Search Results (19)

Background: Ovarian carcinoma (OC) is one of the foremost factors in female carcinoma-related fatalities worldwide. Matrix metalloproteinases (MMPs) are key mediators of tissue remodeling and are linked to tumor aggressiveness, yet there is still a lack of information on the link between genetic changes in MMPs-1,3 and the onset and progression of OC in Egyptian women. This study examines the effects of immunoreactive biomolecule variations of MMPs-1,3, as well as the MMP-1 (1607 1G/2G) and MMP-3 (-1171 5A/6A) genetic variants, on OC risk and progression in Egyptian women. Methods: Tissue specimens embedded in paraffin from 100 OC patients and 60 controls were stained using immunohistochemistry to examine expression of MMPs-1,3. MMP levels were quantified using ELISA, and single-nucleotide polymorphisms (SNPs) of MMPs-1,3 were genotyped using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). Results: Increased levels of MMPs-1,3 in OC patients relative to controls, with more of an increase in the late stages (III and IV) than in the early OC stages (I and II). Additionally, the MMP-1 2G/2G and MMP-3 6A/6A genotypes were more prevalent in OC patients than in controls. Ovarian MMPs-1,3 were comparatively elevated in the identified genotypes compared to the 1G/1G and 5A/5A genotypes, respectively. The transcriptional activity of MMPs-1,3 showed strong potential for distinguishing patients with epithelial ovarian carcinoma (EOC) from controls, boasting an area under the curve (AUC) of 0.956 and 0.816, respectively. Sensitivity and specificity were 94.0% and 90.0% for MMP-1 and 80.0% and 73.3% for MMP-3, respectively. Conclusions: The MMP-1 2G/2G and MMP-3 6A/6A genotypes are correlated with elevated MMP-1 and MMP-3 levels and immunohistochemical expression in carcinomatous ovarian tissues, particularly in advanced stages of OC. This indicates that genetic variations of MMPs-1,3 could be valuable diagnostic and prognostic markers for OC in Egyptian women. Our findings may carry clinical relevance for optimizing OC therapeutic effectiveness, contribute to the growing body of knowledge on the role of MMPs, and shed new light on the genetic background of OC. Future studies with larger sample sizes and comprehensive MMP genetic profiling are needed for results validation. Full article

Background: Identifying physical activity (PA) and its barriers among middle-aged women may aid in the development of age-specific health promotion interventions. In Egypt, women, particularly those in the workforce, typically face numerous barriers that result in low levels of PA. This research seeks to assess the prevalence of health-enhancing physical activity (HEPA) among working women at Mansoura University and identify the associated barriers. Methods: This cross-sectional study employs a quantitative methodology that includes an analytic component. We studied a non-random sample of 760 Egyptian women employed at Mansoura University. Sociodemographic data were collected, and the international physical activity questionnaire (IPAQ) short form was used to assess the level of PA. Additionally, the Barriers to Being Active Quiz (BBAQ) was used to assess barriers to PA. Results: One-fourth of women engage in HEPA; 44.9% are classified as minimally active, while 30.1% are inactive. Multivariable logistic regression analysis showed the type of job is an independent predictor of HEPA, with ARR of 1.7 for manager and administrative roles. The total BBAQ score significantly predicts HEPA (ARR = 0.94). Social influences and lack of willpower scores are significant independent predictors of HEPA (ARR = 0.9 and 0.8, respectively). Most individuals encounter two to five barriers, with only 11.3% experiencing no PA barriers. The most frequently reported barrier is the lack of energy (80.4%), followed by the lack of resources, willpower, and time (74.04%, 69.6%, and 69.4%, respectively). Conclusions: The prevalence of HEPA is low among working women at Mansoura University. Policymakers can utilize findings to promote engagement with and adherence to physical activity. Full article

Textiles were ubiquitous in the elite Egyptian cultural sphere—from clothing, furniture coverings, and wall decorations to grave goods and temple offerings. The Egyptian world was draped in cloth, yet the producers were often marginalized members of society—immigrants, war captives, and women, who produced for a select few to whom they did not often belong. This paper aims to use textiles as a medium to investigate how the New Kingdom textile industry maintained social inequalities and power differentials. This paper highlights the efforts of marginalized labor in the production of textiles in New Kingdom Egypt, utilizing an intersectional approach to understand the interactions of the producers, varying levels of management, and elite consumers. Textiles were a high-value resource and one of the only goods that increased in value with labor, unlike other crafted goods, like metals, for example. I posit that this was inherently linked to the marginalization of the labor involved. The fabrics woven were a display of the Egyptian hegemony and reaffirmed the social order between the elites and the rest of society. Full article

Young women from urban Egypt are in a context of nutrition transition with a high prevalence of being overweight, excessive energy and sodium intakes, and insufficient iron, vitamin D, and folate intakes. This study, funded by Danone Nutricia Research, investigated the acceptability of dietary recommendations in young urban Egyptian women that have the potential to improve iron intake and nutrient adequacy. Individual interviews and focus groups were conducted in Cairo with 80 middle-class women aged 18–35 years (students, active women, and housewives). Perceived benefits and drawbacks for each recommended food were examined. Motivations and barriers to improving dietary practices were classified into major emerging themes. Analysis of the interviews showed that promoting the recommended foods would be met with both positive and negative feedback (e.g., a positive impact of fruit, vegetables, milk, or yogurt consumption on hair, nails, and skin appearance, and bad taste of vegetables). Motivations for improving dietary practices included the pursuit of aesthetical (e.g., attaining/maintaining body shape, clear skin, bright teeth, strong nails, silky and thick hair) and psychological (e.g., improved self-confidence and self-esteem) benefits. However, the “curative behavior” of the population targeted (i.e., changing dietary practices only when they face a serious issue), some life-stage-related factors (e.g., students and active women consuming most of their meals out-of-home), and sociocultural and economic factors (e.g., social gatherings, the high price of red meat) can constitute barriers for implementing a set of dietary recommendations. This work highlighted that, beyond socio-cultural and economic factors or curative or life-stage-motivated dieting, the pursuit of aesthetical and psychological benefits are essential factors that shape the acceptability of dietary changes. Full article

In patients with mandibular asymmetry, the volume of the mandible divided by the mandibular median plane is significantly larger on the non-deviated (N-Dev) side than on the deviated (Dev) side. However, it has been reported that there is no significant difference between the volumes of the N-Dev and Dev sides when the mandibular ramus and body are divided. The purpose of this study was to investigate which region is responsible for the volume difference between the N-Dev and Dev sides. Cone Beam Computed Tomography (CBCT) images of patients with mandibular asymmetry were analyzed by measuring the volume, and linear analysis of the mandibular body, ramus, and condyle on the N-Dev and Dev side was performed. In this study, CBCT images of 37 patients (8 Japanese, 16 Korean, and 13 Egyptian) aged ≥ 18 years with mandibular asymmetry (men: 20, women: 17) were used to evaluate mandibular asymmetry. In patients with mandibular asymmetry, the N-Dev side showed significantly larger values than the Dev side for both volume and linear condyle, ramus, and mandibular body measurements. These results do not differ according to sex or ethnicity. Therefore, it is suggested that the N-Dev side of mandibular asymmetry is large without any regional specificity in pathophysiology. Full article

(1) Background: Streptococcus agalactiae or Group B Streptococcus (GBS) causes severe neonatal infections with a high burden of disease, especially in Africa. Maternal vaginal colonization and perinatal transmissions represent the common mode of acquiring the infection. Development of an effective maternal vaccine against GBS relies on molecular surveillance of the maternal GBS population to better understand the global distribution of GBS clones and serotypes. (2) Methods: Here, we present genomic data from a collection of colonizing GBS strains from Ismailia, Egypt that were sequenced and characterized within the global JUNO project. (3) Results: A large proportion of serotype VI, ST14 strains was discovered, a serotype which is rarely found in strain collections from the US and Europe and typically not included in the current vaccine formulations. (4) Conclusions: The molecular epidemiology of these strains clearly points to the African origin with the detection of several sequence types (STs) that have only been observed in Africa. Our data underline the importance of continuous molecular surveillance of the GBS population for future vaccine implementations. Full article

Chin morphology is visually impactful and significantly influences harmonious facial appearance. Therefore, it is important to know the morphological characteristics of the chin in relation to gender and skeletal pattern when performing an orthodontic and surgical orthognathic treatment. This study aimed to examine the relationship between chin size, skeletal pattern, age, gender, and ethnicity. In this study, cone-beam computed tomography images of 208 participants (males: 90, females: 118; 63 Koreans and 145 Egyptians), aged 18 years and older, were used to evaluate the size of the chin in linear dimension, volume, and skeletal pattern. The larger the vertical skeletal pattern, the larger the chin volume and the smaller the width (p < 0.01). In the anteroposterior skeletal pattern, Class III showed a larger volume than that of Class II and Class I (p < 0.01). There was no significant association between age and any of the chin-related measurements. Regarding gender, all measurements of chins were larger for men than for women (p < 0.01). In terms of ethnicity, Koreans had larger chin volumes than Egyptians p < 0.01). Chin volume was related to population, sex, anteroposterior skeletal pattern, and vertical skeletal pattern, indicating the combined effects of various factors. Full article

The rise of Egyptian women artists and art teachers at the end of the 1940s appeared in tandem with an active women’s movement that asserted the agency of women in modern Egyptian public life. In this article, we discuss the art career of Menhat Helmy (1925–2004), a 1949 arts graduate of the ma`had al-ali li-ma`lumat al-funun al-jamila (Higher Institute for Women Teachers of the Fine Arts), located in the working-class district of Bulaq in Cairo, and who was among the first Egyptian graduates of the Slade School of Art in London. In a series of etchings executed from around 1956 and through the 1960s, Helmy produced a visual commentary on the dignity of Bulaq’s residents, with emphasis on the active presence of women in its neighborhood and public spaces. Helmy may be viewed in context with the feminism of her fellow women artists, including Gazbia Sirry (1925–2021) and Inji Efflatoun (1924–1986), and in relation to Efflatoun’s two books on feminist causes. As new professional artists and teachers, they advocated the promotion of education and vocational choice for women. Helmy’s choice of this neighborhood as a subject for art allows a comparison to theories about Bulaq’s development and its locus for the arts for which a multidisciplinary approach is required. Full article

In 2020, according to the publications of both the Global Cancer Observatory (GCO) and the World Health Organization (WHO), breast cancer (BC) represents one of the highest prevalent cancers in women worldwide. Almost 47% of the world’s 100,000 people are diagnosed with breast cancer, among females. Moreover, BC prevails among 38.8% of Egyptian women having cancer. Current deep learning developments have shown the common usage of deep convolutional neural networks (CNNs) for analyzing medical images. Unlike the randomly initialized ones, pre-trained natural image database (ImageNet)-based CNN models may become successfully fine-tuned to obtain improved findings. To conduct the automatic detection of BC by the CBIS-DDSM dataset, a CNN model, namely CoroNet, is proposed. It relies on the Xception architecture, which has been pre-trained on the ImageNet dataset and has been fully trained on whole-image BC according to mammograms. The convolutional design method is used in this paper, since it performs better than the other methods. On the prepared dataset, CoroNet was trained and tested. Experiments show that in a four-class classification, it may attain an overall accuracy of 94.92% (benign mass vs. malignant mass) and (benign calcification vs. malignant calcification). CoroNet has a classification accuracy of 88.67% for the two-class cases (calcifications and masses). The paper concluded that there are promising outcomes that could be improved because more training data are available. Full article

Breast cancer is an ancient disease recognized first by the Egyptians as early as 1600 BC. The first cancer-causing gene in a chicken tumor virus was found in 1970. The United States signed the National Cancer Act in 1971, authorizing federal funding for cancer research. Irrespective of multi-disciplinary approaches, diverting a great deal of public and private resources, breast cancer remains at the forefront of human diseases, affecting as many as one in eight women during their lifetime. Because of overarching challenges and changes in the breast cancer landscape, five-year disease-free survival is no longer considered adequate. The absence of a cure, and the presence of drug resistance, severe side effects, and destruction of the patient’s quality of life, as well as the fact that therapy is often expensive, making it unaffordable to many, have created anxiety among patients, families, and friends. One of the reasons for the failure of cancer therapeutics is that the approaches do not consider cancer holistically. Characteristically, all breast cancer cells and their microenvironmental capillary endothelial cells express asparagine-linked (N-linked) glycoproteins with diverse structures. We tested a small biological molecule, Tunicamycin, that blocks a specific step of the protein N-glycosylation pathway in the endoplasmic reticulum (ER), i.e., the catalytic activity of N-acetylglusosaminyl 1-phosphate transferase (GPT). The outcome was overwhelmingly exciting. Tunicamycin quantitatively inhibits angiogenesis in vitro and in vivo, and inhibits the breast tumor progression of multiple subtypes in pre-clinical mouse models with “zero” toxicity. Mechanistic details support ER stress-induced unfolded protein response (upr) signaling as the cause for the apoptotic death of both cancer and the microvascular endothelial cells. Additionally, it interferes with Wnt signaling. We therefore conclude that Tunicamycin can be expected to supersede the current therapeutics to become a glycotherapy for treating breast cancer of all subtypes. Full article

The 2011 Egyptian revolution was associated with significant political and social upheaval, followed by societal changes and attempts by policymakers to reduce the marginalisation of women and promote their inclusion in the economy. Drawing on this background, the authors compare the effect of board gender diversity before and after the revolution. Results indicate that gender diversity in corporate boards is coupled with improvements in firm performance in the immediate post revolution phase. This evidence provides insights into the contextual factors related to diversity and performance relationship and supporting arguments for regulatory changes to further encourage women’s representation on boards. Full article

Sūra 12 of the Qurʾān, Joseph, tells the story of the prophet Joseph. He is bought as a slave by an Egyptian high official, whose wife—tradition calls her Zulaykhā—makes an unsuccessful attempt to seduce him, and is ridiculed by her peers for her failure to do so. She invites them to a banquet, hands them knives, and presents Joseph before them. Upon seeing him, the women cut their hands with the knives they are holding (Qurʾān 12:31). According to the generally accepted exegetical view, they do so because they were so awestruck by Joseph’s beauty that they did not know what they were doing and accidentally cut their hands while thinking that they were cutting some food item, like fruit. Amīn Aḥsan Iṣlāḥī differs from this view. He argues that the women wished to succeed where Zulaykhā had failed, and, unable to persuade Joseph in the beginning, they threatened to kill themselves if Joseph would not listen to them, and, to convince Joseph that they were serious in carrying out the threat, they deliberately cut their hands with knives. This article gives details of Iṣlāḥīʾs interpretation of the Qurʾānic verse in question and discusses how that interpretation calls for re-evaluating some crucial aspects of the Qurʾānic story of Joseph. Full article

In the 1920s and 1930s, conceptions of the “New Woman” and Egyptomania shaped American culture. Employing methods of critical race art history and material culture studies, I focus on a 1925 Callot Soeurs dress and silk pajamas (c. 1920–1929), taking into consideration both the semiotic qualities of Egyptian motifs as they circulated in early twentieth century American visual culture as well as the sensuous material aspects of the garments. Through primary sources like cosmetic advertisements, fashion magazines, and costume manuals, I contextualize the figure of Cleopatra as a symbol of white beauty and power in this period. Weighing both visual and material aspects, I argue that the repeated act of wearing these garments by white-presenting women placed them in a performative valence, where the wearer ironically became a white woman through her appropriation of Cleopatra and Egyptian motifs. Further, these motifs conferred modernity, cosmopolitanism, class status and an acceptable sexuality upon the wearer. As such, I address how material objects shape subjectivity, simultaneously reflecting and producing racialized and gendered discourses. By focusing on white womanhood, I draw upon critical studies of whiteness in order to disrupt its invisible normative status. This essay traces its operational logic and aids in dismantling the pervasive power of white supremacy that continues to circulate today. Full article

Long non-coding RNAs play an important role in tumor growth, angiogenesis, and metastasis in several types of cancer. However, the clinical significance of using lncRNAs as biomarkers for breast cancer diagnosis and prognosis is still poorly investigated. In this study, we analyzed the serum expression levels of lncRNAs PVT1, HOTAIR, NEAT1, and MALAT1, and their associated proteins, PAI-1, and OPN, in breast cancer patients compared to fibroadenoma patients and healthy subjects. Using quantitative real-time PCR (qRT-PCR), we compared the serum expression levels of the four circulating lncRNAs in patients with breast cancer (n = 50), fibroadenoma (n = 25), and healthy controls (n = 25). The serum levels of PAI-1 and OPN were measured using ELISA. Receiveroperating-characteristic (ROC) analysis and multivariate logistic regression were used to evaluate the diagnostic value of the selected parameters. The serum levels of HOTAIR, PAI-1, and OPN were significantly higher in breast cancer patients compared to controls and fibroadenoma patients. The serum level of PVT1 was significantly higher in breast cancer patients than in the controls, while that of NEAT1 was significantly lower in breast cancer patients compared to controls and fibroadenoma patients. Both ROC and multivariate logistic regression analyses revealed that PAI-1 has the greatest power in discriminating breast cancer from the control, whereas HOTAIR, PAI-1, and OPN have the greatest power in discriminating breast cancer from fibroadenoma patients. In conclusion, our data suggest that the serum levels of PVT1, HOTAIR, NEAT1, PAI-1, and OPN could serve as promising diagnostic biomarkers for breast cancer. Full article

Since the 1980s, discourse on religious piety has taken many different forms, from mosque lessons by lay preachers—such as `Amr Khalid—to religious TV programmes and leisure activities. Within this widespread religious culture and cultivation of forms of visible piety, wearing the veil became an almost uncontested norm for women. As Saba Mahmood demonstrated, the veil became a crucial way to express and cultivate a ‘pious self’. Yet especially since the 2011 revolution and its aftermath, many young Egyptians started to question political, religious and patriarchal authorities. Amongst others, this took on open or hidden forms of non-believing, as well as a search for new forms of spirituality. Based on fieldwork and interviews, this contribution looks into the motives and experiences of women who decided to cast off the veil. In view of the hegemonic piety discourse, this is a huge issue, which is met by fierce reactions and accusations of immorality and non-belief. Whereas for some women this decision is an expression of religious doubt or a turn to a non-religious worldview, for others it is a way to contest the current piety discourse in a search for a more personal and spiritual connection with God. While the relationship with religion among my interlocutors might differ, they share a common attempt to uncover their ‘authentic selves’. By unveiling, they express their wish to define their own space and ideas regarding religion, gender and their bodies. Full article