Topic Editors

Dr. Hongzhou Cai
Department of Urology, Jiangsu Cancer Hospital & The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Institute of Cancer Research, Nanjing Medical University, Nanjing, China
Prof. Dr. Lixin Hua
Department of Urology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210009, China
Dr. Mantang Qiu
Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China
Dr. Wenzhi Li
Department of Urology, Shanghai First People's Hospital, Shanghai, China

Advances in Tumor Microenvironment

Abstract submission deadline
20 October 2023
Manuscript submission deadline
20 December 2023
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Topic Information

Dear Colleagues,

Interactions between stromal tissue cells and cancer cells are mutual, dynamic, and complicated rather than stromal tissue being merely a passive bystander in the process of cancer development, progression, and metastasis. It is often claimed that among them, a unique environment called a tumor microenvironment develops. Tumor cells, stromal cells, and portions of the extracellular matrix surrounding them make up the dynamic environment known as the TME.

Contributions are encouraged in areas including, but not limited to:

  • Molecular mechanism of tumor metastasis;
  • Composition of the tumor microenvironment;
  • Immunotherapy targeting the tumor microenvironment.

Dr. Hongzhou Cai
Prof. Dr. Lixin Hua
Dr. Mantang Qiu
Dr. Wenzhi Li
Topic Editors

Keywords

  • molecular mechanisms
  • tumor microenvironment
  • immune therapy
  • tumor cell
  • exosomes

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biology
biology
5.168 2.8 2012 16.7 Days 2000 CHF Submit
Cancers
cancers
6.575 5.8 2009 17.4 Days 2400 CHF Submit
Current Oncology
curroncol
3.109 3.5 1994 20.5 Days 1800 CHF Submit
Hematology Reports
hematolrep
- 1.6 2009 19.7 Days 1000 CHF Submit
Medical Sciences
medsci
- - 2013 26.5 Days 1400 CHF Submit

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Published Papers (2 papers)

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Article
Integrated Analysis of TME and Hypoxia Identifies a Classifier to Predict Prognosis and Therapeutic Biomarkers in Soft Tissue Sarcomas
Cancers 2022, 14(22), 5675; https://doi.org/10.3390/cancers14225675 - 18 Nov 2022
Abstract
Soft tissue sarcoma (STS) is one of the rarest but most aggressive cancer. It is important to note that intratumoral hypoxia and tumor microenvironment (TME) infiltration play a significant role in the growth and therapeutic resistance of STS. The goal of this study [...] Read more.
Soft tissue sarcoma (STS) is one of the rarest but most aggressive cancer. It is important to note that intratumoral hypoxia and tumor microenvironment (TME) infiltration play a significant role in the growth and therapeutic resistance of STS. The goal of this study was therefore to determine whether linking hypoxia-related parameters to TME cells could provide a more accurate prediction of prognosis and therapeutic response. An analysis of 109 hypoxia-related genes and 64 TME cells was conducted in STS. Hypoxia-TME classifier was constructed based on 6 hypoxia prognostic genes and 8 TME cells. As a result, we evaluated the prognosis, tumor, and immune characteristics, as well as the effectiveness of therapies in Hypoxia-TME-defined subgroups. The Lowplus group showed a better prognosis and therapeutic response than any other subgroup. It is possible to unravel these differences based on immune-related molecules and somatic mutations in tumors. Further validation of Hypoxia-TME was done in an additional cohort of 225 STS patients. Additionally, we identified five key genes through differential analysis and RT-qPCR, namely, ACSM5, WNT7B, CA9, MMP13, and RAC3, which could be targeted for therapy. As a whole, the Hypoxia-TME classifier demonstrated a pretreatment predictive value for prognosis and therapeutic outcome, providing new approaches to therapy strategizing for patients. Full article
(This article belongs to the Topic Advances in Tumor Microenvironment)
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Article
Resemblance of the Recurrence Patterns in Primary Systemic, Primary Surgery and Secondary Oncoplastic Surgery
Curr. Oncol. 2022, 29(11), 8874-8885; https://doi.org/10.3390/curroncol29110698 - 17 Nov 2022
Abstract
Purpose: Surgical interventions tend to have an effect on the generation of recurrences in tumor patients due to the anesthesia involved as well as tissue damage and subsequent inflammation. This can also be found in patients with breast cancer. Methods: In this multicenter [...] Read more.
Purpose: Surgical interventions tend to have an effect on the generation of recurrences in tumor patients due to the anesthesia involved as well as tissue damage and subsequent inflammation. This can also be found in patients with breast cancer. Methods: In this multicenter study, we investigated data of 632 patients with breast cancer and the subsequent diagnosis of a recurrence. The patient data were acquired from 1 January 2006 to 31 December 2019 in eight different centers in Germany. The data sets were separated into those with primary surgery, primary systemic therapy with subsequent surgery, and reconstructive surgery. Three different starting points for observation were defined: the date of diagnosis, the date of first surgery, and the date of reconstructive surgery, if applicable. The observational period was divided into steps of six months and maxima of recurrences were compared. Furthermore, the variance was calculated using the difference of the distribution in percent. Results: The descriptive analysis showed no resemblance between the groups. The variance of the difference of the recurrence rates analysis using the surgical date as the starting point showed similarities in the age subgroup. Conclusion: Our clinical analysis shows different metastatic behavior in different analysis and treatment regimes. These findings justify further investigations on a larger database. These results may possibly identify an improved follow-up setting depending on tumor stage, biology, treatment, and patient factors (i.e., age, …). Full article
(This article belongs to the Topic Advances in Tumor Microenvironment)
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