Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (12)

Search Parameters:
Keywords = ISDR

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
21 pages, 4546 KiB  
Article
The Spatiotemporal Dynamics of the Landscape of the Itombwe Nature Reserve and Its Periphery in South Kivu, the Democratic Republic of Congo
by Cléophace Bayumbasire Citwara, Trésor Mbavumoja Selemani, Julien Bwazani Balandi, Nadège Cizungu Cirezi, André Nduwimana, Léonard Mubalama Kakira, Kouagou Raoul Sambieni, Jean-Pierre Mate Mweru, Jean-François Bastin, Hervé Tchekote and Jan Bogaert
Land 2025, 14(4), 907; https://doi.org/10.3390/land14040907 - 21 Apr 2025
Viewed by 656
Abstract
This study examines the evolution of anthropogenic pressures on the Itombwe Nature Reserve and its periphery over the period 1990–2024 using satellite imagery. Two landscape ecology indices were employed: the Percentage of Landscape (PLAND) and the Largest Patch Index (LPI). The PLAND quantifies [...] Read more.
This study examines the evolution of anthropogenic pressures on the Itombwe Nature Reserve and its periphery over the period 1990–2024 using satellite imagery. Two landscape ecology indices were employed: the Percentage of Landscape (PLAND) and the Largest Patch Index (LPI). The PLAND quantifies the overall extent of each habitat type, while the LPI provides insights into their spatial configuration. Eighty-three plots (each 2.5 km per side, i.e., 6.25 km2) were sampled in both the reserve and its periphery to generate robust landscape replications. Analysis focused on three key land use classes: forests, savannahs, and fields. Statistical comparisons using Kruskal–Wallis and Mann-Whitney U tests revealed a decline in forest cover within the reserve and its periphery, accompanied by a steady increase in savannahs and fields. The decline in forest cover is particularly pronounced along the reserve’s periphery. For instance, in the reserve, forest cover decreased from 78.4% in 1990 to approximately 60.2% in 2024, whereas on the periphery, it dropped from 37.5% to about 21.4%. In contrast, the savannah areas increased from 17.7% to 29.5% within the reserve and maintained a marked predominance on the periphery (rising from 53.9% to 55.2%). Additionally, the area dedicated to fields exhibited notable expansion, rising from 3.70% to 10.22% in the reserve and from 7.54% to 21.98% along the periphery. These findings underscore the significant impacts of anthropogenic pressure on the forest ecosystems in both the reserve and its periphery. They highlight the urgent need for enhanced conservation measures within the reserve, as well as the implementation of sustainable land use practices (e.g., agroforestry and sustainable agriculture) in the peripheral zones to reduce the local population’s dependence on forest resources. Full article
Show Figures

Figure 1

13 pages, 4764 KiB  
Article
Impact of Soil Burial Depths on Survival of Weedy Rice Seeds: Implications for Weed Management
by Yu-Ge Tian, Li-Hao Pang, Xiao-Qi Jiang and Bao-Rong Lu
Agronomy 2024, 14(6), 1281; https://doi.org/10.3390/agronomy14061281 - 13 Jun 2024
Cited by 2 | Viewed by 1294
Abstract
Weedy rice (Oryza sativa f. spontanea) is a noxious weed infesting rice fields worldwide and causes great yield losses for cultivated rice. Effective management of this weed is essential for the world’s rice production. Yet, the management of weedy rice is [...] Read more.
Weedy rice (Oryza sativa f. spontanea) is a noxious weed infesting rice fields worldwide and causes great yield losses for cultivated rice. Effective management of this weed is essential for the world’s rice production. Yet, the management of weedy rice is challenging. One of the reasons is that shattered weedy rice seeds stored in soil often trigger great weed proliferation in the succeeding crop seasons. To study the survival of weedy rice seeds in soil seedbanks, we conducted 90-day soil burial experiments at different soil depths from 0–25 cm, using weedy rice seeds from Jiangsu Province in China. Results from two independent experiments under the rice field and laboratory conditions indicated significant differences in seed death ratios (SDRs) and induced seed dormancy ratios (ISDRs) of weedy rice at different soil burial depths. Weedy rice seeds exposed to the soil surface (0 cm burial treatment) had the highest SDRs and lowest ISDRs. An evident pattern of quickly declining SDRs with increased soil burial depths was identified from this study, suggesting rapid losses of seed viability on the surface and in shallow layers of soil. Our findings provide a useful guide for designing strategies to effectively control weedy rice by maintaining shattered seeds on the surface or in shallow layers of soil. The practices can easily be achieved through adopting the no-till farming system, which can substantially minimize viable weedy rice seeds as an important component in comprehensive weed management strategies. Full article
(This article belongs to the Special Issue Weed Biology and Ecology: Importance to Integrated Weed Management)
Show Figures

Figure 1

21 pages, 4883 KiB  
Article
Performance Analysis of a Portable Low-Cost SDR-Based Ionosonde
by Oleksandr Koloskov, Anton Kashcheyev, Oleksandr Bogomaz, Andriy Sopin, Bogdan Gavrylyuk and Andriy Zalizovski
Atmosphere 2023, 14(1), 159; https://doi.org/10.3390/atmos14010159 - 11 Jan 2023
Cited by 7 | Viewed by 3568
Abstract
This work presents a software-defined radio ionosonde (ISDR) developed at the Abdus Salam International Centre for Theoretical Physics (Italy) and the Institute of Radio Astronomy (Ukraine) and installed at the Ukrainian Antarctic Station in 2017. For the first time, the results of the [...] Read more.
This work presents a software-defined radio ionosonde (ISDR) developed at the Abdus Salam International Centre for Theoretical Physics (Italy) and the Institute of Radio Astronomy (Ukraine) and installed at the Ukrainian Antarctic Station in 2017. For the first time, the results of the long-term data comparison of the ISDR with the conventional ionosonde IPS-42 produced by KEL Aerospace are presented and discussed. The matching of the ionograms obtained during the whole year of 2021, as well as a comparison of the critical frequencies and virtual heights of F, E, and Es layers manually scaled from the ionograms showed that the ISDR has a similar level of performance to IPS-42. At the same time, the ISDR is a more versatile instrument that supports a bistatic operation, provides Doppler measurements and polarization information, and has a significantly lower cost and transmission power. Different configurations of the ISDR are considered. The basic configuration allows for using the ISDR as a conventional vertical ionospheric sounder. An enhanced configuration of the ISDR allows for oblique sounding, as well as polarization information that enables the O- and X-propagation modes of the ionospheric signal to be distinguished. The enhanced passive version of the ISDR was successfully tested onboard the research vessel “Noosfera” on distances up to 1,400 km from the transmitting ISDR. Full article
(This article belongs to the Special Issue Ionospheric Science and Ionosonde Applications)
Show Figures

Figure 1

18 pages, 4010 KiB  
Article
Intramedullary Skeletal Distraction Robot: Novel Design and Optimization of Implantable Lengthening Nail
by ShiKeat Lee, Zhenguo Nie, Handing Xu, Kai Hu, Hanwei Lin, Fugui Xie and Xin-jun Liu
Machines 2022, 10(10), 843; https://doi.org/10.3390/machines10100843 - 23 Sep 2022
Viewed by 2819
Abstract
Leg Length Discrepancy (LLD) is a critical problem which not only impacts the quality of life but also causes other physical ailments such as limping and severe back pain. Most people had a non-negligible difference in the length of their two legs, and [...] Read more.
Leg Length Discrepancy (LLD) is a critical problem which not only impacts the quality of life but also causes other physical ailments such as limping and severe back pain. Most people had a non-negligible difference in the length of their two legs, and 0.1% of the population with differences of 20 mm or more are diagnosed as a difference in limb length. The Ilizarov external fixator is commonly used in treating LLD as conventional therapeutic equipment, but often causes serious complications that cannot be prevented. Therefore, intramedullary leg-lengthening treatment has become popular in distraction osteogenesis to eliminate extracorporeal surgery. This paper presents a study on the design and optimization of a novel electromagnetic-driven Intramedullary Skeletal Distraction Robot (ISDR) with robust mechanical stiffness and surplus electromagnetic driving force. Compared with PRECICE, the split structure of ISDR eases the optimal design and manufacturing difficulties to strengthen mechanical stiffness, and the electromagnetic configuration allows improving the distraction force by adjusting the Permanent Magnet Brushless Direct Current (PMBLDC) motor parameters. ISDR, which is implanted in the medullary cavity, has the Von-Mises stress of 952.15 MPa, and the first mode of natural frequency is 28.823 Hz indicating that it can withstand the load during the walking gait phases. On the other hand, the ISDR distraction force encounters resistance from muscle fibers, and an average driving torque of 9 Nmm ensures its distraction. Based on the results, ISDR is proven secure and reliable during and after leg-lengthening treatment, which can significantly reduce lifestyle disruption and medical complications. Full article
(This article belongs to the Topic Advanced Electrical Machines and Drives Technologies)
Show Figures

Figure 1

21 pages, 4905 KiB  
Article
How Climate Change and Land Use/Land Cover Change Affect Domestic Water Vulnerability in Yangambi Watersheds (D. R. Congo)
by David Ushindi Chishugi, Denis Jean Sonwa, Jean-Marie Kahindo, Destin Itunda, Josué Bahati Chishugi, Fiyo Losembe Félix and Muhindo Sahani
Land 2021, 10(2), 165; https://doi.org/10.3390/land10020165 - 6 Feb 2021
Cited by 15 | Viewed by 4715
Abstract
In the tropics, the domestic water supply depends principally on ecosystem services, including the regulation and purification of water by humid, dense tropical forests. The Yangambi Biosphere Reserve (YBR) landscape is situated within such forests in the Democratic Republic of Congo (DRC). Surprisingly, [...] Read more.
In the tropics, the domestic water supply depends principally on ecosystem services, including the regulation and purification of water by humid, dense tropical forests. The Yangambi Biosphere Reserve (YBR) landscape is situated within such forests in the Democratic Republic of Congo (DRC). Surprisingly, given its proximity to the Congo River, the YBR is confronted with water issues. As part of its ecosystem function, the landscape is expected to reduce deterioration of water quality. However, environmental consequences are increasing due to conversion of its dense forest into other types of land use/land cover (LULC) in response to human activities. It is therefore important to check how the physicochemical quality parameters of water resources are influenced by landscape parameters—and to know if the population can adapt to this water vulnerability. To do this, we analyzed the watershed typology (including morphometric and LULC characteristics) and the physical and chemical parameters of water within the principal watershed’s rivers. We also analyzed data from surveys and the Yangambi meteorological station. We found that some landscape indices related to LULC significantly influence water quality deterioration in Yangambi. On average, each person in the Yangambi landscape uses 29–43 liters of water per day. Unfortunately, this falls short of World Health Organization standards regarding some parameters. The best fitted simple linear regression model explains the variation in pH as a function of edge density of perturbed forest, edge density of crop land and patch density of dense forest up to 94%, 92% and 90%, respectively. While many researchers have identified the consequences of climate change and human activities on these water resources, the population is not well-equipped to deal with them. These results suggest that water management policies should consider the specificities of the Yangambi landscape in order to develop better mitigation strategies for a rational management of water resources in the YBR in the context of climate change. Full article
(This article belongs to the Special Issue Impact of Land-Use Change on Water Resources)
Show Figures

Figure 1

23 pages, 4128 KiB  
Article
Multi-Risk Assessment and Management—A Comparative Study of the Current State of Affairs in Chile and Ecuador
by Stefan Greiving, Leonie Schödl, Karl-Heinz Gaudry, Iris Katherine Quintana Miralles, Benjamín Prado Larraín, Mark Fleischhauer, Myriam Margoth Jácome Guerra and Jonathan Tobar
Sustainability 2021, 13(3), 1366; https://doi.org/10.3390/su13031366 - 28 Jan 2021
Cited by 13 | Viewed by 6159
Abstract
In Chile and Ecuador, multiple hazards and dynamic processes in vulnerability pose a high risk. Spatial planning and emergency management can contribute to disaster risk management but they follow different goals. However, global goals, such as from UN-ISDR (United Nations International Strategy for [...] Read more.
In Chile and Ecuador, multiple hazards and dynamic processes in vulnerability pose a high risk. Spatial planning and emergency management can contribute to disaster risk management but they follow different goals. However, global goals, such as from UN-ISDR (United Nations International Strategy for Disaster Risk Reduction) and UN SDGs (Sustainable Development Goals) can potentially support cities and regions in defining concerted action. This paper aims at measuring the performance of Chile and Ecuador in regard to the aforementioned policy goals. Although both countries show considerable progresses in the implementation of the UN strategies, it is doubtful that the existing global monitoring approach is appropriately designed for measuring the real situation on the ground. Our paper is based on a desktop research combined with stakeholder workshops and expert interviews. Overall, both countries made considerable progress in regard to disaster preparedness and monitoring. However, multi-risks are rarely considered and there is still increasing vulnerability due to the expansion of informal settlements. The risk management is characterized by an imbalanced distribution of financial resources and institutional capacities between the metropolitan regions and smaller municipalities, and by low public participation and hardly community-based approaches. The paper underlines the importance for more qualitative, in-depth studies on the root causes of disaster risk which could complement the global monitoring which is very much focused on quantitative data and shows inconsistency between input and output indicators. Full article
Show Figures

Figure 1

22 pages, 4911 KiB  
Article
Living under a Fluctuating Climate and a Drying Congo Basin
by Denis Jean Sonwa, Mfochivé Oumarou Farikou, Gapia Martial and Fiyo Losembe Félix
Sustainability 2020, 12(7), 2936; https://doi.org/10.3390/su12072936 - 7 Apr 2020
Cited by 14 | Viewed by 4873
Abstract
Humid conditions and equatorial forest in the Congo Basin have allowed for the maintenance of significant biodiversity and carbon stock. The ecological services and products of this forest are of high importance, particularly for smallholders living in forest landscapes and watersheds. Unfortunately, in [...] Read more.
Humid conditions and equatorial forest in the Congo Basin have allowed for the maintenance of significant biodiversity and carbon stock. The ecological services and products of this forest are of high importance, particularly for smallholders living in forest landscapes and watersheds. Unfortunately, in addition to deforestation and forest degradation, climate change/variability are impacting this region, including both forests and populations. We developed three case studies based on field observations in Cameroon, the Central African Republic, and the Democratic Republic of Congo, as well as information from the literature. Our key findings are: (1) the forest-related water cycle of the Congo Basin is not stable, and is gradually changing; (2) climate change is impacting the water cycle of the basin; and, (3) the slow modification of the water cycle is affecting livelihoods in the Congo Basin. Developmental and environmental actions in the Congo Basin need to properly consider the slight modification of this water cycle in watersheds that affect products and services from the forest. Full article
(This article belongs to the Special Issue Sustainable Global Water Management)
Show Figures

Figure 1

10 pages, 933 KiB  
Article
Baseline Amino Acid Substitutions in the NS5A ISDR and PKR Binding Domain of Hepatitis C and Different Fibrosis Levels and Levels of Development of Hepatocellular Carcinoma in Patients Treated with DAAs
by Stefania Paolucci, Antonio Piralla, Federica Novazzi, Alice Fratini, Renato Maserati, Roberto Gulminetti, Stefano Novati, Giorgio Barbarini, Paolo Sacchi, Annalisa De Silvestri and Fausto Baldanti
Viruses 2020, 12(3), 255; https://doi.org/10.3390/v12030255 - 25 Feb 2020
Cited by 2 | Viewed by 2971
Abstract
Variations in the interferon sensitivity-determining region (ISDR) within the NS5A region were related to the development of hepatocellular carcinoma (HCC) in patients infected with hepatitis C virus (HCV). The aim of the study was to investigate a relationship between ISDR/PKR substitutions and their [...] Read more.
Variations in the interferon sensitivity-determining region (ISDR) within the NS5A region were related to the development of hepatocellular carcinoma (HCC) in patients infected with hepatitis C virus (HCV). The aim of the study was to investigate a relationship between ISDR/PKR substitutions and their association with liver fibrosis or HCC development. A total of 316 patients infected with HCV and treated with DAAs were evaluated. HCV RNA was quantified and sequenced before treatment. The liver fibrosis stage was assessed by transient elastography and equalized to METAVIR scores. Multivariate analysis showed that ≥3 substitutions in ISDR and ≥6 in PKR-bd were significantly associated with advanced fibrosis. Advanced fibrosis was observed in patients with higher substitutions in ISDR and PKR-bd. A higher correlation between advanced fibrosis and a high frequency of ≥3 substitutions in ISDR and ≥6 in PKR-bd was observed in patients infected with genotype 2c. In addition, in a higher proportion of HCC patients, advanced fibrosis (40.4% vs. 88.2%; p < 0.001) and ≥6 substitutions in PKR-bd (15.4% vs. 41.2%; p = 0.01) was observed. In conclusion, a higher number of substitutions in ISDR and PKR-bd were associated with advanced liver fibrosis, suggesting a use of like predictors for progression in the liver damage. A significantly higher number of PKR-bd substitutions was observed in HCC patients; in particular, in patients infected with HCV genotype 2c. Full article
(This article belongs to the Section Animal Viruses)
Show Figures

Figure 1

22 pages, 4169 KiB  
Article
Fragility Analysis of Concrete-Filled Steel Tubular Frame Structures with BRBs under Multiple Earthquakes Considering Strain Rate Effects
by Hao Zhang, Chao Li, Si-Meng Jiang, Peng-Fei Liu and Qing-Meng Gao
Appl. Sci. 2020, 10(1), 165; https://doi.org/10.3390/app10010165 - 24 Dec 2019
Cited by 5 | Viewed by 2741
Abstract
The fragility of concrete-filled steel tubular (CFST) frame structures with buckling-restrained braces (BRBs) subjected to multiple earthquakes is studied in this paper. First, a fiber beam element model with rate-dependent concrete and steel material properties is developed for CFST members and, then, the [...] Read more.
The fragility of concrete-filled steel tubular (CFST) frame structures with buckling-restrained braces (BRBs) subjected to multiple earthquakes is studied in this paper. First, a fiber beam element model with rate-dependent concrete and steel material properties is developed for CFST members and, then, the effect of the strain rate on the seismic response of the CFST frame structure is investigated numerically. The influence of BRBs on the seismic response of the CFST frame structure is then comparatively analyzed. The seismic responses of the CFST frame structure with BRBs under single mainshocks and earthquake sequences are investigated, and the fragility curves are generated using probabilistic seismic demand analysis. The obtained roof displacement and inter-story drift ratio (ISDR) of the structure decreased by 10.2% and 6.9%, respectively, when obtained while considering the strain rate effect, compared with those obtained without consideration of the strain rate effect. BRBs can effectively improve the seismic performance of the CFST frame structure in that the maximum roof displacement and ISDR can be reduced by 45.1% and 43.9%, respectively. Compared with those under single mainshocks, the maximum roof displacement and ISDR of the structure with BRBs under earthquake sequences significantly increase. The fragility of the BRB structure under earthquake sequences is more severe than that under single mainshocks. Therefore, the influences of the strain rate effect and earthquake sequence should be considered to realistically evaluate the seismic fragility of CFST structures. Full article
Show Figures

Figure 1

17 pages, 3465 KiB  
Article
Enhancing Target Speech Based on Nonlinear Soft Masking Using a Single Acoustic Vector Sensor
by Yuexian Zou, Zhaoyi Liu and Christian H. Ritz
Appl. Sci. 2018, 8(9), 1436; https://doi.org/10.3390/app8091436 - 23 Aug 2018
Cited by 8 | Viewed by 3171
Abstract
Enhancing speech captured by distant microphones is a challenging task. In this study, we investigate the multichannel signal properties of the single acoustic vector sensor (AVS) to obtain the inter-sensor data ratio (ISDR) model in the time-frequency (TF) domain. Then, the monotone functions [...] Read more.
Enhancing speech captured by distant microphones is a challenging task. In this study, we investigate the multichannel signal properties of the single acoustic vector sensor (AVS) to obtain the inter-sensor data ratio (ISDR) model in the time-frequency (TF) domain. Then, the monotone functions describing the relationship between the ISDRs and the direction of arrival (DOA) of the target speaker are derived. For the target speech enhancement (SE) task, the DOA of the target speaker is given, and the ISDRs are calculated. Hence, the TF components dominated by the target speech are extracted with high probability using the established monotone functions, and then, a nonlinear soft mask of the target speech is generated. As a result, a masking-based speech enhancement method is developed, which is termed the AVS-SMASK method. Extensive experiments with simulated data and recorded data have been carried out to validate the effectiveness of our proposed AVS-SMASK method in terms of suppressing spatial speech interferences and reducing the adverse impact of the additive background noise while maintaining less speech distortion. Moreover, our AVS-SMASK method is computationally inexpensive, and the AVS is of a small physical size. These merits are favorable to many applications, such as robot auditory systems. Full article
(This article belongs to the Special Issue Modelling, Simulation and Data Analysis in Acoustical Problems)
Show Figures

Figure 1

18 pages, 329 KiB  
Article
Intra-Individual Variability from a Lifespan Perspective: A Comparison of Latency and Accuracy Measures
by Delphine Fagot, Nathalie Mella, Erika Borella, Paolo Ghisletta, Thierry Lecerf and Anik De Ribaupierre
J. Intell. 2018, 6(1), 16; https://doi.org/10.3390/jintelligence6010016 - 14 Mar 2018
Cited by 30 | Viewed by 9147
Abstract
Within-task variability across trials (intra-individual variability (IIV)) has been mainly studied using latency measures but rarely with accuracy measures. The aim of the Geneva Variability Study was to examine IIV in both latency and accuracy measures of cognitive performance across the lifespan, administering [...] Read more.
Within-task variability across trials (intra-individual variability (IIV)) has been mainly studied using latency measures but rarely with accuracy measures. The aim of the Geneva Variability Study was to examine IIV in both latency and accuracy measures of cognitive performance across the lifespan, administering the same tasks to children, younger adults, and older adults. Six processing speed tasks (Response Time (RT) tasks, 8 conditions) and two working memory tasks scored in terms of the number of correct responses (Working Memory (WM)—verbal and visuo-spatial, 6 conditions), as well as control tasks, were administered to over 500 individuals distributed across the three age periods. The main questions were whether age differences in IIV would vary throughout the lifespan according (i) to the type of measure used (RTs vs. accuracy); and (ii) to task complexity. The objective of this paper was to present the general experimental design and to provide an essentially descriptive picture of the results. For all experimental tasks, IIV was estimated using intra-individual standard deviation (iSDr), controlling for the individual level (mean) of performance and for potential practice effects. As concerns RTs, and in conformity with a majority of the literature, younger adults were less variable than both children and older adults, and the young children were often the most variable. In contrast, IIV in the WM accuracy scores pointed to different age trends—age effects were either not observed or, when found, they indicated that younger adults were the more variable group. Overall, the findings suggest that IIV provides complementary information to that based on a mean performance, and that the relation of IIV to cognitive development depends on the type of measure used. Full article
(This article belongs to the Special Issue Cognitive Development and Individual Variability)
14 pages, 955 KiB  
Article
Effect of Hepatitis C Virus Genotype 1b Core and NS5A Mutations on Response to Peginterferon Plus Ribavirin Combination Therapy
by Shingo Nakamoto, Fumio Imazeki, Makoto Arai, Shin Yasui, Masato Nakamura, Yuki Haga, Reina Sasaki, Tatsuo Kanda, Hiroshi Shirasawa and Osamu Yokosuka
Int. J. Mol. Sci. 2015, 16(9), 21177-21190; https://doi.org/10.3390/ijms160921177 - 7 Sep 2015
Cited by 2 | Viewed by 5654
Abstract
We examined whether hepatitis C virus (HCV) genotype 1b core- and NS5A-region mutations are associated with response to peginterferon α-2b plus ribavirin combination therapy. A total of 103 patients with high HCV genotype 1b viral loads (≥100 KIU/mL) were treated with the combination [...] Read more.
We examined whether hepatitis C virus (HCV) genotype 1b core- and NS5A-region mutations are associated with response to peginterferon α-2b plus ribavirin combination therapy. A total of 103 patients with high HCV genotype 1b viral loads (≥100 KIU/mL) were treated with the combination therapy. Pretreatment mutations in the core region and interferon sensitivity determining region (ISDR) in the NS5A region were analyzed. In univariate analysis, arginine and leucine at positions 70 and 91 in the core region, defined as double wild (DW)-type, were associated with early virologic response (p = 0.002), sustained virologic response (SVR) (p = 0.004), and non-response (p = 0.005). Non-threonine at position 110 was associated with SVR (p = 0.004). Multivariate analysis showed the following pretreatment predictors of SVR: hemoglobin level ≥ 14 g/dL (odds ratio (OR) 6.2, p = 0.04); platelet count ≥ 14 × 104/mm3 (OR 5.2, p = 0.04); aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio < 0.9 (OR 6.17, p = 0.009); DW-type (OR 6.8, p = 0.02); non-threonine at position 110 (OR 14.5, p = 0.03); and ≥2 mutations in the ISDR (OR 12.3, p = 0.02). Patients with non-DW-type, non-threonine at position 110, and <2 ISDR mutations showed significantly lower SVR rates than others (11/45 (24.4%) vs. 27/37 (73.0%), respectively; p < 0.001). SVR can be predicted through core and NS5A region mutations and host factors like hemoglobin, platelet count, and AST/ALT ratio in HCV genotype 1b-infected patients treated with peginterferon and ribavirin combination therapy. Full article
(This article belongs to the Special Issue Viral Hepatitis Research)
Show Figures

Figure 1

Back to TopTop