Search Results (12)

Fc gamma receptors (FcγRs) control humoral and cellular immune responses and maintain the immune system balance. Functional polymorphisms of FcγRs, whose prevalence was dependent on ethnic origin, were found to be associated with systemic lupus erythematosus (SLE) or kidney injuries in several ethnic groups. We aimed at investigating the association between the functional single-nucleotide polymorphisms (SNPs) of FcγRIIa-H131R (rs1801274), FcγRIIb-I232T (rs1050501), FcγRIIIa-V158F (rs396991) and FcγRIIIb variants (NA1 and NA2) and lupus erythematosus systemic in an indigenous African Caribbean population. We compared the frequencies of the functional SNPs of FCGR2A (FcγRIIa-H131R, rs1801274), FCGR2B (FcγRIIb-I232T, rs1050501), FCGR3A (FcγRIIIa-V158F, rs396991) and FCGR3B variants (FcγRIIIb NA1 and NA2) between lupus and healthy controls in an indigenous African Caribbean population. We highlighted an association between the FCGR3B-NA1/NA1 and FCGR3A-158F alleles and systemic lupus erythematosus, in addition to an association between FCGR2A-131R and lupus nephritis. Furthermore, an increase in the 131R-158V haplotype in lupus nephritis (30.4%) vs. lupus non-nephritis (15.8%) was noticed. Surprisingly, in spite of the high frequency of the FCGR2B-232T allele in our population, our study did not highlight any association of this allele either with SLE or lupus nephritis (a severe and frequent form of SLE). CD72-Hap1, which has been shown to confer resistance to SLE against T232 allele, was not enhanced in the control group. Our results emphasize an association between FCGR2A-131R and lupus nephritis with a distinctive FCGR polymorphism distribution in an indigenous African Caribbean population, confirming the important variation in the FCGR locus depending on ethnic origin. Full article

In African patriarchal contexts, women have borne the dual responsibilities of mental and physical caregiving for their households and communities. These responsibilities often contribute to significant emotional, social, and economic burdens imposed by deeply entrenched gender and power structures. Alternative psychological coping mechanisms emerge to navigate these challenges, some deeply rooted in cultural and historical practices. One such practice is soil eating, which has been observed in various African communities. Historically linked to cultural and spiritual beliefs, soil eating has been largely unexplored from a psychological perspective. This paper examined soil eating as a coping strategy among women in Africa, investigating its role as a means of emotional relief, resistance, or a symbolic reclamation of agency in the face of oppression. Drawing on the indigenous knowledge systems (IKS) of eZiko siPheka siSophula as a psychological framework, this study engaged sixteen women aged 20 to 89 in Ha Makintane Lesotho to participate in focus group discussions and reveal their personal narratives, cultural traditions, and the intersections of gender, race, and class to understand how this practice helps them manage their mental and emotional toll of patriarchal dominance. This research contributes to discussions on resilience, survival, and the psychological strategies developed by marginalized communities, shedding light on the complex interplay between cultural practices, mental health, and gendered experiences of power. Full article

Cassava/Yuca/Manioc: This staple of Indigenous Caribbean diets has gone from being decried for its danger and denigrated for its supposed inferiority to wheat by the early colonists, to being among the few foods that nourished slaves, to creolizing into postcolonial national dishes, and to being touted as a wonder food resistant to the climate disaster and dietary breakdowns that manifest the slow violence of the colonial project. Is the uplifting of cassava the rise of the Caribbean plot, the next step in neocolonial globalist expropriation of things Caribbean, or something of both? This paper traces discourses of cassava from the writings of early colonialists like Pere Labat through Caribbean cookbooks of the independence era where it was creolized with African, European, and Asian techniques and traditions and into postcolonial diasporic food writing and commercial projects from Carmeta’s Bajan food independence through contemporary global agriculture projects promoting cassava. Cassava/Yuca/Manioc, this paper argues, continues to be deterritorialized on a global scale at the same time as, in the Caribbean, it continues to nourish locally grounded persistence, adaptation, resistance, and thriving. Full article

The narrative of the colonisation of South Africa that prevailed and continues to prevail in certain segments of contemporary South African society is that of the white coloniser as an industrious, noble, peaceful and innocent being, divinely tasked with the project of bringing civilisation to the country’s indigenous Black tribal people—people bereft of religion, cognitive competence and incapable of responsible land ownership. In this article, I reflect on the genesis of anti-Blackness over three and a half centuries and argue that despite Black resistance over this period, the systematic orchestration of anti-Blackness through repressive violence, constantly morphing policy legislation and relentless propaganda machinery has imprinted on the psyche of South Africans in particular ways. Black academe in South Africa has been systematically frustrated with Western Eurocentric epistemologies and ontologies and struggle to engage in any substantive epistemological or ontological delinking. Inspiration from decolonial theory is invoked to offer an analysis of the paralysis of the new Black political, economic and academic elite, as they occupy a zone of being co-opted into the stranglehold of white economic and cultural hegemony. Full article

Antimicrobial resistance is considered a “One-Health” problem, impacting humans, animals, and the environment. The problem of the rapid development and spread of bacteria resistant to multiple antibiotics is a rising global health threat affecting both rich and poor nations. Low- and middle-income countries are at highest risk, in part due to the lack of innovative research on the surveillance and discovery of novel therapeutic options. Fast and effective drug discovery is crucial towards combatting antimicrobial resistance and reducing the burden of infectious diseases. African medicinal plants have been used for millennia in folk medicine to cure many diseases and ailments. Over 10% of the Southern African vegetation is applied in traditional medicine, with over 15 species being partially or fully commercialized. These include the genera Euclea, Ficus, Aloe, Lippia. And Artemisia, amongst many others. Bioactive compounds from indigenous medicinal plants, alone or in combination with existing antimicrobials, offer promising solutions towards overcoming multi-drug resistance. Secondary metabolites have different mechanisms and modes of action against bacteria, such as the inhibition and disruption of cell wall synthesis; inhibition of DNA replication and ATP synthesis; inhibition of quorum sensing; inhibition of AHL or oligopeptide signal generation, broadcasting, and reception; inhibition of the formation of biofilm; disruption of pathogenicity activities; and generation of reactive oxygen species. The aim of this review is to highlight some promising traditional medicinal plants found in Africa and provide insights into their secondary metabolites as alternative options in antibiotic therapy against multi-drug-resistant bacteria. Additionally, synergism between plant secondary metabolites and antibiotics has been discussed. Full article

The following case study clarifies how these three different functions of mission are discursively entangled with one another. Mission as a bridge-builder (between people, cultures, and religions of different origin), as a traitor (cooperating with corrupt colonial and imperial powers), and as a victim (finding misery and death on the mission field). Each of these three terms (bridge-builder, traitor, victim) is, to an extent, applicable to the events that took place during the night of 19–20 October 1896 in Akeri on the slopes of Mount Meru (former German East Africa, today Tanzania). Using the concept of entanglement history, I will analyze the death of two young German missionaries of the Lutheran Leipzig Mission, “caught in the crossfire” between the African community to be outreached and the German colonial military. We will see how various symbolic systems collide in the year 1896 at Akeri. The systems are represented by: (1) German Lutheran missions activities; (2) A German colonial and military expedition; and (3) The resistance of African Maasai societies’ leadership. “Akeri 1896” (I will continue to refer to this event specifically as “Akeri 1896” throughout the article) had become in the following 100 years a complex entanglement of metaphoric meanings. The same event can be a placeholder for victory, for defeat, for disaster, for martyrdom, for Christ-centredness (of the missionaries in their own perception), as well as for evil-centredness (the Africans in their perception of the Western foreigners). Full article

Helichrysum caespititium (DC.) Sond. Ex Harv., (Asteraceae) is a medicinal plant indigenous to South Africa. Its non-polar extracts exhibit significant antimicrobial and, in particular, antigonorrheal activity. This study aimed at isolating and purifying the active antigonorrheal compound from its chloroform extract and validating its inhibition potential on quorum sensing (QS) and biofilm formation of multi-drug resistant (MDR) pathogens. Phytochemical investigation of aerial parts of H. caespititium afforded a diterpene lactone (CF6). The effect of CF6 on violacein production and biofilm formation was studied using in vitro quantitative violacein inhibition (Chromobacterium violaceum) and biofilm formation (Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Neisseria gonorrhoeae, and Pseudomonas aeruginosa). The structure of CF6 was characterized using FTIR, NMR, and UPLC-MS data accordingly, as 10-methyl-8-(propan-17-ylidene)naphthalen-9-yl)-11-vinyl-14-hydroxyfuran-16-one. The susceptibility testing of the pathogens against CF6 revealed Neisseria gonorrhoeae was noticeably susceptible with a MIC value of 60 µg/mL, while Streptococcus pyogenes and Staphylococcus aureus showed MIC of 125 µg/mL. All gram-negative pathogens, Escherichia coli, Klebsiella pneumonia and Pseudomonas aeruginosa were inhibited at 250 µg/mL. CF6 also inhibited the production of violacein by 51.88% at 250 µg/mL and prevented cell attachment by 40.76–81.18%, with N. gonorrhoeae being highly prohibited from forming biofilm. In conclusion, 10-methyl-8-(propan-17-ylidene)naphthalen-9-yl)-11-vinyl-14-hydroxyfuran-16-one is the first of its kind to be isolated from the non-polar (chloroform) extract of South African Helichrysum caespititium with antigonorrheal, antimicrobial, antiquorum sensing, and antibiofilm properties. The compound may serve as a drug candidate against MDR pathogens. Full article

The bovine lymphocyte antigen (BoLA-DRB3) gene is an important region that codes for glycoproteins responsible for the initiation of an immune response. BoLA-DRB3 alleles have been demonstrated to be associated with disease resistance/tolerance. Therefore, great genetic diversity is correlated with better adaptation, fitness, and robustness. The current study was conducted to assess the population genetic structure of the BoLA-DRB3 gene in Nguni crossbred cattle using polymerase chain reaction-sequence based typing (PCR-SBT). High genetic diversity was detected, with 30 alleles, 11 of which are novel to the study. Alleles DRB3*0201, DRB3*0701, DRB*0901, and DRB*1601 were present in all populations and accounted for nearly around 50% of all observed alleles. A mean genetic diversity (H_E) of 0.93 was detected. The high overall genetic diversity is possibly associated with pathogen-assisted selection and heterozygote advantage. Such high diversity might explain the hardiness of the Nguni crossbred cattle to the Southern African region. Low population genetic structure was identified (F_ST = 0.01), suggesting possible gene flow between populations and retention of similar alleles. The study was undertaken to bridge the dearth of such studies in South African breeds and it is imperative for effective sustainability of indigenous breeds and the implementation of effective breeding strategies. Full article

During the first few decades of the 20th century, the Nkhoma mission of the Dutch Reformed Church of South Africa became involved in an ecumenical venture that was initiated by the Church of Scotland’s Blantyre mission, and the Free Church of Scotland’s Livingstonia mission in central Africa. Geographically sandwiched between these two Scots missions in Nyasaland (presently Malawi) was Nkhoma in the central region of the country. During a period of history when the DRC in South Africa had begun to regressively disengage from ecumenical entanglements in order to focus on its developing discourse of Afrikaner Christian nationalism, this venture in ecumenism by one of its foreign missions was a remarkable anomaly. Yet, as this article illustrates, the ecumenical project as finalized at a conference in 1924 was characterized by controversy and nearly became derailed as a result of the intransigence of white DRC missionaries on the subject of eating together with black colleagues at a communal table. Negotiations proceeded and somehow ended in church unity despite the DRC’s missionaries’ objection to communal eating. After the merger of the synods of Blantyre, Nkhoma and Livingstonia into the unified CCAP, distinct regional differences remained, long after the colonial missionaries departed. In terms of its theological predisposition, especially on the hierarchy of social relations, the Nkhoma synod remains much more conservative than both of its neighboring synods in the CCAP to the south and north. Race is no longer a matter of division. More recently, it has been gender, and especially the issue of women’s ordination to ministry, which has been affirmed by both Blantyre and Livingstonia, but resisted by the Nkhoma synod. Back in South Africa, these events similarly had an impact on church history and theological debate, but in a completely different direction. As the theology of Afrikaner Christian nationalism and eventually apartheid came into positions of power in the 1940s, the DRC’s Nkhoma mission in Malawi found itself in a position of vulnerability and suspicion. The very fact of its participation in an ecumenical project involving ‘liberal’ Scots in the formation of an indigenous black church was an intolerable digression from the normative separatism that was the hallmark of the DRC under apartheid. Hence, this article focuses on the variegated entanglements of Reformed Church history, mission history, theology and politics in two different 20th-century African contexts, Malawi and South Africa. Full article

Combretum erythrophyllum is an indigenous southern African tree species, a metal hyperaccumulator that has been used as a phytoextraction option for tailing dams in Johannesburg, South Africa. In hyperaccumulators, metal detoxification has also been linked or attributed to the activities of endophytes, and, in this regard, metal detoxification can be considered a form of endophytic behavior. Therefore, we report herein on the identification of proteins that confer heavy metal resistance, the in vitro characterization of heavy metal resistance, and the production of plant growth-promoting (PGP) volatiles by Methylobacterium radiotolerans MAMP 4754. Multigenome comparative analyses of M. radiotolerans MAMP 4754 against eight other endophytic strains led to the identification of zinc, copper, and nickel resistance proteins in the genome of this endophyte. The maximum tolerance concentration (MTC) of this strain towards these metals was also investigated. The metal-exposed cells were analyzed by transmission electron microscopy (TEM). The ethyl acetate and chloroform extracts (1:1 v/v) of heavy metal untreated M. radiotolerans MAMP 4754 were also screened for the production of PGP compounds by Gas Chromatography–Mass Spectroscopy (GC/MS). The MTC was recorded at 15 mM, 4 mM, and 12 mM for zinc, copper, and nickel, respectively. The TEM analysis showed the accumulation of metals in the intracellular environment of M. radiotolerans MAMP 4754, while the GC/MS analysis revealed several plant growth-promoting compounds, including alcohols, phthalate esters, alkenes, ketones, sulfide derivatives, phenols, and thiazoles. Our findings suggest that the genetic makeup of M. radiotolerans MAMP 4754 encodes heavy metal resistant proteins that indicate hyperaccumulator-specific endophytic behavior and the potential for application in bioremediation. The production of plant growth-promoting volatiles in pure culture by M. raditotolerans MAMP 4754 is a characteristic feature for plant growth-promoting bacteria. Full article

Indigenous sheep play an important role in the livelihoods of communal farmers in the Southern Africa Development Community (SADC), and this underlines the need to curb the genetic erosion of these valuable resources. This contribution reports that the phenotypic performance and genetics gains of institutional and commercial sheep in Southern Africa are well recorded. In contrast, there is a dearth of knowledge as far as the performance and genetic gains of indigenous ovine genetic resources utilized by smallholder farmers are concerned. High levels of genetic diversity have been observed in exotic breeds, whereas low levels of genetic diversity were found in the Zulu and Namaqua Afrikaner breeds. Phenotypic measurements for indigenous resources include linear measurements indicative of size and reproduction for Zulu sheep. Lamb survival, reproduction and resistance to ticks of the indigenous, fat-tailed Namaqua Afrikaner sheep, as well as growth and reproduction have also been recorded for Sabi and Landim sheep. This review discusses ways to sustainably utilize ovine genetic resources, which includes the suggested implementation of structured breeding and conservation programs, marketing, improving feed resources, health and diseases, as well as gender and age issues. Clearly, there is ample room for further research and development as far as the performance and improvement of African indigenous sheep are concerned. Full article

Botrytis cinerea is a fungus that causes gray mold on many fruit crops. Despite the availability of a large number of botryticides, the chemical control of gray mold has been hindered by the emergence of resistant strains. In this paper, tests were done to determine the botryticidal efficacy of selected plant extracts alone or combined with kresoxim-methyl. In total, eight South African medicinal plants viz Artemisia afra, Elyptropappus rhinocerotis, Galenia africana, Hypoxis hemerocallidea, Siphonochilus aetheopicus, Sutherlandia frutescens, Tulbaghia violacea and Tulbaghia alliacea were screened. Allium sativum, a plant species known to have antifungal activity, was included in the in vivo studies. For the in vitro studies, synergistic interactions between the plant extracts and the kresoxim-methyl fungicide were tested with radial growth assays. Data indicated synergistic inhibitory effects between the fungicide and the plant extracts. Next, different doses of plant extracts combined with kresoxim-methyl were used for decay inhibition studies on Granny Smith apples. Synergistic and additive effects were observed for many of the combinations. Even though this study was done using only one strain of B. cinerea, results showed that the tested indigenous South African plant species possess natural compounds that potentiate the activity of kresoxim-methyl. Full article