Search Results (8)

Biotechnology and artificial intelligence have sparked a revolution in dentistry, with a focus on restoring natural tissue functions. This transformation has given rise to bioactive materials, inspired by biomimetics, aimed at replicating the processes found in nature. As synthetic biology advances, there is a heightened focus on signaling systems crucial for bio-based diagnostics and therapeutics. Dentistry now harnesses synthetic proteins for tissue regeneration and dental material enhancement. A current research priority is bacterial biofilm inhibition, vital for dental health. Given the role of Streptococcus mutans in dental caries, the development of synthetic antimicrobial peptides targeting this bacterium is underway. The balance of dental enamel between demineralization and remineralization impacts caries formation. Factors such as the presence of hydroxyapatite and salivary peptides influence enamel health. Recent studies have spotlighted salivary protein-inspired peptides for enhanced remineralization. In the realm of bone regeneration, synthetic proteins like bone morphogenetic proteins (BMP) have been spotlighted, earning FDA approval. Research is currently delving into peptides such as cementum protein 1 peptide (CEMP-1-p1) and parathyroid hormone variants like PTH (1-34), underscoring their potential in advancing dental and bone health. Full article

Active vitamin D is a true steroid hormone with pleiotropic biological effects that go beyond the classical concept of bone metabolism regulation. In fact, adequate serum levels of 25-hydroxyvitamin D (>40 ng/mL) are required to support several biological functions, including the control of innate and adaptive immunity in course of infectious, inflammatory and autoimmune diseases. SARS-CoV-2 is responsible for the COVID-19 pandemic and deficient/insufficient serum levels of 25-hydroxyvitamin D are reported in very large cohorts of patients. Of note, vitamin D is involved in different pathophysiological processes, such as expression of SARS-CoV-2 receptor (ACE2), activation of innate (neutrophils with their extracellular traps, monocytes/macrophages, dendritic cells, natural killer cells) and adaptive (T and B lymphocytes) immune cells and clinical manifestations, such as coagulation/thrombotic disorders and acute respiratory distress syndrome. Randomized clinical trials regarding vitamin D supplementation in COVID-19 patients have shown favorable effects on the control of inflammation markers, arterial oxygen saturation/inspired fraction of oxygen ratio, admission to hospital intensive care units and mortality. A target of serum 25-hydroxyvitamin D > 50 ng/mL has been identified as protective for the course of COVID-19, potentially playing an ancillary role in the treatment of the disease. Full article

Visiting sacred spaces is becoming a growing trend in tourism in the Central Asian region. Sacred sites are said to have the power to heal the body, enlighten the mind, and inspire the heart. This study explored the motivations for visiting sacred spaces among tourists from three Central Asian countries—Kazakhstan, Kyrgyzstan, and Uzbekistan. The study used a sequential mixed methods research design. In the first stage, a general list of motivations was produced, based on the analysis of 14 semi-structured interviews. The second stage quantitative survey was conducted with a sample of 211 tourists from Central Asia. Data collection took place during tours to sacred sites in the city of Turkestan in South Kazakhstan. Data analysis included descriptive statistics, factor analysis, and regression analysis. The relationships between motivation factors and destination loyalty were tested. The results show that among the five motivational factors identified in this study, only three (Spiritual and Religious Motives, Cultural and Historical Motives, and Wellness and Healing) have a significant relationship with sacred site destination loyalty. The remaining two factors (Nature, Fun, and Social Contact) have not been proven to have a significant relationship with destination loyalty. The study adds value to the literature on traveling to religious sites, especially those in formerly atheist countries, and provides recommendations to practitioners and policymakers to enable them to develop a niche tourism area by segmenting tourists’ motivations and destination loyalty in their sacred places. It also contributes to the diversification of tourism products in those destinations that have historical religious heritage resources. Full article

Water-driven music technology has been one of the primary sources of human leisure from prehistoric times up until the present. Water powered, along with air pressure organs, have been used throughout history. One of them was an organ of fountains located inside a formal garden. Throughout ancient mythology, several different gods have been linked to music in many civilizations, in particular, Minoa, Mehrgarh, and Gandhara. Water deities were usually significant amid civilizations located next to a sea or an ocean, or even a great river like the Indus River in Pakistan, the Nile River in the Middle East or the Ganga River in India. These fountains performed a wide range of songs from Classical to contemporary Arabic, and even included other worldly music. The study of water-driven music technology demonstrates the diachronic evolution and the revelation that ancient people had impressive knowledge of the engineering needed for water exploitation and manipulation. This revelation is still both fascinating and intriguing for today’s water engineers. This paper also shows the relationship between water in nature and music, and furthermore, how nature has inspired composers throughout history. This research shows the sustainability of different kinds of water-driven musical instruments, not only through their use in past centuries, but their relevance in music therapy and other purposes of today. This study is useful for researchers in the fields of history, music, engineering and sustainable development. Full article

Crowdsourcing as a model for distributed problem solving has been rapidly gaining in popularity. In investigating what drives the solvers to participate in crowdsourcing, the extant research has one-dimensionally only viewed the origins of motivation. While these studies have revealed that crowdsourcing systems’ use is driven by both intrinsic and extrinsic motivations, they fall short of explaining how these motivations change over time from initial to continued use. To address this research gap, our study highlights the dynamic nature of human motivation and shows that by including the aims of motivation in the analysis, we can better capture the dynamic nature of motivation across time. With a case study of a photography crowdsourcing platform, we illustrate how the solvers’ motivations change from the initial use to sustained participation. While initial use seems to be inspired by selfish motivations, continued use requires both selfish and social motivations to be satisfied. This study contributes to theory by extending our understanding of the motivational factors driving the use of crowdsourcing systems by looking into both the origins and the aims of motivation together with the temporal dimension. It also contributes to practice by providing suggestions in terms of communication strategies for crowdsourcing organizers. Full article

The ability of natural systems to change functions in response to altered environmental conditions has inspired scientists during the last decades to fabricate smart materials that respond to different stimuli (e.g., temperature, ionic strength, light, mechanical stress, electromagnetic radiation, mechanical stress, chemical additives).[...] Full article

Inspired by the simplicity of how nature solves its problems, this paper presents a novel approach that would enable a swarm of ant robotic agents (robots with limited sensing, communication, computational and memory resources) form a visual representation of distributed hazardous substances within an environment dominated by diffusion processes using a decentralized approach. Such a visual representation could be very useful in enabling a quicker evacuation of a city’s population affected by such hazardous substances. This is especially true if the ratio of emergency workers to the population number is very small. Full article

It is my great pleasure to welcome you to a new open access journal, Robotics, which is dedicated to both the foundations of artificial intelligence, bio-mechanics, mechatronics and control theories, and the real-world applications of robotic perception, cognition and actions. This includes the innovative scientific trends, and discovery resulting from solving new challenges in the field of robotics. Its open access and rapid dissemination are the unique features separating this journal from all existing journals dedicated to robotics. [...] Full article