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Authors = Roberto Argazzi

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19 pages, 3633 KB  
Article
Evaluation of Anticancer Activity of Nucleoside–Nitric Oxide Photo-Donor Hybrids
by Elena Marchesi, Elisabetta Melloni, Fabio Casciano, Elena Pozza, Roberto Argazzi, Carmela De Risi, Lorenzo Preti, Daniela Perrone and Maria Luisa Navacchia
Molecules 2024, 29(14), 3383; https://doi.org/10.3390/molecules29143383 - 18 Jul 2024
Cited by 1 | Viewed by 1748
Abstract
Herein, we report the synthesis of a new hybrid compound based on a 2′-deoxyuridine nucleoside conjugated with a NO photo-donor moiety (dU-t-NO) via CuAAC click chemistry. Hybrid dU-t-NO, as well as two previously reported 2′-deoxyadenosine based hybrids (dAdo-S-NO and dAdo-t-NO), were evaluated for [...] Read more.
Herein, we report the synthesis of a new hybrid compound based on a 2′-deoxyuridine nucleoside conjugated with a NO photo-donor moiety (dU-t-NO) via CuAAC click chemistry. Hybrid dU-t-NO, as well as two previously reported 2′-deoxyadenosine based hybrids (dAdo-S-NO and dAdo-t-NO), were evaluated for their cytotoxic and cytostatic activities in selected cancer cell lines. dAdo-S-NO and dAdo-t-NO hybrids displayed higher activity with respect to dU-t-NO. All hybrids showed effective release of NO in the micromolar range. The photochemical behavior of the newly reported hybrid, dU-t-NO, was studied in the RKO colon carcinoma cell line, whereas the dAdo-t-NO hybrid was tested in both colon carcinoma RKO and hepatocarcinoma Hep 3B2.1-7 cell lines to evaluate the potential effect of NO released upon irradiation on cell viability. A customized irradiation apparatus for in vitro experiments was also designed. Full article
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16 pages, 3243 KB  
Article
Self-Assembled Multinuclear Complexes for Cobalt(II/III) Mediated Sensitized Solar Cells
by Edoardo Marchini, Stefano Caramori, Rita Boaretto, Vito Cristino, Roberto Argazzi, Alessandro Niorettini and Carlo Alberto Bignozzi
Appl. Sci. 2021, 11(6), 2769; https://doi.org/10.3390/app11062769 - 19 Mar 2021
Cited by 3 | Viewed by 2722
Abstract
In this work, we designed a tetranuclear self-assembled dye 4 (2Z907-Ag+-(Ru(TMAM))) exploiting a combination of the antenna effect and positively-charged groups designed to repel the oxidized form of cationic cobalt redox mediators, in order to reduce recombination and increase the efficiency [...] Read more.
In this work, we designed a tetranuclear self-assembled dye 4 (2Z907-Ag+-(Ru(TMAM))) exploiting a combination of the antenna effect and positively-charged groups designed to repel the oxidized form of cationic cobalt redox mediators, in order to reduce recombination and increase the efficiency of dye sensitized solar cells (DSSCs). Charge transfer and excited dynamics were probed by photoelectrochemical and photophysical measurements. The sensitized cell performance, recorded with a [Co(bpy)3]3+/2+ redox mediator and PEDOT counter electrode, showed an improvement when passing from Z907 to the multinuclear systems. The enhancement of the efficiency compared to Z907 resulted mainly from a superior steric and electrostatic shielding determined by the simultaneous presence of long alkyl chains and quaternary ammonia ion units in the architecture of 4. Full article
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14 pages, 4529 KB  
Article
Photoelectrochemical Behavior of Electrophoretically Deposited Hematite Thin Films Modified with Ti(IV)
by Nicola Dalle Carbonare, Rita Boaretto, Stefano Caramori, Roberto Argazzi, Maurizio Dal Colle, Luca Pasquini, Renzo Bertoncello, Marcello Marelli, Claudio Evangelisti and Carlo Alberto Bignozzi
Molecules 2016, 21(7), 942; https://doi.org/10.3390/molecules21070942 - 20 Jul 2016
Cited by 6 | Viewed by 6756
Abstract
Doping hematite with different elements is a common strategy to improve the electrocatalytic activity towards the water oxidation reaction, although the exact effect of these external agents is not yet clearly understood. Using a feasible electrophoretic procedure, we prepared modified hematite films by [...] Read more.
Doping hematite with different elements is a common strategy to improve the electrocatalytic activity towards the water oxidation reaction, although the exact effect of these external agents is not yet clearly understood. Using a feasible electrophoretic procedure, we prepared modified hematite films by introducing in the deposition solution Ti(IV) butoxide. Photoelectrochemical performances of all the modified electrodes were superior to the unmodified one, with a 4-fold increase in the photocurrent at 0.65 V vs. SCE in 0.1 M NaOH (pH 13.3) for the 5% Ti-modified electrode, which was the best performing electrode. Subsequent functionalization with an iron-based catalyst led, at the same potential, to a photocurrent of ca. 1.5 mA·cm−2, one of the highest achieved with materials based on solution processing in the absence of precious elements. AFM, XPS, TEM and XANES analyses revealed the formation of different Ti(IV) oxide phases on the hematite surface, that can reduce surface state recombination and enhance hole injection through local surface field effects, as confirmed by electrochemical impedance analysis. Full article
(This article belongs to the Special Issue Photocatalytic Water Splitting—the Untamed Dream)
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14 pages, 786 KB  
Article
Efficient Dye-Sensitized Solar Cells Using Red Turnip and Purple Wild Sicilian Prickly Pear Fruits
by Giuseppe Calogero, Gaetano Di Marco, Silvia Cazzanti, Stefano Caramori, Roberto Argazzi, Aldo Di Carlo and Carlo Alberto Bignozzi
Int. J. Mol. Sci. 2010, 11(1), 254-267; https://doi.org/10.3390/ijms11010254 - 20 Jan 2010
Cited by 233 | Viewed by 24863
Abstract
Dye-sensitized solar cells (DSSCs) were assembled by using the bougainvillea flowers, red turnip and the purple wild Sicilian prickly pear fruit juice extracts as natural sensitizers of TiO2 films. The yellow orange indicaxanthin and the red purple betacyanins are the main components [...] Read more.
Dye-sensitized solar cells (DSSCs) were assembled by using the bougainvillea flowers, red turnip and the purple wild Sicilian prickly pear fruit juice extracts as natural sensitizers of TiO2 films. The yellow orange indicaxanthin and the red purple betacyanins are the main components in the cocktail of natural dyes obtained from these natural products. The best overall solar energy conversion efficiency of 1.7% was obtained, under AM 1.5 irradiation, with the red turnip extract, that showed a remarkable current density (Jsc = 9.5 mA/cm2) and a high IPCE value (65% at λ = 470 nm). Also the purple extract of the wild Sicilian prickly pear fruit showed interesting performances, with a Jsc of 9.4 mA/cm2, corresponding to a solar to electrical power conversion of 1.26%. Full article
(This article belongs to the Special Issue Solar Cells)
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