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Keywords = 2-arylbenzothiazoles

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13 pages, 248 KiB  
Article
Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products
by Yasmeen Gull, Nasir Rasool, Mnaza Noreen, Faiz-ul-Hassan Nasim, Asma Yaqoob, Shazia Kousar, Umer Rashid, Iftikhar Hussain Bukhari, Muhammad Zubair and Md. Saiful Islam
Molecules 2013, 18(8), 8845-8857; https://doi.org/10.3390/molecules18088845 - 25 Jul 2013
Cited by 23 | Viewed by 7386
Abstract
In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease [...] Read more.
In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC50 value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100µg/mL. Full article
(This article belongs to the Section Medicinal Chemistry)
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9 pages, 175 KiB  
Article
Green and Highly Efficient Synthesis of 2-Arylbenzothiazoles Using Glycerol without Catalyst at Ambient Temperature
by Kamal Usef Sadek, Ramadan Ahmed Mekheimer, Afaf Mohamed Abdel Hameed, Fatma Elnahas and Mohamed Hilmy Elnagdi
Molecules 2012, 17(5), 6011-6019; https://doi.org/10.3390/molecules17056011 - 18 May 2012
Cited by 39 | Viewed by 7121
Abstract
A one-pot and clean synthesis of 2-arylbenzothiazoles via the ambient temperature reaction of 2-aminothiophenols and aromatic aldehydes without catalyst in glycerol as a green solvent has been reported. Full article
(This article belongs to the Section Organic Chemistry)
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7 pages, 172 KiB  
Article
Cerium (IV) Ammonium Nitrate (CAN) Catalyzed One-pot Synthesis of 2-Arylbenzothiazoles
by Fawzia Al-Qalaf, Ramadan Ahmed Mekheimer and Kamal Usef Sadek
Molecules 2008, 13(11), 2908-2914; https://doi.org/10.3390/molecules13112908 - 24 Nov 2008
Cited by 51 | Viewed by 14455
Abstract
A one-pot synthesis of 2-arylbenzothiazoles from the reaction of 2-aminothiophenol and aromatic aldehydes catalysed by cerium (IV) ammonium nitrate (CAN) is reported. Full article
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