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Search Results (3)

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Keywords = Homo-N-nucleoside

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24 pages, 29758 KB  
Review
Structure, Oligomerization and Activity Modulation in N-Ribohydrolases
by Massimo Degano
Int. J. Mol. Sci. 2022, 23(5), 2576; https://doi.org/10.3390/ijms23052576 - 25 Feb 2022
Cited by 8 | Viewed by 3494
Abstract
Enzymes catalyzing the hydrolysis of the N-glycosidic bond in nucleosides and other ribosides (N-ribohydrolases, NHs) with diverse substrate specificities are found in all kingdoms of life. While the overall NH fold is highly conserved, limited substitutions and insertions can account for differences in [...] Read more.
Enzymes catalyzing the hydrolysis of the N-glycosidic bond in nucleosides and other ribosides (N-ribohydrolases, NHs) with diverse substrate specificities are found in all kingdoms of life. While the overall NH fold is highly conserved, limited substitutions and insertions can account for differences in substrate selection, catalytic efficiency, and distinct structural features. The NH structural module is also employed in monomeric proteins devoid of enzymatic activity with different physiological roles. The homo-oligomeric quaternary structure of active NHs parallels the different catalytic strategies used by each isozyme, while providing a buttressing effect to maintain the active site geometry and allow the conformational changes required for catalysis. The unique features of the NH catalytic strategy and structure make these proteins attractive targets for diverse therapeutic goals in different diseases. Full article
(This article belongs to the Special Issue Protein Oligomerization)
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15 pages, 194 KB  
Article
Synthesis of Novel Homo-N-Nucleoside Analogs Composed of a Homo-1,4-Dioxane Sugar Analog and Substituted 1,3,5-Triazine Base Equivalents
by Qiang Yu, Dirk Schwidom, Alexander Exner and Per Carlsen
Molecules 2008, 13(12), 3092-3106; https://doi.org/10.3390/molecules13123092 - 10 Dec 2008
Cited by 6 | Viewed by 13490
Abstract
Enantioselective syntheses from dimethyl tartrate of 1,3,5-triazine homo-N-nucleoside analogs, containing a 1,4-dioxane moiety replacing the sugar unit in natural nucleosides, were accomplished. The triazine heterocycle in the nucleoside analogs was further substituted with combinations of NH2, OH and Cl [...] Read more.
Enantioselective syntheses from dimethyl tartrate of 1,3,5-triazine homo-N-nucleoside analogs, containing a 1,4-dioxane moiety replacing the sugar unit in natural nucleosides, were accomplished. The triazine heterocycle in the nucleoside analogs was further substituted with combinations of NH2, OH and Cl in the 2,4-triazine positions. Full article
(This article belongs to the Special Issue Nucleic Acids)
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13 pages, 301 KB  
Article
Enantioselective Synthesis of Homo-N-Nucleosides Containing a 1,4-Dioxane Sugar Analog
by Qiang Yu and Per Carlsen
Molecules 2008, 13(12), 2962-2974; https://doi.org/10.3390/molecules13122962 - 3 Dec 2008
Cited by 5 | Viewed by 10223
Abstract
A dioxane homo-sugar analog, (2S,5S)-and (2R,5S)-5-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-iodomethyl-1,4-dioxane was prepared from (2R,3R)-dimethyl tartrate, and further elaborated into the corresponding homo-N-nucleoside analogs by its reactions with uracil and adenine, respectively. Full article
(This article belongs to the Special Issue Nucleic Acids)
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