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Communication

A Miniature Bio-Photonics Companion Diagnostics Platform for Reliable Cancer Treatment Monitoring in Blood Fluids

1
Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, Heroon Polytehneiou 9, 15780 Athens, Greece
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Biomedical Research Foundation of the Academy of Athens, Soranou Ephessiou 4, 11527 Athens, Greece
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Future Diagnostic Solutions B.V., Nieuweweg 279, 6603 BN Wijchen, The Netherlands
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LioniX International B.V., P.O. Box 456, 7500 AL Enschede, The Netherlands
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SurfiX B.V., Plus Ultra Building—Bronland 12 B-1, 6708 WH Wageningen, The Netherlands
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CSEM SA, Untere Gründlistrasse 1, 6055 Alpnach, Switzerland
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LRE Medical, Hofer Strasse 5, 86720 Noerdlingen, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Ryoji Kurita
Sensors 2021, 21(6), 2230; https://doi.org/10.3390/s21062230
Received: 3 February 2021 / Revised: 13 March 2021 / Accepted: 17 March 2021 / Published: 23 March 2021
(This article belongs to the Special Issue Nanosensors for Biomedical Applications)
In this paper, we present the development of a photonic biosensor device for cancer treatment monitoring as a complementary diagnostics tool. The proposed device combines multidisciplinary concepts from the photonic, nano-biochemical, micro-fluidic and reader/packaging platforms aiming to overcome limitations related to detection reliability, sensitivity, specificity, compactness and cost issues. The photonic sensor is based on an array of six asymmetric Mach Zender Interferometer (aMZI) waveguides on silicon nitride substrates and the sensing is performed by measuring the phase shift of the output signal, caused by the binding of the analyte on the functionalized aMZI surface. According to the morphological design of the waveguides, an improved sensitivity is achieved in comparison to the current technologies (<5000 nm/RIU). This platform is combined with a novel biofunctionalization methodology that involves material-selective surface chemistries and the high-resolution laser printing of biomaterials resulting in the development of an integrated photonics biosensor device that employs disposable microfluidics cartridges. The device is tested with cancer patient blood serum samples. The detection of periostin (POSTN) and transforming growth factor beta-induced protein (TGFBI), two circulating biomarkers overexpressed by cancer stem cells, is achieved in cancer patient serum with the use of the device. View Full-Text
Keywords: analysis of blood serum; cancer therapy treatment monitoring; point of care; biosensor; optical sensor analysis of blood serum; cancer therapy treatment monitoring; point of care; biosensor; optical sensor
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MDPI and ACS Style

Chatzipetrou, M.; Gounaridis, L.; Tsekenis, G.; Dimadi, M.; Vestering-Stenger, R.; F. Schreuder, E.; Trilling, A.; Besselink, G.; Scheres, L.; van der Meer, A.; Lindhout, E.; G. Heideman, R.; Leeuwis, H.; Graf, S.; Volden, T.; Ningler, M.; Kouloumentas, C.; Strehle, C.; Revol, V.; Klinakis, A.; Avramopoulos, H.; Zergioti, I. A Miniature Bio-Photonics Companion Diagnostics Platform for Reliable Cancer Treatment Monitoring in Blood Fluids. Sensors 2021, 21, 2230. https://doi.org/10.3390/s21062230

AMA Style

Chatzipetrou M, Gounaridis L, Tsekenis G, Dimadi M, Vestering-Stenger R, F. Schreuder E, Trilling A, Besselink G, Scheres L, van der Meer A, Lindhout E, G. Heideman R, Leeuwis H, Graf S, Volden T, Ningler M, Kouloumentas C, Strehle C, Revol V, Klinakis A, Avramopoulos H, Zergioti I. A Miniature Bio-Photonics Companion Diagnostics Platform for Reliable Cancer Treatment Monitoring in Blood Fluids. Sensors. 2021; 21(6):2230. https://doi.org/10.3390/s21062230

Chicago/Turabian Style

Chatzipetrou, Marianneza, Lefteris Gounaridis, George Tsekenis, Maria Dimadi, Rachel Vestering-Stenger, Erik F. Schreuder, Anke Trilling, Geert Besselink, Luc Scheres, Adriaan van der Meer, Ernst Lindhout, Rene G. Heideman, Henk Leeuwis, Siegfried Graf, Tormod Volden, Michael Ningler, Christos Kouloumentas, Claudia Strehle, Vincent Revol, Apostolos Klinakis, Hercules Avramopoulos, and Ioanna Zergioti. 2021. "A Miniature Bio-Photonics Companion Diagnostics Platform for Reliable Cancer Treatment Monitoring in Blood Fluids" Sensors 21, no. 6: 2230. https://doi.org/10.3390/s21062230

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