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Keywords = Callicarpa hypoleucophylla

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Article
Clerodane Diterpenoids from Callicarpa hypoleucophylla and Their Anti-Inflammatory Activity
by Yu-Chi Lin, Jue-Jun Lin, Shu-Rong Chen, Tsong-Long Hwang, Shu-Yen Fang, Michal Korinek, Ching-Yeu Chen, Yun-Sheng Lin, Tung-Ying Wu, Ming-Hong Yen, Chih-Hsin Wang and Yuan-Bin Cheng
Molecules 2020, 25(10), 2288; https://doi.org/10.3390/molecules25102288 - 13 May 2020
Cited by 18 | Viewed by 3938
Abstract
Plants of the genus Callicarpa are known to possess several medicinal effects. The constituents of the Taiwan endemic plant Callicarpa hypoleucophylla have never been studied. Therefore, C. hypoleucophylla was selected for our phytochemical investigation. Two new clerodane-type diterpenoids, named callihypolins A (1 [...] Read more.
Plants of the genus Callicarpa are known to possess several medicinal effects. The constituents of the Taiwan endemic plant Callicarpa hypoleucophylla have never been studied. Therefore, C. hypoleucophylla was selected for our phytochemical investigation. Two new clerodane-type diterpenoids, named callihypolins A (1) and B (2), along with seven known compounds were isolated from the leaves and twigs of the Lamiaceae plant C. hypoleucophylla and then characterized. The structures of compounds 1 and 2 were elucidated by spectroscopic data analysis, specifically, two-dimension nuclear magnetic resonance (NMR). The anti-inflammatory activity of compounds 19 based on the suppression of superoxide anion generation and elastase release was evaluated. Among the isolates, compounds 24 showed anti-inflammatory activity (9.52−32.48% inhibition at the concentration 10 μm) by suppressing superoxide anion generation and elastase release. Our findings not only expand the description of the structural diversity of the compounds present in plants of the genus Callicarpa but also highlight the possibility of developing anti-inflammatory agents from Callicarpa endemic species. Full article
(This article belongs to the Special Issue Food and Drug Analysis)
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