Search Results (5)

The concentralized distribution logistics in cruise-building imported materials (CDL-CIMs) constitute a complex process that requires a high degree of coordination between the multi-link and multi-participator. Delayed delivery, materials damaged, and cost overruns occur because of increasing uncertainties and risks, which may cause disjointedness in cruise construction planning. Therefore, it is essential to conduct a risk assessment of the CDL-CIMs to examine their adverse impacts on cruise construction. Drawing on the advantages of the failure modes and effects analysis (FMEA) method in risk assessment, an effective and efficient model is developed using a novel hybrid method in this paper, namely the rule-based Bayesian network (RBN) and utility function. The approach has its superiorities in dealing with vague and uncertainty risk information. In addition, the risk parameters from multiple perspectives concerning “occurrence likelihood”, “detection”, “delayed schedule”, “damaged quality”, and “additional cost” facilitate the understanding of the risk characteristics of the CDL-CIMs. The applicability and robustness of the proposed method are demonstrated by an empirical study for the first cruise constructed in China. The results reveal that the highest-priority threats are the poor management for the actors in the logistics chain (MR1), human errors (MR5), limited storage ability and poor environment of warehouse (ER2), and ignorance of good handling practices during the operation of loading and unloading (OR2). The conclusion can provide insight into the implementation of risk response strategies for cruise-building logistics management in China and other countries. Full article

Magnetic/conducting polymeric hybrid core-shell typed zinc ferrite (ZnFe₂O₄)/poly(N-methyl aniline) (PMA) particles were fabricated and adopted as electrorheological (ER) and magnetorheological (MR) fluids, and their rheological properties were examined. Solvo-thermally synthesized ZnFe₂O₄ was coated with a conducting PMA through chemical oxidation polymerization. The size, shape, and chemical composition of the final core-shell shaped particles were scrutinized by scanning electron microscopy, transmission electron microscopy, and Fourier transform-infrared spectroscopy. The crystal faces of the particles before and after coating with PMA were analyzed by X-ray diffraction. The ZnFe₂O₄/PMA products were suspended in silicone oil to investigate the rheological response to electro- or magnetic stimuli using a rotating rheometer. The shear stresses were analyzed using the CCJ equation. The dynamic yield stress curve was suitable for the conductivity mechanism with a slope of 1.5. When magnetic fields of various intensities were applied, the flow curve was analyzed using the Hershel–Bulkley equation, and the yield stresses had a slope of 1.5. Optical microscopy further showed that the particles dispersed in insulating medium form chain structures under electric and magnetic fields. Via this core-shell fabrication process, not only spherical conducting particles were obtained but also their dual ER and MR responses were demonstrated for their wide potential applications. Full article

Breast cancer remains one of the most important health problems worldwide. The family of steroid receptors (SRs), which comprise estrogen (ER), progesterone (PR), androgen (AR), glucocorticoid (GR) and mineralocorticoid (MR) receptors, along with a receptor for a secosteroid—vitamin D, play a crucial role in the pathogenesis of the disease. They function predominantly as nuclear receptors to regulate gene expression, however, their full spectrum of action reaches far beyond this basic mechanism. SRs are involved in a vast variety of interactions with other proteins, including extensive crosstalk with each other. How they affect the biology of a breast cell depends on such factors as post-translational modifications, expression of coregulators, or which SR isoform is predominantly synthesized in a given cellular context. Although ER has been successfully utilized as a breast cancer therapy target for years, research on therapeutic application of other SRs is still ongoing. Designing effective hormone therapies requires thorough understanding of the molecular function of the SRs. Over the past decades, huge amount of data was obtained in multiple studies exploring this field, therefore in this review we attempt to summarize the current knowledge in a comprehensive way. Full article

Core-shell (C/S) structured upconversion coated Fe₃O₄ nanoparticles (NPs) are of great interest due to their potential as magnetic resonance imaging (MRI) and upconversion luminescent (UCL) imaging agents, as well as near-infrared activated photodynamic therapy (PDT) platforms. When C/S structured Fe₃O₄@Mn²⁺-doped NaYF₄:Yb/Er NPs were prepared previously, well-defined C/S-NPs could not be formed without the doping of Mn²⁺ during synthesis. Here, the role of Mn²⁺ doping on the synthesis of core-shell structured magnetic-upconversion nanoparticles (MUCNPs) is investigated in detail. Core-shell-shell nanoparticles (C/S/S-MUCNPs) with Fe₃O₄ as the core, an inert layer of Mn²⁺-doped NaYF₄ and an outer shell consisting of Mn²⁺-doped NaYF₄:Yb/Er were prepared. To further develop C/S/S-MUCNPs applications in the biological field, amphiphilic poly(maleic anhydride-alt-1-octadecene) (C₁₈PMH) modified with amine functionalized methoxy poly(ethylene glycol) (C₁₈PMH-mPEG) was used as a capping ligand to modify the surface of C/S/S-MUCNPs to improve biocompatibility. UCL imaging, T₁-weighted MRI ascribed to the Mn²⁺ ions and T₂-weighted MRI ascribed to the Fe₃O₄ core of C/S/S-MUCNPs were then evaluated. Finally, chlorine e6 (Ce6) was loaded on the C/S/S-MUCNPs and the PDT performance of these NPs was explored. Mn²⁺ doping is an effective method to control the formation of core-shell structured MUCNPs, which would be potential candidate as multifunctional nanoprobes for future T₁/T₂-weighted MR/UCL imaging and PDT platforms. Full article

Core-shell structured electrorheological (ER) and magnetorheological (MR) particles have attracted increasing interest owing to their outstanding field-responsive properties, including morphology, chemical and dispersion stability, and rheological characteristics of shear stress and yield stress. This study covers recent progress in the preparation of core-shell structured materials as well as their critical characteristics and advantages. Broad emphasises from the synthetic strategy of various core-shell particles to their feature behaviours in the magnetic and electric fields have been elaborated. Full article