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Keywords = Cinnamomum cassia

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14 pages, 3580 KiB  
Article
Cinnamomum cassia Alleviates Neuropsychiatric Lupus in a Murine Experimental Model
by Georges Maalouly, Youakim Saliba, Joelle Hajal, Anna Zein-El-Din, Luana Fakhoury, Rouaa Najem, Viviane Smayra, Hussein Nassereddine and Nassim Fares
Nutrients 2025, 17(11), 1820; https://doi.org/10.3390/nu17111820 - 27 May 2025
Viewed by 556
Abstract
Background: The pathogenesis of neuropsychiatric lupus erythematosus (NPSLE) is very complex and is associated with neuroinflammation and blood–brain barrier compromise. Experimental investigations of NPSLE have classically relied on spontaneous models. Recently, TLR7 agonist-induced lupus has been shown to exhibit similar neuropsychiatric manifestations to [...] Read more.
Background: The pathogenesis of neuropsychiatric lupus erythematosus (NPSLE) is very complex and is associated with neuroinflammation and blood–brain barrier compromise. Experimental investigations of NPSLE have classically relied on spontaneous models. Recently, TLR7 agonist-induced lupus has been shown to exhibit similar neuropsychiatric manifestations to spontaneous ones. Cinnamon is a widespread spice and natural flavoring agent. It has been proven to modulate vascular endothelial tight junctions, neuroinflammation, and autoimmunity pathways, but it has never been tested in relation to lupus. Hypothesis/Purpose: In this pilot study, we aimed to explore the disease-modifying effect of Cinnamomum cassia on NPSLE in a TLR7 agonist-induced model. Study Design: An experimental design was followed in this study. Methods: Lupus was induced in C57BL/6J female mice via the direct application of imiquimod, a TLR7 agonist (5% imiquimod cream, 1.25 mg three times weekly), to the skin. Mice were divided into five groups (n = 8 per group): a sham group (S), a sham group supplemented with cinnamon (SC), an imiquimod-treated group (L), an imiquimod-treated group supplemented with cinnamon starting from induction (LC), and an imiquimod-treated group supplemented with cinnamon beginning two weeks prior to induction (CLC). This protocol was followed for six consecutive weeks. Cinnamomum cassia powder was administered orally at 200 mg/kg, 5 days per week. Results: Behavioral alterations were significantly ameliorated in the CLC group compared to lupus mice. Neuronal shrinkage and nuclear chromatin condensation were visible in the hippocampal cornu ammonis and dentate gyrus zones of lupus mice, with an increased expression of TLR7 and NLRP3, versus significantly less neurodegeneration and TLR7 and NLRP3 expression in the CLC group. In addition, the expression of the blood–brain barrier endothelial cell tight junction proteins claudin-1, occludin, and ZO-1 was abnormally modified in lupus mice and was restored in the CLC group. Moreover, while the cell–cell border delocalization of claudin-1 was documented in cultured blood–brain barrier endothelial cells treated with the plasma of lupus mice to a punctate intracytoplasmic fluorescence pattern, only cells treated with the plasma of the CLC group exhibited a complete reversal of this redistribution of claudin-1. Finally, cinnamaldehyde seemed to interact with TLR7 at multiple sites. Conclusions:Cinnamomum cassia seems to alleviate the pathogenesis of NPSLE. Supplementation with Cinnamomum cassia could be of great interest to modulate the activity and severity of the disease. Full article
(This article belongs to the Section Nutritional Immunology)
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23 pages, 6834 KiB  
Article
Genetic Algorithm-Back Propagation Neural Network Model- and Response Surface Methodology-Based Optimization of Polysaccharide Extraction from Cinnamomum cassia Presl, Isolation, Purification and Bioactivities
by Qicong Chen, Wenqing Zhang, Yali Wang, Weifeng Cai, Qian Ni, Cuiping Jiang, Jiyu Li and Chunyan Shen
Foods 2025, 14(4), 686; https://doi.org/10.3390/foods14040686 - 17 Feb 2025
Cited by 3 | Viewed by 909
Abstract
Ultrasonic-assisted enzymatic extraction (UAEE) was utilized to obtain the polysaccharides from the bark of Cinnamomum cassia Presl. (C. cassia). Taking the yield of the crude polysaccharides from C. cassia (CCCP) as the assessment indicator, response surface methodology (RSM) and a genetic [...] Read more.
Ultrasonic-assisted enzymatic extraction (UAEE) was utilized to obtain the polysaccharides from the bark of Cinnamomum cassia Presl. (C. cassia). Taking the yield of the crude polysaccharides from C. cassia (CCCP) as the assessment indicator, response surface methodology (RSM) and a genetic algorithm-back propagation (GA-BP) artificial neural network model were employed to forecast and contrast the optimal parameters for UAEE. The outcomes demonstrated that the GA-BP model, which was superior in prediction accuracy and optimization capabilities to the RSM and BP models, identified the following conditions as optimal for the UAEE of CCCP: cellulase was employed, the temperature for enzymatic hydrolysis was 50.0 °C, the pH value was 5.248, the addition of enzyme was 3%, and the ultrasonic time was 70.153 min. Under these parameters, the yield of CCCP was significantly increased to 28.35%. Then, UAEE-extracted CCCP under optimal conditions was further separated and purified using a DEAE-52 column and SephadexG-100 column, yielding five purified polysaccharides from C. cassia (CCPs). All of these five fractions were acidic polysaccharides with safety at 3 mg/mL. The CCPs did not significantly affect the viability of HaCaT cells affected by UVB exposure. The CCPs demonstrated differential inhibition of nitric oxide production in RAW264.7 cells stimulated by lipopolysaccharide. Full article
(This article belongs to the Section Food Engineering and Technology)
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18 pages, 4100 KiB  
Article
Seasonal Variation in Chemical Composition and Antioxidant and Antibacterial Activity of Essential Oil from Cinnamomum cassia Leaves
by Yanrong Cheng, Ying Fu, Dingze Gu, Yan Huang, Yongqi Lu, Yujie Liu, Xiulan Li, Xinyue Yao, Xinxuan Zhang, Wanying Jian, Peiwei Liu, Hong Wu and Yanqun Li
Plants 2025, 14(1), 81; https://doi.org/10.3390/plants14010081 - 30 Dec 2024
Cited by 2 | Viewed by 1271
Abstract
Cinnamomum cassia has been extensively utilized in traditional medicine systems worldwide. The essential oil (EO) content and composition are influenced by various external and internal factors, such as climate and harvest season, making it vital to determine the optimal harvest period for high-quality [...] Read more.
Cinnamomum cassia has been extensively utilized in traditional medicine systems worldwide. The essential oil (EO) content and composition are influenced by various external and internal factors, such as climate and harvest season, making it vital to determine the optimal harvest period for high-quality EO production. This study is the first to evaluate the chemical profiles, as well as the antioxidant and antibacterial activities, of C. cassia leaf oil across the four seasons. GC–MS and FTIR analyses revealed significant seasonal variations in the components. Spring and autumn leaf oils contained the highest EO (2.20% and 1.95%, respectively) and trans-cinnamaldehyde (92.59% and 91.10%, respectively). Temperature and humidity primarily affected EO and trans-cinnamaldehyde accumulation. C. cassia leaf oil demonstrated the strongest antibacterial activity, with a minimum inhibitory concentration (MIC) of 0.25 mg/mL against S. aureus and L. monocytogenes for the spring oil. The MICs for the other three seasonal samples were 0.5 mg/mL for S. aureus, M. luteus, and L. monocytogenes, and 1.0 mg/mL for P. putida. The minimum bactericidal concentration (MBC) of the EOs across all seasons against S. aureus ranged from 0.5 to 1 mg/mL. Winter leaf oil exhibited high antioxidant activity, primarily due to the presence of cis-cinnamaldehyde, caryophyllene, humulene, alloaromadendrene, γ-muurolene, cis-bisabolene, o-methoxycinnamaldehyde, and phenolics. This study provides essential data and valuable references for optimizing resource utilization and determining the ideal harvest time for C. cassia leaves. Full article
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16 pages, 4377 KiB  
Article
Biochemical and Physiological Responses of Weeds to the Application of a Botanical Herbicide Based on Cinnamon Essential Oil
by Sofiene Ben Kaab, Juan Antonio Fernández Pierna, Berenice Foncoux, Philippe Compère, Vincent Baeten and M. Haïssam Jijakli
Plants 2024, 13(23), 3432; https://doi.org/10.3390/plants13233432 - 6 Dec 2024
Cited by 1 | Viewed by 1601
Abstract
The use of chemical herbicides induces negative impacts on the environment, animals, and human health. It also leads to the development of herbicide-resistant weeds. In this context, natural and efficacious herbicides are highly sought after. Essential oils are natural compounds with antibacterial, fungicidal, [...] Read more.
The use of chemical herbicides induces negative impacts on the environment, animals, and human health. It also leads to the development of herbicide-resistant weeds. In this context, natural and efficacious herbicides are highly sought after. Essential oils are natural compounds with antibacterial, fungicidal, and phytotoxic properties. For this reason, we studied the post-emergence phytotoxic effect of cinnamon essential oil (cinnamon EO) from Cinnamomum cassia under greenhouse conditions, testing it against Trifolium incarnatum (T. incarnatum) and Lolium perenne (L. perenne). The content of malondialdehyde (MDA), percentage of water loss, electrolyte leakage, and the fluorescence of treated leaves by cinnamon EO were determined in order to understand the physiological and biochemical responses. In addition, transmission electron microscopy (TEM) was used to study the effect of cinnamon EO on cellular organelles in different tissues of T. incarnatum leaves. Results showed that cinnamon EO quickly induced oxidative stress in treated leaves by increasing MDA content, impacting membrane integrity and causing water loss. TEM observations confirmed the cell desiccation by cellular plasmolysis and showed an alteration of the membrane integrity and chloroplast damages. Moreover, Raman analysis confirms the disturbance of the plant metabolism by the disappearance of some scattering bands which correspond to primary metabolites. Through our finding, we confirm that cinnamon essential oil (EO) could be proposed in the future as a potential bioherbicide and a suitable source of natural phytotoxic compounds with a multisite action on weeds. Full article
(This article belongs to the Special Issue Biopesticides for Plant Protection)
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22 pages, 7698 KiB  
Article
2′-Hydroxycinnamaldehyde, a Natural Product from Cinnamon, Alleviates Ischemia/Reperfusion-Induced Microvascular Dysfunction and Oxidative Damage in Rats by Upregulating Cytosolic BAG3 and Nrf2/HO-1
by Yu-Hsuan Cheng, Chih-Yao Chiang, Chung-Hsin Wu and Chiang-Ting Chien
Int. J. Mol. Sci. 2024, 25(23), 12962; https://doi.org/10.3390/ijms252312962 - 2 Dec 2024
Cited by 3 | Viewed by 1401
Abstract
2′-Hydroxycinnamaldehyde (HCA), a natural product isolated from the bark of Cinnamomum cassia, has anti-inflammatory and anti-tumor activities. In this study, we explored whether HCA preconditioning could protect the heart against ischemia/reperfusion (I/R)-induced oxidative injury through cytosolic Bcl-2-associated athanogene 3 (BAG3) upregulation. In [...] Read more.
2′-Hydroxycinnamaldehyde (HCA), a natural product isolated from the bark of Cinnamomum cassia, has anti-inflammatory and anti-tumor activities. In this study, we explored whether HCA preconditioning could protect the heart against ischemia/reperfusion (I/R)-induced oxidative injury through cytosolic Bcl-2-associated athanogene 3 (BAG3) upregulation. In vivo HCA preconditioning was performed intraperitoneally in adult male Wistar rats (50 mg/kg body weight) three times/week for 2 weeks before cardiac I/R injury. The animals were divided into sham control (sham), I/R, and HCA preconditioning plus I/R (HCA+I/R) groups. We examined left ventricular pressure cardiac hemodynamics, the microcirculation, electrocardiograms, infarct size, and oxidative stress and performed Western blots, immunohistochemistry, and cytokine array assays. HCA pretreatment, via BAG3 overexpression, inhibited H2O2-induced H9c2 cell death. Cardiac I/R injury increased ST-segment elevation, left ventricular end-diastolic pressure, infarct size, myocardial disruption, tissue edema, erythrocyte accumulation, leukocyte infiltration, reactive oxygen species, malondialdehyde, 8-isoprostane, caspase 3-mediated apoptosis, 4HNE/GPX4-mediated ferroptosis, and fibrosis but decreased the microcirculation, cytosolic BAG3, and Beclin-1/LC3 II-mediated autophagy in the I/R hearts. HCA preconditioning significantly decreased these oxidative injuries by increasing cardiac cytosolic BAG3 and Nrf2/HO-1 signaling. HCA preconditioning significantly decreased cardiac I/R-enhanced mitochondrial fission DRP1 expression. Our data suggest that HCA preconditioning can efficiently improve myocardial I/R injury-induced cardiac dysfunction, apoptosis, ferroptosis, mitochondrial fission, and autophagy inhibition through cardiac BAG3 and Nrf2/HO-1 upregulation. Full article
(This article belongs to the Section Molecular Pharmacology)
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9 pages, 276 KiB  
Communication
Sustainable Bacterial Control of Hatching Eggshells Using Essential Oils
by Igor Rafael Ribeiro Vale, Gabriel da Silva Oliveira, Luana Maria de Jesus, Marcio Botelho de Castro, Concepta McManus and Vinícius Machado dos Santos
Antibiotics 2024, 13(11), 1025; https://doi.org/10.3390/antibiotics13111025 - 31 Oct 2024
Cited by 1 | Viewed by 1253
Abstract
Background: Decontamination of poultry surfaces through appropriate hygiene and sanitation measures can partially mitigate bacterial problems, as this process does not result in the complete elimination of bacteria. Thus, the remaining bacteria can persist and contaminate eggshells. Therefore, regardless of the rigor of [...] Read more.
Background: Decontamination of poultry surfaces through appropriate hygiene and sanitation measures can partially mitigate bacterial problems, as this process does not result in the complete elimination of bacteria. Thus, the remaining bacteria can persist and contaminate eggshells. Therefore, regardless of the rigor of the sanitary standards applied on farms, it is suggested that hatching eggs be subjected to the sanitization process. Here, we investigated the effectiveness of essential oil-based antibacterial agents in sanitizing eggs. Results: The results indicated that essential oils from Cinnamomum cassia (L.) J. Presl. (CCEO), Syzygium aromaticum (L.) Merr. & L.M. Perry (SAEO) and Cymbopogon nardus (L.) Rendle (CNEO), at specific concentrations, have antibacterial effects in vitro, reducing the load of mesophilic bacteria and enterobacteria in the eggshell by at least 3 and 2 log10 CFU/mL, respectively. Conclusion: The adoption of CCEO, SAEO and CNEO to reduce the bacterial load on eggshells could be a favorable change to the conventional protocol of egg sanitization with formaldehyde, especially on farms where sanitary standards are insufficient. Full article
(This article belongs to the Special Issue The Search for Antimicrobial Agents from Natural Products)
19 pages, 3039 KiB  
Article
Rubber-Based Agroforestry Ecosystems Enhance Soil Enzyme Activity but Exacerbate Microbial Nutrient Limitations
by Wenxian Xu, Yingying Zhang, Ashar Tahir, Yumiao Cao, Changgeng Kuang, Xinwei Guo, Rui Sun, Wenjie Liu, Zhixiang Wu and Qiu Yang
Forests 2024, 15(10), 1827; https://doi.org/10.3390/f15101827 - 19 Oct 2024
Cited by 2 | Viewed by 1562
Abstract
Agroforestry ecosystems are an efficient strategy for enhancing soil nutrient conditions and sustainable agricultural development. Soil extracellular enzymes (EEAs) are important drivers of biogeochemical processes. However, changes in EEAs and chemometrics in rubber-based agroforestry systems and their mechanisms of action are still not [...] Read more.
Agroforestry ecosystems are an efficient strategy for enhancing soil nutrient conditions and sustainable agricultural development. Soil extracellular enzymes (EEAs) are important drivers of biogeochemical processes. However, changes in EEAs and chemometrics in rubber-based agroforestry systems and their mechanisms of action are still not fully understood. Distribution of EEAs, enzymatic stoichiometry, and microbial nutrient limitation characteristics of rubber plantations under seven planting patterns (RM, rubber monoculture system; AOM, Hevea brasiliensis-Alpinia oxyphylla Miq; PAR, Hevea brasiliensis-Pandanus amaryllifolius Roxb; AKH, Hevea brasiliensis-Alpinia katsumadai Hayata; CAA, Hevea brasiliensis-Coffea Arabica; CCA, Hevea brasiliensis-Cinnamomum cassia (L.) D. Don, and TCA, Hevea brasiliensis-Theobroma Cacao) were analyzed to investigate the metabolic limitations of microorganisms and to identify the primary determinants that restrict nutrient limitation. Compared with rubber monoculture systems, agroforestry ecosystems show increased carbon (C)-acquiring enzyme (EEAC), nitrogen (N)-acquiring enzyme (EEAN), and phosphorus (P)-acquiring enzyme (EEAP) activities. The ecoenzymatic stoichiometry model demonstrated that all seven plantation patterns experienced C and N limitation. Compared to the rubber monoculture system, all agroforestry systems exacerbated the microbial limitations of C and N by reducing the vector angle and increasing vector length. P limitation was not detected in any plantation pattern. In agroforestry systems, progression from herbs to shrubs to trees through intercropping results in a reduction in soil microbial nutrient constraints. This is primarily because of the accumulation of litter and root biomass in tree-based systems, which enhances the soil nutrient content (e.g., soil organic carbon, total nitrogen, total phosphorus, and ammonium nitrogen) and accessibility. Conversely, as soil depth increased, microbial nutrient limitations tended to become more pronounced. Partial least squares path modelling (PLS-PM) indicated that nutrient ratios and soil total nutrient content were the most important factors influencing microbial C limitation (−0.46 and 0.40) and N limitation (−0.30 and −0.42). This study presented novel evidence regarding the constraints and drivers of soil microbial metabolism in rubber agroforestry systems. Considering the constraints of soil nutrients and microbial metabolism, intercropping of rubber trees with arboreal species is recommended over that of herbaceous species to better suit the soil environment of rubber plantation areas on Hainan Island. Full article
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15 pages, 2881 KiB  
Article
Antidiabetic and Anti-Inflammatory Effect of Cinnamomum cassia Oil in Alloxan-Induced Diabetic Rats
by Paula Cordero-Pérez, Flor Edith Hernández-Cruz, Daniel Garza-Guzmán, Diana Patricia Moreno-Peña, Concepción Sánchez-Martínez, Liliana Torres-González, Linda E. Muñoz-Espinosa, Homero Zapata-Chavira, Idalia Cura-Esquivel, Marisol Idalí Serrano-Sandoval and Diana Raquel Rodríguez-Rodríguez
Pharmaceuticals 2024, 17(9), 1135; https://doi.org/10.3390/ph17091135 - 29 Aug 2024
Cited by 2 | Viewed by 2214
Abstract
Diabetes mellitus presents a great diversity of treatments that cause adverse effects; therefore, plants are a source of compounds that may have fewer adverse effects; Cinnamomum cassia (C. cassia) has compounds with potential antidiabetic activity. The objective was to evaluate the [...] Read more.
Diabetes mellitus presents a great diversity of treatments that cause adverse effects; therefore, plants are a source of compounds that may have fewer adverse effects; Cinnamomum cassia (C. cassia) has compounds with potential antidiabetic activity. The objective was to evaluate the antidiabetic effect of C. cassia oil (CCO) and its impact on oxidative stress in Wistar rats. Five groups were evaluated: (1) sham (SH), (2) 300 mg/kg CCO (CCO), (3) diabetic (D) induced with alloxan, (4) D + 300 mg/kg of CCO (D + CCO), and (5) D + 500 mg/kg of metformin (D + MET); all were treated for 5 days. CCO did not show alteration in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) vs. SH. D + CCO vs. D significantly reduced glucose (333 ± 109 vs. 458 ± 81 mg/dL), ALT (66 ± 15 vs. 160 ± 54 U/L), AST (119 ± 26 vs. 243 ± 104 U/L), and blood urea nitrogen (18.8 ± 2.3 vs. 29.2 ± 6.9 mg/dL). No significant changes were observed in D + CCO vs. D in malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD), whereas a significant reduction in MDA and GSH was achieved in D + MET, with an increase in SOD. There was a reduction in Rela and Gpx in D + CCO and D + MET vs. D. CCO has antidiabetic and anti-inflammatory effects and reduces ALT, AST, and BUN levels. Full article
(This article belongs to the Special Issue Discovery of Natural Products as Potential Antidiabetic Agents)
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15 pages, 2330 KiB  
Article
Antioxidant and Anti-Apoptotic Neuroprotective Effects of Cinnamon in Imiquimod-Induced Lupus
by Georges Maalouly, Christine-Marie-Anne Martin, Yara Baz, Youakim Saliba, Anna-Maria Baramili and Nassim Fares
Antioxidants 2024, 13(7), 880; https://doi.org/10.3390/antiox13070880 - 22 Jul 2024
Cited by 2 | Viewed by 2151
Abstract
Background: Despite accumulating evidence correlating oxidative stress with lupus disease activity, the brain redox pathways are still poorly investigated. Cinnamomum cassia, a widely used spice with powerful antioxidant properties, could be a novel therapeutic candidate in lupus. Methods: C57BL/6J female mice were divided [...] Read more.
Background: Despite accumulating evidence correlating oxidative stress with lupus disease activity, the brain redox pathways are still poorly investigated. Cinnamomum cassia, a widely used spice with powerful antioxidant properties, could be a novel therapeutic candidate in lupus. Methods: C57BL/6J female mice were divided into five groups: sham, sham-cinnamon, lupus, lupus-cinnamon starting from induction, and lupus-cinnamon starting two weeks before induction. Lupus was induced by skin application on the right ear with 1.25 mg of 5% imiquimod cream three times per week for six weeks. Cinnamomum cassia was given orally, five days per week, at 200 mg/kg. Results: Concomitant to TLR7-MYD88 pathway activation, the p-NRF2/NRF2 and p-FOXO3/FOXO3 ratios were increased in the hippocampus and alleviated by cinnamon treatment. BCL-2 positivity was enhanced in hippocampal neurons and reversed only by preventive cinnamon administration. In vitro, exposure of hippocampal cells to the plasma of different groups induced a surge in oxidative stress. This was associated with an increased t-BID/BID ratio. Cinnamon treatment, particularly in the preventive arm, normalized these modifications. Conclusions: Our study shows a neuroprotective effect of cinnamon by rescuing brain redox and apoptosis homeostasis in lupus, paving the way for its use as a natural therapeutic compound in the clinical management of lupus. Full article
(This article belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)
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18 pages, 11358 KiB  
Article
Study on Oleum cinnamomi Inhibiting Cutibacterium acnes and Its Covalent Inhibition Mechanism
by Huayong Peng, Chenliang Chu, Lu Jin, Jianing Zhang, Zilei Yang, Longping Zhu, Depo Yang and Zhimin Zhao
Molecules 2024, 29(13), 3165; https://doi.org/10.3390/molecules29133165 - 3 Jul 2024
Cited by 3 | Viewed by 1767
Abstract
Oleum cinnamomi (OCM) is a volatile component of the Cinnamomum cassia Presl in the Lauraceae family, which displays broad-spectrum antibacterial properties. It has been found that OCM has a significant inhibitory effect against Cutibacterium acnes (C. acnes), but the precise target [...] Read more.
Oleum cinnamomi (OCM) is a volatile component of the Cinnamomum cassia Presl in the Lauraceae family, which displays broad-spectrum antibacterial properties. It has been found that OCM has a significant inhibitory effect against Cutibacterium acnes (C. acnes), but the precise target and molecular mechanism are still not fully understood. In this study, the antibacterial activity of OCM against C. acnes and its potential effect on cell membranes were elucidated. Metabolomics methods were used to reveal metabolic pathways, and proteomics was used to explore the targets of OCM inhibiting C. acnes. The yield of the OCM was 3.3% (w/w). A total of 19 compounds were identified, representing 96.213% of the total OCM composition, with the major constituents being phenylpropanoids (36.84%), sesquiterpenoids (26.32%), and monoterpenoids (15.79%). The main component identified was trans-cinnamaldehyde (85.308%). The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of OCM on C. acnes were 60 µg/mL and 180 µg/mL, respectively. The modified proteomics results indicate that cinnamaldehyde was the main bioactive ingredient within OCM, which covalently modifies the ABC transporter adenosine triphosphate (ATP)-binding protein and nicotinamide adenine dinucleotide (NADH)-quinone oxidoreductase, hindering the amino acid transport process, and disrupting the balance between NADH and nicotinamide adenine dinucleoside phosphorus (NAD+), thereby hindering energy metabolism. We have reported for the first time that OCM exerts an antibacterial effect by covalent binding of cinnamaldehyde to target proteins, providing potential and interesting targets to explore new control strategies for gram-positive anaerobic bacteria. Full article
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16 pages, 24286 KiB  
Article
Exploring the Metabolic Effects of a Herbal Remedy of Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum cassia Extracts: Unraveling Its Therapeutic Potential as a Topical Application for Atopic Dermatitis Treatment
by Gakyung Lee, Byung Hwa Jung, Taemin Lee, Jae Hyeon Park, Hyung Sik Kim, Hocheol Kim and Hyun Ok Yang
Antioxidants 2024, 13(5), 563; https://doi.org/10.3390/antiox13050563 - 2 May 2024
Cited by 1 | Viewed by 2571
Abstract
Our previous study demonstrated that our novel herbal remedy, a mixture of Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum Cassia extracts, exhibits a therapeutic effect in 1-chloro-2,4-dinitrobenzene (DNCB)-induced mice by inhibiting the Th-2 inflammatory response upon oral administration. It also ameliorated imbalances [...] Read more.
Our previous study demonstrated that our novel herbal remedy, a mixture of Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum Cassia extracts, exhibits a therapeutic effect in 1-chloro-2,4-dinitrobenzene (DNCB)-induced mice by inhibiting the Th-2 inflammatory response upon oral administration. It also ameliorated imbalances in lipid metabolism related to the skin barrier function in keratinocytes, indicating its potential as a topical agent. This study aims to further investigate the therapeutic effects and metabolic mechanisms of its topical application. The anti-atopic effect was evaluated using dermatitis scores, histopathological analysis, and immune cell factors in DNCB-induced mice. Metabolomic profiling of serum and lesional skin was conducted to elucidate the metabolic mechanisms. The topical application significantly reduced dermatitis scores, mast cell infiltration, and serum levels of immunoglobulin E (IgE), IFN-γ, interleukin (IL)-4, IL-17, and thymic stromal lymphopoietin (TSLP), demonstrating its effectiveness in treating atopic dermatitis (AD). Serum metabolomics revealed alterations in fatty acid metabolism related to the pro-inflammatory response. In lesional skin, metabolic markers associated with oxidative stress, immune regulation, and AD symptoms were restored. This study demonstrated its potential as a topical agent in suppressing Th-2 inflammatory responses and improving metabolic abnormalities related to AD symptoms, providing crucial insights for developing natural AD treatments. Full article
(This article belongs to the Topic Plant Extracts and Their Therapeutic Effects)
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20 pages, 2799 KiB  
Article
Nuclear Magnetic Resonance Fingerprints and Mini DNA Markers for the Authentication of Cinnamon Species Ingredients Used in Food and Natural Health Products
by Subramanyam Ragupathy, Arunachalam Thirugnanasambandam, Varathan Vinayagam and Steven G. Newmaster
Plants 2024, 13(6), 841; https://doi.org/10.3390/plants13060841 - 14 Mar 2024
Cited by 1 | Viewed by 1935
Abstract
Cinnamomum verum (syn C. zeylanicum) is considered ‘true’ cinnamon. However, it is reported that less expensive sources of cinnamon from C. cassia (syn C. aromaticum), C. loureiroi, and C. burmannii (toxic coumarin) may be used in the place of C. [...] Read more.
Cinnamomum verum (syn C. zeylanicum) is considered ‘true’ cinnamon. However, it is reported that less expensive sources of cinnamon from C. cassia (syn C. aromaticum), C. loureiroi, and C. burmannii (toxic coumarin) may be used in the place of C. verum. We lack the quality assurance tools that are required to differentiate C. verum from other cinnamon species when verifying that the correct species is sourced from ingredient suppliers. The current research on cinnamon species authentication using DNA tools is limited to a few species and the use of high-quality DNA extracted from raw leaf materials. The cinnamon bark traded in the supply chain contains much less DNA and poorer-quality DNA than leaves. Our research advances DNA methods to authenticate cinnamon, as we utilized full-length chloroplast genomes via a genome skimming approach for C. burmannii and C. cassia to facilitate the design of optimal mini DNA markers. Furthermore, we developed and validated the use of NMR fingerprints for several commercial cinnamon species, including the quantification of 16 molecules. NMR fingerprints provided additional data that were useful for quality assessment in cinnamon extract powders and product consistency. Both the new mini DNA markers and NMR fingerprints were tested on commercial cinnamon products. Full article
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15 pages, 2085 KiB  
Article
Gastric Mucosal Protective Effects of Cinnamomum cassia in a Rat Model of Ethanol-Induced Gastric Injury
by Young-Min Han, Moon-Young Song, Da-Young Lee, Seung-Won Lee, Hye-Rin Ahn, Jihee Yoo, Hyo Jun Kim and Eun-Hee Kim
Nutrients 2024, 16(1), 55; https://doi.org/10.3390/nu16010055 - 23 Dec 2023
Cited by 3 | Viewed by 2943
Abstract
Cinnamomum cassia (cassia) is a tropical aromatic evergreen tree of the Lauraceae family well known for its fragrance and spicy flavor and widely used in Asian traditional medicine. It has recently garnered attention for its diverse potential health benefits, including anti-inflammatory, anti-cancer, and [...] Read more.
Cinnamomum cassia (cassia) is a tropical aromatic evergreen tree of the Lauraceae family well known for its fragrance and spicy flavor and widely used in Asian traditional medicine. It has recently garnered attention for its diverse potential health benefits, including anti-inflammatory, anti-cancer, and anti-diabetic properties. However, the gastroprotective effect of C. cassia, particularly against ethanol-induced gastric damage, remains unclear. We investigated the potential gastroprotective property of C. cassia and the underlying mechanisms of action in a rat model of ethanol-induced gastric injury. To assess its effectiveness, rats were fed C. cassia for a 14-day period prior to inducing gastric damage by oral administration of ethanol. Our results indicated that pre-treatment with C. cassia mitigated ethanol-induced gastric mucosal lesions and bleeding. Reduced gastric acid secretion and expression of acid secretion-linked receptors were also observed. Additionally, pretreatment with C. cassia led to decreased levels of inflammatory factors, including TNF-α, p-p65, and IκBα. Notably, C. cassia upregulated the expressions of HO1 and HSP90, with particular emphasis on the enhanced expression of PAS and MUC, the crucial gastric mucosa defense molecules. These findings suggest that C. cassia has protective effects on the gastric mucosa and can effectively reduce oxidative stress and inflammation. Full article
(This article belongs to the Section Phytochemicals and Human Health)
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14 pages, 1977 KiB  
Article
Essential Oils of Mentha arvensis and Cinnamomum cassia Exhibit Distinct Antibacterial Activity at Different Temperatures In Vitro and on Chicken Skin
by Iglė Vepštaitė-Monstavičė, Bazilė Ravoitytė, Jurga Būdienė, Algirdas Valys, Juliana Lukša and Elena Servienė
Foods 2023, 12(21), 3938; https://doi.org/10.3390/foods12213938 - 27 Oct 2023
Cited by 7 | Viewed by 3125
Abstract
The bacterial contamination of meat is a global concern, especially for the risk of Salmonella infection that can lead to health issues. Artificial antibacterial compounds used to preserve fresh meat can have negative health effects. We investigated the potential of natural essential oils [...] Read more.
The bacterial contamination of meat is a global concern, especially for the risk of Salmonella infection that can lead to health issues. Artificial antibacterial compounds used to preserve fresh meat can have negative health effects. We investigated the potential of natural essential oils (EOs), namely Mentha arvensis (mint) and Cinnamomum cassia (cinnamon) EOs, to prevent contamination of the food pathogen, Salmonella enterica subsp. enterica serotype Typhimurium, in vitro and on chicken skin. The gas chromatography–mass spectrometry (GC-MS) technique was used to determine the compositions of mint EO (MEO) and cinnamon EO (CEO); the most abundant compound in MEO was menthol (68.61%), and the most abundant compound was cinnamaldehyde (83.32%) in CEO. The antibacterial activity of MEO and CEO were examined in vapor and direct contact with S. typhimurium at temperatures of 4 °C, 25 °C, and 37 °C. The minimal inhibitory concentration at 37 °C for MEO and CEO reached 20.83 µL/mL, and the minimal bactericidal concentration of CEO was the same, while for MEO, it was two-fold higher. We report that in most tested conditions in experiments performed in vitro and on chicken skin, CEO exhibits a stronger antibacterial effect than MEO. In the vapor phase, MEO was more effective against S. typhimurium than CEO at 4 °C. In direct contact, the growth of S. typhimurium was inhibited more efficiently by MEO than CEO at small concentrations and a longer exposure time at 37 °C. The exploration of CEO and MEO employment for the inhibition of Salmonella bacteria at different temperatures and conditions expands the possibilities of developing more environment- and consumer-friendly antibacterial protection for raw meat. Full article
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Article
Astragalus membranaceus and Cinnamomum cassia Stimulate the Hair Follicle Differentiation-Related Growth Factor by the Wnt/β-Catenin Signaling Pathway
by Mi Hye Kim, Seong Chul Jin, Hee Kyung Baek and Woong Mo Yang
Curr. Issues Mol. Biol. 2023, 45(11), 8607-8621; https://doi.org/10.3390/cimb45110541 - 26 Oct 2023
Cited by 1 | Viewed by 3387
Abstract
Astragalus membranaceus and Cinnamomum cassia are used as spices and flavorful ingredients, or medicinal herbs with pharmacological effects. In this study, the hair-growth-promoting effects of the YH complex, a newly developed formula consisting of membranaceus and C. cassia, are investigated with [...] Read more.
Astragalus membranaceus and Cinnamomum cassia are used as spices and flavorful ingredients, or medicinal herbs with pharmacological effects. In this study, the hair-growth-promoting effects of the YH complex, a newly developed formula consisting of membranaceus and C. cassia, are investigated with the prediction of its molecular mechanism. The target gene of the YH complex was about 74.8% overlapped with the gene set of ‘Hair growth’ on the GO Biological Process database. The oral administration of the YH complex promoted hair regrowth and increased hair-shaft thickness in depilated hair loss mice. In addition, the anagen/telogen hair follicle ratio was significantly increased by the YH complex. The growth factors affecting the growth of hair follicles were dose-dependently increased by treatment with the YH complex. The Wnt/β-catenin signaling pathway expressions in skin tissues were apparently increased by the administration of the YH complex. In conclusion, the YH complex consisting of A. membranaceus and C. cassia induced hair follicle differentiation and preserved the growing-anagen phase by increasing growth factors and the Wnt/β-catenin signaling pathway, leading to the restoration of hair loss. The YH complex can be a remedy for hair loss diseases, such as alopecia areata, androgenetic alopecia, telogen effluvium, and chemotherapy-induced alopecia. Full article
(This article belongs to the Special Issue Natural Products and Their Biological Activities)
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