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Authors = René G. Heideman

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13 pages, 4273 KiB  
Communication
A Miniature Bio-Photonics Companion Diagnostics Platform for Reliable Cancer Treatment Monitoring in Blood Fluids
by Marianneza Chatzipetrou, Lefteris Gounaridis, George Tsekenis, Maria Dimadi, Rachel Vestering-Stenger, Erik F. Schreuder, Anke Trilling, Geert Besselink, Luc Scheres, Adriaan van der Meer, Ernst Lindhout, Rene G. Heideman, Henk Leeuwis, Siegfried Graf, Tormod Volden, Michael Ningler, Christos Kouloumentas, Claudia Strehle, Vincent Revol, Apostolos Klinakis, Hercules Avramopoulos and Ioanna Zergiotiadd Show full author list remove Hide full author list
Sensors 2021, 21(6), 2230; https://doi.org/10.3390/s21062230 - 23 Mar 2021
Cited by 13 | Viewed by 6877
Abstract
In this paper, we present the development of a photonic biosensor device for cancer treatment monitoring as a complementary diagnostics tool. The proposed device combines multidisciplinary concepts from the photonic, nano-biochemical, micro-fluidic and reader/packaging platforms aiming to overcome limitations related to detection reliability, [...] Read more.
In this paper, we present the development of a photonic biosensor device for cancer treatment monitoring as a complementary diagnostics tool. The proposed device combines multidisciplinary concepts from the photonic, nano-biochemical, micro-fluidic and reader/packaging platforms aiming to overcome limitations related to detection reliability, sensitivity, specificity, compactness and cost issues. The photonic sensor is based on an array of six asymmetric Mach Zender Interferometer (aMZI) waveguides on silicon nitride substrates and the sensing is performed by measuring the phase shift of the output signal, caused by the binding of the analyte on the functionalized aMZI surface. According to the morphological design of the waveguides, an improved sensitivity is achieved in comparison to the current technologies (<5000 nm/RIU). This platform is combined with a novel biofunctionalization methodology that involves material-selective surface chemistries and the high-resolution laser printing of biomaterials resulting in the development of an integrated photonics biosensor device that employs disposable microfluidics cartridges. The device is tested with cancer patient blood serum samples. The detection of periostin (POSTN) and transforming growth factor beta-induced protein (TGFBI), two circulating biomarkers overexpressed by cancer stem cells, is achieved in cancer patient serum with the use of the device. Full article
(This article belongs to the Special Issue Nanosensors for Biomedical Applications)
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33 pages, 11871 KiB  
Review
Hybrid Integrated Semiconductor Lasers with Silicon Nitride Feedback Circuits
by Klaus-J. Boller, Albert van Rees, Youwen Fan, Jesse Mak, Rob E. M. Lammerink, Cornelis A. A. Franken, Peter J. M. van der Slot, David A. I. Marpaung, Carsten Fallnich, Jörn P. Epping, Ruud M. Oldenbeuving, Dimitri Geskus, Ronald Dekker, Ilka Visscher, Robert Grootjans, Chris G. H. Roeloffzen, Marcel Hoekman, Edwin J. Klein, Arne Leinse and René G. Heideman
Photonics 2020, 7(1), 4; https://doi.org/10.3390/photonics7010004 - 21 Dec 2019
Cited by 116 | Viewed by 20549
Abstract
Hybrid integrated semiconductor laser sources offering extremely narrow spectral linewidth, as well as compatibility for embedding into integrated photonic circuits, are of high importance for a wide range of applications. We present an overview on our recently developed hybrid-integrated diode lasers with feedback [...] Read more.
Hybrid integrated semiconductor laser sources offering extremely narrow spectral linewidth, as well as compatibility for embedding into integrated photonic circuits, are of high importance for a wide range of applications. We present an overview on our recently developed hybrid-integrated diode lasers with feedback from low-loss silicon nitride (Si 3 N 4 in SiO 2 ) circuits, to provide sub-100-Hz-level intrinsic linewidths, up to 120 nm spectral coverage around a 1.55 μ m wavelength, and an output power above 100 mW. We show dual-wavelength operation, dual-gain operation, laser frequency comb generation, and present work towards realizing a visible-light hybrid integrated diode laser. Full article
(This article belongs to the Special Issue Semiconductor Laser Dynamics: Fundamentals and Applications)
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10 pages, 2310 KiB  
Article
Asymmetric Mach–Zehnder Interferometer Based Biosensors for Aflatoxin M1 Detection
by Tatevik Chalyan, Romain Guider, Laura Pasquardini, Manuela Zanetti, Floris Falke, Erik Schreuder, Rene G. Heideman, Cecilia Pederzolli and Lorenzo Pavesi
Biosensors 2016, 6(1), 1; https://doi.org/10.3390/bios6010001 - 6 Jan 2016
Cited by 56 | Viewed by 10682
Abstract
In this work, we present a study of Aflatoxin M1 detection by photonic biosensors based on Si3N4 Asymmetric Mach–Zehnder Interferometer (aMZI) functionalized with antibodies fragments (Fab′). We measured a best volumetric sensitivity of 104 rad/RIU, leading to a Limit [...] Read more.
In this work, we present a study of Aflatoxin M1 detection by photonic biosensors based on Si3N4 Asymmetric Mach–Zehnder Interferometer (aMZI) functionalized with antibodies fragments (Fab′). We measured a best volumetric sensitivity of 104 rad/RIU, leading to a Limit of Detection below 5 × 10−7 RIU. On sensors functionalized with Fab′, we performed specific and non-specific sensing measurements at various toxin concentrations. Reproducibility of the measurements and re-usability of the sensor were also investigated. Full article
(This article belongs to the Special Issue Optical Sensors for Biomedical Applications)
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