Search Results (23)

New generation antibiotics are needed to combat the development of resistance to antimicrobials. One of the most promising new classes of antibiotics is cannabidiol (CBD). It is a non-toxic and low-resistance chemical that can be used to treat bacterial infections. The antibacterial activity of Cannabis sativa L. byproducts, specifically CBD, has been of growing interest in the field of novel therapeutics. As research continues to define and characterize the antibacterial activity that CBD possesses against a wide variety of bacterial species, it is important to examine potential interactions between CBD and common therapeutics such as broad-spectrum antibiotics. In this study it is demonstrated that CBD-antibiotic (combination of CBD and antibiotic) co-therapy can effectively fight Salmonella typhimurium (S. typhimurium) via membrane integrity disruption. This research serves to examine the potential synergy between CBD and three broad-spectrum antibiotics (ampicillin, kanamycin, and polymyxin B) for potential CBD-antibiotic co-therapy. In this study, it is revealed that S. typhimurium growth is inhibited at very low dosages of CBD-antibiotic. This interesting finding demonstrates that CBD and CBD-antibiotic co-therapies are viable novel alternatives to combating S. typhimurium. Full article

Glial fibrillary acidic protein (GFAP) is the major intermediate filament III protein of astroglia cells which is upregulated in traumatic brain injury (TBI). Here we reported that GFAP is truncated at both the C- and N-terminals by cytosolic protease calpain to GFAP breakdown products (GBDP) of 46-40K then 38K following pro-necrotic (A23187) and pro-apoptotic (staurosporine) challenges to primary cultured astroglia or neuron-glia mixed cells. In addition, with another pro-apoptotic challenge (EDTA) where caspases are activated but not calpain, GFAP was fragmented internally, generating a C-terminal GBDP of 20 kDa. Following controlled cortical impact in mice, GBDP of 46-40K and 38K were formed from day 3 to 28 post-injury. Purified GFAP protein treated with calpain-1 and -2 generates (i) major N-terminal cleavage sites at A-56*A-61 and (ii) major C-terminal cleavage sites at T-383*Q-388, producing a limit fragment of 38K. Caspase-6 treated GFAP was cleaved at D-78/R-79 and D-225/A-226, where GFAP was relatively resistant to caspase-3. We also derived a GBDP-38K N-terminal-specific antibody which only labels injured astroglia cell body in both cultured astroglia and mouse cortex and hippocampus after TBI. As a clinical translation, we observed that CSF samples collected from severe human TBI have elevated levels of GBDP-38K as well as two C-terminally released GFAP peptides (DGEVIKES and DGEVIKE). Thus, in addition to intact GFAP, both the GBDP-38K as well as unique GFAP released C-terminal proteolytic peptides species might have the potential in tracking brain injury progression. Full article

Due to resource restrictions related to the COVID-19 pandemic, many pediatric patients are facing substantial delays for surgery, potentially resulting in additional distress for caregivers. We aimed to assess the experiences and psychosocial distress of parents during COVID-19 as they relate to the pandemic, waiting for surgery, and the combined effects of both events. The was a cross-sectional qualitative study. Parents with children who faced treatment delays during the initial wave of the COVID-19 pandemic for elective, non-emergent procedures across a variety of surgical specialties were recruited. Semi-structured telephone interviews and thematic analysis were utilized. Thematic saturation was reached with eighteen participants. Four themes were identified: coping with COVID-19, distress levels, quality and nature of communication with the surgical team, and the experience of COVID-19 related hospital restrictions. Participants reported varying levels of distress due to the delay in surgery, such as the fear of developmental delay or disease progression for their child. They also indicated their own physical and mental health had been impacted by emotional distress related to both COVID-19 and delays in treatment. Most participants experienced the COVID-19-related hospital restrictions as distressing. This related predominantly to limiting in-hospital caregivers to only one caregiver. Participants were found to have substantial levels of psychosocial distress. Targeted social and emotional support may be helpful in reducing parental distress as the pandemic timeframe continues. Within the limits of individual health systems, reducing restrictions to the number of allowed care givers may help allay distress felt by parents. Full article

inVIVO Planetary Health (inVIVO) is a progressive scientific movement providing evidence, advocacy, and inspiration to align the interests and vitality of people, place, and planet. Our goal is to transform personal and planetary health through awareness, attitudes, and actions, and a deeper understanding of how all systems are interconnected and interdependent. Here, we present the abstracts and proceedings of our 8th annual conference, held in Detroit, Michigan in May 2019, themed “From Challenges, to Opportunities”. Our far-ranging discussions addressed the complex interdependent ecological challenges of advancing global urbanization, including the biopsychosocial interactions in our living environment on physical, mental, and spiritual wellbeing, together with the wider community and societal factors that govern these. We had a strong solutions focus, with diverse strategies spanning from urban-greening and renewal, nature-relatedness, nutritional ecology, planetary diets, and microbiome rewilding, through to initiatives for promoting resilience, positive emotional assets, traditional cultural narratives, creativity, art projects for personal and community health, and exploring ways of positively shifting mindsets and value systems. Our cross-sectoral agenda underscored the importance and global impact of local initiatives everywhere by contributing to new normative values as part of a global interconnected grass-roots movement for planetary health. Full article

With digital media, not only are media extensions of their human users, as McLuhan posited, but there is a flip or reversal in which the human users of digital media become an extension of those digital media as these media scoop up their data and use them to the advantage of those that control these media. The implications of this loss of privacy as we become “an item in a data bank” are explored and the field of captology is described. The feedback of the users of digital media become the feedforward for those media. Full article

We address the question of whether AI, and in particular the Singularity—the notion that AI-based computers can exceed human intelligence—is a fallacy or a great opportunity. We have invited a group of scholars to address this question, whose positions on the Singularity range from advocates to skeptics. No conclusion can be reached as the development of artificial intelligence is still in its infancy, and there is much wishful thinking and imagination in this issue rather than trustworthy data. The reader will find a cogent summary of the issues faced by researchers who are working to develop the field of artificial intelligence and in particular artificial general intelligence. The only conclusion that can be reached is that there exists a variety of well-argued positions as to where AI research is headed. Full article

It is argued that of Block’s (On a confusion about a function of consciousness, 1995; The Nature of Consciousness: Philosophical Debates, 1997) two types of consciousness, namely phenomenal consciousness (p-consciousness) and access consciousness (a-consciousness), that p-consciousness applies to all living things but that a-consciousness is uniquely human. This differs from Block’s assertion that a-consciousness also applies to some non-human organisms. It is suggested that p-consciousness, awareness, experience and perception are basically equivalent and that human consciousness has in addition to percept-based p-consciousness, concept-based a-consciousness, a verbal and conceptual form of consciousness that can be utilized to coordinate, organize and plan activities for rational decision-making. This argument is based on Logan’s (The Extended Mind: The Emergence of Language, The Human Mind and Culture, 1997) assertion that humans are uniquely capable of reasoning and rationality because they are uniquely capable of verbal language and hence the ability to conceptualize. Full article

Important aspects of human cognition are considered in terms of patterning, which we claim represents a shift from focusing on what is present to what is absent. We make use of Deacon’s notion of absentials and apply it to the patterning that underscores human cognition. Several important aspects of human cognition are considered that represent a shift from focusing on what is present to what is absent, namely, language as representing the transition from percept to concept-based thinking, mathematical grouping and patterning of items into sets that gave rise to verbal language, as well as imaginative thinking which is so critical for the development of the arts, mathematics and science. The connection between information and absence is also examined, in which we claim that information is an absential, paralleling an idea of Deacon’s. Full article

An analysis is made of Pope Francis’ Encyclical Laudato Si from a general systems approach. A call is made for a dialogue between theologians and environmental scientist. A parallel is found between the Pope’s identification of rapidification as a root cause of global warming and McLuhan’s notion of the speedup of modern life due to the emergence of electric technology. An analysis of Hebrew Scriptures is made, suggesting that rather than subduing the earth, the translation of Gen 1:28 seems to indicate that the intention was to occupy and tend the land. The Jewish notion of Bal Tashchit one of the 613 mitzvos or commandments from Scripture, supports this interpretation as it calls for stewardship of G-d’s gifts. Full article

We propose that the ability of humans to identify and create patterns led to the unique aspects of human cognition and culture as a complex emergent dynamic system consisting of the following human traits: patterning, social organization beyond that of the nuclear family that emerged with the control of fire, rudimentary set theory or categorization and spoken language that co-emerged, the ability to deal with information overload, conceptualization, imagination, abductive reasoning, invention, art, religion, mathematics and science. These traits are interrelated as they all involve the ability to flexibly manipulate information from our environments via pattern restructuring. We argue that the human mind is the emergent product of a shift from external percept-based processing to a concept and language-based form of cognition based on patterning. In this article, we describe the evolution of human cognition and culture, describing the unique patterns of human thought and how we, humans, think in terms of patterns. Full article

Given that consciousness is an essential ingredient for achieving Singularity, the notion that an Artificial General Intelligence device can exceed the intelligence of a human, namely, the question of whether a computer can achieve consciousness, is explored. Given that consciousness is being aware of one’s perceptions and/or of one’s thoughts, it is claimed that computers cannot experience consciousness. Given that it has no sensorium, it cannot have perceptions. In terms of being aware of its thoughts it is argued that being aware of one’s thoughts is basically listening to one’s own internal speech. A computer has no emotions, and hence, no desire to communicate, and without the ability, and/or desire to communicate, it has no internal voice to listen to and hence cannot be aware of its thoughts. In fact, it has no thoughts, because it has no sense of self and thinking is about preserving one’s self. Emotions have a positive effect on the reasoning powers of humans, and therefore, the computer’s lack of emotions is another reason for why computers could never achieve the level of intelligence that a human can, at least, at the current level of the development of computer technology. Full article

Making use of the techniques of media ecology we argue that the premise of the technological Singularity based on the notion computers will one day be smarter that their human creators is false. We also analyze the comments of other critics of the Singularity, as well supporters of this notion. The notion of intelligence that advocates of the technological singularity promote does not take into account the full dimension of human intelligence. They treat artificial intelligence as a figure without a ground. Human intelligence as we will show is not based solely on logical operations and computation, but also includes a long list of other characteristics that are unique to humans, which is the ground that supporters of the Singularity ignore. The list includes curiosity, imagination, intuition, emotions, passion, desires, pleasure, aesthetics, joy, purpose, objectives, goals, telos, values, morality, experience, wisdom, judgment, and even humor. Full article

We examine the spiral structure of the thinking and the work of Marshall McLuhan, which we believe will provide a new way of viewing McLuhan’s work. In particular, we believe that the way he reversed figure and ground, reversed content and medium, reversed cause and effect, and the relationship he established between the content of a new medium and the older media it obsolesced all contain a spiral structure going back and forth in time. Finally, the time structure of his Laws of Media in which a new medium obsolesced an older medium, while retrieving an even older medium and then when pushed far enough flipped into a still newer medium has the feeling of a spiral. We will also examine the spiral structure of the thinking and work of those thinkers and artists that most influenced McLuhan such as Vico, Hegel, Marx, Freud, Joyce, TS Eliot, Wyndham Lewis and the Vorticism movement. Full article