Search Results (45)

Objectives: The primary objective of this study was to determine whether motor disorders are significantly more prevalent in children with Autism Spectrum Disorder (ASD) without co-occurring genetic or neurological conditions compared to neurotypical children. Another aim was to explore the applicability of the MABC-2 test for assessing motor skills in a Polish cohort of children with ASD. Additionally, this study sought to develop a basic framework for motor skill assessment in children with autism. Methods: This study included 166 Caucasian children, both sexes, aged 5–12 years, without intellectual disability (IQ ≥ 70), without concomitant genetic or neurological disorders, particularly epilepsy or cerebral palsy. The study group consisted of children with ASD (n = 71), and the control group consisted of neurotypical children (n = 95). The participants were assessed with the Movement Assessment Battery for Children–second edition (MABC-2), MABC-2 checklist and the Developmental Coordination Disorder Questionnaire (DCDQ), used as a reference point. Results: The children with ASD obtained significantly lower MABC-2 test results in all subtests in comparison with the control group. The children with suspected or diagnosed coordination disorders were characterized by a significantly greater number of co-occurring non-motor factors than the other participants of this study. MABC-2 test showed greater consistency with DCDQ than with the MABC-2 questionnaire. Conclusions: Children with ASD present a lower level of manual dexterity and balance and greater difficulties in performing tasks, including throwing and catching, in comparison with neurotypical children. The MABC-2 test with the MABC-2 checklist and DCDQ questionnaire constitute a complementary diagnostic tool. Full article

Rapid and accurate diagnosis of mycobacterial infections is crucial for guiding therapeutic decisions. This study presents the first evaluation of a novel molecular assay, the Mycobacterium RealTime PCR Kit Vircell (MRTVircell), a real-time PCR-based test designed for the specific detection of Mycobacterium tuberculosis complex (MTBC), Mycobacterium avium complex (MAC), Mycobacterium abscessus complex (MABC), and other nontuberculous mycobacteria (NTM) in both respiratory and non-respiratory samples. The evaluation was conducted under routine workflow conditions using 721 clinical specimens, including 559 respiratory and 162 non-respiratory samples. Among these, 5.69% were smear-positive, 6.38% were culture-positive for MTBC, and 9.85% were culture-positive for NTM. The performance of the MRTVircell was compared to both culture results and the Anyplex MTB/NTM real-time PCR assay. The two PCR systems demonstrated a 96.95% overall concordance rate for the detection of MTBC, NTM, and negative specimens. Based on culture as the reference method, the sensitivity, specificity, positive predictive value, and negative predictive value of the MRTVircell for MTBC detection were 80.43%, 99.64%, 94.87%, and 98.41%, respectively, while for Anyplex MTB/NTM (Seegene), these values were 76.09%, 99.64%, 94.59%, and 98.06%, respectively. For NTM detection, the sensitivity, specificity, positive predictive value, and negative predictive values were 28.17%, 99.29%, 83.33% and 91.63% for MRTVircell and 21.13%, 99.11%, 75%, and 91.67% for Anyplex MTB/NTM, respectively. MRTVircell is a rapid and reliable tool for the detection and differentiation of MTBC, MAC, MABC, and other NTM in clinical samples. Full article

The aim of this study was to verify the effects of laboratory learning on children’s fundamental movement skills (FMS) through an intervention designed and implemented by specially trained generalist teachers. A total of 114 children attending 1st and 2nd grade of primary school (6.7 ± 0.8 yo) and 28 children attending preschool (4.1 ± 0.9 yo) in Naples (Italy) participated in the study. To assess FMS, the Movement ABC-2 (MABC-2) was administered. A two-way ANOVA for repeated measures was used to compare data. The laboratory was effective in improving coordination in primary school children, with a significant reduction in medium/severe movement difficulties from 23.7% to 12.4%. The results showed significant changes in the execution time of several MABC-2 tests, indicating an improvement in FMS, particularly hand-eye coordination and dynamic balance. However, the intervention was less effective in preschool children, with a limited improvement of 2.9%, highlighting that the intervention only had an impact on some specific skills. Targeted interventions can be effective in improving FMS, providing a basis for educational programs that respond to movement needs of students. Full article

Developmental Coordination Disorder (DCD) is one of the most prevalent neurodevelopmental disorders in childhood. DCD is classified as a motor learning deficit because it interferes with the ability to learn and automate movement skills. There is a lack of information on how these children acquire complex motor skills relevant to their daily recreational or sports activities. Evidence to guide physical trainers, educators, and health professionals to select an effective type of training to improve physical fitness for children with poor motor coordination is scarce. The purpose of this study was to analyze the effect of an 8-week task-oriented basketball training program on motor coordination and motor skill-related fitness for DCD children in the school context. Motor performance and motor skill-related fitness were evaluated before and after the intervention using the Movement Assessment Battery for Children-2 (MABC-2) and Performance and Fitness Test Battery (PERF-FIT). A total of 52 children with DCD aged 8 to 9 were invited to join the intervention. Parents of 18 children accepted for their child to participate in the training program. In the remaining children, 20 identified as the most similar based on the diagnostic criteria for DCD (DSM-5) and anthropometric features (age, BMI) and were asked to participate as the usual care group. The difference in improvement on the MABC-2 and the PERF-FIT between the two groups on the two test occasions was compared using Mann–Whitney U tests. Within-group pre-post comparison on these test items was performed using the Wilcoxon signed rank test. Significant differences in all performance scores were found in favor of the training group. Post-hoc analysis revealed that the DCD training group improved significantly on MABC-2 total and subscores (p < 0.001) and on all PERF-FIT items (p < 0.001). No significant changes were found on any of the test items in the DCD usual care group. Group-based training in a more natural environment (playing games with peers in school) might help children with DCD as an adjunct to or before individual therapy. Based on our findings, we believe it is possible to work in large groups (n = 18), led by trained physical education teachers and special educators, to lessen the impact of motor coordination and physical fitness problems in children with neurodevelopmental disorders so that they can participate more easily in active games. Results of the usual care group showed that extra instruction and practice are needed for children with DCD. Full article

Background: Children with motor delays often experience challenges in health-related fitness, but the impact on running skills remains unclear. Previous research has shown that children with motor coordination problems have lower cardiorespiratory fitness, muscle strength, endurance, and higher body weight compared to peers. Few studies have examined anaerobic capacity, muscular power, endurance, running performance, and fatigue in children with developmental coordination disorder (DCD). This study aims to compare repetitive running and running-induced fatigue in typically developing children and those with varying degrees of motor coordination problems. Methods: Groups were classified using the Movement Assessment Battery for Children, second edition (MABC-2), as probably having DCD (p-DCD, ≤5th percentile, age 9.7 (SD 1.6), n = 141), at risk for DCD (r-DCD, 6th–16th percentile, age 9.9 (SD1.6), n = 160), and typically developing (TD, >16th percentile, age 9.6 (SD 1.6), n = 191). Anaerobic fitness and fatigue were assessed using the Children’s Repetitive and Intermittent Sprinting Performance test (CRISP), while lower and upper body muscular strength, running, and agility were measured with the performance and fitness (PERF-FIT) test battery Power and Agility subscale. Age groups (6–9 and 10–12 years) were analyzed to determine when performance deficits emerged. Results: The p-DCD group was significantly slower, had less power, and fatigued more than the r-DCD and TD children (p < 0.01). This was already clearly the case in the 6–9-year-olds, who slowed down already after the first runs, while the older poorly coordinated children started slower than their peers and showed a more gradual decrease in performance over the runs. Conclusions: Moderate coordination differences between r-DCD and TD children did not significantly impact fatigue, but p-DCD children exhibited greater fatigue due to overestimating their start speed, higher body weight, lower power, and reduced agility, especially in younger age groups. (Too) High starting speed, especially in the younger less coordinated children (p-DCD), is likely to lead to more fatigue. Full article

The primary aim of this descriptive cross-sectional study was to examine the relationship between ocular motility and motor skills in school-age children. Participants included 142 schoolchildren (mean age: 7.08 ± 0.61 years) who completed a computerised version of the Developmental Eye Movement (DEM) test while their eye movements were recorded, and Northeastern State University College of Optometry's Oculomotor test (NSUCO). Children were classified into three groups based on their level of motor performance, which was measured by the Movement Assessment Battery for Children-2 (MABC-2). The group with typical motor performance had higher percentiles for both vertical and horizontal time, fewer errors, number of saccades, fixations, and regressions, and faster test performance. Visual test results correlate with the motor assessment outcomes; correlations are weak or moderate. Our findings emphasise the interconnectedness of motor and ocular motility. Hence, including evaluation of visual and motor proficiencies at school age would help to detect struggles in these crucial areas of development. Full article

Neurodevelopmental outcomes for preschool-age children in the United States with in utero Zika virus (ZIKV) exposure have not yet been reported. We performed a case-control study to assess whether children exposed in utero to ZIKV have abnormal neurodevelopment at age 4–5 years compared to unexposed controls. Thirteen ZIKV-exposed cases that did not have microcephaly or other specific features of congenital Zika syndrome and 12 controls were evaluated between ages 4–5 years. Child neurodevelopment was assessed using the Pediatric Evaluation of Disability Inventory, Behavior Rating Inventory of Executive Function, Peabody Picture Vocabulary Test, Bracken School Readiness Assessment (BSRA), and Movement Assessment Battery for Children (MABC). Caregivers answered questions on the child’s medical history and family demographics. Cases and controls were evaluated at mean (SD) ages 4.9 (0.3) and 4.8 (0.4) years, respectively. Caregivers reported more behavior and mood problems in cases than controls. MABC scores showed more gross and fine motor coordination difficulties among cases than controls. Controls trended towards higher performance on concepts underlying school readiness on BSRA. Three cases had a diagnosis of autism spectrum disorder or global developmental delay. Continued follow-up through school age for children with prenatal ZIKV exposure is needed to understand the impact of in utero ZIKV exposure on motor coordination, cognition, executive function, and academic achievement. Full article

Early childhood is a crucial time for children to develop their fundamental motor skills (FMS), serving as a foundation for engagement in lifelong physical activity (PA). With increasing concerns over the declining levels of PA and motor competence (MC), the aim of this study was to explore the predictors of PA in children in a play-based curriculum. A secondary purpose was to explore levels of PA and MC during the school day. The final aim was to explore whether there were sex differences. Children (N = 94; Mage = 68.96 months, SD = 8.25) in five classes from four different schools in Wales were tested on the TGMD-2, standing long jump, and MABC-2. Levels of PA were measured using ActiGraph GT3X-BT accelerometers, and 85 children met the wear time criteria. Object control (OC) skills, standing long jump, and age significantly predicted the percentage of time spent performing sedentary behaviours F(10,73) = 3.026, p = 0.003, $R^2$ = 0.29 (adj $R^2$ = 0.20) and time spent on MVPA F(10,73) = 3.597, p < 0.001, $R^2$ = 0.33 (adj $R^2$ = 0.24). Children spent an average of 48.7% of the school day performing sedentary behaviours and 9.1% performing moderate to vigorous physical activity (MVPA) and did not achieve 60 min of MVPA. The MABC revealed that 67% were below the 15th percentile. Girls spent more time than boys performing sedentary behaviours (p = 0.014), and boys spent more time than girls on MVPA (p = 0.004). Boys outperformed girls at OC skills (p < 0.001), while girls outperformed boys at locomotor skills (p < 0.001). These findings reinforce the pivotal role teachers and parents play in providing opportunities for children to be PA. OC skills and jump were positively associated with PA, emphasising the importance of developing FMS in early childhood. There were also sex disparities for both PA and MC, along with low levels of MC, highlighting the need for investing in comprehensive programmes and initiatives that prioritise the development of FMS during early childhood. Full article

This cross-sectional study assessed the psychometric properties of the movement assessment battery for children second edition (M-ABC2) in Italian children with typical development, focusing on reliability and percentile rank establishment. The M-ABC2 is widely utilized but lacks validation in Italian populations. One hundred and eight children were recruited. Test-retest reliability was evaluated using intra-class correlation coefficients (ICCs), indicating good to excellent reliability across age groups, albeit with outliers requiring further scrutiny. Standard scores and percentile ranks were established, revealing age-related variations in motor performance. Noteworthy differences in completion times and error rates were observed among the age groups, highlighting the dynamic nature of motor development. While the findings provide valuable insights for clinicians and researchers, limitations such as sample size and geographic representation should be addressed in future studies. This study underscores the importance of employing reliable assessment tools for comprehensive understanding and effective intervention in pediatric motor development. Full article

The present study aimed to examine precision and variability in dart throwing performance and the relationships between these outcomes and bouncing, throwing and catching tasks in children with and without DCD. Children between the ages of 8 and 10 years (n = 165) were classified according to results obtained on the Movement Assessment Battery for Children (MABC-2) and divided into three groups: 65 children with severe DCD (s-DCD), 45 with moderate DCD (m-DCD) and 55 typically developing children (TD). All children performed the dart throwing test and the ball skill items of the Performance and Fitness Test (PERF-FIT). The accuracy and variability of dart throwing tasks were significantly different between TD and s-DCD (p < 0.01), and also between m-DCD and s-DCD (p < 0.01). Participants with s-DCD were also found to perform significantly worse on all PERF-FIT ball skill items than m-DCD (p < 0.001), and m-DCD were significantly poorer than TD (p < 0.001). The dart score and coefficient of variation of the long-distance task appear to be significant predictors for the ball skills and explain between 24 to 29% of their variance. In conclusion, poor results in aiming tasks using darts in children with DCD corroborate with the explanation of deficits in predictive control since the tasks require ballistic movements. Full article

This study aimed (1) to investigate the effect of a brief 9-week bike program on preschool motor competence levels and (2) to know the effects of the intervention program on gender. A total of 98 schoolchildren (3.86 ± 0.91 years) from La Coruña (Spain) participated. A pre–post-test quasi-experimental design was used with a control group (CG) made up of 39 students (18 boys) and an experimental group (EG) made up of 59 students (29 boys). Data were gathered using the Movement Assessment Battery for Children-2 (MABC-2). The data demonstrate that the CG and the EG differ significantly from one another before the intervention program in favour of CG in manual dexterity (MD; p < 0.001), balance (Bal; p = 0.003), total test score (TTS; p = 0.001), and total percentile score (TPS; p < 0.001), except in aiming and catching (A&C, p = 0.588). After the application of the 9-week intervention program based on the balance bike, these differences disappear (i.e., MD (p = 0.166), A&C (p = 0.372), Bal (p = 0.219), TTS (p = 0.306), and in TPS (p = 0.259)). The information gathered indicates that implementing intervention programs such as the one applied in this study could have a positive impact on improving motor competence in preschool-aged boys and girls, increasing its level. Full article

Deficits in fine motor skills have been reported in some children with neurodevelopmental disorders such as amblyopia or strabismus. Therefore, monitoring the development of motor skills and any potential improvement due to therapy is an important clinical goal. The aim of this study was to test the feasibility of performing a kinematic assessment within an optometric setting using inexpensive, portable, off-the-shelf equipment. The study also assessed whether kinematic data could enhance the information provided by a routine motor function screening test (the Movement Assessment Battery for Children, MABC). Using the MABC-2, upper limb dexterity was measured in a cohort of 47 typically developing children (7–15 years old), and the Leap motion capture system was used to record hand kinematics while children performed a bead-threading task. Two children with a history of amblyopia were also tested to explore the utility of a kinematic assessment in a clinical population. For the typically developing children, visual acuity and stereoacuity were within the normal range; however, the average standardized MABC-2 scores were lower than published norms. Comparing MABC-2 and kinematic measures in the two children with amblyopia revealed that both assessments provide convergent results and revealed deficits in fine motor control. In conclusion, kinematic assessment can augment standardized tests of fine motor skills in an optometric setting and may be useful for measuring visuomotor function and monitoring treatment outcomes in children with binocular vision anomalies. Full article

Executive functions (EFs) and motor skills are essential for many school and daily tasks. Many school-based occupational therapists need help addressing EFs. The current study aims to provide new insights into the relationship between executive functions and motor development by considering confounding factors. Ninety-six second-grade children were tested in one state-funded (public) school and another state-subsidised private school. Children were assessed with the Movement Assessment Battery for Children-2 (MABC-2), Neuropsychological Assessment of Executive Functions in Children, and Test of Perception of Differences–R. Families completed a sociodemographic questionnaire, and teachers completed a previous questionnaire and subsequently evaluated the information the occupational therapist provided. Mixed results were obtained regarding the correlation between motor and executive skills. Furthermore, children who received worse scores on the MABC-2 had more difficulties on the EFs tests. The Impulsivity Control Index was not correlated with any motor variable. Our results show that sociodemographic variables (except gender) correlate more with EFs than motor skills. The teachers showed a high degree of agreement with the occupational therapist (4.0 ± 0.8), even in children with good academic performance. They expressed the need for additional training and classroom interventions. A joint vision of motor-executive functioning can facilitate the design of effective interventions, especially in schools with more disadvantaged populations. Full article

Phage therapy is still in its infancy, but it is increasingly promising as a future alternative for treating antibiotic-resistant bacteria. To investigate the effect of phages on Mycobacterium abscessus complex (MABC), we isolated 113 environmental phages, grown them to high titres, and assayed them on MABC clinical strains through the spot test. Of all the phages, only 16 showed killing activity. Their activity was so temperate to MABC that they could not generate any plaque-forming units (PFUs). The Appelmans method of directed evolution was carried out to evolve these 16 phages into more lytic ones. After only 11 of 30 rounds of evolution, every single clinical strain in our collection, including those that were unsusceptible up to this point, could be lysed by at least one phage. The evolved phages were able to form PFUs on the clinical strains tested. Still, they are temperate at best and require further training. The genomes of one random parental phage and three random evolved phages from Round 13 were sequenced, revealing a diversity of clusters and genes of a variety of evolutionary origins, mostly of unknown function. These complete annotated genomes will be key for future molecular characterisations. Full article

Children with autism exhibit more pronounced symptoms of both problem behaviors and motor coordination difficulties. Yoga, recognized as an effective intervention modality, can be valuable after assessing its efficacy in addressing problem behaviors and motor coordination challenges, ultimately contributing to symptom alleviation in autism. The randomized controlled trial (RCT) was used to divide 17 children with autism into an intervention group (n = 9) and a control group (n = 8). The intervention group participated in an 8-week yoga intervention training (three sessions/week, 45–50 min/session), and the control group did not participate in yoga training but only in daily program activities. Pre-test, mid-test, post-test, and after delayed test, teachers assessed the effect of yoga intervention on problem behaviors of children with autism through the Aberrant Behavior Checklist (ABC) and the effect of yoga intervention on motor coordination through the Movement Assessment Battery for Children—Second Edition (MABC2). Results show that the yoga intervention is effective in reducing problem behaviors and improving motor coordination in children with autism. Yoga intervention significantly reduces irritability and social withdrawal in children with autism. Yoga intervention had the most significant improvement in ball skills and static and dynamic balance. Full article