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Enantioselective Synthesis of Homo-N-Nucleosides Containing a 1,4-Dioxane Sugar Analog

Department of Chemistry, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway
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Molecules 2008, 13(12), 2962-2974; https://doi.org/10.3390/molecules13122962
Received: 3 September 2008 / Revised: 30 October 2008 / Accepted: 7 November 2008 / Published: 3 December 2008
(This article belongs to the Special Issue Nucleic Acids)
A dioxane homo-sugar analog, (2S,5S)-and (2R,5S)-5-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-iodomethyl-1,4-dioxane was prepared from (2R,3R)-dimethyl tartrate, and further elaborated into the corresponding homo-N-nucleoside analogs by its reactions with uracil and adenine, respectively. View Full-Text
Keywords: Sugar analog; Nucleoside analogs; Homo-N-Nucleoside; 1; 4-Dioxane; Hetero-cycles Sugar analog; Nucleoside analogs; Homo-N-Nucleoside; 1; 4-Dioxane; Hetero-cycles
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Yu, Q.; Carlsen, P. Enantioselective Synthesis of Homo-N-Nucleosides Containing a 1,4-Dioxane Sugar Analog. Molecules 2008, 13, 2962-2974.

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