7)

The Great Wall of China, one of the nation’s most remarkable military defense structures, possesses a history spanning several millennia and is associated with numerous heritage sites. Today, it stands as a world-renowned cultural heritage asset. Vegetation growing on the ruins of the Great Wall can exert both detrimental and protective effects on the structure. Indiscriminate removal of such vegetation may lead to unintended damage to the heritage site. Drawing on the theory of “evaluative conservation”, this study integrates the analytic hierarchy process (AHP) and the Delphi method to develop a resistance assessment system for vegetation removal. A case study was conducted on 40 plant species or categories located along the Ming-era Guangwu section of the Great Wall, with spatial zoning analysis applied to inform removal strategies. The results reveal the structure, key factors, and classification criteria of the resistance evaluation system. Corresponding management recommendations are proposed, including strategies such as “preservation”, “partial preservation”, “removal”, and “subsequent removal and management”. This research provides a foundational reference for the conservation and restoration of the Great Wall heritage, and for the management of associated vegetation. Full article

Patients with infiltrative-type gastric cancer (GC) (Ming’s classification) have a poor prognosis due to more metastasis and recurrence. Cancer-associated fibroblasts (CAFs) in infiltrative-type extracellular matrix (ECM) have specific characteristics compared with those of expansive types with respect to metastasis, but the mechanism is still unclear. Based on our proteomics data, TCGA data analysis, and immunohistochemical staining results, significantly higher expression of IGFBP7 was observed in GC, especially in the infiltrative type, and was associated with a poor prognosis. Combining single-cell transcriptome data from GEO and multiple immunofluorescence staining on tissue showed that the differential expression of IGFBP7 mainly originated from myofibroblastic CAFs, the subgroup with higher expression of PDGFRB and α-SMA. After treating primary normal fibroblasts (NFs) with conditional medium or recombined protein, it was demonstrated that XGC-1-derived TGF-β1 upregulated the expression of IGFBP7 in the cells and its secretion via the P-Smad2/3 pathway and mediated its activation with higher FAP, PDGFRB, and α-SMA expression. Then, either conditional medium from CAFs with IGFBP7 overexpression or recombined IGFBP7 protein promoted the migration, invasion, colony formation, and sphere growth ability of XGC-1 and MGC-803, respectively. Moreover, IGFBP7 induced EMT in XGC-1. Therefore, our study clarified that in the tumor microenvironment, tumor-cell-derived TGF-β1 induces the appearance of the IGFBP7⁺ CAF subgroup, and its higher IGFBP7 extracellular secretion level accelerates the progression of tumors. Full article

GC is a fatal disease with high heterogeneity and invasiveness. Recently, SPP1 has been reported to be involved in the tumor progression of multiple human cancers; however, the role of SPP1 in GC heterogeneity and whether it is associated with the invasiveness and mortality of GC remain unclear. Here, we combined multiple RNA sequencing approaches to evaluate the impact of SPP1 on GC. Through bulk RNA sequencing (bulk RNA-seq) and immunohistochemistry (IHC), we found that SPP1 was highly expressed in GC, and high levels of SPP1 were associated with macrophage infiltration, an advanced tumor stage, and higher mortality for advanced GC patients. Furthermore, through simultaneous single-cell and spatial analysis, we demonstrated that SPP1⁺ macrophages are tumor-specific macrophages unique to cancer and enriched in the deep layer of GC tissue. Cell—cell communication analysis revealed that SPP1/CD44 interactions between SPP1⁺ macrophages and their localized tumor epithelial cells could activate downstream target genes in epithelial cells to promote dynamic changes in intratumor heterogeneity. Moreover, these activated genes were found to be closely associated with poor clinical GC outcomes and with cancer-related pathways that promote GC progression, as shown by survival analysis and enrichment analysis, respectively. Collectively, our study reveals that tumor-specific SPP1⁺ macrophages drive the architecture of intratumor heterogeneity to evolve with tumor progression and that SPP1 may serve as a prognostic marker for advanced GC patients, as well as a potential therapeutic target for GC. Full article

Reconstruction of historical land uses helps to understand patterns, drivers, and impacts of land-use change, and is essential for finding solutions to land-use sustainability. In order to analyze the relationship between land-use change and urban flooding, this study used the Classification and Regression Tree (CART) method to extract modern (2017) land-use data based on remote sensing images. Then, the Paleo-Land-Use Reconstruction (PLUR) program was used to reconstruct the land-use maps of Xi’an during the Ming (1582) and Qing (1766) dynasties by consulting and collecting records of land-use change in historical documents. Finally, the Flo-2D model was used to simulate urban flooding under different land-use scenarios. Over the past 435 years (1582–2017), the urban construction land area showed a trend of increasing, while the unused land area and water bodies were continuously decreasing. The increase in urban green space and buildings was 20.49% and 19.85% respectively, and the unused land area changed from 0.32 km² to 0. Urban flooding in the modern land-use scenario is the most serious. In addition to the increase in impervious areas, the increase in building density and the decrease in water areas are also important factors that aggravate urban flooding. This study can provide a reference for future land-use planning and urban flooding control policy formulation and revision in the study area. Full article

Point cloud semantic segmentation has played an important role in the scan-to-BIM process of the Ming and Qing Dynasties’ official-style architecture roof. To overcome the complexity of roof components’ shape and the scale differences between different roof component types, a point cloud semantic segmentation method for the MQDOAs roof considering the construction regulations is proposed in this paper. This method is composed of two stages. In the first stage, the features from the construction rules of MQDOAs, including the normalized symmetrical distance (NSD), relative height (RH) and local height difference (LHD), are extracted alongside the regular geometric features. To lower the influence of scale differences, a multi-scale feature connection strategy is also applied to construct the feature classification vector. In the second stage, RF method is applied to classify the point cloud. To verify the efficiency of the proposed method, we took the Hall of Complete Harmony as the study case. The experiments showed that our method achieved segmentation result in overall classification accuracy and reached 96.8%. Full article

The Field Trip for Measured Survey of Built Heritage carried out by Tianjin University every summer aims to educate students in each practice session, i.e., on-site data acquisition, condition investigation, classification of the component library, taking observation notes, and accomplishing HBIM deliverables. Under the risks posed by the ongoing COVID-19 pandemic, the students could not leave the campus as a provisional arrangement. Only a team of five people was allowed to visit the Kuiwen Pavilion in the Temple of Confucius (Qufu, China). Therefore, the field trip for students had to be replaced with remote solutions, which consists of the following methods: on-site data acquisition; post-processing; online education, observation, modeling, delivery. Kuiwen Pavilion in the Temple of Confucius is a library with the official architectural style of the Ming and Qing Dynasties (14th to 20th century), for which building regulations are commonly recognized, and are suitable for survey education. In this context, this article focuses on the remote practice methods applied and tested throughout the case study. During the practice of the course, students who managed to finish the course, through the virtual tours and other online methods, finally achieved delivery of the HBIM models. Full article

The Ming and Qing Dynasty type of official-style architecture roof can provide plenty of prior knowledge relating to the structure and size of these works of architecture, and plays an important role in the fields of 3D modeling, semantic recognition and culture inheriting. In this paper, we take the 3D point cloud as the data source, and an automatic classification method for the roof type of Ming and Qing Dynasty official-style architecture based on the hierarchical semantic network is illustrated. To classify the roofs into the correct categories, the characteristics of different roof types are analyzed and features including SoRs, DfFtR, DoPP and NoREs are first selected; subsequently, the corresponding feature extraction methods are proposed; thirdly, aiming at the structure of the ridges, a matching graph relying on the attributed relational graph of the ridges is given; based on the former work, a hierarchical semantic network is proposed and the thresholds are determined with the help of the construction rules of the Ming and Qing Dynasty official-style architecture. In order to fully verify the efficiency of our proposed method, various types of Ming and Qing Dynasty official-style architecture roof are identified, and the experimental results show that all structures are classified correctly. Full article