Search Results (94)

Claoxylon longifolium (Euphorbiaceae) is an indigenous vegetable that has been used in southern Thai traditional medicine and cuisine. A bioassay-guided approach was adopted to investigate the phytochemicals and chemopreventive potential of C. longifolium leaves and stems. Phytochemical investigation of the active MeOH fractions afforded six known compounds, including caffeic acid (1), isovitexin (2), and vicenins 1–3 (3–5) from leaves and hexadecanoic acid methyl ester (6) from stems. Their structures were determined by spectroscopic means. Ten constituents were tentatively identified from the oily fractions of stems by GC-MS. Non-cytotoxic concentrations of compounds 1–6 were identified using the MTT cell viability assay. The ability of compounds 1–6 at non-cytotoxic concentrations to induce Nrf2 activation, correlating to their potential chemopreventive properties, was determined using a luciferase reporter assay in the AREc32 cell line. Only vicenin 1 (3) was considered to be a potent chemopreventive compound, as it increased luciferase activity by 2.3-fold. In silico studies on compounds 2–5 and vitexin (16) revealed the potential of these compounds as cancer chemopreventive and chemotherapeutic agents. This study provides the first report on the chemopreventive properties of C. longifolium. All identified and isolated compounds are reported here for the first time from this species. Full article

The cryopreservation of boar sperm effectively extends its storage period but often leads to increased reactive oxygen species (ROS) production, compromising sperm quality. Plant extracts, rich in bioactive compounds such as polyphenols and flavonoids, have been shown to reduce ROS. Djulis (Chenopodium formosanum), also known as the “ruby of cereals”, is nutritionally rich and holds potential as a cryoprotective additive. This study aimed to determine the optimal concentration of extracts from different parts of djulis, including unhulled seeds and stems, for effective boar semen cryopreservation. Fresh semen from Taiwan indigenous boars was diluted with a modified GLT-cryoprotectant extender containing glycerol, low-density lipoprotein (LDL), and trehalose. The experimental groups included DSS25, DSS50, DS25, and DS50—representing djulis unshelled seed at 25 mg/mL and 50 mg/mL, and djulis stem at 25 mg/mL and 50 mg/mL in distilled water, respectively—alongside a control group without additives. Post-thaw assessments included sperm motility, kinetic parameters, viability, acrosome integrity, and the antioxidant properties of djulis extracts, such as DPPH radical scavenging activity and total phenolic acid content. Results showed that total motility (TM) was significantly higher in the DSS25 (48.8 ± 3.9), DSS50 (49.0 ± 6.7), and DS50 (49.0 ± 2.4) groups compared to the control group (31.3 ± 4.8). Similarly, progressive motility (PM) was significantly improved in DSS25 (27.5 ± 2.7) and DSS50 (26.8 ± 4.1) versus the control (12.8 ± 3.2). However, for straightness (STR), the control group (87.8 ± 1.3) exhibited significantly higher values than the DS50 group (83.5 ± 1.3) (p < 0.05). Viability and acrosome integrity showed no significant differences across groups. In conclusion, djulis extracts positively influence sperm motility and forward movement, with 1% djulis extract confirmed to enhance the quality of cryopreserved semen. Future research will focus on determining the optimal dosage of djulis extract for improved cryopreservation outcomes. Full article

In the face of the growing challenges of the Anthropocene—marked by climate change, biodiversity loss, and increasing rates of disease and despair—this paper explores the need for holistic solutions that integrate cultural and spiritual transformation as essential dimensions of change. Recognizing that the interconnected challenges to planetary health stem from destructive socio-political agendas and unhealthy economic structures, we underscore the importance of worldviews and value systems as root causes of social and ecological injustices. Solutions require an understanding of the complex interdependence of systems, fostering mutualistic mindsets, and healing the ‘relationship crisis’ between humans and the natural world by cultivating a deeper level of consciousness. In response to these urgent needs, we describe Earthrise—a community of engaged contemplative practice led by the Nova Institute for Health in collaboration with the Planetary Health Alliance—dedicated to spiritual and cultural transformation in the face of today’s complex crises. Through intentional spiritual relationships—with ourselves, each other, and the natural world—our community emphasizes the power of narrative co-creation in building social cohesion and collective action for environmental stewardship. Our work is not solely contemplative, but also relational and integrative—embodying values through lived practice, community, and ecological engagement. Our activities focus on developing cultural capacities and self-awareness as essential foundations for fair and sustainable social transformation. By integrating diverse perspectives, including ancestral wisdom and Indigenous knowledge systems, we enrich worldviews and deepen our connection to the planet. The Earthrise community seeks to cultivate a sense of belonging, nurturing the meaningful relationships that foster compassion and care. Central to our approach is the use of creative emergence, leveraging the arts to inspire change and catalyze new paradigms. Through this exploration of interconnected themes, we contend that spiritual and cultural transformation is vital to advancing a thriving future, where human flourishing and planetary health are understood as inseparable and interconnected goals. Full article

In the Spanish Empire, the term mestizo/mestiza denoted, overwhelmingly, people of so-called “mixed” European and indigenous ancestry, but there existed also some regional adaptations with differing genealogies such as the mestizos de sangley in the Philippines. The article traces some developments of the application and racialization of the term mestizo shortly after the end of the Spanish Empire in the Philippines under U.S. rule. It will look at photographs that were taken in by Dean Worcester, secretary of the interior, and his staff, in order to apply and develop theories of the biologist racism, which in the early twentieth century was en vogue all over the globe. Worcester and his crew took the photographs during their expeditions and used them to illustrate their hypotheses about racialized taxonomies, adapting and further developing Spanish colonial ideas. I will contrast them with a photograph from a local studio in Mindanao. The photographs stem from the photographic collection of the Rautenstrauch-Joest Museum in Cologne, Germany. Full article

For many Native American students, the thirty-seven existing tribal colleges improve their access to post-secondary education, especially for those living in reservation communities and surrounding rural areas. They also support tribal nations’ goals of offering accredited degree programs, as well honoring Indigenous knowledge. This is important for students enrolled in STEM courses since Native Americans are under-represented in these fields. In the early 2000s, Chief Dull Knife College (CDKC), the tribal college of the Northern Cheyenne Nation, was supported by National Science Foundation funding in developing a new math program to meet the unique cultural and instructional needs of its students. In this case study of a culturally responsive math program, we hypothesize that students participating in the new developmental math program attempt and earn more credits compared to cohorts participating in previous math programs and take less time on average to reach college-level math. We present information on the math outcomes of the participants in two variations of the math program reforms that have addressed the obstacles to student retention and achievement. The panel data available include students’ demographic characteristics, placement test scores, and math course grades and the credits for all students enrolled from 2006 to 2019. While the number of credits attempted or earned did not differ statistically across the cohorts, the qualitative data further show that the students appreciate the culturally responsive aspects of the program. Ultimately, we have found that these aspects resulted in increased confidence of the students in their academic skills, stronger Native identities and engagement as students, as well as an improved sense of belonging in this higher education environment, all of which were important goals of the developmental math program. Full article

Ultra-high-performance liquid chromatography coupled to Orbitrap high-resolution mass spectrometry (UHPLC-HRMS) was recently employed in many fields to obtain a rapid characterization of plant extracts. Kigelia africana (family Bignoniaceae) is a quintessential African herbal medicinal plant with immense indigenous medicinal and non-medicinal applications. The aim of the present research was to obtain an in-depth metabolite profiling of the K. africana stem bark extract using UHPLC-HRMS and to conduct a preliminary screening of its anticancer activity against a panel of malignant human cell lines of different origin. The UHPLC-HRMS analysis revealed 63 secondary metabolites including phenolic acids, gallo- and ellagitannins, iridoids, naphthoquinones, and anthraquinones. A total of 34 of all annotated compounds are reported for the first time in K. africana stem bark. The studied profile was dominated by trimethylellagic acid, dimethylellagic acid isomers, and ellagic acid. In all tumor models, we established a pronounced inhibition of cell growth in a mostly dose-dependent manner, with IC₅₀ values ranging near and well below (4–30 µg/mL) the lowest treatment concentration of 25 µg/mL. The established cytotoxicity profile of the K. africana extract, highly biased toward malignantly transformed but not normal cells, suggests specific modulation of defined molecular tumor targets. This study revealed K. africana stem bark as a new source of gallo- and ellagitannins, and highlighted the studied herbal drug as an antiproliferative agent with potential pharmaceutical application. Full article

Meaningful learning is central to every teaching and learning exercise. The attainment of this goal in the face of the cultural diversity of students suggests the use of culturally sensitive approaches. Several studies have shown that teachers are adopting tenets of culturally relevant education to promote meaningful learning of STEM subjects for culturally, linguistically, and socially diverse populations of learners. In Africa, the culturo-techno-contextual approach (CTCA) has witnessed great exploration in Science Technology, Engineering, and Mathematics (STEM) education to ensure students learn meaningfully. However, missing in the literature is a systematic review study on the use of CTCA in STEM teaching and learning. By synthesizing the findings of studies on the use of CTCA, this review highlights the unique contributions of CTCA to promoting meaningful learning of STEM subjects for African learners through quality research reports connecting CTCA to students’ positive outcomes in science, technology, and mathematics from 2015 to 2025. Data were sought from peer-reviewed experimental studies found in Google Scholar, ResearchGate, Scopus, and Web of Science with specific selection criteria, and 24 studies were found eligible for inclusion. The findings demonstrated that CTCA has been repeatedly effective in breaking the barriers to meaningful learning of STEM subjects, helping students to understand difficult STEM concepts and improving their academic achievement. Additionally, the findings indicated several implications for practice and future research on the use of CTCA. Hence, we concluded that this review study will be a useful reference for teachers, STEM educators, and educational researchers willing to rewrite the narratives of STEM learning in Africa by decolonizing STEM education and bringing the African indigenous knowledge to the frontier of STEM teaching and learning. Full article

Phytophthora sojae is the causal agent of the Phytophthora root and stem rot in soybean, which has resulted in a significant increase in the incidence of the disease and substantial yield losses on a global scale. The proliferation of Phytophthora sojae can be mitigated through the development of Phytophthora-resistant soybean cultivars. A fundamental understanding of the genetic diversity and dynamic changes within the P. sojae population is essential for disease management and the development of new P. sojae-resistant varieties. Although a large number of pathogen samples can lead to more comprehensive interpretations and better conclusions, only six indigenous P. sojae isolates were available in the Republic of Korea at the time of the experiments. Due to the limited availability, this study preliminarily aimed to assess the pathotypes and genetic variation of the six P. sojae isolates collected in the Republic of Korea. The virulence patterns of all the six P. sojae isolates differed based on the 15 soybean differentials known for P. sojae resistance. The six isolates displayed high levels of pathotype complexities, ranging from 8 to 15, which is notably higher than those observed in other countries. Furthermore, 18 of the 21 simple sequence repeat markers used exhibited polymorphisms. The mean allele number (3.8) shows higher genetic variability compared to that (2.5) of isolates from the USA. The gene diversity (0.624) and the mean polymorphic information content (0.579) also displayed high levels of variation among the six isolates. A low mean heterozygosity (0.019) indicated a rare but possible outcrossing between the isolates, which was detected by the SSR marker PS07. Genetic dissimilarity assessments were employed to categorize the six P. sojae isolates into three groups using a neighbor-joining phylogenetic tree and principal component analysis. Although on a small scale, the phenotypic and genotypic assay results obtained indicated a significant variability in the pathotypes and genetic variation within the P. sojae isolates in the Republic of Korea. Though limited in scope, these results will be a cornerstone for elucidating the virulence pathotype and genetic diversity of the P. sojae population in future analyses. These findings also have the potential to improve the soybean breeding strategies aimed at enhancing resistance to P. sojae in the Republic of Korea. Full article

Salmon recovery planning in the Columbia River Basin depends upon what we argue are best practices of scenario planning in social–ecological systems. We examine how resilience science informs the concepts of stability landscapes and scenario mapping, and how this fits into the current state of salmonid recovery planning. We analyze proposed “scenarios” and “perspectives” that reflect the current state of the U.S. federal planning process for salmonid recovery. We argue that only proposed “scenarios” that adhere to best practices, employ the resilience perspective, and adopt holistic social–ecological thought can be mapped onto a stability landscape. We demonstrate how such scenarios have the potential to increase insight into the viability of proposed recovery actions and avoid self-contradictory efforts stemming from a failure to see the basin-wide social–ecological system as a whole. We discuss and illustrate the potential of employing backcasting and post-normal science in terms of indigenous perspectives on salmon recovery. Full article

Background/Objectives: The World Federation of the Deafblind Global Report 2023 reports that many countries do not have a comprehensive identification, assessment, and referral system for persons with deafblindness, a combination of hearing and vision loss, across all age groups and geographic regions. The scan seeks to inform researchers, policymakers, and community-based organizations about the status of and gaps in sensory healthcare initiatives in Canada, with the intent to raise awareness to enhance the integration and coordination of eye and ear care services. Methods: We conducted an environmental scan of Canada’s healthcare system and current public health policies addressing vision and hearing care in Canada at the federal and provincial levels. The scan was conducted using published literature searches from five scientific databases—Embase, Medline, PsycINFO, PubMed, and CINAHL—in combination with the gray literature review of federal, provincial, and territorial governments and non-profit organizations’ websites from April 2011–October 2022. Out of 1257 articles screened, 86 studies were included that met the inclusion/exclusion criteria. In total, 13 reports were included in the gray literature search, with 99 total articles used in the analysis. Results: The thematic findings indicate stigma and discrimination toward individuals with disabilities and marginalized communities (Indigenous people, rural communities, recent immigrants, people of older age, and people with disabilities), including hearing, vision, or dual sensory loss, persist. Barriers to vision and hearing healthcare access include inadequate policies, underinvestment in vision and/or hearing services, limited collaboration and coordinated services between hearing and vision services, discrepancies in insurance coverages, and lack of health system support. Conclusions: This scan demonstrates the persisting barriers to vision and/or hearing services present in Canada, stemming from inadequate policy and limited service coordination. Future work to address gaps, evaluate public education, and develop integrated sensory healthcare initiatives to enhance coordinated eye and ear care services, as recommended in the WHO Report on Hearing and Vision, is imperative. Full article

There are differences between Western mainstream culture and traditional Indigenous culture in the way they address sustainable development. The spirit of sustainability has been emphasized and practiced by Indigenous cultures for hundreds or even thousands of years, but it is increasingly disappearing over time due to the threat of natural disasters. It is necessary to recover this practice of sustainable development from its roots in traditional Indigenous knowledge. This study considers the possibility and utility of incorporating science, technology, engineering, and mathematics (STEM) into Indigenous education for sustainability, a topic that has not been addressed by other studies. Based on a literature review, the proposed framework and content for this study focus on Indigenous disaster prevention. The specific topic was chosen to be most relevant to young Indigenous children. STEM indicators from the US next-generation science standards (NGSS) were referenced to create the proposed STEM teaching objectives, which were designed to be specifically appropriate for Indigenous curricula and teaching activities. Additionally, the cultural curriculum model was adopted to reform the Indigenous curriculum and teaching model by utilizing the transformation and social action approaches. Finally, the five-stage learning cycle was used as the framework to implement the curriculum, intertwined with the principles of the spiral curriculum, to co-construct an instructional example of Indigenous education for sustainability for future reference. Full article

Since Norwegian compulsory education increasingly recognises Sámi rights and the Sámi as an Indigenous people, the question of how we can provide inclusive education for Sámi pupils by recognising Sámi culture in teaching remains. I argue in this literary research, that inclusive education, both as a concept and as a practice in school, stems from a pathological field, targeting individual needs, and therefore misses the target when educating pupils with an Indigenous cultural belonging. Inclusion as a concept centres on practices such as fellowship, participation, equal access, quality, equity and justice, but its legacy is anchored in individual needs, influencing how we think about inclusion and implementing inclusive measures. This way of thinking still guides the national strategy for inclusive education but will not be sufficient for Sámi pupils, since they, as a group, are not disabled. So-called inclusive measures will rather enhance the integration of Sámi pupils into the Norwegian framework of schooling defined by the majority’s expectations for fellowship, participation and so forth. While Indigenous inclusion takes integrative measures which uphold the status quo, thus dependent on a majority perspective, indigenising has an Indigenous baseline. I argue that non-Sámi society needs to re-contextualise itself towards the Sámi society if we want an education for all. Full article

Green space is needed in urban areas to increase resilience to climate change and other shocks, as well as for human health and wellbeing. Urban green space (UGS) is increasingly considered as green infrastructure and highly complementary to engineered urban infrastructure, such as water and transport networks. The needs for resilient, sustainable and equitable future wellbeing require strategic planning, designing and upgrading of UGS, especially in areas where it has been underprovided. We explore the implications of these needs for urban development through a detailed review of cited UGS analyses conducted on the larger cities in Aotearoa New Zealand (AoNZ). There are important differences in UGS availability (i.e., quantity), accessibility and quality within and between cities. Some of these differences stem from ad hoc patterns of development, as well as topography. They contribute to apparently growing inequities in the availability and accessibility of UGS. Broader health and wellbeing considerations, encompassing Indigenous and community values, should be at the heart of UGS design and decisionmaking. Most of AoNZ’s cities aim (at least to some extent) at densification and decarbonisation to accommodate a growing population without costly sprawl; however, to date, sprawl continues. Our findings indicate a clear need for the design and provision of high-quality, well-integrated UGS within and servicing areas of denser housing, which are typically areas in cities with a demonstrable UGS deficiency. Full article

The chemical composition of Sedum ewersii Ledeb., a plant indigenous to Kazakhstan and traditionally utilized in folk medicine, was comprehensively investigated, with a focus on its various plant parts. Fresh samples collected in May 2023 from the Almaty region underwent hydrodistillation to extract volatile components, followed by analysis using gas chromatography coupled with mass spectrometric detection, which identified a total of 71 compounds across different plant parts, including the root (underground part), root (aerial part), leaf, stem, and flowering aerial part. The predominant biologically active compound identified across all plant parts was Ethyl α-D-glucopyranoside. Monoterpenes, recognized as primary secondary metabolites, were notably abundant in each plant part, with varying compositions: the root (underground part) contained 28.58% aliphatic monoterpenes, 54.41% oxygenated monoterpenoids, 1.42% diterpenoids, and 15.59% other compounds; the root (aerial part) exhibited 1.34% aliphatic monoterpenes, 31.28% oxygenated monoterpenoids, 6.16% diterpenoids, and 61.22% other compounds; the stem and leaves showed 3.06% aliphatic monoterpenes, 21.49% oxygenated monoterpenoids, 17.99% diterpenoids, and 57.46% other compounds; and the flowering aerial part displayed 8.20% aliphatic monoterpenes, 53.18% oxygenated monoterpenoids, 23.75% diterpenoids, and 14.87% other compounds. Diterpenes, particularly Phytol, were prominently present in the leaf, stem, and flowering aerial parts. Additionally, a diverse array of organic acids, ketones, and phenolic compounds were identified across the plant parts, each potentially offering distinct pharmacological benefits. The presence of exclusive compounds in specific plant parts, such as Dihydroxyacetone in the root (aerial part), underscored the pharmacological diversity of S. ewersii. This study provides valuable insights into the chemical diversity and pharmacological potential of S. ewersii, suggesting promising applications in pharmaceutical and medicinal fields. Further research aimed at elucidating the individual and synergistic pharmacological effects of these compounds is crucial to fully harness the therapeutic benefits of this plant. Full article

Dust storms, which are common aversive occurrences in northern China, result from high winds, dry soil or dust, and soil surface disturbance. Exposure to dust storms, regardless of duration, can induce varying mental and physical distress levels. Recognizing the urgency of comprehending the impact of dust storms on residents and the scarcity of information on their effects on the indigenous civilians there, this study aims to address this gap by qualitatively sampling 29 participants from Beijing, a typical city in northern China. The current study seeks to gain insights into residents’ dust storm experiences and explore their perspectives on effective coping mechanisms. The findings align with existing knowledge regarding the mental and physical repercussions of dust storms while identifying some emerging patterns of coping mechanisms already employed by residents in Beijing. Concerns regarding mental well-being, either directly influenced by the environmental conditions or indirectly stemming from disruptions to life routines on a broader scale, persistently dominate people’s perceptions of dust storms. New themes emerged following the step-by-step exploration of feelings and coping mechanisms. This study aims to enlighten the public about the ramifications of the dust storms in Beijing and advocate for essential policy support. Full article